Vale, Ronald D.

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 1,993

The Molecular Motor Toolbox for Intracellular Transport

Vale, R. D. (2003) · Cell

Microtubule and mitosis dynamicsNuclear Structure and Function

Cited by 1,982

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Hui, E., Cheung, J., Zhu, J., Su, X., Taylor, M. J., Wallweber, H. A., Sasmal, D. K., Huang, J., Kim, J. M., Mellman, I., et al. (2017) · Science

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 1,689

The Way Things Move: Looking Under the Hood of Molecular Motor Proteins

Vale, R. D., & Milligan, R. A. (2000) · Science

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 1,503

Kinesin Walks Hand-Over-Hand

Yildiz, A., Tomishige, M., Vale, R. D., & Selvin, P. R. (2004) · Science

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 965

Movement of microtubules by single kinesin molecules

Howard, J., Hudspeth, A. J., & Vale, R. D. (1989) · Nature

Microtubule and mitosis dynamicsForce Microscopy Techniques and Applications

Cited by 885

A structural change in the kinesin motor protein that drives motility

Rice, S., Lin, A. W., Safer, D., Hart, C. L., Naber, N., Carragher, B. O., Cain, S. M., Pechatnikova, E., Wilson-Kubalek, E. M., Whittaker, M., et al. (1999) · Nature

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 798

Direct observation of single kinesin molecules moving along microtubules

Vale, R. D., Funatsu, T., Pierce, D. W., Romberg, L., Harada, Y., & Yanagida, T. (1996) · Nature

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 711

The design plan of kinesin motors

Vale, R. D., & Fletterick, R. J. (1997) · Annual Review of Cell and Developmental Biology

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 474

Microtubule interaction site of the kinesin motor

Woehlke, G., Ruby, A. K., Hart, C. L., Ly, B., Hom-Booher, N., & Vale, R. D. (1997) · Cell

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 386

Intramolecular Strain Coordinates Kinesin Stepping Behavior along Microtubules

Yildiz, A., Tomishige, M., Gennerich, A., & Vale, R. D. (2008) · Cell

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 313

Mechanisms for focusing mitotic spindle poles by minus end–directed motor proteins

Goshima, G., Nédélec, F., & Vale, R. D. (2005) · The Journal of Cell Biology

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 259

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

McKenney, R. J., Huynh, W., Vale, R. D., & Sirajuddin, M. (2016) · The EMBO Journal

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 232

Accelerating scientific publication in biology

Vale, R. D. (2015) · Proceedings of the National Academy of Sciences

Academic Publishing and Open AccessAcademic Writing and Publishing

Cited by 208

How kinesin waits between steps

Mori, T., Vale, R. D., & Tomishige, M. (2007) · Nature

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 171

Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase

Mennella, V., Rogers, G. C., Rogers, S. L., Buster, D. W., Vale, R. D., & Sharp, D. J. (2005) · Nature Cell Biology

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 154

Cloning and localization of a conventional kinesin motor expressed exclusively in neurons

Niclas, J., Navone, F., Hom-Booker, N., & Vale, R. D. (1994) · Neuron

Microtubule and mitosis dynamicsHereditary Neurological Disorders

Cited by 153

Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules

Vale, R. D., Coppin, C. M., Malik, F., Kull, F. J., & Milligan, R. A. (1994) · Journal of Biological Chemistry

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 111

Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell

Li, W., Zou, W., Yang, Y., Chai, Y., Chen, B., Cheng, S., Tian, D., Wang, X., Vale, R. D., & Ou, G. (2012) · Journal of Cell Biology

Autophagy in Disease and TherapyPhagocytosis and Immune Regulation

Cited by 84

De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography

Chen, Z., Shiozaki, M., Haas, K. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Kaake, R. M., Vale, R. D., et al. (2022) · Cell

Advanced Electron Microscopy Techniques and ApplicationsSperm and Testicular Function

Cited by 82

De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking

Chen, Z., Shiozaki, M., Haas, K. M., Skinner, W. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Lishko, P. V., et al. (2023) · Cell

Advanced Electron Microscopy Techniques and ApplicationsSperm and Testicular Function

Cited by 82