Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
Abstract
Brain-derived neurotrophic factor (BDNF) was expressed via injection of viral vector into the substantia nigra pars compacta (SNc) to investigate its influence on nigrostriatal dopaminergic activity and locomotor behavior. The recombinant adeno-associated virus (rAAV) vector, pTR-BDNFmyc, incorporated the neuron-specific enolase (NSE) promoter and the internal ribosome entry site (IRES) element driving expression of both epitope-tagged BDNF and green fluorescent protein (GFP) bicistronically. The control vector, pTR-UF4, incorporated NSE promoter-driven GFP expression only. Transgene expression persisted in both vector groups throughout the 9 month course of the study. Partial 6-hydroxydopamine (6-OHDA) lesions were conducted in the SNc ipsilateral to, and 6 months after, transduction with either the pTR-BDNFmyc or the pTR-UF4. Transgenic BDNFmyc had no effect on the number of tyrosine hydroxylase (TH)-labeled neurons in the SNc after 6-OHDA-lesions, but did block the amphetamine-induced, ipsiversive, turning-behavior caused by the lesion in the pTR-UF4 group. The BDNFmyc-transduced group also demonstrated more locomotor activity and rotational activity contralateral to the lesioned side than did the pTR-UF4-transduced group. Long-term, stable expression of BDNF can therefore modulate locomotor activity without significantly affecting nigrostriatal dopaminergic survival.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the vast majority of studies with BDNF administration before induction of parkinsonism, the results revealed at least partial prevention of neuronal cell loss.
“In the vast majority of studies with BDNF administration before induction of parkinsonism, the research results revealed at least partial prevention of neuronal cell loss [89,90,92,93,99,101].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [90]
Some studies showed no increase in neuronal survival when BDNF was applied before intoxication with 6-hydroxydopamine in a Parkinson's disease animal model.
“However, the reports are not consistent; some have shown no increase in neuronal survival when BDNF was applied before intoxication with 6-hydroxydopamine (6-OHDA) in PD animal model [90,91].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [90]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Xiao, X., Li, J., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2224-2232.1998 · Cited by 1,381 · see citing works
Kaplitt, M. G., Leone, P., Samulski, R. J., Xiao, X., Pfaff, D. W., O’Malley, K. L., & During, M. J. (1994) · Nature Genetics · doi:10.1038/ng1094-148 · Cited by 1,031 · see citing works
Maisonpierre, P. C., Beau, M. M. L., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S. P., Furth, M. E., & Yancopoulos, G. D. (1991) · Genomics · doi:10.1016/0888-7543(91)90436-i · Cited by 511 · see citing works
McCown, T. J., Xiao, X., Li, J., Breese, G. R., & Samulski, R. J. (1996) · Brain Research · doi:10.1016/0006-8993(95)01488-8 · Cited by 450 · see citing works
Forss‐Petter, S., Danielson, P. E., Catsicas, S., Battenberg, E., Price, J. A., Nerenberg, M. I., & Sutcliffe, G. (1990) · Neuron · doi:10.1016/0896-6273(90)90308-3 · Cited by 365 · see citing works
Mandel, R. J., Spratt, S. K., Snyder, R. O., & Leff, S. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14083 · Cited by 328 · see citing works
Peel, A., Zolotukhin, S., Schrimsher, G. W., Muzyczka, N., & Reier, P. J. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300358 · Cited by 289 · see citing works
Self-citationAltar, C. A., Boylan, C. B., Jackson, C., Hershenson, S., Miller, J., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11347 · Cited by 275 · see citing works
Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works
Frim, D. M., Uhler, T. A., Galpern, W. R., Beal, M. F., Breakefield, X. O., & Isacson, O. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5104 · Cited by 269 · see citing works
Klein, R. L., Meyer, E. M., Peel, A. L., Zolotukhin, S., Meyers, C., Muzyczka, N., & King, M. A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6736 · Cited by 252 · see citing works
Self-citationMorse, J., Wiegand, S., Anderson, K., You, Y., Cai, N., Carnahan, J., Miller, J., DiStefano, P., Altar, C., & Lindsay, R. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04146.1993 · Cited by 251 · see citing works
Dicistronic transcription units for gene expression in mammalian cells
Dirks, W. G., Wirth, M., & Häuser, H. (1993) · Gene · doi:10.1016/0378-1119(93)90569-o · Cited by 176 · see citing works
Martin-Iverson, M. T., Todd, K. G., & Altar, C. A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01262.1994 · Cited by 170 · see citing works
Altar, C. A., Boylan, C. B., Fritsche, M., Jones, B. E., Jackson, C., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63031021.x · Cited by 138 · see citing works
Sauer, H., Fischer, W., Nikkhah, G., Wiegand, S. J., Brundin, P., Lindsay, R. M., & Björklund, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90560-a · Cited by 121 · see citing works
Hagg, T. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6684 · Cited by 98 · see citing works
Shen, R. Y., Altar, C. A., & Chiodo, L. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8920 · Cited by 87 · see citing works
Klein, R. L., Muir, D. F., King, M. A., Peel, A. L., Zolotukhin, S., Möller, J. C., Krüttgen, A., Heymach, J. V., Muzyczka, N., & Meyer, E. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00537-5 · Cited by 84 · see citing works
Self-citationMartin-Iverson, M. T., & Altar, C. A. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01313.x · Cited by 32 · see citing works
Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer
Klein, R. L., McNamara, R. K., King, M. A., Lenox, R. H., Muzyczka, N., & Meyer, E. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01482-1 · Cited by 29 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells*
Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 108 · see citing works
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works
GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration
Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820 · see citing works
BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Martin, K. R. G., Quigley, H. A., Zack, D. J., Levkovitch-Verbin, H., Kielczewski, J., Valenta, D., Baumrind, L., Pease, M. E., Klein, R. L., & Hauswirth, W. W. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-1332 · Cited by 362 · see citing works
Self-citationEffect of CNTF on retinal ganglion cell survival in experimental glaucoma
Pease, M. E., Zack, D. J., Berlinicke, C., Bloom, K., Cone, F., Wang, Y., Klein, R. L., Hauswirth, W. W., & Quigley, H. A. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-3013 · Cited by 222 · see citing works
Self-citationDopaminergic Cell Loss Induced by Human A30P α -Synuclein Gene Transfer to the Rat Substantia Nigra
Klein, R. L., King, M. A., Hamby, M. E., & Meyer, E. M. (2002) · Human Gene Therapy · doi:10.1089/10430340252837206 · Cited by 209 · see citing works
Self-citationRecombinant AAV-mediated gene delivery to the central nervous system
Tenenbaum, L., Chtarto, A., Lehtonen, E., Velu, T. J., Brotchi, J., & Levivier, M. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.506 · Cited by 204 · see citing works
Wang, R., & Holsinger, R. M. D. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.002 · Cited by 194 · see citing works
Gene Therapy for Parkinson’s Disease, An Update
Axelsen, T. M., & Woldbye, D. P. D. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-181331 · Cited by 175 · see citing works
Adeno-associated virus vectors: activity and applications in the CNS
Peel, A. L., & Klein, R. L. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00183-7 · Cited by 155 · see citing works
Self-citationNeurotrophic factor therapy for Parkinson’s disease
Rangasamy, S. B., Soderstrom, K. E., Bakay, R. A. E., & Kordower, J. H. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)84013-0 · Cited by 155 · see citing works
Sun, M., Kong, L., Wang, X., Lu, X.-G., Gao, Q., & Geller, A. I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.072 · Cited by 154 · see citing works
Eaton, M. J., Blits, B., Ruitenberg, M. J., Verhaagen, J., & Oudega, M. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301814 · Cited by 146 · see citing works
Spieles-Engemann, A. L., Behbehani, M. M., Collier, T. J., Wohlgenant, S. L., Steece‐Collier, K., Paumier, K. L., Daley, B. F., Gombash, S. E., Madhavan, L., Mandybur, G. T., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.009 · Cited by 131 · see citing works
Kang, S. S., Zhang, Z., Liu, X., Manfredsson, F. P., Benskey, M. J., Cao, X., Xu, J., Sun, Y. E., & Ye, K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713969114 · Cited by 131 · see citing works
Park, H., Lim, S., Joo, W. S., Yin, C.-S., Lee, H., Lee, H., Seo, J.-C., Leem, K., Son, Y.-S., Kim, Y.-J., et al. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(02)00031-6 · Cited by 129 · see citing works
The Role of Astrocytes in the Neurorepair Process
Chiareli, R. A., Carvalho, G. A., Marques, B. L., Mota, L. S., Oliveira‐Lima, O. C., Gomes, R. M., Birbrair, A., Gomez, R. S., Simão, F., Klempin, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665795 · Cited by 126 · see citing works
Seung Taik, L. I. M., Airavaara, M., & Harvey, B. K. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.10.002 · Cited by 126 · see citing works
Murray, T. K., Whalley, K., Robinson, C. S., Ward, M., Hicks, C. A., Lodge, D., Vandergriff, J. L., Baumbarger, P. J., Siuda, E. R., Gates, M. R., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049445 · Cited by 107 · see citing works
Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro
Volpicelli, F., Caiazzo, M., Greco, D., Consales, C., Leone, L., Perrone‐Capano, C., D’Amato, L. C., & di Porzio, U. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04494.x · Cited by 100 · see citing works
Furler, S., Paterna, J. C., Weibel, M., & Büeler, H. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301469 · Cited by 101 · see citing works
Gordon, R., Neal, M. P., Luo, J. D., Langley, M. R., Harischandra, D. S., Panicker, N., Charli, A., Jin, H., Anantharam, V., Woodruff, T. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12932 · Cited by 99 · see citing works
Klein, R. L., Hirko, A. C., Meyers, C., Grimes, J. R., Muzyczka, N., & Meyer, E. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02634-2 · Cited by 84 · see citing works
Self-citationRuitenberg, M. J., Blits, B., Dijkhuizen, P. A., Beek, E. T. T., Bakker, A., van Heerikhuize, J. J., Pool, C. W., Hermens, W. T. J., Boer, G. J., & Verhaagen, J. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.018 · Cited by 80 · see citing works
Visanji, N. P., Orsi, A., Johnston, T. H., Howson, P. A., Dixon, K., Callizot, N., Brotchie, J. M., & Rees, D. D. (2008) · The FASEB Journal · doi:10.1096/fj.07-095398 · Cited by 78 · see citing works
Halbach, O. V. B. U., Minichiello, L., & Unsicker, K. (2005) · The FASEB Journal · doi:10.1096/fj.05-3845fje · Cited by 77 · see citing works
Hernandez-Chan, N. G., Bannon, M. J., Orozco-Barrios, C. E., Escobedo, L., Zamudio, S., De la Cruz, F., Gongora-Alfaro, J. L., Armendáriz-Borunda, J., Reyes-Corona, D., Espadas-Alvarez, A. J., et al. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0166-7 · Cited by 73 · see citing works
Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging
Ryu, Y., Go, J., Park, H., Choi, Y., Seo, Y. J., Choi, J. H., Rhee, M., Lee, T. G., Lee, C., & Kim, K. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108173 · Cited by 74 · see citing works
Ruitenberg, M. J., Eggers, R., Boer, G. J., & Verhaagen, J. (2002) · Methods · doi:10.1016/s1046-2023(02)00222-0 · Cited by 72 · see citing works
Cerri, S., Greco, R., Levandis, G., Ghezzi, C., Mangione, A. S., Armentero, M., Bonizzi, A., Avanzini, M. A., Maccario, R., & Blandini, F. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0023 · Cited by 70 · see citing works
Manfredsson, F. P., Bürger, C., Sullivan, L. F., Muzyczka, N., Lewin, A. S., & Mandel, R. J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.019 · Cited by 70 · see citing works
Self-citationElectrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease
Yadav, A. P., & Nicolelis, M. (2017) · Movement Disorders · doi:10.1002/mds.27033 · Cited by 62 · see citing works
Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
Cai, J., Hua, F., Yuan, L., Tang, W., Lu, J., Yu, S., Wang, X., & Hu, Y. (2014) · BioMed Research International · doi:10.1155/2014/601084 · Cited by 66 · see citing works
Nie, S., Yan, X., Chen, G., Ma, K., Han, C., Guo, Z., Zhang, Z., Ye, K., & Cao, X. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.016 · Cited by 65 · see citing works
GDNF therapy for Parkinson’s disease
Hong, M. G. L., Mukhida, K., & Mendez, I. M. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.7.1125 · Cited by 64 · see citing works
Pröschel, C., Stripay, J. L., Shih, C., Munger, J. C., & Noble, M. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302878 · Cited by 64 · see citing works
O’Neill, M. J., Murray, T. K., Whalley, K., Ward, M., Hicks, C. A., Woodhouse, S., Osborne, D. J., & Skolnick, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.12.023 · Cited by 62 · see citing works
Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson’s disease
Dass, B., Olanow, C., & Kordower, J. (2006) · Neurology · doi:10.1212/wnl.66.10_suppl_4.s89 · Cited by 67 · see citing works
Ren, R., Li, Y., Liu, Z., Liu, K., & He, S. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8484 · Cited by 60 · see citing works
Stahl, K., Mylonakou, M. N., Skare, Ø., Amiry-Moghaddam, M. R., & Torp, R. (2011) · Brain Research · doi:10.1016/j.brainres.2010.12.090 · Cited by 59 · see citing works
Autotransplantation of Bone Marrow-Derived Stem Cells as a Therapy for Neurodegenerative Diseases
Kan, I., Melamed, E., & Offen, D. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68976-8_10 · Cited by 58 · see citing works
Baker, S. A., Stanford, L. E., Brown, R. E., & Hagg, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.052 · Cited by 55 · see citing works
Nosheny, R. L., Ahmed, F. A. K. M., Yakovlev, A. G., Meyer, E. M., Ren, K., Tessarollo, L., & Mocchetti, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05506.x · Cited by 53 · see citing works
Self-citationNezhadi, A., Sheibani, V., Esmaeilpour, K., Shabani, M., & Esmaeili‐Mahani, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.019 · Cited by 52 · see citing works
Dass, B., Iravani, M. M., Jackson, M. J., Engber, T. M., Galdes, A., & Jenner, P. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00214-2 · Cited by 52 · see citing works
Adeno-Associated Virus Vectors for Therapeutic Gene Transfer
Stilwell, J. L., & Samulski, R. J. (2003) · BioTechniques · doi:10.2144/03341dd01 · Cited by 52 · see citing works
Wang, Z.-H., Wu, W., Kang, S. S., Liu, X., Wu, Z., Peng, J., Yu, S. P., Manfredsson, F. P., Sandoval, I. M., Liu, X., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99007 · Cited by 52 · see citing works
Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity
Cao, Q., Zou, Q., Zhao, X. Y., Zhang, Y., Qu, Y., Wang, N., Murayama, S., Qi, Q., Hashimoto, K., Lin, S., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01063-9 · Cited by 47 · see citing works
Chen, L.-W., Zhang, J., Shum, D. K., & Chan, Y. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21014 · Cited by 47 · see citing works
Chronic Spinal Cord Electrical Stimulation Protects Against 6-hydroxydopamine Lesions
Yadav, A. P., Fuentes, R., Zhang, H., Vinholo, T., Wang, C.-H., Freire, M., & Nicolelis, M. (2014) · Scientific Reports · doi:10.1038/srep03839 · Cited by 43 · see citing works
Production and Application of Multicistronic Constructs for Various Human Disease Therapies
Shaimardanova, A. A., Chulpanova, D. S., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110580 · Cited by 45 · see citing works
Kang, S. S., Wu, Z., Liu, X., Edgington‐Mitchell, L. E., & Ye, K. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01248-1 · Cited by 43 · see citing works
Fenner, M. E., Achim, C. L., & Fenner, B. M. (2013) · Journal of Molecular Histology · doi:10.1007/s10735-013-9562-z · Cited by 42 · see citing works
Adeno‐associated virus‐mediated gene delivery approaches for the treatment of CNS disorders
Terzi, D., & Zachariou, V. (2008) · Biotechnology Journal · doi:10.1002/biot.200800284 · Cited by 42 · see citing works
Nosheny, R. L., Mocchetti, I., & Bachis, A. (2005) · Neurotoxicity Research · doi:10.1007/bf03033829 · Cited by 41 · see citing works
Álvarez-Maya, I., Navarro-Quiroga, I., Meraz‐Ríos, M. A., Aceves, J., & Martínez‐Fong, D. (2001) · Molecular Medicine · doi:10.1007/bf03401952 · Cited by 41 · see citing works
Advances in the delivery of treatments for Parkinson’s disease
Johnston, T. H., Fox, S. H., & Brotchie, J. M. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.6.1059 · Cited by 41 · see citing works
Use of growth factors for the treatment of Parkinson’s disease
Yasuda, T., & Mochizuki, H. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.55 · Cited by 41 · see citing works
Neuroprotective effect of BDNF in young and aged 6-OHDA treated rat model of Parkinson disease.
Singh, S. T., Ahmad, R., Mathur, D., Sagar, R., & Krishana, B. (2006) · PubMed · Cited by 36 · see citing works
Park, H., & Chang, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218129 · Cited by 34 · see citing works
Clarke, E., Stocki, P., Sinclair, E. H., Gauhar, A., Fletcher, E. J. R., Krawczun-Rygmaczewska, A., Duty, S., Walsh, F. S., Doherty, P., & Rutkowski, J. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071335 · Cited by 32 · see citing works
Chen, L.-W., Hu, H., Liu, L., Yung, K. K. L., & Chan, Y. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.020 · Cited by 32 · see citing works
Gene Therapy for Parkinson's Disease
Denyer, R., & Douglas, M. R. (2012) · Parkinson s Disease · doi:10.1155/2012/757305 · Cited by 31 · see citing works
Mocchetti, I., Nosheny, R. L., Tanda, G., Ren, K., & Meyer, E. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1403.010 · Cited by 30 · see citing works
Self-citationDickerson, J. W., Hemmerle, A. M., Numan, S., Lundgren, K. H., & Seroogy, K. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.008 · Cited by 29 · see citing works
Live Attenuated Vaccine Based on Duck Enteritis Virus against Duck Hepatitis A Virus Types 1 and 3
Zou, Z., Ma, J., Huang, K. L., Chen, H., Liu, Z., & Jin, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01613 · Cited by 29 · see citing works
Recombinant adeno-associated virus vector design and gene expression in the mammalian brain
Paterna, J., & Büeler, H. (2002) · Methods · doi:10.1016/s1046-2023(02)00225-6 · Cited by 29 · see citing works
Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling
Zhao, Y., Luo, D., Ning, Z., Rong, J., & Lao, L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00496 · Cited by 28 · see citing works
Chemokine receptors and neurotrophic factors: Potential therapy against aids dementia?
Mocchetti, I., Bachis, A., & Masliah, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21492 · Cited by 27 · see citing works
Dass, B., Iravani, M. M., Huang, C.-S., Barsoum, J., Engber, T. M., Galdes, A., & Jenner, P. G. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0227-7 · Cited by 26 · see citing works
Developmental Expression of Neurotrophins and Their Receptors in Postnatal Rat Ventral Midbrain
Numan, S., Gall, C. M., & Seroogy, K. B. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:2:245 · Cited by 25 · see citing works
Prospects for the treatment of Parkinson’s disease using neurotrophic factors
Hurelbrink, C. B., & Barker, R. A. (2001) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2.10.1531 · Cited by 25 · see citing works
Fu, A., Zhang, M., Gao, F., Xu, X., & Chen, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059642 · Cited by 24 · see citing works
Neurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound?
Stefani, A., Pierantozzi, M., Cardarelli, S., Stefani, L., Cerroni, R., Conti, M., Garasto, E., Mercuri, N. B., Marini, C., & Sucapane, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.846681 · Cited by 23 · see citing works
Komnig, D., Dagli, T. C., Habib, P., Zeyen, T., Schulz, J. B., & Falkenburger, B. H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14575 · Cited by 24 · see citing works
Mocchetti, I., Bachis, A., Nosheny, R. L., & Tanda, G. (2007) · Neurotoxicity Research · doi:10.1007/bf03033922 · Cited by 24 · see citing works
Mocchetti, I., Bachis, A., Campbell, L. A., & Avdoshina, V. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9488-y · Cited by 23 · see citing works
Enna, S. J., Reisman, S. A., & Stanford, J. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.004 · Cited by 21 · see citing works
Neurotrophic factors for the treatment of Parkinson's disease
Chiocco, M. J., Harvey, B. K., Wang, Y., & Hoffer, B. J. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70024-5 · Cited by 20 · see citing works
Gene delivery with viral vectors for cerebrovascular diseases
Gan, Y. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e607 · Cited by 20 · see citing works
Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 19 · see citing works
Expression of BDNF-Associated lncRNAs in Parkinson’s disease
Akbari, M., Gholipour, M., Hussen, B. M., Taheri, M. N., Eslami, S., Sayad, A., & Ghafouri‐Fard, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00946-1 · Cited by 19 · see citing works
Preclinical development of gene therapy for Parkinson's disease
Porras, G., & Bézard, E. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.08.003 · Cited by 19 · see citing works
Gene therapy for Parkinson's disease
Lawlor, P. A., & During, M. J. (2004) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940400746x · Cited by 18 · see citing works
Are growth factors the answer?
Ramaswamy, S., & Kordower, J. H. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70809-0 · Cited by 17 · see citing works
Pietropaolo, S., Paterna, J., Büeler, H., Feldon, J., & Yee, B. K. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282da0bf6 · Cited by 15 · see citing works
Neurotrophic Support of Midbrain Dopaminergic Neurons
Halbach, O. V. B. U., & Unsicker, K. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0322-8_7 · Cited by 15 · see citing works
Er, Ş., & Airavaara, M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220770 · Cited by 14 · see citing works
Gene therapy in Parkinson?s disease
Eberhardt, O., & Schulz, J. B. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0947-x · Cited by 14 · see citing works
Pre- and post-synaptic modification by neurotrophins
Kojima, M., Klein, R. L., & Hatanaka, H. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00034-2 · Cited by 13 · see citing works
Self-citationGene therapy approaches for the treatment of Parkinson's disease
DASS, B., & Kordower, J. H. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)84045-0 · Cited by 11 · see citing works
Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system
Klein, R. L., Mandel, R. J., & Muzyczka, N. (2000) · Advances in virus research · doi:10.1016/s0065-3527(00)55015-5 · Cited by 11 · see citing works
Self-citationGazing into the future: Parkinson's disease gene therapeutics to modify natural history
Maguire‐Zeiss, K. A., Mhyre, T. R., & Federoff, H. J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.09.030 · Cited by 11 · see citing works
Alimohammadi, S., Mohaddes, G., Keyhanmanesh, ., Athari, S. Z., Azizifar, N., & Farajdokht, F. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110180 · Cited by 10 · see citing works
O’Neill, M. J., Messenger, M. J., Lakics, V., Murray, T. K., Karran, E. H., Szekeres, P. G., Nisenbaum, E. S., & Merchant, K. (2006) · International review of neurobiology · doi:10.1016/s0074-7742(06)77006-4 · Cited by 10 · see citing works
Can cinnamon bring aroma in Parkinson′s disease treatment?
Pahan, P., & Pahan, K. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.150647 · Cited by 10 · see citing works
Pharmacological approaches to disease-modifying therapies in Parkinson’s disease
O’Neill, M. J., & Siemers, E. (2002) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2.6.819 · Cited by 10 · see citing works
Fiandaca, M. S., Bankiewicz, K. S., & Federoff, H. J. (2012) · Pharmaceuticals · doi:10.3390/ph5060553 · Cited by 10 · see citing works
Application of adeno-associated viral vectors in behavioral research
Nair, H. P., & Young, L. J. (2002) · Methods · doi:10.1016/s1046-2023(02)00223-2 · Cited by 8 · see citing works
- Authors
- Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M.
- Affiliations
- University of Florida (US)
- Corresponding author
- Klein, Ronald L.
- ORCID
- Lewis, Mark H.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 847
- Issue
- 2
- Pages
- 314-320
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1987647111
- Cited by
- 128
- References
- 22
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- National Institutes of Health (2r01gm035723-15)
- National Heart, Lung, and Blood Institute (HL 53665, HL/DK 50257, R01HL053665)
- National Institute of General Medical Sciences (GM35723)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK050257)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, 6-hydroxydopamine lesion, substantia nigra pars compacta, gene transfer, adeno-associated virus vectors, neuron-specific enolase promoter, internal ribosome entry site, amphetamine-induced rotation, locomotor activity, dopaminergic neuron survival, tyrosine hydroxylase, neuroprotection
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Animals, Genetic Vectors, Humans, Motor Activity, Parkinson Disease, Substantia Nigra, Oxidopamine, Rats, Sprague-Dawley, Gene Transfer Techniques, Adrenergic Agents, Brain-Derived Neurotrophic Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
