The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition
Open accessAbstract
Increasing evidence demonstrates a connection between growth factor function (including brain-derived neurotrophic factor, BDNF), glucocorticoid levels (one of the steroid hormones), and the pathophysiology of depressive disorders. Because both BDNF and glucocorticoids regulate synaptic function in the central nervous system, their functional interaction is of major concern. Interestingly, alterations in levels of estrogen, another steroid hormone, may play a role in depressive-like behavior in postpartum females with fluctuations of BDNF-related molecules in the brain. BDNF and cytokines, which are protein regulators of inflammation, stimulate multiple intracellular signaling cascades involved in neuropsychiatric illness. Pro-inflammatory cytokines may increase vulnerability to depressive symptoms, such as the increased risk observed in patients with cancer and/or autoimmune diseases. In this review, we discuss the possible relationship between inflammation and depression, in addition to the cross-talk among cytokines, BDNF, and steroids. Further, since nutritional status has been shown to affect critical pathways involved in depression through both BDNF function and the monoamine system, we also review current evidence surrounding diet and supplementation (e.g., flavonoids) on BDNF-mediated brain functions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numakawa et al. showed that significant correlations can be made regarding BDNF and SOD specific activity.
“Moreover, Numakawa et al. [230] showed that significant correlations can be made regarding BDNF and SOD specific activity.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [230]
A similar PANSS factor (PANSS depressive factor) can be correlated with the interaction between BDNF and GPX.
“Furthermore, a similar PANSS factor (PANSS depressive factor) can be correlated with the interaction between BDNF and GPX.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [230]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Calamita, E., Schmid, M., Kunz, M., Ndebele-Murisa, M. R., Magadza, C. H. D., Nyambe, I., & Wehrli, B. (2019) · Figshare · doi:10.26181/6153922fe919c · Cited by 4,222 · see citing works
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151 · see citing works
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works
IL-6/IL-6 receptor system and its role in physiological and pathological conditions
Mihara, M., Hashizume, M., Yoshida, H., Suzuki, M., & Shiina, M. (2011) · Clinical Science · doi:10.1042/cs20110340 · Cited by 911 · see citing works
Prevalence of suicidality during pregnancy and the postpartum
Lindahl, V., Pearson, J. L., & Colpe, L. (2005) · Archives of Women’s Mental Health · doi:10.1007/s00737-005-0080-1 · Cited by 795 · see citing works
Estrogen synthesis and signaling pathways during aging: from periphery to brain
Cui, J., Shen, Y., & Li, R. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.007 · Cited by 785 · see citing works
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0706 · Cited by 781 · see citing works
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 747 · see citing works
TNF and MAP kinase signalling pathways
Sabio, G., & Davis, R. J. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.02.009 · Cited by 705 · see citing works
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Jang, S., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913572107 · Cited by 689 · see citing works
Hormones and Menopausal Status as Predictors of Depression in Womenin Transition to Menopause
Freeman, E. W., Sammel, M. D., Liu, L., Gracia, C. R., Nelson, D. B., & Hollander, L. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.62 · Cited by 647 · see citing works
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works
The SLC39 family of zinc transporters
Jeong, J., & Eide, D. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.05.011 · Cited by 453 · see citing works
Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors
Lund, T. D., Rovis, T., Chung, W. C. J., & Handa, R. J. (2005) · Endocrinology · doi:10.1210/en.2004-1158 · Cited by 436 · see citing works
Dahl, J., Ormstad, H., Aass, H. C. D., Malt, U. F., Bendz, L. T., Sandvik, L., Brundin, L., & Andreassen, O. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.019 · Cited by 424 · see citing works
Huang, L., & Tepaamorndech, S. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.05.008 · Cited by 343 · see citing works
Pawlby, S. J., Hay, D. F., Sharp, D., Waters, C. S., & O’Keane, V. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.018 · Cited by 333 · see citing works
Depression in cancer: new developments regarding diagnosis and treatment
Raison, C. L., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00413-x · Cited by 333 · see citing works
Liang, J., & Shang, Y. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183708 · Cited by 319 · see citing works
Myers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318 · see citing works
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
Kim, H., Chen, L. L., Lim, G., Sung, B., Wang, S.-X., McCabe, M. F., Rusanescu, G., Yang, L.-L., Tian, Y.-H., & Mao, J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61884 · Cited by 310 · see citing works
González‐Vallinas, M., González-Castejón, M., Rodríguez‐Casado, A., & de Molina, A. R. (2013) · Nutrition Reviews · doi:10.1111/nure.12051 · Cited by 306 · see citing works
Cortisol and depression: three questions for psychiatry
Herbert, J. (2013) · Psychological Medicine · doi:10.1017/s0033291712000955 · Cited by 301 · see citing works
Depressive-like behavior induced by tumor necrosis factor-α in mice
Kaster, M. P., Gadotti, V. M., Calixto, J. B., Santos, A. R. S., & Rodrigues, A. L. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.018 · Cited by 294 · see citing works
Zinc homeostasis and neurodegenerative disorders
Szewczyk, B. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00033 · Cited by 288 · see citing works
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00776.2010 · Cited by 284 · see citing works
Bluthé, R.-M., Layé, S., Michaud, B., Combe, C., Dantzer, R., & Parnet, P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.01348.x · Cited by 283 · see citing works
Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse
Huang, Y. Z., Pan, E., Xiong, Z., & McNamara, J. O. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.026 · Cited by 275 · see citing works
Panchal, S. K., Poudyal, H., & Brown, L. (2012) · Journal of Nutrition · doi:10.3945/jn.111.157263 · Cited by 271 · see citing works
The neuroprotective roles of BDNF in hypoxic ischemic brain injury
CHEN, A., XIONG, L.-J., TONG, Y., & MAO, M. (2013) · Biomedical Reports · doi:10.3892/br.2012.48 · Cited by 267 · see citing works
Sterner, E. Y., & Kalynchuk, L. E. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.005 · Cited by 259 · see citing works
Tong, L., Prieto, G. A., Kramár, E. A., Smith, E. D., Cribbs, D. H., Lynch, G., & Cotman, C. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1253-12.2012 · Cited by 254 · see citing works
Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity
Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., & Nakao, K. (2011) · Endocrinology · doi:10.1210/en.2011-0004 · Cited by 247 · see citing works
Sukoff Rizzo, S. J., Neal, S. J., Hughes, Z. A., Beyna, M., Rosenzweig-Lipson, S., Moss, S. J., & Brandon, N. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.120 · Cited by 241 · see citing works
Lopresti, A. L., & Drummond, P. D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.005 · Cited by 231 · see citing works
The phenomenology and treatment of interferon-induced depression
Loftis, J. M., & Hauser, P. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.04.002 · Cited by 227 · see citing works
Wu, A., Molteni, R., Ying, Z., & Gómez‐Pinilla, F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00154-4 · Cited by 223 · see citing works
Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction
Tong, L., Balazs, R., Soiampornkul, R., Thangnipon, W., & Cotman, C. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.027 · Cited by 222 · see citing works
Psychological Distress and Cancer Survival: A Follow-Up 10 Years After Diagnosis
Brown, K. W., Levy, A. R., Rosberger, Z., & Edgar, L. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000077503.96903.a6 · Cited by 213 · see citing works
Ohgi, Y., Futamura, T., Kikuchi, T., & Hashimoto, K. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.003 · Cited by 208 · see citing works
The Na,K-ATPase hypothesis for bipolar illness
El‐Mallakh, R. S., & Wyatt, R. J. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00201-d · Cited by 204 · see citing works
Interleukin-6, Cortisol, and Depressive Symptoms in Ovarian Cancer Patients
Lutgendorf, S. K., Weinrib, A., Penedo, F. J., Russell, D. W., DeGeest, K., Costanzo, E. S., Henderson, P. J., Sephton, S. E., Rohleder, N., Lucci, J. A., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.1978 · Cited by 201 · see citing works
Fineberg, A. M., & Ellman, L. M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.001 · Cited by 200 · see citing works
Sasayama, D., Hattori, K., Wakabayashi, C., Teraishi, T., Hori, H., Ota, M., Yoshida, S., Arima, K., Higuchi, T., Amano, N., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.12.001 · Cited by 198 · see citing works
Self-citationDonner, N. C., & Handa, R. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.046 · Cited by 197 · see citing works
Suarez, E. C., Lewis, J. G., Krishnan, R. R., & Young, K. H. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.01.002 · Cited by 185 · see citing works
Numakawa, T., Adachi, N., Richards, M., Chiba, S., & Kunugi, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.073 · Cited by 180 · see citing works
Self-citationZinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory
Sindreu, C. B., Palmiter, R. D., & Storm, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019166108 · Cited by 176 · see citing works
Yang, L.-C., Zhang, Q.-G., Zhou, C.-F., Yang, F., Zhang, Y.-D., Wang, R.-M., & Brann, D. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009851 · Cited by 163 · see citing works
High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission
Valladolid‐Acebes, I., Merino, B., Principato, A., Fole, A., Barbas, C., Lorenzo, M. P., Garcı́a, A., Olmo, N. D., Ruiz‐Gayo, M., & Cano, V. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00343.2011 · Cited by 155 · see citing works
Chen, J., Chua, K., Chua, C. C., Yu, H., Pei, A., Chua, B. H. L., Hamdy, R. C., Xu, X., & Liu, C.-F. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.054 · Cited by 153 · see citing works
Effect of diet on serotonergic neurotransmission in depression
Shabbir, F., Patel, A. A., Mattison, C., Bose, S. K., Krishnamohan, R., Sweeney, E., Sandhu, S., Nel, W., Rais, A., Sandhu, R., et al. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.014 · Cited by 147 · see citing works
Neurulation and neurite extension require the zinc transporter ZIP12 ( <i>slc39a12</i> )
Chowanadisai, W., Graham, D. M., Keen, C. L., Rucker, R. B., & Messerli, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222142110 · Cited by 140 · see citing works
Pyter, L. M., Pineros, V., Galang, J., McClintock, M. K., & Prendergast, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811949106 · Cited by 138 · see citing works
Zinc deficiency induces depression-like symptoms in adult rats
Tassabehji, N. M., Corniola, R. S., Alshingiti, A., & Levenson, C. W. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.06.017 · Cited by 138 · see citing works
Inflammation, Heart Disease, and Depression
Halaris, A. E. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0400-5 · Cited by 135 · see citing works
Spencer-Segal, J. L., Tsuda, M. C., Mattei, L., Waters, E. M., Romeo, R. D., Milner, T. A., McEwen, B. S., & Ogawa, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.035 · Cited by 133 · see citing works
Mehta, D., Newport, D. J., Frishman, G., Kraus, L., Rex‐Haffner, M., Ritchie, J., Lori, A., Knight, B. T., Stagnaro, E., Ruepp, A., et al. (2014) · Psychological Medicine · doi:10.1017/s0033291713003231 · Cited by 132 · see citing works
Szatmáry, Z., Garabedian, M. J., & Vilček, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406568200 · Cited by 132 · see citing works
Martinez, J. M., Garakani, A., Yehuda, R., & Gorman, J. M. (2012) · Depression and Anxiety · doi:10.1002/da.20876 · Cited by 131 · see citing works
Interactions Between Tamoxifen and Antidepressants via Cytochrome P450 2D6
Desmarais, J. E., & Looper, K. J. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04856blu · Cited by 131 · see citing works
Smith, C. C., Vedder, L. C., & McMahon, L. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.003 · Cited by 129 · see citing works
Briones, T. L., & Woods, J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.031 · Cited by 129 · see citing works
Jiang, M., Peng, Q., Liu, X., Jin, J., Hou, Z., Zhang, J., Mori, S., Ross, C. A., Ye, K., & Duan, W. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt098 · Cited by 129 · see citing works
Bhutada, P., Mundhada, Y. R., Bansod, K. U., Ubgade, A., Quazi, M., Umathe, S. N., & Mundhada, D. R. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.025 · Cited by 128 · see citing works
Wang, X., Wu, H., & Miller, A. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001339 · Cited by 128 · see citing works
Oestrogens and progestins for preventing and treating postpartum depression
Dennis, C., Ross, L. E., & Herxheimer, A. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001690.pub2 · Cited by 126 · see citing works
Kawabata, K., Kawai, Y., & Terao, J. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.008 · Cited by 125 · see citing works
Song, C., Zhang, Y., & Dong, Y. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-59 · Cited by 123 · see citing works
Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice
Kaczmarczyk, M. M., Machaj, A. S., Chiu, G. S., Lawson, M. A., Gainey, S. J., York, J. M., Meling, D. D., Martin, S. A., Kwakwa, K. A., Newman, A. F., et al. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.01.004 · Cited by 123 · see citing works
Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling
Wang, R., Tu, J., Zhang, Q., Zhang, X., Zhu, Y., Ma, W., Cheng, C., Brann, D. W., & Yang, F. (2013) · Hippocampus · doi:10.1002/hipo.22126 · Cited by 121 · see citing works
Barha, C. K., Dalton, G. L., & Galea, L. A. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.161 · Cited by 121 · see citing works
Popovics, P., & Stewart, A. J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0517-1 · Cited by 120 · see citing works
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder
Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.018 · Cited by 116 · see citing works
De Crescenzo, F., Perelli, F., Armando, M., & Vicari, S. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.019 · Cited by 114 · see citing works
Ichim, G., Tauszig-Delamasure, S., & Mehlen, P. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.03.006 · Cited by 108 · see citing works
Kohli, M., Salyakina, D., Pfennig, A., Lucae, S., Horstmann, S., Menke, A., Kloiber, S., Hennings, J., Bradley, B., Ressler, K., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.201 · Cited by 106 · see citing works
Maniam, J., & Morris, M. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.005 · Cited by 104 · see citing works
Harte‐Hargrove, L. C., MacLusky, N. J., & Scharfman, H. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.029 · Cited by 100 · see citing works
Leuner, B., Fredericks, P. J., Nealer, C., & Albin-Brooks, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089912 · Cited by 100 · see citing works
Holsen, L. M., Spaeth, S. B., Lee, J., Ogden, L. A., Klibanski, A., Whitfield, S., & Goldstein, J. M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.11.024 · Cited by 97 · see citing works
Kim, S. S., Lim, J., Bang, Y., Gal, J., Lee, S., Cho, Y.-C., Yoon, G., Kang, B. Y., Cheon, S. H., & Choi, H. J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.07.012 · Cited by 97 · see citing works
Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves
ENGLISH, A. W., Liu, K., Nicolini, J., Mulligan, A., & Ye, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303646110 · Cited by 91 · see citing works
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression
Hantsoo, L. V., Ward-O’Brien, D., Czarkowski, K. A., Gueorguieva, R. V., Price, L. H., & Epperson, C. N. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3316-1 · Cited by 90 · see citing works
Neurotrophic Factors, Clinical Features and Gender Differences in Depression
Cardoso, T. D. A., Mondin, T. C., Wiener, C. D., Marques, M. B., Fucolo, B. A., Pinheiro, R. T., Souza, L. D. D. M., da Silva, R. A., Jansen, K., & Oses, J. P. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1349-4 · Cited by 90 · see citing works
Association study of the estrogen receptor gene ESR1 with postpartum depression—a pilot study
Pinsonneault, J. K., Sullivan, D., Sadée, W., Soares, C. N., Hampson, E., & Steiner, M. S. (2013) · Archives of Women s Mental Health · doi:10.1007/s00737-013-0373-8 · Cited by 83 · see citing works
Synaptic Zn2+Inhibits Neurotransmitter Release by Promoting Endocannabinoid Synthesis
Perez‐Rosello, T., Anderson, C. T., Schopfer, F. J., Zhao, Y., Gilad, D., Salvatore, S. R., Freeman, B. Α., Hershfinkel, M., Aizenman, E., & Tzounopoulos, T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0237-13.2013 · Cited by 81 · see citing works
Rasgon, N., Dunkin, J. J., Fairbanks, L. A., Altshuler, L. L., Troung, C., Elman, S., Wroolie, T., Brunhuber, M. V., & Rapkin, A. J. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.03.009 · Cited by 79 · see citing works
Martinac, M., Pehar, D., Karlović, D., Babic, D. D., Marčinko, D., & Jakovljević, M. (2014) · PubMed · Cited by 78 · see citing works
Młyniec, K., Doboszewska, U., Szewczyk, B., Sowa-Kućma, M., Misztak, P., Piekoszewski, W., Trela, F., Ostachowicz, B., & Nowak, G. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.001 · Cited by 76 · see citing works
Wosiski‐Kuhn, M., Erion, J., Gómez-Sánchez, E. P., Gómez-Sánchez, C. E., & Stranahan, A. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.020 · Cited by 76 · see citing works
Woo, J., Shin, K. O., Park, S., Jang, K. S., & Kang, S. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-144 · Cited by 75 · see citing works
Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level
Elfving, B., Buttenschøn, H. N., Foldager, L., Poulsen, P. H. P., Andersen, J. H., Grynderup, M. B., Hansen, Å. M., Kolstad, H. A., Kærlev, L., Mikkelsen, S., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.05.003 · Cited by 72 · see citing works
Furuta, M., Numakawa, T., Chiba, S., Ninomiya, M., Kajiyama, Y., Adachi, N., Akema, T., & Kunugi, H. (2013) · Endocrinology · doi:10.1210/en.2012-2136 · Cited by 72 · see citing works
Self-citationThe role of the GPR39 receptor in zinc deficient-animal model of depression.
Młyniec, K., Budziszewska, B., Reczynski, W., Sowa-Kućma, M., & Nowak, G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.020 · Cited by 71 · see citing works
Zinc Deficiency Is Common in Several Psychiatric Disorders
Grønli, O., Kvamme, J., Friborg, O., & Wynn, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082793 · Cited by 71 · see citing works
Fargali, S., Sadahiro, M., Jiang, C. S., Frick, A. L., Indall, T., Cogliani, V., Welagen, J., Lin, W., & Salton, S. R. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9790-9 · Cited by 69 · see citing works
Cancer induces inflammation and depressive-like behavior in the mouse: Modulation by social housing
Lamkin, D. M., Lutgendorf, S. K., Lubaroff, D. M., Sood, A. K., Beltz, T. G., & Johnson, A. K. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.010 · Cited by 66 · see citing works
Schiller, C. E., O’Hara, M. W., Rubinow, D. R., & Johnson, A. K. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.06.009 · Cited by 64 · see citing works
Sleep research and mental illness
Oswald, I. (1975) · Psychological Medicine · doi:10.1017/s0033291700007145 · Cited by 64 · see citing works
Li, Z., Zhang, Y., Wang, Z., Chen, J., Fan, J., Guan, Y., Zhang, C., Yuan, C., Hong, W., Wang, Y., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.10.003 · Cited by 63 · see citing works
Comasco, E., Sylvén, S. M., Papadopoulos, F. C., Oreland, L., Poromaa, I. S., & Skalkidou, A. (2011) · Archives of Women s Mental Health · doi:10.1007/s00737-011-0239-x · Cited by 62 · see citing works
Murphy, M. L., Carballedo, A., Fagan, A. J., Morris, D. W., Fahey, C., Meaney, J. F., & Frodl, T. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.015 · Cited by 61 · see citing works
Patani, N., Jiang, W. G., & Mokbel, K. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-23 · Cited by 60 · see citing works
Kenis, G., Prickaerts, J., van Os, J., Koek, G. H., Robaeys, G., Steinbusch, H. W. M., & Wichers, M. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000830 · Cited by 58 · see citing works
Anisman, H., Poulter, M. O., Gandhi, R., Merali, Z., & Hayley, S. P. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.02.008 · Cited by 57 · see citing works
Tarantino, L. M., Sullivan, P. F., & Meltzer-Brody, S. E. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00044 · Cited by 55 · see citing works
Carvalho, A. F., Hyphantis, T. N., Sales, P. M. G., Soeiro‐de‐Souza, M. G., Macêdo, D. S., Cha, D. S., McIntyre, R. S., & Pavlidis, N. A. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.09.009 · Cited by 54 · see citing works
Chen, M., & Lin, P. (2000) · Obesity Research · doi:10.1038/oby.2000.65 · Cited by 48 · see citing works
Hayley, S., Scharf, J., & Anisman, H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.023 · Cited by 48 · see citing works
Chaieb, L., Antal, A., Ambrus, G. G., & Paulus, W. (2014) · Neurogenetics · doi:10.1007/s10048-014-0393-1 · Cited by 47 · see citing works
Duthie, G. G., & Morrice, P. C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/165127 · Cited by 46 · see citing works
Srivastava, D. P., Woolfrey, K. M., & Evans, P. D. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.004 · Cited by 45 · see citing works
Babayan, A. H., & Kramár, E. A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12108 · Cited by 45 · see citing works
Jembrek, M. J., Vukovic, L. D., Puhović, J., Erhardt, J., & Oršolić, N. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9737-1 · Cited by 43 · see citing works
Bredemann, T. M., & McMahon, L. L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.004 · Cited by 43 · see citing works
Pariante, C. M., Pearce, B. D., Pisell, T. L., Sanchez, C. I., Po, C., Su, C., & Miller, A. H. (1999) · Endocrinology · doi:10.1210/en.140.9.4359 · Cited by 40 · see citing works
Brain-Derived Neurotrophic Factor Levels in Women with Postpartum Affective Disorder and Suicidality
Pinheiro, R., Pinheiro, K. T., Coelho, F. M. D. C., Quevedo, L. D. Á., Gazal, M., da Silva, R. A., Giovenardi, M., Lucion, A. B., de Souza, D. D., Portela, L. V., et al. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0851-9 · Cited by 39 · see citing works
Marqués‐Iturria, I., Garolera, M., Pueyo, R., Segura, B., Hernán, I., García‐García, I., Sánchez‐Garre, C., Vernet‐Vernet, M., Palacios, M. J. S., Narberhaus, A., et al. (2014) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32229 · Cited by 39 · see citing works
Zhang, Y., Chen, M., Wu, Z., Chen, J., Yu, S., Fang, Y., & Zhang, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072652 · Cited by 39 · see citing works
Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses
Sindreu, C. B., Bayés, À., Altafaj, X., & Pérez‐Clausell, J. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-16 · Cited by 38 · see citing works
Omega-3 fatty acids influence mood in healthy and depressed individuals
Giles, G. E., Mahoney, C. R., & Kanarek, R. B. (2013) · Nutrition Reviews · doi:10.1111/nure.12066 · Cited by 36 · see citing works
Stranahan, A. M., Arumugam, T. V., & Mattson, M. P. (2010) · Neuroendocrinology · doi:10.1159/000322808 · Cited by 34 · see citing works
Differential changes in areas of social adjustment from depressive episodes through recovery
Perugi, G., Maremmani, I., McNair, D. M., Cassano, G. B., & Akiskal, H. S. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90007-9 · Cited by 34 · see citing works
Prenatal exposure to escitalopram and/or stress in rats
Bourke, C. H., Capello, C. F., Rogers, S. M., Yu, M. L., Boss-Williams, K. A., Weiss, J. M., Stowe, Z. N., & Owens, M. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3030-z · Cited by 34 · see citing works
Kirshenbaum, G. S., Burgess, C. R., Déry, N., Fahnestock, M., Peever, J. H., & Roder, J. C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.011 · Cited by 33 · see citing works
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice.
Nikseresht, S., Etebary, S., Karimian, M., Nabavizadeh, F., Zarrindast, M., & Sadeghipour, H. R. (2012) · PubMed · Cited by 33 · see citing works
Xu, H. J., Gao, H., Zheng, W., Xin, N., Chi, Z., Bai, S., & Wang, Z. (2010) · Hippocampus · doi:10.1002/hipo.20767 · Cited by 31 · see citing works
Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans
Hong, K., Lim, J., Go, M. J., Shin, Y. S., Ahn, Y., Han, B., & Oh, B. (2011) · Obesity · doi:10.1038/oby.2011.352 · Cited by 31 · see citing works
Complexity of cytokine network regulation of innate lymphoid cells in protective immunity
Seillet, C., Belz, G. T., & Mielke, L. A. (2014) · Cytokine · doi:10.1016/j.cyto.2014.06.002 · Cited by 29 · see citing works
Cordeira, J., Felsted, J. A., Teillon, S., Daftary, S. S., Panessiti, M., Wirth, J. R., Sena‐Esteves, M., & Rios, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1572-13.2014 · Cited by 29 · see citing works
Francis, H., Mirzaei, M., Pardey, M. C., Haynes, P. A., & Cornish, J. L. (2013) · PROTEOMICS · doi:10.1002/pmic.201300124 · Cited by 28 · see citing works
Huth, L., Rose, M., Kloubert, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102558 · Cited by 26 · see citing works
Beckley, E. H., Scibelli, A. C., & Finn, D. A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.11.004 · Cited by 20 · see citing works
Maternal Depression Model: Long-Lasting Effects on the Mother Following Separation from Pups
Toigo, E. V. P., Diehl, L. A., Ferreira, A. G. K., Mackendanz, V., Krolow, R., Benitz, A. N. D., Noschang, C. G., Huffell, A. P., Silveira, P. P., Wyse, Â. T. D. S., et al. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0590-3 · Cited by 19 · see citing works
Wong, J. H. K., Brummelte, S., & Galea, L. A. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02169.x · Cited by 19 · see citing works
Cucinelli, F., Soranna, L., Barini, A., Perri, C., Leoni, F., Mancuso, S., & Lanzone, A. (2002) · Metabolism · doi:10.1053/meta.2002.29971 · Cited by 18 · see citing works
Jalsrai, A., Numakawa, T., Ooshima, Y., Adachi, N., & Kunugi, H. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500086 · Cited by 17 · see citing works
Self-citationChamorro, M., Collado, P. S., & Gallego, J. G. (2004) · Dialnet (Universidad de la Rioja) · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Animal models of major depression and their clinical implications
Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375 · see citing works
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“[230] showed that significant correlations can bemade regarding BDNF and SOD specific activity.”
BackgroundEffect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology
van Velzen, L. S., Schmaal, L., Jansen, R., Milaneschi, Y., Opmeer, E. M., Elzinga, B. M., van der Wee, N. J. A., Veltman, D. J., & Penninx, B. W. J. H. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw086 · Cited by 58 · see citing works
Fidika, A., Herle, M., & Goldbeck, L. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-205 · Cited by 46 · see citing works
Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression
Caldieraro, M. A., McKee, M., Leistner-Segal, S., Vares, E. A., Kubaski, F., Spanemberg, L., Brusius-Facchin, A. C., Fleck, M. P., & Mischoulon, D. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1347713 · Cited by 39 · see citing works
- Authors
- Numakawa, T., Richards, M., Nakajima, S., Adachi, N., Furuta, M., Odaka, H., & Kunugi, H.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- University of California, Los Angeles (US)
- St. Marianna University School of Medicine (JP)
- Corresponding author
- Numakawa, Tadahiro
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2014-09-26
- Volume
- 5
- Pages
- 136-136
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC4175905
- OpenAlex
- W2168921497
- Cited by
- 86
- References
- 144
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 12 · 2020: 7 · 2019: 2 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Center of Neurology and Psychiatry (24-11)
- Japan Society for the Promotion of Science (24300139)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, comorbid depression, glucocorticoids, steroid hormones, estrogen, inflammatory cytokines, inflammation and depression, monoaminergic systems, nutritional status, diet, flavonoids, postpartum depression, autoimmune disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review