Serotonin and hallucinogens

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International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

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Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli

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Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents

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5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex

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A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS

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SERUM VASOCONSTRICTOR (SEROTONIN)

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5-Hydroxytryptamine _2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

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Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its Determination

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Two components of transmitter release at a central synapse.

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SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

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Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells

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Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis

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Lysergic acid diethylamide: Sensitive neuronal units in the midbrain raphe

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Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism

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Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens

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ACTION OF PSYCHOTOGENIC DRUGS ON SINGLE MIDBRAIN RAPHE NEURONS

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Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites

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Lysergic acid diethylamide and serotonin: Direct actions on serotonin-containing neurons in rat brain

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SERUM VASOCONSTRICTOR (SEROTONIN)

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Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100,907

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Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex

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Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2 -activated interneuron

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Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons

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EFFECTS OF LSD-25 ON BRAIN SEROTONIN

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Chronic Administration of Serotonergic Antidepressants Attenuates the Subjective Effects of LSD in Humans

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Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.

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LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.

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Do classical hallucinogens act as 5-HT2 agonists or antagonists?

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Distinct Ca2+ and Sr2+ Binding Properties of Synaptotagmins

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Comparison of psilocin with psilocybin, mescaline and LSD-25

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Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain

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Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2antagonists

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5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by μ-opiate receptor activation

Marek, G. J., & Aghajanian, G. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00043-8 · Cited by 89 · see citing works

Some Serotoninlike Activities of Lysergic Acid Diethylamide

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A 5-hydroxytryptamine2 agonist augments γ-aminobutyric acid and excitatory amino acid inputs to noradrenergic locus coeruleus neurons

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Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity

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Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148

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Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli

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Studies on the Diethylamide of Lysergic Acid (LSD-25)

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LSD-25 action in normal subjects treated with a monoamine oxidase inhibitor

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Accentuation of the psychological effects of LSD-25 in normal subjects treated with reserpine

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Molecular, pharmacological and functional diversity of 5-HT receptors

Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works

Psychedelics

Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works

Serotonin Receptors

Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895 · see citing works

Opponent interactions between serotonin and dopamine

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Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder

Moreno, F. A., Wiegand, C. B., Taitano, E. K., & Delgado, P. L. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1110 · Cited by 789 · see citing works

Serotonin and brain function: a tale of two receptors

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The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

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Effects of Ketamine in Normal and Schizophrenic Volunteers

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Mechanisms of synesthesia: cognitive and physiological constraints

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Serotonin model of schizophrenia: emerging role of glutamate mechanisms

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Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study

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Psychobiology of Altered States of Consciousness.

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Serotonin research: contributions to understanding psychoses

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The neural basis of the complex mental task of meditation: neurotransmitter and neurochemical considerations

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A systems model of altered consciousness: integrating natural and drug-induced psychoses

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The Physiological Role of 5-HT_2AReceptors in Working Memory

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Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex

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Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways

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Pharmacogenetics and the serotonin system: initial studies and future directions

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Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation

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Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

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Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.

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Neuropharmacology of N,N-dimethyltryptamine

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Serotonin 2A Receptors and Visual Hallucinations in Parkinson Disease

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Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?

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Mismatch negativity predicts psychotic experiences induced by nmda receptor antagonist in healthy volunteers

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The Mechanistic Classification of Addictive Drugs

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Dimers and beyond: The functional puzzles of class C GPCRs

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The Serotonin System and Spiritual Experiences

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Synaptic plasticity and mental health: methods, challenges and opportunities

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Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex

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Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

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The behavioral pharmacology of hallucinogens

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Psychedelic-inspired drug discovery using an engineered biosensor

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Brain serotonergic circuitries

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Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia

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Clinical applications of hallucinogens: a review

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Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

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Serotonin 5-HT2 receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus

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The serotonergic system in Parkinson's disease

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Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions

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Effects of the 5-HT2A Agonist Psilocybin on Mismatch Negativity Generation and AX-Continuous Performance Task: Implications for the Neuropharmacology of Cognitive Deficits in Schizophrenia

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Serotonin, But Not N -Methyltryptamines, Activates the Serotonin 2A Receptor Via a β-Arrestin2/Src/Akt Signaling Complex In Vivo

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DARPP-32 mediates the actions of multiple drugs of abuse

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A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain

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Functional internal complexity of amygdala: focus on gene activity mapping after behavioral training and drugs of abuse.

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Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities

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Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

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Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats

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Pharmacology of stimulants prohibited by the World Anti‐Doping Agency (WADA)

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Dimensions of consciousness and the psychedelic state

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The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment

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Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences

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PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

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Brain mechanisms of hallucinogens and entactogens

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Of Roots and Fruits: A Comparison of Psychedelic and Nonpsychedelic Mystical Experiences

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