The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels
Open accessAbstract
Inactivation of the TCA cycle enzyme, fumarate hydratase (FH), drives a metabolic shift to aerobic glycolysis in FH-deficient kidney tumors and cell lines from patients with hereditary leiomyomatosis renal cell cancer (HLRCC), resulting in decreased levels of AMP-activated kinase (AMPK) and p53 tumor suppressor, and activation of the anabolic factors, acetyl-CoA carboxylase and ribosomal protein S6. Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1α, but not HIF-2α. Silencing of HIF-1α or activation of AMPK diminishes invasive activities, indicating that alterations of HIF-1α and AMPK contribute to the oncogenic growth of FH-deficient cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Strong evidence implicates dysfunctional cell signaling stimulated by succinate and/or fumarate, which accumulate to high levels in SDH/FH-deficient tumors.
“Strong evidence implicates dysfunctional cell signaling stimulated by succinate and/or fumarate, which accumulate to high levels in the tumors.”
From Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? (2012) · cites this paper as Tong et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941 · see citing works
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works
Metformin and reduced risk of cancer in diabetic patients
Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005) · BMJ · doi:10.1136/bmj.38415.708634.f7 · Cited by 2,388 · see citing works
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,207 · see citing works
Mutations in <i>SDHD</i> , a Mitochondrial Complex II Gene, in Hereditary Paraganglioma
Baysal, B. E., Ferrell, R. E., Willett-Brozick, J. E., Lawrence, E. C., Myssiorek, D., Bosch, A., Mey, A. V. D., Taschner, P. E. M., Rubinstein, W. S., Myers, E. N., et al. (2000) · Science · doi:10.1126/science.287.5454.848 · Cited by 1,638 · see citing works
The Multiple Leiomyoma Consortium (2002) · Nature Genetics · doi:10.1038/ng849 · Cited by 1,635 · see citing works
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2904 · Cited by 1,454 · see citing works
Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N., & Struhl, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2994 · Cited by 1,115 · see citing works
Tumor suppressors and cell metabolism: a recipe for cancer growth
Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085 · see citing works
The role of iron regulatory proteins in mammalian iron homeostasis and disease
Rouault, T. A. (2006) · Nature Chemical Biology · doi:10.1038/nchembio807 · Cited by 1,055 · see citing works
Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959 · see citing works
Isaacs, J. S., Jung, Y. J., Mole, D. R., Lee, S., Torres-Cabala, C., Chung, Y.-L., Merino, M., Trepel, J., Zbar, B., Toro, J., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.017 · Cited by 958 · see citing works
Self-citationRaval, R. R., Lau, K. W., Tran, M. G. B., Sowter, H. M., Mandriota, S. J., Li, J.-L., Pugh, C. W., Maxwell, P. H., Harris, A. L., & Ratcliffe, P. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5675-5686.2005 · Cited by 940 · see citing works
Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 923 · see citing works
Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II
Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M., & Rao, Z. (2005) · Cell · doi:10.1016/j.cell.2005.05.025 · Cited by 881 · see citing works
Pollard, P. J., Brière, J. J., Alam, N. A., Barwell, J., Barclay, E., Wortham, N. C., Hunt, T., Mitchell, M., Olpin, S., Moat, S. J., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi227 · Cited by 865 · see citing works
Marsin, A.-S., Bertrand, L., Rider, M. H., Deprez, J., Beauloye, C., Vincent, M. F., den Berghe, G. V., Carling, D., & Hue, L. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00742-9 · Cited by 818 · see citing works
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., & Kaelin, W. G. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00043-0 · Cited by 761 · see citing works
Hao, H.-X., Khalimonchuk, O., Schraders, M., Dephoure, N., Bayley, J.-P., Kunst, H., Devilee, P., Cremers, C. W. R. J., Schiffman, J. D., Bentz, B. G., et al. (2009) · Science · doi:10.1126/science.1175689 · Cited by 702 · see citing works
Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701 · see citing works
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
King, A., Selak, M. A., & Gottlieb, E. (2006) · Oncogene · doi:10.1038/sj.onc.1209594 · Cited by 672 · see citing works
Inherited susceptibility to uterine leiomyomas and renal cell cancer
Launonen, V., Vierimaa, O., Kiuru, M., Isola, J., Roth, S., Pukkala, E., Sistonen, P., Herva, R., & Aaltonen, L. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051633798 · Cited by 669 · see citing works
Toro, J. R., Nickerson, M. L., Wei, M.-H., Warren, M. B., Glenn, G. M., Turner, M. L. C., Stewart, L., Duray, P. H., Tourre, O., Sharma, N. D., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/376435 · Cited by 633 · see citing works
Shaw, R. J. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.005 · Cited by 543 · see citing works
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
Zhang, H., Cicchetti, G., Onda, H., Koon, H. B., Asrican, K., Bajraszewski, N., Vázquez, F., Carpenter, C. L., & Kwiatkowski, D. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17222 · Cited by 538 · see citing works
LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
Zhang, H., Cicchetti, G., Onda, H., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317222 · Cited by 482 · see citing works
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Semenza, G. L. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.009 · Cited by 469 · see citing works
Hypoxia-inducible factors: central regulators of the tumor phenotype
Gordan, J. D., & Simon, M. C. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.006 · Cited by 450 · see citing works
Laderoute, K. R., Amin, K., Calaoagan, J. M., Knapp, M., Le, T., Orduna, J. M., Foretz, M., & Viollet, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-06 · Cited by 443 · see citing works
Maranchie, J. K., Vasselli, J. R., Riss, J., Bonifacino, J. S., Linehan, W. M., & Klausner, R. D. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00044-2 · Cited by 433 · see citing works
AMPK, the metabolic syndrome and cancer
Luo, Z., Saha, A. K., Xiang, X., & Ruderman, N. B. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.011 · Cited by 426 · see citing works
Merino, M. J., Torres-Cabala, C. A., Pinto, P. A., & Linehan, W. M. (2007) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31804375b8 · Cited by 408 · see citing works
Hypoxic regulation of erythropoiesis and iron metabolism
Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347 · see citing works
Imamura, K., Ogura, T., Kishimoto, A., Kaminishi, M., & Esumi, H. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5627 · Cited by 345 · see citing works
Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC
Wu, K., Polack, A., & Dalla‐Favera, R. (1999) · Science · doi:10.1126/science.283.5402.676 · Cited by 328 · see citing works
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
Sanchez, M., Galy, B., Muckenthaler, M. U., & Hentze, M. W. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1222 · Cited by 294 · see citing works
Xiang, X., Saha, A. K., Wen, R., Ruderman, N. B., & Luo, Z. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.133 · Cited by 250 · see citing works
AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle
Musi, N., Hayashi, T., FUJII, N. L., Hirshman, M. F., Witters, L. A., & Goodyear, L. J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e677 · Cited by 219 · see citing works
Sudarshan, S., Sourbier, C., Kong, H.-S., Block, K., Romero, V. A. V., Yang, Y., Galindo, C., Mollapour, M., Scroggins, B., Goode, N., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00483-09 · Cited by 217 · see citing works
Self-citationKaelin, W. G., & Thompson, C. B. (2010) · Nature · doi:10.1038/465562a · Cited by 198 · see citing works
Zimmer, M., Ebert, B. L., Neil, C., Brenner, K., Papaioannou, I., Melas, A., Tolliday, N., Lamb, J., Pantopoulos, K., Golub, T., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.004 · Cited by 191 · see citing works
Pollard, P. J., Spencer‐Dene, B., Shukla, D., Howarth, K. M., Nye, E. L., El-Bahrawy, M. A., Deheragoda, M. G., Kolatsi‐Joannou, M., McDonald, S. A. C., Martin, A., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.005 · Cited by 177 · see citing works
Histological evaluation of AMPK signalling in primary breast cancer
Hadad, S. M., Baker, L., Quinlan, P., Robertson, K. E., Bray, S. E., Thomson, G., Kellock, D., Jordan, L. B., Purdie, C. A., Hardie, D. G., et al. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-307 · Cited by 173 · see citing works
Chen, J., Zhao, S., Nakada, K., Kuge, Y., Tamaki, N., Okada, F., Wang, J., 進藤, 正., Higashino, F., Takeda, K., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63924-7 · Cited by 170 · see citing works
Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms
Tabuchi, M., Tanaka, N., Nishida-Kitayama, J., Ohno, H., & Kishi, F. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-03-0165 · Cited by 141 · cited 1× · see citing works
“We observed that the protein levels of DMT1 (Tabuchi et al., 2002), which transport iron from the endosome into the cytosol after iron uptake via TfR1 (Mims and Prchal, 2005), were extremely low in UOK262 cells (Figure 5A).”
Yang, Y., Valera, V., Padilla‐Nash, H. M., Sourbier, C., Vocke, C. D., Vira, M. A., Abu-Asab, M. S., Bratslavsky, G., Tsokos, M., Merino, M. J., et al. (2009) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2009.08.018 · Cited by 138 · see citing works
Cooperation of two mRNA-Binding proteins drives metabolic adaptation to iron deficiency
Puig, S., Vergara, S. V., & Thiele, D. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.010 · Cited by 135 · see citing works
Mims, M. P., & Prchal, J. T. (2005) · Hematology · doi:10.1080/10245330500093419 · Cited by 123 · see citing works
Dang, D. T., Chen, F., Gardner, L. B., Cummins, J. M., Rago, C., Bunz, F., Kantsevoy, S. V., & Dang, L. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2887 · Cited by 122 · see citing works
Bayley, J., & Devilee, P. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.02.008 · Cited by 117 · see citing works
Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment
Inoki, K., & Guan, K. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp032 · Cited by 98 · see citing works
Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest
Zhang, F., Wang, W., Tsuji, Y., Torti, S. V., & Torti, F. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806432200 · Cited by 90 · see citing works
Haurie, V., Boucherie, H., & Sagliocco, F. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307447200 · Cited by 87 · see citing works
Maffettone, C., Chen, G., Drozdov, I. A., Ouzounis, C. A., & Pantopoulos, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010163 · Cited by 68 · see citing works
FER-1, an Enhancer of the Ferritin H Gene and a Target of E1A-Mediated Transcriptional Repression
Tsuji, Y., Akebi, N., Lam, T. K., Nakabeppu, Y., Torti, S. V., & Torti, F. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.5152 · Cited by 54 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works
Role of Mitochondria in Ferroptosis
Gao, M., Yi, J., Zhu, J., Minikes, A. M., Monian, P., Thompson, C. B., & Jiang, X. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.042 · Cited by 2,120 · see citing works
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621 · see citing works
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
The Cancer Genome Atlas Research Network (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505917 · Cited by 1,336 · see citing works
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell · doi:10.1016/j.cell.2012.02.032 · Cited by 858 · see citing works
Epidemiology of Renal Cell Carcinoma: 2022 Update
Bukavina, L., Bensalah, K., Bray, F., Carlo, M. I., Challacombe, B. J., Karam, J. A., Kassouf, W., Mitchell, T. J., Montironi, R., O’Brien, T., et al. (2022) · European Urology · doi:10.1016/j.eururo.2022.08.019 · Cited by 805 · see citing works
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
Sullivan, L. B., Gui, D. Y., & Heiden, M. G. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.85 · Cited by 406 · see citing works
Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
Schödel, J., Grampp, S., Maher, E. R., Moch, H., Ratcliffe, P. J., Russo, P., & Mole, D. R. (2015) · European Urology · doi:10.1016/j.eururo.2015.08.007 · Cited by 411 · see citing works
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Andrejeva, G., & Rathmell, J. C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.004 · Cited by 368 · see citing works
Menko, F. H., Maher, E. R., Schmidt, L. S., Middelton, L. A., Aittomäki, K., Tomlinson, I. P. M., Richard, S., & Linehan, W. M. (2014) · Familial Cancer · doi:10.1007/s10689-014-9735-2 · Cited by 357 · see citing works
The Metabolic Basis of Kidney Cancer
Linehan, W. M., Schmidt, L. S., Crooks, D. R., Wei, D., Srinivasan, R., Lang, M., & Ricketts, C. J. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1354 · Cited by 336 · see citing works
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
Sullivan, L. B., Martinez-Garcia, E., Nguyen, H., Mullen, A. R., Dufour, E., Sudarshan, S., Licht, J. D., Deberardinis, R. J., & Chandel, N. S. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.003 · Cited by 304 · see citing works
Role of mitochondrial dysfunction in cancer progression
Hsu, C., Tseng, L., & Lee, H. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216641787 · Cited by 306 · see citing works
Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeuticsPreprint
Linehan, W. M. (2012) · Genome Research · doi:10.1101/gr.131110.111 · Cited by 240 · see citing works
Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer
Ricketts, C. J., Shuch, B. M., Vocke, C. D., Metwalli, A. R., Bratslavsky, G., Middelton, L. A., Yang, Y., Wei, M.-H., Pautler, S. E., Peterson, J. C., et al. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.08.030 · Cited by 239 · see citing works
Palma, F. R., He, C., Danes, J. M., Paviani, V., Coelho, D. R., Gantner, B. N., & Bonini, M. G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7962 · Cited by 229 · see citing works
Linehan, W. M., & Rouault, T. A. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0304 · Cited by 223 · see citing works
Oncometabolites in renal cancer
Yong, C., Stewart, G. D., & Frezza, C. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0210-z · Cited by 212 · see citing works
Acetyl-CoA Carboxylases and Diseases
Wang, Y., Yu, W., Li, S., Guo, D., He, J., & Wang, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.836058 · Cited by 225 · see citing works
The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption
Anderson, S. A., Nizzi, C. P., Chang, Y.-I., Deck, K. M., Schmidt, P. J., Galy, B., Damnernsawad, A., Broman, A. T., Kendziorski, C., Hentze, M. W., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.007 · Cited by 211 · see citing works
Hereditary Kidney Cancer Syndromes
Haas, N. B., & Nathanson, K. L. (2013) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2013.10.001 · Cited by 209 · see citing works
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
Vernieri, C., Casola, S., Foiani, M., Pietrantonio, F., de Braud, F., & Longo, V. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0615 · Cited by 202 · see citing works
Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies
Zadra, G., Batista, J. L., & Loda, M. F. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0068 · Cited by 196 · see citing works
You, Y.-H., Quach, T., Saito, R., Pham, J., & Sharma, K. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015030302 · Cited by 191 · see citing works
Fumarate hydratase in cancer: A multifaceted tumour suppressor
Schmidt, C., Sciacovelli, M., & Frezza, C. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.002 · Cited by 163 · see citing works
Genetic predisposition to kidney cancer
Schmidt, L. S., & Linehan, W. M. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2016.09.001 · Cited by 160 · see citing works
Teicher, B. A., Linehan, W. M., & Helman, L. J. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2587 · Cited by 152 · see citing works
Qu, C., Zhang, W., Zheng, G., Zhang, Z., Yin, J., & He, Z. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1845-x · Cited by 149 · see citing works
The metabolic basis of kidney cancer
Linehan, W. M., & Ricketts, C. J. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.06.002 · Cited by 148 · see citing works
Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo
Pereira, M., Chen, T., Buang, N. B., Olona, A., Ko, J., Prendecki, M. F., Costa, A. S. H., Nikitopoulou, E., Tronci, L., Pusey, C. D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.039 · Cited by 138 · see citing works
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
Ryan, D. G., Yang, M., Prag, H. A., Blanco, G. R., Nikitopoulou, E., Segarra-Mondejar, M., Powell, C. A., Young, T., Burger, N., Miljković, J. L., et al. (2021) · eLife · doi:10.7554/elife.72593 · Cited by 138 · see citing works
Fessel, J. P., Hamid, R., Wittmann, B. M., Robinson, L. J., Blackwell, T., Tada, Y., Tanabe, N., Tatsumi, K., Hemnes, A. R., & West, J. D. (2012) · Pulmonary Circulation · doi:10.4103/2045-8932.97606 · Cited by 138 · see citing works
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy
Vila, I. K., Yao, Y., Kim, G., Xia, W., Kim, H.-J., Kim, S.-J., Park, M.-K., Hwang, J. P., González‐Billalabeitia, E., Hung, M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.01.003 · Cited by 129 · see citing works
SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery
Saxena, N., Maio, N., Crooks, D. R., Ricketts, C. J., Yang, Y., Wei, M.-H., Fan, T. W. ‐., Lane, A. N., Sourbier, C., Singh, A., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv287 · Cited by 121 · see citing works
Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism
Valcárcel-Jiménez, L., & Frezza, C. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02412-w · Cited by 115 · see citing works
Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer
Sourbier, C., Ricketts, C. J., Matsumoto, S., Crooks, D. R., Liao, P., Mannes, P. Z., Yang, Y., Wei, M.-H., Srivastava, G. K., Ghosh, S., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.005 · Cited by 108 · see citing works
Regulation of iron homeostasis by the p53-ISCU pathway
Funauchi, Y., Tanikawa, C., Lo, P. H. Y., Mori, J., Daigo, Y., Takano, A., Miyagi, Y., Okawa, A., Nakamura, Y., & Matsuda, K. (2015) · Scientific Reports · doi:10.1038/srep16497 · Cited by 109 · see citing works
New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease
Srinivasan, R., Ricketts, C. J., Sourbier, C., & Linehan, W. M. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2993 · Cited by 108 · see citing works
The Warburg Effect in Diabetic Kidney Disease
Zhang, G., Darshi, M., & Sharma, K. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.01.002 · Cited by 106 · see citing works
Integrated Molecular Characterization of Fumarate Hydratase–deficient Renal Cell Carcinoma
Sun, G., Zhang, X., Liang, J., Pan, X., Zhu, S., Liu, Z., Armstrong, C. M., Chen, J., Lin, W., Liao, B., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3788 · Cited by 102 · see citing works
Yang, Y., Lane, A. N., Ricketts, C. J., Sourbier, C., Wei, M.-H., Shuch, B. M., Pike, L. S., Wu, M., Rouault, T. A., Boros, L. G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072179 · Cited by 103 · see citing works
Iommarini, L., Kurelac, I., Capristo, M., Calvaruso, M. A., Giorgio, V., Bergamini, C., Ghelli, A. M., Nanni, P., Giovanni, C. D., Carelli, V., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt533 · Cited by 101 · see citing works
Metabolic alterations in renal cell carcinoma
Massari, F., Ciccarese, C., Santoni, M., Brunelli, M., Piva, F., Modena, A., Bimbatti, D., Fantinel, E., Santini, D., Liang Cheng, C., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.07.002 · Cited by 97 · see citing works
Aerobic glycolysis: a novel target in kidney cancer
Shuch, B. M., Linehan, W. M., & Srinivasan, R. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/era.13.57 · Cited by 92 · see citing works
Carling, D., & Viollet, B. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.005 · Cited by 89 · see citing works
Zhou, L., Ou, S., Liang, T. B., Li, M., Xiao, P., Cheng, J., Zhou, J., & Yuan, L. (2023) · FEBS Journal · doi:10.1111/febs.16768 · Cited by 89 · see citing works
Zhang, X., & Li, X. (2022) · Metabolites · doi:10.3390/metabo12010058 · Cited by 89 · see citing works
Sourbier, C., Scroggins, B. T., Ratnayake, R., Prince, T. L., Lee, S., Lee, M.-J., Nagy, P., Lee, Y. H., Trepel, J. B., Beutler, J. A., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.12.007 · Cited by 87 · see citing works
Greene, C. J., Attwood, K., Sharma, N. J., Gross, K. W., Smith, G. J., Xu, B., & Kauffman, E. C. (2017) · Oncotarget · doi:10.18632/oncotarget.22323 · Cited by 87 · see citing works
Estèves, P., Pecqueur, C., Ransy, C., Esnous, C., Lenoir, V., Bouillaud, F., Bulteau, A., Lombès, A., Prip‐Buus, C., Ricquier, D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3383 · Cited by 86 · see citing works
Li, M., Li, L., Zheng, J., Li, Z., Li, S., Wang, K., & Chen, X. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01745-7 · Cited by 85 · see citing works
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells
Raggi, C., Gammella, E., Correnti, M., Buratti, P., Forti, E., Andersen, J. B., Alpini, G. D., Glaser, S. S., Alvaro, D., Invernizzi, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17804-1 · Cited by 87 · see citing works
Boros, L. G., D’Agostino, D. P., Katz, H. E., Roth, J. P., Meuillet, E. J., & Somlyai, G. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.11.016 · Cited by 84 · see citing works
Crooks, D. R., Maio, N., Lang, M., Ricketts, C. J., Vocke, C. D., Gurram, S., Turan, S., Kim, Y., Cawthon, G. M., Sohelian, F., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abc4436 · Cited by 85 · see citing works
Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research
Ooi, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.016 · Cited by 83 · see citing works
Adrenal Nodular Hyperplasia in Hereditary Leiomyomatosis and Renal Cell Cancer
Shuch, B. M., Ricketts, C. J., Vocke, C. D., Valera, V., Chen, C. C., Gautam, R., Gupta, G. N., Gómez-Macias, G. S., Merino, M. J., Bratslavsky, G., et al. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.07.139 · Cited by 79 · see citing works
Buelow, B., Cohen, J. N., Nagymányoki, Z., Frizzell, N., Joseph, N. M., McCalmont, T. H., & Garg, K. (2016) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000626 · Cited by 79 · see citing works
Laurenti, G., & Tennant, D. A. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160099 · Cited by 79 · see citing works
Zhou, X., Curbo, S., Li, F., Krishnan, S., & Karlsson, A. (2018) · BMC Cancer · doi:10.1186/s12885-018-4443-1 · Cited by 75 · see citing works
The Tricarboxylic Acid Cycle at the Crossroad Between Cancer and Immunity
Scagliola, A., Mainini, F., & Cardaci, S. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7974 · Cited by 73 · see citing works
Hoerner, C. R., Chen, V. J., & Fan, A. C. (2019) · Kidney Cancer · doi:10.3233/kca-180043 · Cited by 68 · see citing works
Liu, X., Ma, F., Liu, C., Zhu, K., Li, W., Xu, Y., Li, G., Niu, Z., Liu, J., Du, C., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-019-2194-9 · Cited by 66 · see citing works
Su, X., Yu, W., Liu, A., Wang, C., Li, X., Gao, J., Liu, X.-F., Jiang, W., Yang, Y., & Lv, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.808867 · Cited by 66 · see citing works
Yang, Y., Valera, V., Sourbier, C., Vocke, C. D., Wei, M., Pike, L., Huang, Y. K., Merino, M. A., Bratslavsky, G., Wu, M., et al. (2012) · Cancer Genetics · doi:10.1016/j.cancergen.2012.05.001 · Cited by 65 · see citing works
Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney
Mahapatra, G., Varughese, A., Ji, Q., Lee, I., Liu, J., Vaishnav, A., Sinkler, C., Kapralov, A. A., Moraes, C. T., Sanderson, T. H., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744664 · Cited by 61 · see citing works
Shanmugasundaram, K., Nayak, B., Shim, E., Livi, C. B., Block, K. L., & Sudarshan, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568162 · Cited by 60 · see citing works
Xu, Y., Kong, W., Cao, M., Wang, J., Wang, Z., Zheng, L., Wu, X. O., Cheng, R., He, W., Yang, B., et al. (2022) · European Urology · doi:10.1016/j.eururo.2022.05.029 · Cited by 60 · see citing works
Metabolic control of signalling pathways and metabolic auto‐regulation
Lorendeau, D., Christen, S., Rinaldi, G., & Fendt, S. (2015) · Biology of the Cell · doi:10.1111/boc.201500015 · Cited by 59 · see citing works
Jeong, S., Eskandari, R., Park, S. M., Alvarez, J. A., Sui, S.-T., Weissleder, R., Kharas, M., Lee, H.-H., & Keshari, K. (2017) · Science Advances · doi:10.1126/sciadv.1700341 · Cited by 57 · see citing works
FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer
Wilde, B. R., Chakraborty, N., Matulionis, N., Hernandez, S., Ueno, D., Gee, M. E., Esplin, E. D., Ouyang, K., Nykamp, K., Shuch, B. M., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0874 · Cited by 57 · see citing works
Metabolic alterations in hereditary and sporadic renal cell carcinoma
Coffey, N. J., & Simon, M. C. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00800-2 · Cited by 54 · see citing works
The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy
Wu, J., Liu, N., Chen, J., Tao, Q., Li, Q., Li, J., Chen, X., & Peng, C. (2024) · Research · doi:10.34133/research.0351 · Cited by 57 · see citing works
Wang, J., Zhang, P., Zhong, J., Tan, M., Ge, J., Tao, L., Li, Y., Zhu, Y., Wu, L., Qiu, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8382 · Cited by 52 · see citing works
Targeted therapeutic strategies for the management of renal cell carcinoma
Singer, E. A., Gupta, G. N., & Srinivasan, R. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328351c646 · Cited by 51 · see citing works
Evolving therapeutic targets in renal cell carcinoma
Singer, E. A., Gupta, G. N., Marchalik, D., & Srinivasan, R. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835fc857 · Cited by 51 · see citing works
UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control
Luby, A., & Alves‐Guerra, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315077 · Cited by 53 · see citing works
Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC)
Udager, A. M., Alva, A. S., Chen, Y., Siddiqui, J., Lagstein, A., Tickoo, S. K., Reuter, V. E., Chinnaiyan, A. M., & Mehra, R. (2014) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000127 · Cited by 50 · see citing works
Immunometabolism: A new target for improving cancer immunotherapy
Guo, C., Chen, S., Liu, W., Ma, Y., Li, J., Fisher, P. B., Fang, X., & Wang, X. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.004 · Cited by 52 · see citing works
Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
Xu, X., Ding, G., Liu, C., Ding, Y., Chen, X. L., Huang, X., Zhang, C., Lu, S., Zhang, Y., Huang, Y., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00565-y · Cited by 47 · see citing works
Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns
Qu, L., He, X., Tang, Q., Xiao, F., Liu, J., & Lin, A. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200194 · Cited by 48 · see citing works
Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander?
Rowlands, D. J. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.019 · Cited by 48 · see citing works
Vernieri, C., Pusceddu, S., Fucà, G., Indelicato, P., Centonze, G., Castagnoli, L., Ferrari, E., Ajazi, A., Pupa, S. M., Casola, S. S., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32042 · Cited by 46 · see citing works
Mitochondrial Alterations During Carcinogenesis
Wang, X., Peralta, S., & Moraes, C. T. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00004-6 · Cited by 46 · see citing works
Rescue of TCA Cycle Dysfunction for Cancer Therapy
Marquez, J. C., Flores, J., Kim, A. H., Nyamaa, B., Nguyen, A. T. T., Park, N., & Han, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122161 · Cited by 46 · see citing works
Leiomyoma Cutis: A Focused Review on Presentation, Management, and Association with Malignancy
Malik, K., Patel, P. S., Chen, J., & Khachemoune, A. (2015) · American Journal of Clinical Dermatology · doi:10.1007/s40257-015-0112-1 · Cited by 45 · see citing works
MacLennan, G. T., & Liang Cheng, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-23380-2_35 · Cited by 43 · see citing works
Linehan, W. M., & Rathmell, W. K. (2012) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.08.021 · Cited by 43 · see citing works
Hou, C., Wang, Y., Zhu, E., Yan, C., Zhao, L., Wang, X., Qiu, Y., Shen, H., Sun, X., Feng, Z., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.12.020 · Cited by 42 · see citing works
Global metabolomic profiling of uterine leiomyomas
Heinonen, H.-R., Mehine, M. M., Mäkinen, N., Pasanen, A. M., Pitkänen, E., Karhu, A., Sarvilinna, N. S., Sjöberg, J., Heikinheimo, O., Bützow, R. C., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.361 · Cited by 42 · see citing works
Linehan, W. M., Srinivasan, R., & Garcia, J. A. (2013) · Seminars in Oncology · doi:10.1053/j.seminoncol.2013.05.009 · Cited by 41 · see citing works
Expression and prognosis analysis of mitochondrial ribosomal protein family in breast cancer
Lin, X., Guo, L., Lin, X., Wang, Y., & Zhang, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-14724-7 · Cited by 37 · see citing works
Metabolic Drivers in Hereditary Cancer Syndromes
Sciacovelli, M., Schmidt, C., Maher, E. R., & Frezza, C. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033612 · Cited by 37 · see citing works
Ooi, A., & Furge, K. A. (2012) · 癌症：英文版 · doi:10.5732/cjc.012.10102 · Cited by 37 · see citing works
Zhong, Z.-F., Tan, W., Qiang, W. W., Scofield, V. L., Tian, K., Wang, C., Qiang, W., & Wang, Y. (2016) · Molecular BioSystems · doi:10.1039/c6mb00003g · Cited by 36 · see citing works
Khan, M. I., Dębski, K. J., Dąbrowski, M., Czarnecka, A. M., & Szczylik, C. A. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00138.2016 · Cited by 37 · see citing works
Yu, Y., Lu, Q., Chen, F., Wang, S., Niu, C., Liao, J., Wang, H., & Chen, F. (2022) · Food & Function · doi:10.1039/d1fo04396j · Cited by 36 · see citing works
Discoveries, therapies and opportunities
Linehan, W. M., & Ricketts, C. J. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.262 · Cited by 35 · see citing works
Shuch, B. M., & Zhang, J. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.79.2523 · Cited by 35 · see citing works
Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma
Lindner, A. K., Tulchiner, G. A., Seeber, A., Siska, P. J., Thurnher, M., & Pichler, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.906014 · Cited by 35 · see citing works
Zhang, G., Yang, P., Guo, P.-D., Miele, L., Sarkar, F. H., Wang, Z. P., & Zhou, Q. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.03.001 · Cited by 34 · see citing works
- Authors
- Tong, W.-H., Sourbier, C., Kovtunovych, G., Jeong, S. Y., Vira, M., Ghosh, M., Romero, V. V., Sougrat, R., Vaulont, S., Viollet, B., Kim, Y.-S., Lee, S., Trepel, J., Srinivasan, R., Bratslavsky, G., Yang, Y., Linehan, W. M., & Rouault, T. A.
- Affiliations
- National Institutes of Health (US)
- National Cancer Institute (US)
- Albert Einstein College of Medicine (US)
- King Abdullah University of Science and Technology (SA)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Linehan, W. Marston
- Rouault, Tracey A.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 20
- Issue
- 3
- Pages
- 315-327
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3174047
- OpenAlex
- W2003921338
- Cited by
- 212
- References
- 61
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 22 · 2021: 11 · 2020: 15 · 2019: 20 · 2018: 10 · 2017: 12 · 2016: 18 · 2015: 20 · 2014: 10 · 2013: 20 · 2012: 16
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Cancer Institute
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- fumarate hydratase deficiency, aerobic glycolysis, AMPK, iron regulatory proteins, HIF-1α, acetyl-CoA carboxylase, ribosomal protein S6, p53, tumor invasion, renal cell carcinoma
- MeSH terms
- Iron Deficiencies, Endothelial PAS Domain-Containing Protein 1, Solute Carrier Family 11, Member 2, Acetyl-CoA Carboxylase, Acetyl Coenzyme A, Animals, Fumarate Hydratase, Glycolysis, Humans, Kidney Neoplasms, NADP, Neoplastic Syndromes, Hereditary, Ribose, Skin Neoplasms, Thenoyltrifluoroacetone, Uterine Neoplasms, Tumor Suppressor Protein p53, Leiomyomatosis, Cation Transport Proteins, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Ribosomal Protein S6, Cell Line, Tumor, Mice, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
