Wellen, Kathryn E.

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 4,143

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 2,298

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., et al. (2012) · Nature

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

Cited by 1,985

Obesity-induced inflammatory changes in adipose tissue

Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 1,823

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 563

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

Zhao, S., Jang, C., Liu, J., Uehara, K., Gilbert, M., Izzo, L., Zeng, X., Trefely, S., Fernandez, S., Carrer, A., et al. (2020) · Nature

Diet, Metabolism, and DiseaseLipid metabolism and biosynthesis

Cited by 553

A two-way street: reciprocal regulation of metabolism and signalling

Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 528

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

McDonald, O. G., Li, X., Saunders, T., Tryggvadottir, R., Mentch, S. J., Warmoes, M. O., Word, A. E., Carrer, A., Salz, T. H., Natsume, S., et al. (2017) · Nature Genetics

Epigenetics and DNA MethylationPancreatic and Hepatic Oncology Research

Cited by 494

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Jiang, P., Du, W., Mancuso, A., Wellen, K. E., & Yang, X. (2013) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 491

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

Wellen, K. E., & Thompson, C. B. (2010) · Molecular Cell

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 486

ATP-citrate lyase controls a glucose-to-acetate metabolic switch

Zhao, S., Torres, A., Henry, R. A., Trefely, S., Wallace, M., Lee, J. V., Carrer, A., Sengupta, A., Campbell, S. L., Kuo, Y.-M., et al. (2016) · Cell Reports

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 394

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B. (2010) · Genes & Development

Cancer, Hypoxia, and MetabolismGlycosylation and Glycoproteins Research

Cited by 377

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Carrer, A., Trefely, S., Zhao, S., Campbell, S. L., Norgard, R. J., Schultz, K. C., Sidoli, S., Parris, J. L. D., Affronti, H. C., Sivanand, S., et al. (2019) · Cancer Discovery

Cancer, Lipids, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 313

Acetyl-CoA metabolism in cancer

Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 303

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

Sivanand, S., Rhoades, S., Jiang, Q., Lee, J. V., Benci, J., Zhang, J., Yuan, S., Viney, I., Zhao, S., Carrer, A., et al. (2017) · Molecular Cell

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 295

Compartmentalised acyl-CoA metabolism and roles in chromatin regulation

Trefely, S., Lovell, C. D., Snyder, N. W., & Wellen, K. E. (2020) · Molecular Metabolism

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 272

Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis

Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S. (2007) · Cell

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 222

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

Kopinski, P. K., Janssen, K. A., Schaefer, P. M., Trefely, S., Perry, C. E., Potluri, P., Tintos-Hernandez, J. A., Singh, L. N., Karch, K. R., Campbell, S. L., et al. (2019) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyEpigenetics and DNA Methylation

Cited by 159

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

Aird, K. M., Worth, A. J., Snyder, N. W., Lee, J. V., Sivanand, S., Liu, Q., Blair, I. A., Wellen, K. E., & Zhang, R. (2015) · Cell Reports

Telomeres, Telomerase, and SenescenceMetabolism, Diabetes, and Cancer

Cited by 113

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

Campbell, S., Mesaros, C., Izzo, L., Affronti, H., Noji, M., Schaffer, B. E., Tsang, T., Sun, K., Trefely, S., Kruijning, S., et al. (2021) · eLife

Glycosylation and Glycoproteins ResearchCancer, Hypoxia, and Metabolism

Cited by 58

Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

Bechard, M. E., Smalling, R., Hayashi, A., Zhong, Y., Word, A. E., Campbell, S. L., Tran, A. V., Weiss, V. L., Iacobuzio-Donahue, C., Wellen, K. E., et al. (2020) · Nature Communications

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 33