Klein, Ronald L.

Gene therapy with brain-derived neurotrophic factor as a protection: Retinal ganglion cells in a rat glaucoma model

Martin, K. R. G., Quigley, H. A., Zack, D. J., Levkovitch-Verbin, H., Kielczewski, J., Valenta, D., Baumrind, L., Pease, M. E., Klein, R. L., & Hauswirth, W. W. (2003) · Investigative Opthalmology & Visual Science

Glaucoma and retinal disordersVirus-based gene therapy research

Cited by 362

Effect of CNTF on retinal ganglion cell survival in experimental glaucoma

Pease, M. E., Zack, D. J., Berlinicke, C., Bloom, K., Cone, F., Wang, Y., Klein, R. L., Hauswirth, W. W., & Quigley, H. A. (2009) · Investigative Opthalmology & Visual Science

Glaucoma and retinal disordersNerve injury and regeneration

Cited by 222

Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins

Klein, R. L., Dayton, R. D., Leidenheimer, N. J., Jansen, K., Golde, T. E., & Zweig, R. M. (2006) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 200

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

Klein, R. L., Dayton, R. D., Tatom, J. B., Henderson, K. M., & Henning, P. P. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 196

Gene delivery to the eye using adeno-associated viral vectors

Martin, K. R. G., Klein, R. L., & Quigley, H. A. (2002) · Methods

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 149

The advent of AAV9 expands applications for brain and spinal cord gene delivery

Dayton, R. D., Wang, D. B., & Klein, R. L. (2012) · Expert Opinion on Biological Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 144

Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer

Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M. (1999) · Brain Research

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 128

A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy

Mihic, S. J., Whiting, P. J., Klein, R. L., Wafford, K. A., & Harris, R. A. (1994) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 110

A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson's Disease

Pabon, M. M., Jernberg, J. N., Morganti, J., Contreras, J., Hudson, C. E., Klein, R. L., & Bickford, P. C. (2012) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 90

AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats

Jackson, K. L., Dayton, R. D., & Klein, R. L. (2015) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchAmyotrophic Lateral Sclerosis Research

Cited by 49

Regulation of GABAA Receptor Structure and Function by Chronic Drug Treatments In Vivo and with Stably Transfected Cells

Klein, R. L., & Harris, R. A. (1996) · Japanese Journal of Pharmacology

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 41

Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists.

Klein, R. L., Mascia, M. P., Harkness, P. C., Hadingham, K. L., Whiting, P. J., & Harris, R. A. (1995) · The Journal of Pharmacology and Experimental Therapeutics

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 40

The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease

Qureshi, Y. H., Berman, D. E., Marsh, S. E., Klein, R. L., Patel, V. M., Simoes, S., Kannan, S., Petsko, G. A., Stevens, B., & Small, S. A. (2022) · Cell Reports

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 31

Gene Transfer Induced Hypercholesterolemia in Amyloid Mice

Grames, M. S., Dayton, R. D., Lu, X., Schilke, R. M., Alexander, J. S., Orr, A. W., Barmada, S. J., Woolard, M. D., & Klein, R. L. (2018) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 4