Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders

Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation

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Isoprostanes: markers and mediators of oxidative stress

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Lipoic Acid as a Potential Therapy for Chronic Diseases Associated with Oxidative Stress

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Direct antioxidant properties of creatine

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F 2 -Isoprostanes as markers of oxidative stress in vivo : An overview

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Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects

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Creatine Supplementation Enhances Isometric Strength and Body Composition Improvements Following Strength Exercise Training in Older Adults

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Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders

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Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases

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Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity

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Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy

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Creatine monohydrate increases strength in patients with neuromuscular disease

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Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress

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A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods

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Coenzyme Q10 and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits

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Mitochondrial Cytopathies

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Mitochondrial Myopathies: Diagnosis, Exercise Intolerance, and Treatment Options

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Efficacy of unilateral deep brain stimulation of the vim nucleus of the thalamus for essential head tremor

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Coenzyme Q 10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease

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Patients with dystrophinopathy show evidence of increased oxidative stress

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Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial

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Coenzyme Q10 Treatment in Mitochondrial Encephalomyopathies

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Nutritional cofactor treatment in mitochondrial disorders

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Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders

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A placebo-controlled crossover trial of creatine in mitochondrial diseases

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Effectiveness of creatine monohydrate in mitochondrial encephalomyopathies

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Long-term treatment with idebenone and riboflavin in a patient with MELAS

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Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo‐controlled, double‐blind ³¹P‐MRS crossover study

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The treatment of mitochondrial myopathies and encephalomyopathies

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Nutritional and exercise-based therapies in the treatment of mitochondrial disease

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Coenzyme Q 10 Improves Lactic Acidosis, Strokelike Episodes, and Epilepsy in a Patient With MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike episodes)

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Treatment of mitochondrial encephalomyopathy with a combination of cytochrome C and vitamins B1 and B2

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Effect of high‐dose vitamins, coenzyme Q and high‐fat diet in paediatric patients with mitochondrial diseases

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Effect of α-Lipoic Acid Combined with Creatine Monohydrate on Human Skeletal Muscle Creatine and Phosphagen Concentration

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Increased 8-Hydroxy-2′-Deoxyguanosine in Leukocyte DNA in Leber’s Hereditary Optic Neuropathy

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Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy

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Biochemical monitoring of the treatment in paediatric patients with mitochondrial disease

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Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation

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Untitled work

Tarnopolsky (1999) · doi:10.1002/(sici)1097-4598(199909)22:9

Mitochondrial diseases

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The creatine kinase system and pleiotropic effects of creatine

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Mitochondrial optic neuropathies—Disease mechanisms and therapeutic strategies

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Diagnosis and management of mitochondrial disease: a consensus statement from the mitochondrial medicine society

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MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

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Treatment for mitochondrial disorders

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Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

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Mitochondrial Diseases of the Brain

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Functions and effects of creatine in the central nervous system

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Mitochondrial Encephalopathy, Lactic Acidosis, and Strokelike Episodes

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What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

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Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options

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Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

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Mitochondrial DNA maintenance defects

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Mitochondrial Approaches for Neuroprotection

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The Neuro-ophthalmology of Mitochondrial Disease

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Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment

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Creatine as an antioxidant

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Therapies for mitochondrial diseases and current clinical trials

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Creatine for treating muscle disorders

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New treatments for mitochondrial disease—no time to drop our standards

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Diagnosis and treatment of mitochondrial myopathies

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The mitochondrial cocktail: Rationale for combined nutraceutical therapy in mitochondrial cytopathies

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A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

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Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

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Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence

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Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

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Coenzyme Q10 in Neuromuscular and Neurodegenerative Disorders

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A randomized trial of coenzyme Q 10 in mitochondrial disorders

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Antioxidants halt axonal degeneration in a mouse model of X‐adrenoleukodystrophy

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Perspectives on Exertional Rhabdomyolysis

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Power of mitochondrial drug delivery systems to produce innovative nanomedicines

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Oxidative Stress and Mitochondrial Dysfunction in Down Syndrome

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Mitochondrial medicine therapies: rationale, evidence, and dosing guidelines

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Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

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Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome

Pallardó, F. V., Lloret, A., Lebel, M., d’Ischia, M., Cogger, V. C., Couteur, D. G. L., Gadaleta, M. N., Castello, G., & Pagano, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9269-4 · Cited by 107 · see citing works

Treatment of Mitochondrial Disorders

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Metabolic Myopathies: Update 2009

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Liver Disease in Mitochondrial Disorders

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Mitochondrial dysfunction in ocular disease: Focus on glaucoma

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Inherited Metabolic Disorders and Stroke Part 1

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Mitochondrial Transplantation as a Novel Therapeutic Strategy for Mitochondrial Diseases

Park, A., Oh, M., Lee, S. H., Oh, K., Lee, E., Lee, S.-W., Bae, K., Han, B., & Kim, W. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094793 · Cited by 97 · see citing works

Mitochondrial cytopathies

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Review of clinical trials for mitochondrial disorders: 1997-2012

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Physical activity and COVID-19. The basis for an efficient intervention in times of COVID-19 pandemic

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Young-Onset Dementia

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A critical approach to the therapy of mitochondrial respiratory chain and oxidative phosphorylation diseases

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The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease

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Therapeutic Options in Hereditary Optic Neuropathies

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Mitochondrial disorders in children: toward development of small‐molecule treatment strategies

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Mitochondrial Encephalopathy With Lactic Acidosis and Stroke-like Episodes (MELAS) May Respond to Adjunctive Ketogenic Diet

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Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy

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Mitochondrial disorders: Challenges in diagnosis & treatment

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Nonpharmacologic Treatment of Dyslipidemia

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Creatine supplementation prevents the inhibition of myogenic differentiation in oxidatively injured C2C12 murine myoblasts

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Current and Emerging Clinical Treatment in Mitochondrial Disease

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Therapeutic Approaches to Treat Mitochondrial Diseases: “One-Size-Fits-All” and “Precision Medicine” Strategies

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The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

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The Psychiatric Presentation of Mitochondrial Disorders in Adults

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Development of pharmacological strategies for mitochondrial disorders

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Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development

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Mitochondrial dysfunction in central nervous system white matter disorders

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Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis

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N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease

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Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders

Tarnopolsky, M. A. (2007) · Subcellular Biochemistry · doi:10.1007/978-1-4020-6486-9_10 · Cited by 67 · see citing works

Creatine and Creatine Kinase in Health and Disease

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Nutritional interventions in primary mitochondrial disorders: Developing an evidence base

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Mitochondrial therapies for Parkinson's disease

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Metabolic Myopathies

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Treatment of hereditary optic neuropathies

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Treatment Options for Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke‐Like Episodes (MELAS) Syndrome

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Oxidative Stress and Down Syndrome. Do Antioxidants Play a Role in Therapy?

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Mitochondrial functions and rare diseases

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Leigh syndrome associated with mitochondrial complex I deficiency due to novel mutations In NDUFV1 and NDUFS2

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Arginine and Citrulline for the Treatment of MELAS Syndrome

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The Mutations and Clinical Variability in Maternally Inherited Diabetes and Deafness: An Analysis of 161 Patients

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POLG-Related Disorders

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Conjugated Linoleic Acid Combined with Creatine Monohydrate and Whey Protein Supplementation during Strength Training

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MELAS with recurrent complex partial seizures, nonconvulsive status epilepticus, psychosis, and behavioral disturbances: Case analysis with literature review

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Recent topics: the diagnosis, molecular genesis, and treatment of mitochondrial diseases

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Mitochondrial response to controlled nutrition in health and disease

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Oxidative Stress Treatment for Clinical Trials in Neurodegenerative Diseases

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Creatine as a therapeutic strategy for myopathies

Tarnopolsky, M. A. (2011) · Amino Acids · doi:10.1007/s00726-011-0876-4 · Cited by 52 · see citing works

Isoprostanes in fetal and neonatal health and disease

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Clinical Characteristics of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes

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A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression

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Advances in primary mitochondrial myopathies

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Therapy for mitochondrial disorders: Little proof, high research activity, some promise

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Genetics of ischaemic stroke in young adults

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Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?

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Coenzyme Q10 and Neurological Diseases

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Nuclear magnetic resonance-based serum metabolomic analysis reveals different disease evolution profiles between septic shock survivors and non-survivors

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Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes

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Therapeutic use of creatine in brain or heart ischemia: Available data and future perspectives

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The regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease

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Mitochondrial Energy Depletion in Depression with Somatization

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Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review

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Supplementation with α-Lipoic Acid, CoQ10, and Vitamin E Augments Running Performance and Mitochondrial Function in Female Mice

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Coenzyme Q10 in the Treatment of Mitochondrial Disease

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Mitochondrial Agents for Bipolar Disorder

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Nutraceutical Cofactor Therapy in Mitochondrial Disease

Rodriguez, M. C. (2006) · MacSphere (McMaster University) · doi:10.71548/6767

The mitochondrial cocktail: Rationale for combined nutraceutical therapy in mitochondrial cytopathies

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A randomized trial of coenzyme Q 10 in mitochondrial disorders

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Coenzyme Q 10 Improves Lactic Acidosis, Strokelike Episodes, and Epilepsy in a Patient With MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike episodes)

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Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q 10 therapy

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