Block, Steven M.

Direct observation of kinesin stepping by optical trapping interferometry

Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 1,910

Bead movement by single kinesin molecules studied with optical tweezers

Block, S. M., Goldstein, L. S. B., & Schnapp, B. J. (1990) · Nature

Microtubule and mitosis dynamicsOrbital Angular Momentum in Optics

Cited by 1,038

Single kinesin molecules studied with a molecular force clamp

Visscher, K., Schnitzer, M. J., & Block, S. M. (1999) · Nature

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 1,027

Force and velocity measured for single kinesin molecules

Svoboda, K., & Block, S. M. (1994) · Cell

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 909

Kinesin hydrolyses one ATP per 8-nm step

Schnitzer, M. J., & Block, S. M. (1997) · Nature

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 771

Force production by single kinesin motors

Schnitzer, M. J., Visscher, K., & Block, S. M. (2000) · Nature Cell Biology

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 572

Kinesin Moves by an Asymmetric Hand-Over-Hand Mechanism

Asbury, C. L., Fehr, A. N., & Block, S. M. (2003) · Science

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 511

Kinesin Motor Mechanics: Binding, Stepping, Tracking, Gating, and Limping

Block, S. M. (2007) · Biophysical Journal

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 338

Probing the kinesin reaction cycle with a 2D optical force clamp

Block, S. M., Asbury, C. L., Shaevitz, J. W., & Lang, M. J. (2003) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 295

Fluctuation analysis of motor protein movement and single enzyme kinetics.

Svoboda, K., Mitra, P. P., & Block, S. M. (1994) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsAdvanced Thermodynamics and Statistical Mechanics

Cited by 294

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

Valentine, M. T., Fordyce, P. M., Krzysiak, T. C., Gilbert, S. P., & Block, S. M. (2006) · Nature Cell Biology

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 260

A universal pathway for kinesin stepping

Clancy, B. E., Behnke-Parks, W. M., Andreasson, J. O. L., Rosenfeld, S. S., & Block, S. M. (2011) · Nature Structural & Molecular Biology

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 202

Stepping and Stretching

Rosenfeld, S. S., Fordyce, P. M., Jefferson, G. M., King, P. H., & Block, S. M. (2003) · Journal of Biological Chemistry

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 188

Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain

Guydosh, N. R., & Block, S. M. (2006) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 132

Direct observation of the binding state of the kinesin head to the microtubule

Guydosh, N. R., & Block, S. M. (2009) · Nature

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 121

Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms

Schweikhard, V., Meng, C., Murakami, K., Kaplan, C. D., Kornberg, R. D., & Block, S. M. (2014) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsRNA and protein synthesis mechanisms

Cited by 92

Statistical Kinetics of Macromolecular Dynamics

Shaevitz, J. W., Block, S. M., & Schnitzer, M. J. (2005) · Biophysical Journal

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 86

Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping

Gutiérrez-Medina, B., Fehr, A. N., & Block, S. M. (2009) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 37

Direct observation of processive exoribonuclease motion using optical tweezers

Fazal, F. M., Koslover, D. J., Luisi, B. F., & Block, S. M. (2015) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsForce Microscopy Techniques and Applications

Cited by 29

Not So Lame After All: Kinesin Still Walks with a Hobbled Head

Guydosh, N. R., & Block, S. M. (2007) · The Journal of General Physiology

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 8