Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis

Wellen, Kathryn E.; Fucho, Raquel; Gregor, Margaret F.; Furuhashi, Masato; Morgan, Carlos; Lindstad, Torstein; Vaillancourt, Eric; Gorgun, Cem Z.; Saatcioglu, Fahri; Hotamisligil, Gökhan S.

doi:10.1016/j.cell.2007.02.049

Cited by 222Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis

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Wellen, Kathryn E., Fucho, Raquel, Gregor, Margaret F., Furuhashi, Masato, Morgan, Carlos, Lindstad, Torstein, Vaillancourt, Eric, Gorgun, Cem Z. +2 more·2007·Cell

DOI 10.1016/j.cell.2007.02.049PMC PMC2408881

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Abstract

Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to metabolic dysregulation under conditions of chronic stress. Thus, we hypothesized that mechanisms might exist to prevent overt inflammatory responses during physiological fluctuations in nutrients or under nutrient-rich conditions, and we identified the six-transmembrane protein STAMP2 as a critical modulator of this integrated response system of inflammation and metabolism in adipocytes. Lack of STAMP2 in adipocytes results in aberrant inflammatory responses to both nutrients and acute inflammatory stimuli. Similarly, in whole animals, visceral adipose tissue of STAMP2(-/-) mice exhibits overt inflammation, and these mice develop spontaneous metabolic disease on a regular diet, manifesting insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty liver disease. We conclude that STAMP2 participates in integrating inflammatory and metabolic responses and thus plays a key role in systemic metabolic homeostasis.

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Cell, Volume 129 Supplemental Data Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis
Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Vaillancourt, E., Görgün, C. Z., Saatcioglu, F., & Hotamışlıgil, G. S. (2015)
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Authors: Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S.
Affiliations: Harvard University (US)
University of Oslo (NO)
ORCID: Wellen, Kathryn E.
Fucho, Raquel
Gregor, Margaret F.
Furuhashi, Masato
Morgan, Carlos
Vaillancourt, Eric
Saatcioglu, Fahri
Venue: Cell
Publisher: Elsevier BV
Published: 2007-05
Volume: 129
Issue: 3
Pages: 537-548
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2007.02.049
PMC: PMC2408881
OpenAlex: W2134888531
Cited by: 222
References: 40
Citations by year: 2026: 3 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 12 · 2020: 9 · 2019: 11 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 8 · 2014: 13 · 2013: 15 · 2012: 16
FWCI: 11.00
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2269 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion, cc-by)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK52539, R01DK052539, T90DK070078, P30DK040561)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: STAMP2, adipocytes, metabolic homeostasis, inflammation, nutrient sensing, metabolic inflammation, visceral adipose tissue, insulin resistance, impaired glucose tolerance, hepatic steatosis, dyslipidemia, chronic stress, metabolic disorders
MeSH terms: Adipose Tissue, Animals, Cells, Cultured, Female, Food, Glucose, Homeostasis, Inflammation, Insulin, Insulin Resistance, Liver, Male, Membrane Proteins, Mice, Inbred C57BL, Mutation, Adipocytes, Metabolic Syndrome, 3T3-L1 Cells, Lipid Metabolism, Mice, Metabolic Networks and Pathways

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Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis

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