Numakawa, Tadahiro

Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex

Chiba, S., Numakawa, T., Ninomiya, M., Richards, M. C., Wakabayashi, C., & Kunugi, H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 673

Interface between hypothalamic‐pituitary‐adrenal axis and brain‐derived neurotrophic factor in depression

Kunugi, H., Hori, H., Adachi, N., & Numakawa, T. (2010) · Psychiatry and Clinical Neurosciences

Stress Responses and CortisolTreatment of Major Depression

Cited by 200

Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release

Yagasaki, Y., Numakawa, T., Kumamaru, E., Hayashi, T., Su, T.-P., & Kunugi, H. (2006) · Journal of Biological Chemistry

Pharmacological Receptor Mechanisms and EffectsTreatment of Major Depression

Cited by 122

Impact of glucocorticoid on neurogenesis

Numakawa, T., Odaka, H., & Adachi, N. (2017) · Neural Regeneration Research

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 93

The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition

Numakawa, T., Richards, M., Nakajima, S., Adachi, N., Furuta, M., Odaka, H., & Kunugi, H. (2014) · Frontiers in Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 86

Behavioral and molecular evidence for psychotropic effects in l-theanine

Wakabayashi, C., Numakawa, T., Ninomiya, M., Chiba, S., & Kunugi, H. (2012) · Psychopharmacology

Neuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Cited by 65

ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons

Yamagishi, S., Matsumoto, T., Numakawa, T., Yokomaku, D., Adachi, N., Hatanaka, H., Yamada, M., Shimoke, K., & Ikeuchi, T. (2005) · Brain Research

Cell death mechanisms and regulationProtein Kinase Regulation and GTPase Signaling

Cited by 22

IL-1 Receptor-Antagonist (IL-1Ra) Knockout Mice Show Anxiety-like Behavior by Aging

Wakabayashi, C., Numakawa, T., Odaka, H., Ooshima, Y., Kiyama, Y., Manabe, T., Kunugi, H., & Iwakura, Y. (2015) · Neuroscience Letters

Stress Responses and CortisolTryptophan and brain disorders

Cited by 14