Tyrosine: Effects on catecholamine release
Abstract
Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments that accelerate nigrostriatal firing, but not in untreated rats. We examined the possibility that the amino acid might actually enhance dopamine release in untreated animals, but that the technique of measuring striatal dopamine metabolism was too insensitive to demonstrate such an effect. Dopamine release was assessed directly, using brain microdialysis of striatal extracellular fluid. Tyrosine administration (50-200 mg/kg IP) did indeed cause a dose related increase in extracellular fluid dopamine levels with minor elevations in levels of DOPAC and HVA, its major metabolites, which were not dose-related. The rise in dopamine was short-lived, suggesting that receptor-mediated feedback mechanisms responded to the increased dopamine release by diminishing neuronal firing or sensitivity to tyrosine. These observations indicate that measurement of changes in striatal DOPAC and HVA, if negative, need not rule out increases in nigrostriatal dopamine release.
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Supplementation of TYR, or TYR-containing diets, increases plasma TYR and enhances brain DA and NE release.
“The supplementation of TYR, or TYR-containing diets, increase plasma TYR and enhance brain DA and NE release (Lehnert et al., 1984; Reinstein et al., 1984; Acworth et al., 1988; During et al., 1988; see Deijen, 2005, for a comprehensive review).”
From Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task (2013) · cites this paper as Acworth et al., 1988
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- Authors
- Acworth, I. N., During, M. J., & Wurtman, R. J.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 21
- Issue
- 3
- Pages
- 473-477
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2101137162
- Cited by
- 49
- References
- 28
- Citations by year
- 2020: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 3
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Air Force Office of Scientific Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- tyrosine, dopamine release, striatum, nigrostriatal pathway, catecholamine release, DOPAC, homovanillic acid, dopamine metabolites, cerebral microdialysis, dose-response relationship
- MeSH terms
- Animals, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Homovanillic Acid, Injections, Intraperitoneal, Male, Rats, Inbred Strains, Time Factors, Tyrosine, 3,4-Dihydroxyphenylacetic Acid, Rats
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