Schaum, Nicholas

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,247

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

The Tabula Sapiens Consortium*, Jones, R. C., Karkanias, J., Krasnow, M. A., Pisco, A. O., Quake, S. R., Salzman, J., Yosef, N., Bulthaup, B., Brown, P., et al. (2022) · Science

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 1,056

Undulating changes in human plasma proteome profiles across the lifespan

Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., et al. (2019) · Nature Medicine

Genetics, Aging, and Longevity in Model OrganismsAdvanced Proteomics Techniques and Applications

Cited by 981

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Agam, M., Maat, C. A., Losada, P. M., Chen, M. B., Schaum, N., Khoury, N., et al. (2022) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 797

Dysregulation of brain and choroid plexus cell types in severe COVID-19

Yang, A. C., Kern, F., Losada, P. M., Agam, M. R., Maat, C. A., Schmartz, G. P., Fehlmann, T., Stein, J. A., Schaum, N., Lee, D. P., et al. (2021) · Nature

Long-Term Effects of COVID-19Single-cell and spatial transcriptomics

Cited by 620

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

Haney, M. S., Pálovics, R., Munson, C. N., Long, C., Johansson, P. K., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J. C. M., et al. (2024) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 536

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

Davalos, A. R., Kawahara, M., Malhotra, G. K., Schaum, N., Huang, J., Ved, U., Beausejour, C. M., Coppe, J.-P., Rodier, F., & Campisi, J. (2013) · Journal of Cell Biology

Telomeres, Telomerase, and SenescenceAdvanced Glycation End Products research

Cited by 439

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports

Barrier Structure and Function StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 233

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 153

miRNATissueAtlas2: an update to the human miRNA tissue atlas

Keller, A., Gröger, L., Tschernig, T., Solomon, J., Laham, O., Schaum, N., Wagner, V., Kern, F., Schmartz, G. P., Li, Y., et al. (2022) · Nucleic Acids Research

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 143

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

Wiley, C. D., Schaum, N., Alimirah, F., Lopez-Dominguez, J. A., Orjalo, A. V., Scott, G., Desprez, P.-Y., Benz, C., Davalos, A. R., & Campisi, J. (2018) · Scientific Reports

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 124

Cell types of origin of the cell-free transcriptome

Vorperian, S. K., Moufarrej, M. N., Tabula Sapiens Consortium, Overall Project Direction and Coordination, Jones, R. C., Karkanias, J., Krasnow, M., Pisco, A. O., Quake, S. R., Salzman, J., et al. (2022) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 116

Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

Wagner, V., Kern, F., Hahn, O., Schaum, N., Ludwig, N., Fehlmann, T., Engel, A., Henn, D., Rishik, S., Isakova, A., et al. (2024) · Nature Biotechnology

Genetics, Aging, and Longevity in Model OrganismsMicroRNA in disease regulation

Cited by 72

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Maat, C. A., Losada, P. M., Chen, M. B., Agam, M., Schaum, N., Khoury, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

Cited by 48

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

Haney, M. S., Pálovics, R., Munson, C. N., Long, C., Johansson, P., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 20