Linehan, W. Marston

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

Mullen, A. R., Hu, Z., Shi, X., Jiang, L., Boroughs, L. K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L. B., Linehan, W. M., et al. (2014) · Cell Reports

Cancer, Hypoxia, and MetabolismBiochemical Acid Research Studies

Cited by 337

Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma

Eisenhofer, G., Lenders, J. W., Timmers, H., Mannelli, M., Grebe, S. K., Hofbauer, L. C., Bornstein, S. R., Tiebel, O., Adams, K., Bratslavsky, G., et al. (2011) · Clinical Chemistry

Adrenal and Paraganglionic TumorsNeuroendocrine Tumor Research Advances

Cited by 290

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., et al. (2020) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 283

Responses of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin Axes and the Sympathetic System During Controlled Surgical and Anesthetic Stress

UDELSMAN, R., NORTON, J. A., JELENICH, S. E., GOLDSTEIN, D. S., LINEHAN, W. M., LORIAUX, D. L., & CHROUSOS, G. P. (1987) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 278

Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma

WALTHER, M. M., REITER, R., KEISER, H. R., CHOYKE, P. L., VENZON, D., HURLEY, K., GNARRA, J. R., REYNOLDS, J. C., GLENN, G. M., ZBAR, B., et al. (1999) · Journal of Urology

Adrenal and Paraganglionic TumorsEar and Head Tumors

Cited by 255

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Sudarshan, S., Sourbier, C., Kong, H.-S., Block, K., Romero, V. A. V., Yang, Y., Galindo, C., Mollapour, M., Scroggins, B., Goode, N., et al. (2009) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 217

The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

Tong, W.-H., Sourbier, C., Kovtunovych, G., Jeong, S. Y., Vira, M., Ghosh, M., Romero, V. V., Sougrat, R., Vaulont, S., Viollet, B., et al. (2011) · Cancer Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 212

Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel–Lindau syndrome

Eisenhofer, G., Huynh, T.-T., Pacak, K., Brouwers, F. M., Walther, M. M., Linehan, W. M., Munson, P. J., Mannelli, M., Goldstein, D. S., & Elkahloun, A. G. (2004) · Endocrine-Related Cancer

Adrenal and Paraganglionic TumorsAngiogenesis and VEGF in Cancer

Cited by 207

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors

Moore, L. E., Nickerson, M. L., Brennan, P., Toro, J. R., Jaeger, E., Rinsky, J., Han, S. S., Zaridze, D., Matveev, V., Janout, V., et al. (2011) · PLoS Genetics

Renal cell carcinoma treatmentAdrenal and Paraganglionic Tumors

Cited by 199

Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro.

Whitcomb, R. W., Linehan, W. M., & Knazek, R. A. (1988) · Journal of Clinical Investigation

Adrenal Hormones and DisordersMetabolism and Genetic Disorders

Cited by 168

Targeting cancer metabolism

Teicher, B. A., Linehan, W. M., & Helman, L. J. (2012) · Clinical Cancer Research

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 152

Mistaken Identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics

Zeeberg, B. R., Riss, J., Kane, D. W., Bussey, K. J., Uchio, E., Linehan, W. M., Barrett, J. C., & Weinstein, J. N. (2004) · BMC Bioinformatics

Genomics and Phylogenetic StudiesGene expression and cancer classification

Cited by 110

Topotecan Blocks Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Expression Induced by Insulin-Like Growth Factor-I in Neuroblastoma Cells

Beppu, K., Nakamura, K., Linehan, W. M., Rapisarda, A., & Thiele, C. J. (2005) · Cancer Research

Angiogenesis and VEGF in CancerNeuroblastoma Research and Treatments

Cited by 96

Use of suramin in treatment of prostatic carcinoma refractory to conventional hormonal manipulation

LaRocca, R. V., Cooper, M. R., Uhrich, M., Danesi, R., Walther, M. M., Linehan, W. M., & Myers, C. E. (1991) · Urologic Clinics of North America

Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and Treatment

Cited by 57

Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study

Srinivasan, R., Iliopoulos, O., Beckermann, K. E., Narayan, V., Maughan, B. L., Oudard, S., Else, T., Maranchie, J. K., Iversen, A. B., Cornell, J., et al. (2025) · The Lancet Oncology

Renal cell carcinoma treatmentCancer, Hypoxia, and Metabolism

Cited by 50

Phase II Study of the Oral HIF-2α Inhibitor MK-6482 for Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma

Jonasch, E., Donskov, F., Iliopoulos, O., Rathmell, W. K., Narayan, V., Maughan, B. L., Oudard, S., Else, T., Maranchie, J. K., Welsh, S. J., et al. (2020) · Journal of Clinical Oncology

Renal cell carcinoma treatmentCancer, Hypoxia, and Metabolism

Cited by 42

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

Kishimoto, S., Brender, J. R., Crooks, D. R., Matsumoto, S., Seki, T., Oshima, N., Merkle, H., Lin, P., Reed, G., Chen, A. P., et al. (2019) · eLife

Advanced NMR Techniques and ApplicationsCancer, Hypoxia, and Metabolism

Cited by 41

Phase 2 study of belzutifan (MK-6482), an oral hypoxia-inducible factor 2α (HIF-2α) inhibitor, for Von Hippel-Lindau (VHL) disease-associated clear cell renal cell carcinoma (ccRCC).

Srinivasan, R., Donskov, F., Iliopoulos, O., Rathmell, W. K., Narayan, V., Maughan, B. L., Oudard, S., Else, T., Maranchie, J. K., Welsh, S. J., et al. (2021) · Journal of Clinical Oncology

Renal cell carcinoma treatmentCancer, Hypoxia, and Metabolism

Cited by 22

Differences in Tumor VHL Mutation and Hypoxia-inducible Factor 2α Expression Between African American and White Patients with Clear Cell Renal Cell Carcinoma

Callahan, C. L., Moore, L., Lenz, P., Linehan, W. M., Nickerson, M. L., Rothman, N., & Purdue, M. P. (2019) · European Urology

Renal cell carcinoma treatmentCancer, Hypoxia, and Metabolism

Cited by 7