Klausner, Richard D.

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Liu, M. C., Oxnard, G. R., Klein, E. A., Swanton, C., Seiden, M. V., Liu, M. C., Oxnard, G. R., Klein, E. A., Smith, D., Richards, D., et al. (2020) · Annals of Oncology

Cancer Genomics and DiagnosticsEpigenetics and DNA Methylation

Cited by 1,495

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 709

A permease-oxidase complex involved in high-affinity iron uptake in yeast.

Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D., & Dancis, A. (1996) · Science

Fungal and yeast genetics researchIron Metabolism and Disorders

Cited by 683

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell

Trace Elements in HealthIron Metabolism and Disorders

Cited by 659

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 571

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

Letourneur, F., & Klausner, R. D. (1992) · Cell

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 536

Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., & Pause, A. (1999) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysRenal cell carcinoma treatment

Cited by 508

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160

Willey, R. L., Bonifacino, J. S., Potts, B. J., Martin, M. A., & Klausner, R. D. (1988) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentCellular transport and secretion

Cited by 428

AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.

Yamaguchi‐Iwai, Y., Dancis, A., & Klausner, R. D. (1995) · The EMBO Journal

Iron Metabolism and DisordersFungal and yeast genetics research

Cited by 358

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

Rouault, T. A., Hentze, M. W., Caughman, S. W., Harford, J. B., & Klausner, R. D. (1988) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 351

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L., & Rouault, T. A. (1998) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersUbiquitin and proteasome pathways

Cited by 293

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

Hentze, M. W., Rouault, T. A., Caughman, S. W., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 249

Intramembrane Bis-Heme Motif for Transmembrane Electron Transport Conserved in a Yeast Iron Reductase and the Human NADPH Oxidase

Finegold, A. A., Shatwell, K. P., Segal, A. W., Klausner, R. D., & Dancis, A. (1996) · Journal of Biological Chemistry

Metalloenzymes and iron-sulfur proteinsMetal-Catalyzed Oxygenation Mechanisms

Cited by 213

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

Iwai, K., Klausner, R. D., & Rouault, T. A. (1995) · The EMBO Journal

Iron Metabolism and DisordersRNA Research and Splicing

Cited by 211

Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator

Knight, S. A. B., Lesuisse, E., Stearman, R., Klausner, R. D., & Dancis, A. (2002) · Microbiology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 145

Translational repression by a complex between the iron‐responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position‐dependent in vivo.

Goossen, B., Caughman, S. W., Harford, J. B., Klausner, R. D., & Hentze, M. W. (1990) · The EMBO Journal

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 144

Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase

Kim, H.-Y., LaVaute, T., Iwai, K., Klausner, R. D., & Rouault, T. A. (1996) · Journal of Biological Chemistry

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 141

A model for the structure and functions of iron-responsive elements

Hentze, M. W., Caughman, S. W., Casey, J. L., Kodier, D. M., Rouault, T. A., Harford, J. B., & Klausner, R. D. (1988) · Gene

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 116

Involvement of dileucine motifs in the internalization and degradation of the insulin receptor

Haft, C. R., Klausner, R. D., & Taylor, S. I. (1994) · Journal of Biological Chemistry

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 92

Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

Shigdel, U. K., Lee, S.-J., Sowa, M. E., Bowman, B. R., Robison, K., Zhou, M., Pua, K. H., Stiles, D. T., Blodgett, J. A. V., Udwary, D. W., et al. (2020) · Proceedings of the National Academy of Sciences

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 80