During, Matthew J.

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial

Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D., et al. (2007) · The Lancet

Deep Brain Stimulation and Movement DisordersVirus-based gene therapy research

Cited by 1,067

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

During, M. J., Cao, L., Zuzga, D. S., Francis, J. S., Fitzsimons, H. L., Jiao, X., Bland, R. J., Klugmann, M., Banks, W. A., Drucker, D. J., et al. (2003) · Nature Medicine

Neuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Cited by 851

VEGF links hippocampal activity with neurogenesis, learning and memory

Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics

Neurogenesis and neuroplasticity mechanismsAngiogenesis and VEGF in Cancer

Cited by 850

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

MacLaren, R. E., Groppe, M., Barnard, A. R., Cottriall, C. L., Tolmachova, T., Seymour, L., Clark, K. R., During, M. J., Cremers, F. P. M., Black, G. C. M., et al. (2014) · The Lancet

Retinal Development and DisordersVirus-based gene therapy research

Cited by 796

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

Monory, K., Massa, F., Egertová, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., et al. (2006) · Neuron

Cannabis and Cannabinoid ResearchEpilepsy research and treatment

Cited by 706

AAV2-GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery controlled, randomised trial

LeWitt, P. A., Rezai, A. R., Leehey, M. A., Ojemann, S. G., Flaherty, A. W., Eskandar, E. N., Kostyk, S. K., Thomas, K., Sarkar, A., Siddiqui, M. S., et al. (2011) · The Lancet Neurology

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 681

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 660

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Johnen, H., Lin, S., Kuffner, T., Brown, D. A., Tsai, V. W.-W., Bauskin, A. R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., et al. (2007) · Nature Medicine

Regulation of Appetite and ObesityNutrition and Health in Aging

Cited by 612

Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model

Luo, J., Kaplitt, M. G., Fitzsimons, H. L., Zuzga, D. S., Liu, Y., Oshinsky, M. L., & During, M. J. (2002) · Science

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 325

Long-term follow-up after gene therapy for canavan disease

Leone, P., Shera, D., McPhee, S. W. J., Francis, J. S., Kolodny, E. H., Bilaniuk, L. T., Wang, D.-J., Assadi, M., Goldfarb, O., Goldman, H. W., et al. (2012) · Science Translational Medicine

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 307

Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

Feigin, A., Kaplitt, M. G., Tang, C., Lin, T., Mattis, P., Dhawan, V., During, M. J., & Eidelberg, D. (2007) · Proceedings of the National Academy of Sciences

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 181

Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight

Baldock, P. A., Lee, N. J., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E.-J. D., Zhang, L., Enriquez, R. F., Wong, I. P. L., et al. (2009) · PLoS ONE

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 164

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates

Lawlor, P. A., Bland, R. J., Mouravlev, A., Young, D., & During, M. J. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 161

VEGF, a Mediator of the Effect of Experience on Hippocampal Neurogenesis

During, M., & Cao, L. (2006) · Current Alzheimer Research

Neurogenesis and neuroplasticity mechanismsAngiogenesis and VEGF in Cancer

Cited by 131

Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson’s disease

Niethammer, M., Tang, C. C., LeWitt, P. A., Rezai, A. R., Leehey, M. A., Ojemann, S. G., Flaherty, A. W., Eskandar, E. N., Kostyk, S. K., Sarkar, A., et al. (2017) · JCI Insight

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 124

Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

Lawlor, P. A., Bland, R. J., Das, P., Price, R. W., Holloway, V., Smithson, L., Dicker, B. L., During, M. J., Young, D., & Golde, T. E. (2007) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 67

Antiapoptotic and Trophic Effects of Dominant-Negative Forms of Dual Leucine Zipper Kinase in Dopamine Neurons of the Substantia Nigra In Vivo

Chen, X., Rzhetskaya, M., Kareva, T., Bland, R., During, M. J., Tank, A. W., Kholodilov, N., & Burke, R. E. (2008) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsCell death mechanisms and regulation

Cited by 62

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease

Klugmann, M., Leichtlein, C. B., Symes, C. W., Serikawa, T., Young, D., & During, M. J. (2005) · Molecular Therapy

Metabolism and Genetic DisordersVirus-based gene therapy research

Cited by 55

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Charbel Issa, P., De Silva, S. R., Lipinski, D. M., Singh, M. S., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J., & MacLaren, R. E. (2013) · PLoS ONE

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 53

Tyrosine: Effects on catecholamine release

Acworth, I. N., During, M. J., & Wurtman, R. J. (1988) · Brain Research Bulletin

Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Cited by 49

Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine

Heusner, C. L., Hnasko, T. S., Szczypka, M. S., Liu, Y., During, M. J., & Palmiter, R. D. (2003) · Brain Research

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 48