Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma
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BACKGROUND: Pheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD). Testing of multiple genes is often undertaken at considerable expense before a mutation is detected. This study assessed whether measurements of plasma metanephrine, normetanephrine, and methoxytyramine, the O-methylated metabolites of catecholamines, might help to distinguish different hereditary forms of the tumor. METHODS: Plasma concentrations of O-methylated metabolites were measured by liquid chromatography with electrochemical detection in 173 patients with pheochromocytoma, including 38 with multiple endocrine neoplasia type 2 (MEN 2), 10 with neurofibromatosis type 1 (NF1), 66 with von Hippel-Lindau (VHL) syndrome, and 59 with mutations of SDHB or SDHD. RESULTS: In contrast to patients with VHL, SDHB, and SDHD mutations, all patients with MEN 2 and NF1 presented with tumors characterized by increased plasma concentrations of metanephrine (indicating epinephrine production). VHL patients usually showed solitary increases in normetanephrine (indicating norepinephrine production), whereas additional or solitary increases in methoxytyramine (indicating dopamine production) characterized 70% of patients with SDHB and SDHD mutations. Patients with NF1 and MEN 2 could be discriminated from those with VHL, SDHB, and SDHD gene mutations in 99% of cases by the combination of normetanephrine and metanephrine. Measurements of plasma methoxytyramine discriminated patients with SDHB and SDHD mutations from those with VHL mutations in an additional 78% of cases. CONCLUSIONS: The distinct patterns of plasma catecholamine O-methylated metabolites in patients with hereditary pheochromocytoma provide an easily used tool to guide cost-effective genotyping of underlying disease-causing mutations.
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Measurements of plasma methoxytyramine discriminated patients with SDH mutations from those with VHL mutations in a further 78% of cases.
“Additionally, measurements of plasma methoxytyramine discriminated patients with SDH mutations from those with VHL mutations in a further 78% of cases (181).”
From Adrenal incidentaloma (2020) · cites this paper as [181]
In one large study of patients with pheochromocytoma and/or paraganglioma, patients with NF1 and MEN2 mutations could be discriminated from those with VHL and SDH mutations in 99% of cases by the relative concentrations of normetanephrine and metanephrine.
“In 1 large study of patients with pheochromocytoma and/or paraganglioma, patients with NF1 and MEN2 mutations could be discriminated from those with VHL and SDH mutations in 99% of cases by the relative concentrations of normetanephrine and metanephrine, as all patients with NF1 and MEN2 presented with tumors characterized by increased plasma concentrations of metanephrine, in contrast to patients”
From Adrenal incidentaloma (2020) · cites this paper as [181]
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Lenders, J. W. M., Eisenhofer, G., Mannelli, M., & Pacák, K. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67139-5 · Cited by 1,541 · see citing works
Self-citationGerm-Line Mutations in Nonsyndromic Pheochromocytoma
Neumann, H. P. H., Bausch, B., McWhinney, S. R., Bender, B., Gimm, O., Franke, G., Schipper, J., Klisch, J., Altehoefer, C., Zerres, K., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020152 · Cited by 1,350 · see citing works
Biochemical Diagnosis of Pheochromocytoma: Which Test Is Best?
Lenders, J. W. M., Pacak, K., Walther, M. M., Linehan, W. M., Mannelli, M., Friberg, P., Keiser, H. R., Goldstein, D. S., & Eisenhofer, G. (2002) · JAMA · doi:10.1001/jama.287.11.1427 · Cited by 1,134 · see citing works
Self-citationGenetic Testing in Pheochromocytoma or Functional Paraganglioma
Amar, L., Bertherat, J. Y., Baudin, É., Ajzenberg, C., Paillerets, B. B., Chabre, O., Chamontin, B., Delemer, B., Giraud, S., Murat, A., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.1484 · Cited by 683 · see citing works
Pheochromocytoma: recommendations for clinical practice from the First International Symposium
Pacák, K., Eisenhofer, G., Ahlman, H., Bornstein, S. R., Gimenez‐Roqueplo, A., Grossman, A. B., Kimura, N., Mannelli, M., McNicol, A. M., & Tischler, A. S. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0396 · Cited by 675 · see citing works
Self-citationSDHA is a tumor suppressor gene causing paraganglioma
Burnichon, N., Brière, J.-J., Libé, R., Vescovo, L., Rivière, J., Tissier, F., Jouanno, E., Jeunemaı̂tre, X., Bénit, P., Tzagoloff, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq206 · Cited by 645 · see citing works
van Nederveen, F. H., Gaal, J., Favier, J., Korpershoek, E., Oldenburg, R. A., de Bruyn, E. M., Sleddens, H. F. B. M., Derkx, P., Rivière, J., Dannenberg, H., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70164-0 · Cited by 534 · see citing works
Self-citationEisenhofer, G., Goldstein, D. S., Stull, R., Keiser, H. R., Sunderland, T., Murphy, D. L., & Kopin, I. J. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.11.2030 · Cited by 477 · see citing works
Self-citationGermline mutations in TMEM127 confer susceptibility to pheochromocytoma
Qin, Y., Yao, L., King, E. E., Buddavarapu, K., Lenci, R. E., Chocron, E. S., Lechleiter, J. D., Sass, M., Aronin, N., Schiavi, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.533 · Cited by 379 · see citing works
Eisenhofer, G., Lenders, J. W. M., Linehan, W. M., Walther, M. M., Goldstein, D. S., & Keiser, H. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906173402404 · Cited by 346 · see citing works
Self-citationBrouwers, F. M., Eisenhofer, G., Tao, J. J., Kant, J. A., Adams, K. T., Linehan, W. M., & Pacák, K. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0423 · Cited by 314 · see citing works
Self-citationEisenhofer, G., Walther, M. M., Huynh, T., Li, S., Bornstein, S. R., Vortmeyer, A. O., Mannelli, M., Goldstein, D. S., Linehan, W. M., Lenders, J. W. M., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7496 · Cited by 313 · see citing works
Self-citationMannelli, M., Castellano, M., Schiavi, F., Filetti, S., Giacchè, M., Mori, L., Pignataro, V., Bernini, G., Giaché, V., Bacca, A., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2419 · Cited by 300 · see citing works
Self-citationTimmers, H. J. L. M., Kozupa, A., Eisenhofer, G., Raygada, M. J., Adams, K. T., Solis, D. C., Lenders, J. W. M., & Pacák, K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2315 · Cited by 278 · see citing works
Self-citationGill, A. J., Benn, D. E., Chou, A. S. Y., Clarkson, A., Muljono, A., Meyer-Rochow, G. Y., Richardson, A. L., Sidhu, S. B., Robinson, B. G., & Clifton-Bligh, R. J. (2010) · Human Pathology · doi:10.1016/j.humpath.2009.12.005 · Cited by 276 · see citing works
SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma
Bayley, J., Kunst, H. P. M., Cascón, A., Sampietro, M. L., Gaal, J., Korpershoek, E., Hinojar‐Gutiérrez, A., Timmers, H. J. L. M., Hoefsloot, L. H., Hermsen, M. A. J. A., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70007-3 · Cited by 275 · see citing works
Self-citationPheochromocytoma: The expanding genetic differential diagnosis.
Bryant, J., Farmer, J., Kessler, L. J., Townsend, R. R., & Nathanson, K. L. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg024 · Cited by 250 · see citing works
Eisenhofer, G., Keiser, H. R., Friberg, P., Mezey, É., Huynh, T., Hiremagalur, B., Ellingson, T., Duddempudi, S., Eijsbouts, A. M. M., & Lenders, J. W. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4870 · Cited by 242 · see citing works
Self-citationEisenhofer, G., Goldstein, D. S., Sullivan, P., Csákó, G., Brouwers, F. M., Lai, E. W., Adams, K. T., & Pacák, K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2025 · Cited by 234 · see citing works
Self-citationDetermination of metanephrines in plasma by liquid chromatography with electrochemical detection
Lenders, J. W. M., Eisenhofer, G., Armando, I., Keiser, H. R., Goldstein, D. S., & Kopin, I. J. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.1.97 · Cited by 220 · see citing works
Self-citationEisenhofer, G., Lenders, J. W. M., Goldstein, D. S., Mannelli, M., Csákó, G., Walther, M. M., Brouwers, F. M., & Pacák, K. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.045484 · Cited by 207 · see citing works
Self-citationNeumann, H. P. H., Erlic, Z., Boedeker, C. C., Rybicki, L. A., Robledo, M., Hermsen, M. A. J. A., Schiavi, F., Falcioni, M., Kwok, P., Bauters, C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4057 · Cited by 191 · see citing works
Clinical Predictors and Algorithm for the Genetic Diagnosis of Pheochromocytoma Patients
Erlic, Z., Rybicki, L. A., Pęczkowska, M., Golcher, H., Kann, P. H., Brauckhoff, M., Müssig, K., Muresan, M., Schäffler, A., Reisch, N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1237 · Cited by 175 · see citing works
Phaeochromocytoma, new genes and screening strategies
Gimenez‐Roqueplo, A., Lehnert, H., Mannelli, M., Neumann, H., Opocher, G., Maher, E. R., Plouin, P., & on behalf of the European Network for the Study of Adrenal Tumours (ENS@T) Pheochromocytoma Working Group (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02714.x · Cited by 141 · see citing works
Self-citationJiménez, C., Cote, G. J., Arnold, A., & Gagel, R. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2178 · Cited by 135 · see citing works
Genetics of Pheochromocytoma and Paraganglioma in Spanish Patients
Cascón, A., Pita, G., Burnichon, N., Landa, I., López-Jiménez, E. A., Montero‐Conde, C., Leskelä, S., Leandro-Garcia, L. J., Letón, R., Rodríguez‐Antona, C., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2756 · Cited by 134 · see citing works
Genetic screening for pheochromocytoma: should SDHC gene analysis be included?: Figure 1
Mannelli, M., Ercolino, T., Giaché, V., Simi, L., Cirami, C. L., & Parenti, G. (2007) · Journal of Medical Genetics · doi:10.1136/jmg.2007.051045 · Cited by 94 · see citing works
Self-citationEisenhofer, G., Huynh, T., ELKAHLOUN, A. G., Morris, J. C., Bratslavsky, G., Linehan, W. M., Zhuang, Z., Balgley, B. M., Lee, C. S., Mannelli, M., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90591.2008 · Cited by 83 · see citing works
Self-citationThe Approach to the Patient with Paraganglioma
Neumann, H. P. H., & Eng, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0496 · Cited by 75 · see citing works
Pilot quality assurance programme for plasma metanephrines
Pillai, D. N., & Callen, S. (2010) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2009.009153 · Cited by 38 · see citing works
Genetic Testing in Pheochromocytoma
Bornstein, S. R., & Gimenez‐Roqueplo, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1353.010 · Cited by 32 · see citing works
Self-citationCastellano, M., Mori, L., Giacchè, M., Agliozzo, E., Tosini, R., Panarotto, A., Cappelli, C., Mulatero, P., Cumetti, D., Veglio, F., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1353.016 · Cited by 30 · see citing works
Genetic Testing in Pheochromocytoma‐ and Paraganglioma‐Associated Syndromes
Benn, D. E., Richardson, A. L., Marsh, D. J., & Robinson, B. G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1353.011 · Cited by 30 · see citing works
Huynh, T., Pacák, K., Wong, D. L., Linehan, W. M., Goldstein, D. S., ELKAHLOUN, A. G., Munson, P. J., & Eisenhofer, G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1353.026 · Cited by 28 · see citing works
Self-citationSimultaneous Liquid-Chromatographic Determination of Plasma Catecholamines and Metabolites
Eisenhofer, G., Goldstein, D. S., & Kopin, I. J. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.134478 · Cited by 4 · see citing works
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Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline
Lenders, J. W. M., Duh, Q.-Y., Eisenhofer, G., Gimenez-Roqueplo, A.-P., Grebe, S. K. G., Murad, M. H., Naruse, M., Pacak, K., & Young, W. F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1498 · Cited by 2,827 · see citing works
Self-citationComprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma
Fishbein, L. M., Leshchiner, I., Walter, V., Danilova, L., Robertson, A. G., Johnson, A. R., Lichtenberg, T. M., Murray, B. A., Ghayee, H. K., Else, T., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.01.001 · Cited by 795 · see citing works
Pheochromocytoma and Paraganglioma
Neumann, H. P. H., Young, W. F., & Eng, C. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1806651 · Cited by 736 · see citing works
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours
Lam, A. K.-Y. (2017) · Endocrine Pathology · doi:10.1007/s12022-017-9484-5 · Cited by 463 · see citing works
Personalized Management of Pheochromocytoma and Paraganglioma
Nölting, S., Bechmann, N., Taïeb, D., Beuschlein, F., Faßnacht, M., Kroiß, M., Eisenhofer, G., Grossman, A. B., & Pacák, K. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab019 · Cited by 441 · see citing works
Self-citationGenetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas
Welander, J., Söderkvist, P., & Gimm, O. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0170 · Cited by 356 · see citing works
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“Additionally, measurements of plasma methoxytyramine discriminated patients with SDH mutations from those with VHL mutations in a further 78% of cases (181).”
BackgroundMultiple Endocrine Neoplasia Type 2 and Familial Medullary Thyroid Carcinoma: An Update
Wells, S. A., Pacini, F., Robinson, B. G., & Santoro, M. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1204 · Cited by 336 · see citing works
MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma
Burnichon, N., Cascón, A., Schiavi, F., Morales, N. P., Comino‐Méndez, I., Abermil, N., Inglada‐Pérez, L., de Cubas, A. A., Amar, L., Barontini, M., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0160 · Cited by 331 · see citing works
Self-citationNew Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification
Crona, J., Taïeb, D., & Pacák, K. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00062 · Cited by 322 · see citing works
Malignant Pheochromocytoma and Paraganglioma: 272 Patients Over 55 Years
Hamidi, O., Young, W. F., Iñiguez‐Ariza, N. M., Kittah, N. E., Gruber, L., Bancos, C., Tamhane, S. U., & Bancos, I. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00992 · Cited by 315 · see citing works
Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma
Burnichon, N., Vescovo, L., Amar, L., Libé, R., de Reyniès, A., Vénisse, A., Jouanno, E., Laurendeau, I., Parfait, B., Bertherat, J. Y., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr324 · Cited by 304 · see citing works
Fishbein, L. M., Merrill, S. L., Fraker, D. L., Cohen, D. L., & Nathanson, K. L. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-2942-5 · Cited by 242 · see citing works
Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background
Fishbein, L. M., & Nathanson, K. L. (2012) · Cancer Genetics · doi:10.1016/j.cancergen.2012.01.009 · Cited by 206 · see citing works
Pheochromocytoma and paraganglioma: Diagnosis, genetics, management, and treatment
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Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas
Castro‐Vega, L. J., Letouzé, É., Burnichon, N., Buffet, A., Disderot, P.-H., Khalifa, E., Loriot, C., Elarouci, N., Morin, A., Menara, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7044 · Cited by 195 · see citing works
King, K. S., Prodanov, T., Kantorovich, V., Fojo, T., Hewitt, J. K., Zacharin, M., WESLEY, R. A., Lodish, M. B., Raygada, M. J., Gimenez‐Roqueplo, A., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.6353 · Cited by 193 · see citing works
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Eisenhofer, G., Prejbisz, A., Peitzsch, M., Pamporaki, C., Masjkur, J., Rogowski-Lehmann, N., Langton, K., Tsourdi, E., Pęczkowska, M., Fliedner, S., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.291369 · Cited by 181 · see citing works
Self-citationGarcía‐Carbonero, R., Teresa, F. M., Mercader-Cidoncha, E., Mitjavila, M., Robledo, M., Tena, I., Álvarez-Escolá, C., Arístegui, M., Bella-Cueto, M. R., Albiach, C. F., et al. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02622-9 · Cited by 188 · see citing works
DIAGNOSIS OF ENDOCRINE DISEASE: Biochemical diagnosis of phaeochromocytoma and paraganglioma
van Berkel, A., Lenders, J. W. M., & Timmers, H. J. L. M. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0882 · Cited by 177 · see citing works
Self-citationNölting, S., Ullrich, M., Pietzsch, J., Ziegler, C. G., Eisenhofer, G., Grossman, A. B., & Pacák, K. (2019) · Cancers · doi:10.3390/cancers11101505 · Cited by 173 · see citing works
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Jochmanová, I., Yang, C., Zhuang, Z., & Pacák, K. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt201 · Cited by 173 · see citing works
The Diagnosis and Clinical Significance of Paragangliomas in Unusual Locations
Asa, S. L., Ezzat, S., & Mete, Ö. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090280 · Cited by 167 · see citing works
Pheochromocytoma and Paraganglioma
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Gimenez‐Roqueplo, A., Caumont‐Prim, A., Houzard, C., Hignette, C., Hernigou, A., Halimi, P., Niccoli, P., Leboulleux, S., Amar, L., Borson‐Chazot, F., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2975 · Cited by 152 · see citing works
Pathology and genetics of phaeochromocytoma and paraganglioma
Turchini, J., Cheung, V. K.-Y., Tischler, A. S., de Krijger, R. R., & Gill, A. J. (2017) · Histopathology · doi:10.1111/his.13402 · Cited by 148 · see citing works
Crona, J., Lamarca, Á., Ghosal, S., Welin, S., Skogseid, B. M., & Pacák, K. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0024 · Cited by 140 · see citing works
Turková, H., Prodanov, T., Malý, M., Martucci, V. L., Adams, K. T., Widimsky, J., Jr., Chen, C. C., Ling, A. L., Kebebew, E., Stratakis, C. A., et al. (2015) · Endocrine Practice · doi:10.4158/ep15725.or · Cited by 139 · see citing works
Self-citationManagement of medullary thyroid carcinoma and MEN2 syndromes in childhood
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Fonte, J. S., Robles, J., Chen, C. C., Reynolds, J. C., Whatley, M. A., Ling, A. L., MERCADO-ASIS, L. B., Adams, K. T., Martucci, V. L., Fojo, T., et al. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0243 · Cited by 137 · see citing works
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Imaging of Pheochromocytoma and Paraganglioma
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Farrugia, F., & Charalampopoulos, A. A. (2019) · Endocrine Regulations · doi:10.2478/enr-2019-0020 · Cited by 123 · see citing works
Därr, R., Pamporaki, C., Peitzsch, M., Miehle, K., Prejbisz, A., Pęczkowska, M., Weismann, D., Beuschlein, F., Sinnott, R., Bornstein, S. R., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12327 · Cited by 122 · see citing works
Self-citationPeitzsch, M., Prejbisz, A., Kroiß, M., Beuschlein, F., Arlt, W., Januszewicz, A., Siegert, G., & Eisenhofer, G. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2012.012112 · Cited by 120 · see citing works
Self-citationThosani, S., Ayala‐Ramirez, M., Palmer, L. J., Hu, M. I.-N., Rich, T. A., Gagel, R. F., Cote, G. J., Waguespack, S. G., Habra, M. A., & Jiménez, C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1653 · Cited by 119 · see citing works
Eisenhofer, G., Lattke, P., Herberg, M., Siegert, G., Qin, N., Därr, R., Hoyer, J., Villringer, A., Prejbisz, A., Januszewicz, A., et al. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2012.012066 · Cited by 113 · see citing works
Self-citationIntegrative genomics reveals frequent somatic NF1 mutations in sporadic pheochromocytomas
Welander, J., Larsson, C., Bäckdahl, M., Hareni, N., Sivlér, T., Brauckhoff, M., Söderkvist, P., & Gimm, O. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds402 · Cited by 112 · see citing works
Eisenhofer, G., Tischler, A. S., & de Krijger, R. R. (2011) · Endocrine Pathology · doi:10.1007/s12022-011-9188-1 · Cited by 111 · see citing works
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Eisenhofer, G., Pamporaki, C., & Lenders, J. W. M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad011 · Cited by 118 · see citing works
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Jochmanová, I., & Pacák, K. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.11.001 · Cited by 111 · see citing works
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Cawley, N. X., Wetsel, W. C., Murthy, S. R. K., Park, J. J., Pacák, K., & Loh, Y. P. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1039 · Cited by 111 · see citing works
Därr, R., Kuhn, M., Bode, C., Bornstein, S. R., Pacak, K., Lenders, J. W. M., & Eisenhofer, G. (2017) · Endocrine · doi:10.1007/s12020-017-1300-y · Cited by 105 · see citing works
Self-citationRao, D., Peitzsch, M., Prejbisz, A., Hanuš, K., Faßnacht, M., Beuschlein, F., Brugger, C., Fliedner, S. M. J., Langton, K., Pamporaki, C., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0077 · Cited by 104 · see citing works
Self-citationPheochromocytoma and Paraganglioma in Cyanotic Congenital Heart Disease
Opotowsky, A. R., Moko, L. E., Ginns, J. N., Rosenbaum, M., Greutmann, M., Aboulhosn, J., Hageman, A., Kim, Y. Y., Deng, L. X., Grewal, J., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3863 · Cited by 104 · see citing works
Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging
Alrezk, R., Suárez, A., Tena, I., & Pacák, K. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00515 · Cited by 100 · see citing works
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Gläsker, S., Vergauwen, E., Koch, C. A., Kutikov, A., & Vortmeyer, A. O. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s190753 · Cited by 99 · see citing works
Pheochromocytoma and Paraganglioma
Kiernan, C. M., & Solórzano, C. C. (2015) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2015.08.006 · Cited by 97 · see citing works
Mannelli, M., Lenders, J. W. M., Pacák, K., Parenti, G., & Eisenhofer, G. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.10.008 · Cited by 93 · see citing works
Self-citationPheochromocytoma – update on disease management
Därr, R., Lenders, J. W. M., Hofbauer, L. C., Naumann, B., Bornstein, S. R., & Eisenhofer, G. (2012) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018812437356 · Cited by 91 · see citing works
Self-citationLin, E. P., Chin, B. B., Fishbein, L. M., Moritani, T., Montoya, S. P., Ellika, S., & Newlands, S. D. (2022) · Radiology Imaging Cancer · doi:10.1148/rycan.210088 · Cited by 92 · see citing works
Eisenhofer, G., Klink, B., Richter, S., Lenders, J. W. M., & Robledo, M. (2017) · Europe PMC (PubMed Central) · Cited by 84 · see citing works
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Ilanchezhian, M., Jha, A., Pacák, K., & Rivero, J. D. (2020) · Current Treatment Options in Oncology · doi:10.1007/s11864-020-00787-z · Cited by 81 · see citing works
Fishbein, L. M., Orlowski, R. Z., & Cohen, D. L. (2013) · Journal of Clinical Hypertension · doi:10.1111/jch.12084 · Cited by 81 · see citing works
Pheochromocytoma Screening Initiation and Frequency in von Hippel-Lindau Syndrome
Aufforth, R., Ramakant, P., Sadowski, S. M., Mehta, A. R., Trebska-McGowan, K., Nilubol, N., Pacák, K., & Kebebew, E. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3045 · Cited by 79 · see citing works
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Martins, R., & Bugalho, M. J. (2014) · International Journal of Endocrinology · doi:10.1155/2014/794187 · Cited by 80 · see citing works
Schovánek, J., Martucci, V. L., WESLEY, R. A., Fojo, T., Rivero, J. D., Huynh, T., Adams, K. T., Kebebew, E., Fryšák, Z., Stratakis, C. A., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-523 · Cited by 74 · see citing works
Self-citationGupta, G., & Pacák, K. (2017) · Endocrine Practice · doi:10.4158/ep161718.ra · Cited by 76 · see citing works
Phaeochromocytoma: a catecholamine and oxidative stress disorder
Pacák, K. (2011) · Endocrine Regulations · doi:10.4149/endo_2011_02_65 · Cited by 73 · see citing works
Management of von Hippel-Lindau Disease: An Interdisciplinary Review
Schmid, S., Gillessen, S., Binet, I., Brändle, M., Engeler, D. S., Greiner, J., Hader, C., Heinimann, K., Kloos, P., Krek, W., et al. (2014) · Oncology Research and Treatment · doi:10.1159/000369362 · Cited by 70 · see citing works
Pheochromocytomas and paragangliomas: assessment of malignant potential
Korevaar, T. I. M., & Grossman, A. B. (2011) · Endocrine · doi:10.1007/s12020-011-9545-3 · Cited by 70 · see citing works
Pheochromocytoma and Paraganglioma
Pacák, K., & Wimalawansa, S. J. (2015) · Endocrine Practice · doi:10.4158/ep14481.ra · Cited by 70 · see citing works
Interest of systematic screening of pheochromocytoma in patients with neurofibromatosis type 1
Képénékian, L., Mognetti, T., Lifante, J., Giraudet, A., Houzard, C., Pinson, S., Borson‐Chazot, F., & Combemale, P. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0233 · Cited by 70 · see citing works
Beń‐Skowronek, I., & Kozaczuk, S. (2015) · Hormone Research in Paediatrics · doi:10.1159/000431323 · Cited by 68 · see citing works
15 YEARS OF PARAGANGLIOMA: Pathology of pheochromocytoma and paraganglioma
Tischler, A. S., & de Krijger, R. R. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0261 · Cited by 66 · see citing works
Berends, A. M. A., Eisenhofer, G., Fishbein, L. M., van der Horst‐Schrivers, A. N. A., Kema, I. P., Links, T. P., Lenders, J. W. M., & Kerstens, M. N. (2019) · Cancers · doi:10.3390/cancers11081121 · Cited by 63 · see citing works
Self-citationTMEM127Screening in a Large Cohort of Patients with Pheochromocytoma and/or Paraganglioma
Abermil, N., Guillaud-Bataille, M., Burnichon, N., Vénisse, A., Manivet, P., Guignat, L., Drui, D., Chupin, M., Josseaume, C., Affres, H., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3360 · Cited by 64 · see citing works
Weismann, D., Peitzsch, M., Raida, A., Prejbisz, A., Gosk-Przybyłek, M., Riester, A., Willenberg, H. S., Klemm, R., Manz, G., Deutschbein, T., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0730 · Cited by 64 · see citing works
Self-citationPheochromocytomas and Abdominal Paragangliomas: A Practical Guidance
Calissendorff, J., Juhlin, C. C., Bancos, I., & Falhammar, H. (2022) · Cancers · doi:10.3390/cancers14040917 · Cited by 61 · see citing works
Current management of succinate dehydrogenase–deficient gastrointestinal stromal tumors
Neppala, P., Banerjee, S., Fanta, P. T., Yerba, M., Porras, K., Burgoyne, A. M., & Sicklick, J. K. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09818-0 · Cited by 60 · see citing works
MacFarlane, J., Seong, K. C., Bisambar, C., Madhu, B., Allinson, K. S. J., Marker, A. J., Warren, A. Y., Park, S., Giger, O., Challis, B., et al. (2020) · Clinical Endocrinology · doi:10.1111/cen.14289 · Cited by 64 · see citing works
Eisenhofer, G., Deutschbein, T., Constantinescu, G. A., Langton, K., Pamporaki, C., Calsina, B., Monteagudo, M., Peitzsch, M., Fliedner, S. M. J., Timmers, H. J. L. M., et al. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0904 · Cited by 59 · see citing works
Self-citationCalculating optimal surveillance for detection of von Hippel–Lindau-related manifestations
Kruizinga, R. C., Sluiter, W. J., de Vries, E. G. E., Zonnenberg, B. A., Lips, C. J. M., van der Horst‐Schrivers, A. N. A., Walenkamp, A., & Links, T. P. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0308 · Cited by 58 · see citing works
Pheochromocytoma: A Genetic And Diagnostic Update
MERCADO-ASIS, L. B., Wolf, K. I., Jochmanová, I., & Taïeb, D. (2017) · Endocrine Practice · doi:10.4158/ep-2017-0057 · Cited by 58 · see citing works
Catecholamine-induced hypertensive crises: current insights and management
Nazari, M. A., HASAN, M. R., Haigney, M. C., Maghsoudi, A., Lenders, J. W. M., Carey, R. M., & Pacák, K. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00256-5 · Cited by 55 · see citing works
Self-citationThe Clinical Phenotype of SDHC-Associated Hereditary Paraganglioma Syndrome (PGL3)
Else, T., Marvin, M. L., Everett, J. N., Gruber, S. B., Arts, H. A., Stoffel, E. M., Auchus, R. J., & Raymond, V. M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3853 · Cited by 54 · see citing works
An update on the genetics of pheochromocytoma
Karásek, D., Shah, U. A., Fryšák, Z., Stratakis, C. A., & Pacák, K. (2012) · Journal of Human Hypertension · doi:10.1038/jhh.2012.20 · Cited by 54 · see citing works
Zhao, Y., Li, B., Wang, G., Ge, S., Ximing, L., Xu, G., & Liu, H. (2019) · Molecules · doi:10.3390/molecules24142660 · Cited by 52 · see citing works
Lowery, A., Walsh, S. M., McDermott, E. W. M., & Prichard, R. S. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0410 · Cited by 51 · see citing works
Longo, J. F., Weber, S. M., Turner-Ivey, B., & Carroll, S. L. (2018) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000197 · Cited by 51 · see citing works
Familial pheochromocytomas and paragangliomas
King, K. S., & Pacák, K. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.032 · Cited by 49 · see citing works
Predisposition to Pediatric and Hematologic Cancers: A Moving Target
Malkin, D. M., Nichols, K. E., Zelley, K., & Schiffman, J. D. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.e44 · Cited by 46 · see citing works
Osinga, T. E., Korpershoek, E., de Krijger, R. R., Kerstens, M. N., Dullaart, R. P. F., Kema, I. P., van der Laan, B. F. A. M., van der Horst‐Schrivers, A. N. A., & Links, T. P. (2015) · Neuroendocrinology · doi:10.1159/000377703 · Cited by 45 · see citing works
Hernandez, K., Ezzat, S., Morel, C. F., Swallow, C. J., Otremba, M., Dickson, B. C., Asa, S. L., & Mete, Ö. (2015) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-015-1755-2 · Cited by 46 · see citing works
Clinical evaluation and treatment of phaeochromocytoma
Davison, A. S., Jones, D. M., Ruthven, S., Helliwell, T. R., & Shore, S. (2017) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563217739931 · Cited by 46 · see citing works
Parasiliti‐Caprino, M., Lucatello, B. G., Lopez, C., Burrello, J., Maletta, F., Mistrangelo, M., Migliore, E., Tassone, F., Grotta, A. L., Pia, A. R., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0339-y · Cited by 45 · see citing works
The Genetic Basis of Pheochromocytoma and Paraganglioma: Implications for Management
Shuch, B. M., Ricketts, C. J., Metwalli, A. R., Pacák, K., & Linehan, W. M. (2014) · Urology · doi:10.1016/j.urology.2014.01.007 · Cited by 44 · see citing works
Self-citationPęczkowska, M., Kowalska, A., Sygut, J., Waligórski, D., Malinoc, A., Janaszek−Sitkowska, H., Prejbisz, A., Januszewicz, A., & Neumann, H. P. H. (2013) · Clinical Endocrinology · doi:10.1111/cen.12218 · Cited by 43 · see citing works
Impact of LC-MS/MS on the laboratory diagnosis of catecholamine-producing tumors
Eisenhofer, G., Peitzsch, M., & McWhinney, B. C. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2016.01.027 · Cited by 43 · see citing works
Self-citationMucha, L., Leidig‐Bruckner, G., Frank‐Raue, K., Bruckner, T., Kroiß, M., Raue, F., & the German study group for rare thyroid cancer (2017) · Clinical Endocrinology · doi:10.1111/cen.13386 · Cited by 43 · see citing works
Clinical utility of chromogranin A in SDH x‐related paragangliomas
Zuber, S. M., WESLEY, R. A., Prodanov, T., Eisenhofer, G., Pacák, K., & Kantorovich, V. (2014) · European Journal of Clinical Investigation · doi:10.1111/eci.12245 · Cited by 42 · see citing works
Self-citationExtent of surgery for phaeochromocytomas in the genomic era
Rossitti, H. M., Söderkvist, P., & Gimm, O. (2018) · British journal of surgery · doi:10.1002/bjs.10744 · Cited by 42 · see citing works
Sulukan, E., Şenol, O., Baran, A., Kankaynar, M., Yıldırım, S., Kızıltan, T., Bolat, İ., & Ceyhun, S. B. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156391 · Cited by 42 · see citing works
Succinate Dehydrogenase Gene Mutations in Cardiac Paragangliomas
Martucci, V. L., Emaminia, A., Rivero, J. D., Lechan, R. M., Magoon, B. T., Galia, A., Fojo, T., Leung, S., Lorusso, R., Jiménez, C., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.03.020 · Cited by 41 · see citing works
Self-citationSignificance of Alpha-inhibin Expression in Pheochromocytomas and Paragangliomas
Mete, Ö., Pakbaz, S., Lerário, A. M., Giordano, T. J., & Asa, S. L. (2021) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001715 · Cited by 38 · see citing works
Association of urinary bladder paragangliomas with germline mutations in the SDHB and VHL genes
Martucci, V. L., Lorenzo, Z. G., Weintraub, M. D., Rivero, J. D., Ling, A. L., Merino, M. J., Siddiqui, M. M., Shuch, B. M., Vourganti, S., Linehan, W. M., et al. (2015) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2014.11.017 · Cited by 39 · see citing works
Self-citationShankavaram, U. T., Fliedner, S. M. J., ELKAHLOUN, A. G., Barb, J. J., Munson, P. J., Huynh, T., Matro, J. C., Turková, H., Linehan, W. M., Timmers, H. J. L. M., et al. (2013) · Neoplasia · doi:10.1593/neo.122132 · Cited by 38 · see citing works
Self-citationTaïeb, D., Kebebew, E., Castinetti, F., Chen, C. C., Henry, J., & Pacák, K. (2014) · Clinical Endocrinology · doi:10.1111/cen.12513 · Cited by 37 · see citing works
- Authors
- Eisenhofer, G., Lenders, J. W., Timmers, H., Mannelli, M., Grebe, S. K., Hofbauer, L. C., Bornstein, S. R., Tiebel, O., Adams, K., Bratslavsky, G., Linehan, W. M., & Pacak, K.
- Affiliations
- Technische Universität Dresden (DE)
- Radboud University Nijmegen (NL)
- University of Florence (IT)
- Mayo Clinic (US)
- Institute of Clinical Chemistry and Laboratory Medicine and
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- National Institutes of Health (US)
- Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD
- Corresponding author
- Eisenhofer, Graeme
- ORCID
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 57
- Issue
- 3
- Pages
- 411-420
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- PMC
- PMC3164998
- OpenAlex
- W2163960412
- Cited by
- 290
- References
- 35
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 15 · 2022: 16 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 32 · 2016: 19 · 2015: 32 · 2014: 31 · 2013: 27 · 2012: 22
- FWCI
- 30.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Site cant be reached (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Deutsche Forschungsgesellschaft
- Center for Regenerative Therapies Dresden
- Dresden Tumor Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Center for Cancer Research
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- pheochromocytoma, familial pheochromocytoma, methoxytyramine, normetanephrine, metanephrine, von Hippel-Lindau disease, SDHB mutation, SDHD mutation, multiple endocrine neoplasia type 2, neurofibromatosis type 1, genotyping, epinephrine, norepinephrine, dopamine
- MeSH terms
- Adrenal Gland Neoplasms, Diagnosis, Differential, Dopamine, Humans, Metanephrine, Neoplastic Syndromes, Hereditary, Normetanephrine, Pheochromocytoma, Retrospective Studies, Biomarkers, Tumor
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