Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release
Open accessAbstract
Up-regulation of BDNF (brain-derived neurotrophic factor) has been suggested to contribute to the action of antidepressants. However, it is unclear whether chronic treatment with antidepressants may influence acute BDNF signaling in central nervous system neurons. Because BDNF has been shown by us to reinforce excitatory glutamatergic transmission in cultured cortical neurons via the phospholipase-gamma (PLC-gamma)/inositol 1,4,5-trisphosphate (IP3)/Ca2+ pathway (Numakawa, T., Yamagishi, S., Adachi, N., Matsumoto, T., Yokomaku, D., Yamada, M., and Hatanaka, H. (2002) J. Biol. Chem. 277, 6520-6529), we examined in this study the possible effects of pretreatment with antidepressants on the BDNF signaling through the PLC-gamma)/IP3/Ca2+ pathway. Furthermore, because the PLC-gamma/IP3/Ca2+ pathway is regulated by sigma-1 receptors (Hayashi, T., and Su, T. P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 491-496), we examined whether the BDNF signaling is modulated by sigma-1 receptors (Sig-1R). We found that the BDNF-stimulated PLC-gamma activation and the ensued increase in intracellular Ca2+ ([Ca2+]i) were potentiated by pretreatment with imipramine or fluvoxamine, so was the BDNF-induced glutamate release. Furthermore, enhancement of the interaction between PLC-gamma and TrkB (receptor for BDNF) after imipramine pretreatment was observed. Interestingly, BD1047, a potent Sig-1R antagonist, blocked the imipramine-dependent potentiation on the BDNF-induced PLC-gamma activation and glutamate release. In contrast, overexpression of Sig-1R per se, without antidepressant pretreatment, enhances BDNF-induced PLC-gamma activation and glutamate release. These results suggest that antidepressant pretreatment selectively enhance the BDNF signaling on the PLC-gamma/IP3/Ca2+ pathway via Sig-1R, and that Sig-1R plays an important role in BDNF signaling leading to glutamate release.
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Activation of S1R by SSRIs enhances BDNF expression.
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From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [105]
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“Moreover, the brain-derived neurotrophic factor (BDNF)-stimulated PLC-g activation and the ensued increase in intracellular Ca2þ concentration in primary rat cortex neuronal cultures was potentiated by pretreatment with imipramine, again through a s1 proteinmediated effect (Yagasaki et al., 2006).”
BackgroundBarriga, G. G.-D., Giralt, A., Anglada‐Huguet, M., Gaja‐Capdevila, N., Orlandi, J. G., Soriano, J., Canals, J. M., & Alberch, J. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx198 · Cited by 63 · see citing works
“Additionally, PLCc1 specific effects have been observed in other brain diseases, for instance, antidepressant drugs have been found to increase selectively TrkB/PLCc1 signal without Shc activation (81,82).”
BackgroundPenas, C., Pascual-Font, A., Mancuso, R., Forés, J., Casas, C., & Navarro, X. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1674 · Cited by 61 · see citing works
“It has been reported that a Sig-1R agonist increases BDNF expression in the rat brain (Kikuchi-Utsumi and Nakaki, 2008) and it was speculated that this increase would be via glutamatergic activation (Kikuchi-Utsumi and Nakaki, 2008; Yagasaki et al., 2006).”
Kikuchi-Utsumi, K., & Nakaki, T. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.055 · Cited by 59 · see citing works
Sigma-1 Receptor Enhances Neurite Elongation of Cerebellar Granule Neurons via TrkB Signaling
Kimura, Y., Fujita, Y., Shibata, K., Mori, M., & Yamashita, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075760 · Cited by 58 · see citing works
“This assumption might be supported by the finding that Sig-1R increases intracellular Ca levels upon activation [22].”
BackgroundTuerhong, T., Numakawa, T., Adachi, N., Kumamaru, E., Kitazawa, H., Kudo, M., & Kunugi, H. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.013 · Cited by 62 · see citing works
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“In contrast, it has been shown that antidepressants enhance PLC-γ/Ca2+ signalling leading to reduced levels of BDNF that cause decreased Glu release (Numakawa et al., 2002; Yagasaki et al., 2006).”
BackgroundWu, N., Ye, Y., Wan, B.-B., Yu, Y.-D., Liu, C., & Chen, Q. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02524-5 · Cited by 55 · see citing works
“This effect indicates that Sig-1R plays an important role in BDNF signal transduction which leads to glutamate release [101].”
BackgroundNovel sigma (σ) receptor agonists produce antidepressant-like effects in mice
Wang, J., Mack, A. L., Coop, A., & Matsumoto, R. R. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.02.007 · Cited by 51 · see citing works
“Overexpression of σ-1 receptors also enhanced the BDNF-induced effects (Yagasaki et al., 2006), providing further evidence for the involvement of σ receptors in these effects.”
BackgroundInfluentialUsing sigma-ligands as part of a multi-receptor approach to target diseases of the brain
Brimson, J. M., Brimson, S. J., Chomchoei, C., & Tencomnao, T. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1805435 · Cited by 46 · see citing works
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“It is postulated that the chaperone activity of σ1 receptor leads to increased release of BDNF, which, in turn, modulates signalling pathways that promote neuroprotection (Yagasaki et al., 2006).”
BackgroundChiba, S., Numakawa, T., Ninomiya, M., Yoon, H. S., & Kunugi, H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1894-8 · Cited by 37 · see citing works
“Furthermore, we previously showed that antidepressants (imipramine and fluvoxiamine) reinforced the BDNF-triggered glutamate release (Yagasaki et al. 2006).”
BackgroundSelf-citationJi, L.-L., Peng, J., Fu, C.-H., Tong, L., & Wang, Z.-Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7185 · Cited by 42 · see citing works
“Sig-1Rs are well known as the therapeutic targets for antidepressant drugs because of their antidepressant-like effects (15).”
Involvement of sigma-1 receptor modulation in the antidepressant action of venlafaxine.
Dhir, A., & Kulkarni, S. K. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.055 · Cited by 39 · see citing works
Nakano, M., Osada, K., Misonoo, A., Fujiwara, K., Takahashi, M., Ogawa, Y., Haga, T., Kanai, S., Tanaka, D., Sasuga, Y., et al. (2010) · Life Science · doi:10.1016/j.lfs.2009.11.017 · Cited by 38
Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia
Maurice, T., & Goguadze, N. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50174-1_15 · Cited by 42 · see citing works
A Role for Sigma Receptors in Stimulant Self Administration and Addiction
Katz, J. L., Su, T., Hiranita, T., Hayashi, T., Tanda, G., Kopajtic, T. A., & Tsai, S. (2011) · Pharmaceuticals · doi:10.3390/ph4060880 · Cited by 71 · see citing works
“In addition, BD 1047 prevents the potentiation of BDNF-induced PLC-γ activation and GLU release produced by antidepressant drugs [87].”
BackgroundSelf-citationTargeting TrkB neurotrophin receptor to treat depression
Rantamäki, T., & Castrén, E. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.6.705 · Cited by 40 · see citing works
“Antidepressants also activate intracellular endoplasmic reticulum associated sigma-1 receptors [82] , which are known to increase the effects of BDNF on TrkB-mediated PLC γ 1 signaling in neurons [83] .”
BackgroundCarcolé, M., Kummer, S., Gonçalves, L., Zamanillo, D., Merlos, M., Dickenson, A. H., Fernández‐Pastor, B., Cabañero, D., & Maldonado, R. J. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14794 · Cited by 39 · see citing works
“These findings agree with previous studies revealing potentiation of BDNF effects after over‐expression of σ1 receptors (Yagasaki et al., 2006) or chronic σ1 receptor activation (Kikuchi‐Utsumi & Nakaki, 2008).”
ResultChaperone Sigma1R and Antidepressant Effect
Воронин, М. В., Vakhitova, Y. V., & Середенин, С. Б. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197088 · Cited by 40 · see citing works
Espallergues, J., Lapalud, P., Christopoulos, A., Avlani, V. A., Sexton, P. M., Vamvakides, A., & Maurice, T. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707386 · Cited by 33 · see citing works
“…cholinesterase inhibitor used in Alzheimer’s disease (Kato et al., 1999; Maurice et al., 2006; Meunier et al., 2006a, b), or sertraline (Zoloft), fluvoxamine (Floxyfral) and opipramol (Insidon), prescribed as antidepressants (Bergeron et al., 1993; Rogoz and Skuza, 2006; Yagasaki et al., 2006).”
BackgroundMethodSigma-1 receptor: A potential target for the development of antidepressants
Wang, Y., Xia, C., Jia, H., He, J., Lian, W., Yan, Y., Wang, W., Zhang, W., & Xu, J. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105390 · Cited by 57 · see citing works
Dhir, A., & Kulkarni, S. K. (2008) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00605.x · Cited by 32 · see citing works
Lee, I., Chen, S., & Schetz, J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.020 · Cited by 32 · see citing works
“…affinity of fluvoxamine and selected other antidepressants has led some to suggest that sigma1 receptors may play a role in the treatment of depression (Narita et al., 1996; Yagasaki et al., 2006; Wang et al., 2007; Dhir and Kulkarni, 2007) or obsessive-compulsive disorder (Egashira et al., 2007).”
BackgroundCormaci, G., Mori, T., Hayashi, T., & Su, T. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.108415 · Cited by 34 · see citing works
“, 2002), and potentiates brain-derived neurotrophic factor signaling for glutamate release (Yagasaki et al., 2006).”
BackgroundInfluentialSelf-citationLiu, J., Li, Z., Liu, Y.-S., Chu, H.-D., Hu, N.-Y., Wu, D., Huang, L., Li, S.-J., Li, X., Yang, J., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00474-x · Cited by 31 · see citing works
Sigma-1 receptors and animal studies centered on pain and analgesia
Davis, M. P. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1051961 · Cited by 35 · see citing works
“These kinases increase the synaptic strength of neurons and cause long-term potentiation [64,96,100-104].”
BackgroundMeurs, A., Clinckers, R., Ebinger, G., Michotte, Y., & Smolders, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05911.x · Cited by 31
“The dose of 10 lm BD1047 was chosen based on the literature (Matsumoto et al., 1995; Peeters et al., 2004; Yagasaki et al., 2006) and on preliminary dosefinding experiments (data not shown).”
MethodRelationship between Sigma-1 receptor and BDNF in the visual system
Mysona, B., Zhao, J., Smith, S. L., & Bollinger, K. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.10.012 · Cited by 28 · see citing works
“shown to bind S1R and to enhance BDNF expression and signaling (Larsen et al., 2008; Narita et al., 1996; Yagasaki et al., 2006).”
BackgroundLenart, L., Hodrea, J., Hosszú, Á., Kőszegi, S., Zelena, D., Balogh, D., Szkibinszkij, E., Veres-Székely, A., Wagner, L., Vannay, Á., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4209-x · Cited by 28 · see citing works
Kwon, Y., Jeong, Y. C., Kwon, J., Son, J., & Kim, K. (2009) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2009.13.6.425 · Cited by 28
“A supportive finding shows the overactivation of Sig-1R directly enhances brain-derived neurotrophic factor-induced glutamate release (Yagasaki et al., 2006).”
BackgroundGassaway, M. M., Jacques, T., Kruegel, A. C., Karpowicz, R., Li, X.-G., Li, S., Myer, Y., & Sames, D. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.5b00678 · Cited by 27 · see citing works
Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy
Pae, C., Serretti, A., Mandelli, L., Ronchi, D. D., Patkar, A., Jun, T., Kim, J.-J., Lee, C.-U., Lee, S.-J., Lee, C., et al. (2007) · Pharmacogenetics & Genomics · doi:10.1097/01.fpc.0000236330.03681.6d · Cited by 26 · see citing works
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Small noncoding vault RNA modulates synapse formation by amplifying MAPK signaling
Wakatsuki, S., Takahashi, Y., Shibata, M., Adachi, N., Numakawa, T., Kunugi, H., & Araki, T. (2021) · Journal of Cell Biology · doi:10.1083/jcb.201911078 · Cited by 24 · see citing works
“imaging using fluo-3 dye was performed as previously reported (Numakawa et al., 2009; Yagasaki et al., 2006).”
MethodSelf-citationDysbindin (DTNBP1)--a role in psychotic depression?
Domschke, K., Lawford, B., Young, R., Voisey, J., Morris, C. P., Roehrs, T., Hohoff, C., Birosová, E., Arolt, V., & Baune, B. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.09.014 · Cited by 24 · see citing works
“neurotransmission as partly driven by dysbindin has been shown to mediate noradrenergic and serotonergic drug effects in antidepressant response (Yagasaki et al., 2006; Yoshimizu et al., 2006) and in addition to play amajor role in the pathogenesis of schizophrenia as well as in themediation of neuroleptic treatment (…”
BackgroundPark, D. I., Kim, H. G., Jung, W. R., Shin, M. K., & Kim, K. L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.013 · Cited by 22 · see citing works
“Moreover, the effects of chemical anxiolytics and antidepressants have been reported to be mediated through BDNF/TrkB signaling (Saarelainen et al., 2003; Yagasaki et al., 2006; Martinowich et al., 2007).”
Phospholipases in Health and Disease
Yang, Y., Jang, H., Ryu, S., & Suh, P. (2014) · Advances in Biochemistry in Health and Disease · doi:10.1007/978-1-4939-0464-8 · Cited by 22
“Moreover, PLC-γ1-mediated signaling activates CREB, which elevates BDNF, for a long-term antidepressive effect in the hippocampus [ 43 – 45 ].”
BackgroundVakhitova, Y. V., Kalinina, T. S., Zainullina, L. F., Lusta, A. Y., Volkova, A. V., Kudryashov, N. V., Gudasheva, T. A., Shimshirt, A. A., Kadnikov, I. A., Voronin, M. V., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413381 · Cited by 21 · see citing works
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“Interestingly, a Sig-1R-active antidepressant, imipramine, potentiates BDNF-induced activation of the phospholipase C-gamma (PLC-gamma)/inositol 1,4,5-trisphosphate (IP3)/Ca pathway that triggers glutamate release from cortical neurons [54].”
BackgroundSigma-1 receptor as a potential pharmacological target for the treatment of neuropathology
Bolshakova, A. V., Kukanova, E. O., Gainullina, A. N., Zhemkov, V., Korban, S. A., & Борисович, Б. И. (2016) · St Petersburg Polytechnical University Journal Physics and Mathematics · doi:10.1016/j.spjpm.2016.03.003 · Cited by 17 · see citing works
Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
Xu, Z., Lei, Y., Qin, H., Zhang, S., Li, P., & Yao, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147572 · Cited by 14 · see citing works
“The BDNF-TrkB signaling pathway was also modulated by the sigma-1 receptor [90].”
BackgroundFu, Y.-M., Yu, S.-Y., Guo, X.-Y., Li, X., Li, T.-Y., Li, H.-F., & Dong, Y. (2012) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2012.01.008 · Cited by 18 · see citing works
“To study whether fluvoxamine produced its effect via presynaptic sigma-1 receptors, the influence of sigma-1 receptor antagonist BD1047 (1 μM) [31] was observed on the fluvoxamine-induced glutamate release in chronic restraint stress C57BL/6 mice.”
BackgroundVelázquez-Libera, J. L., Rossino, G., Navarro-Retamal, C., Collina, S., & Caballero, J. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00496 · Cited by 17
In vitro and in vivo sigma 1 receptor imaging studies in different disease states.
Agha, H., & McCurdy, C. (2020) · RSC Medicinal Chemistry · doi:10.1039/d0md00186d · Cited by 16 · see citing works
Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids
Scaini, G., Jeremias, G. C., Furlanetto, C. B., Dominguini, D., Comim, C. M., Quevedo, J., Schuck, P. F., Ferreira, G. C., & STRECK, E. L. (2013) · JIMD Reports · doi:10.1007/8904_2013_274 · Cited by 18 · see citing works
“…after drug administration, the effects of antidepressants emerge gradually over several weeks of continuous application, it is possible that in addition to an increase in monoamine levels, other more temporal neuronal events may be responsible for the action of imipramine (Yagasaki et al. 2006).”
BackgroundDARPP-32 expression in rat brain after electroconvulsive stimulation.
Rosa, D. V., Souza, R. P., Souza, B. R., Motta, B. S., Caetano, F., Jornada, L. K., Feier, G., Gomez, M., Quevedo, J., & Romano-Silva, M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.043 · Cited by 15 · see citing works
Li, M., Xie, Y.-Q., Niu, K., & Li, K. (2020) · Cellular and Molecular Biology · doi:10.14715/cmb/2020.66.3.26 · Cited by 14
Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders
Eskandari, K., Bélanger, S.-M., Lachance, V., & Kourrich, S. (2025) · Pharmaceuticals · doi:10.3390/ph18050700 · Cited by 14 · see citing works
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“Long term SSRI treatment promotes BDNF transcription and increases the BDNF concentration [10,11,18].”
BackgroundNeurotrophin Strategies for Neuroprotection: Are They Sufficient?
Steiner, J., & Nath, A. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9533-5 · Cited by 12 · see citing works
“Fluvoxamine rat cortical neurons in vitro (Yagasaki et al. 2006)”
BackgroundBrimson, J., Prasanth, M., Malar, D. S., Verma, K., Plaingam, W., & Tencomnao, T. (2022) · Nutrition and Healthy Aging · doi:10.3233/nha-220161 · Cited by 9 · see citing works
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“Neuronal activity that increases as a result of sympathetic nervous system stimulation [1], such as physical activity [2-4] or administration of antidepressant drugs [5], has been shown to increase levels of peripheral [6] or CNS [4, 7-9] brain-derived neurotrophic factor (BDNF), and whether that activity is electrica…”
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“…a lack of association between DTNBP1 SNPs and MDD (Zill et al. 2004, Pae et al. 2007, Kim et al. 2008, Wray et al. 2008, Arias et al. 2009), while others have shown the impact of DTNBP1 polymorphism on antidepressant treatment response (Yagasaki et al. 2006, Pae et al. 2007, Arias et al. 2009).”
BackgroundLow, Z. X. B., Yong, S. J., AlRasheed, H. A., Al‐Subaie, M. F., Kaabi, N. A., Alfaresi, M. S., Albayat, H., Alotaibi, J., bshabshe, A. A. A. A., Alwashmi, A. S. S., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111279 · Cited by 4 · see citing works
Effect of the Sigma-1 receptor on neurite outgrowth
Kimura, Y., Fujita, Y., & Yamashita, T. (2014) · doi:10.14800/rci.50 · Cited by 1
“This effect of antidepressants was diminished by Sig-1R antagonists and enhanced by Sig-1R overexpression ([30]).”
BackgroundBrain-derived neurotrophic factor in diabetes: A promising target for cognitive restoration
Chandak, G., Kumar, B., Kumar, S., Ashique, S., Bhui, U., Pandey, N., Debnath, B., Al-Salem, F. M., Yasmin, S., Brady, M. S. M., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116658
“40”
Kavuran, İ. B., Önalan, E., Turk, Z. I., & Eröksüz, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1910199
Zhang, B., & Li, C. (2026) · Depression and Anxiety · doi:10.1155/da/1891046
“Mechanistically, BDNF-triggered TrkB activation facilitated rapid glutamate ef fl ux via the downstream PLC-γ /IP3/Ca 2 + and Src/PLC-γ 1 signaling cascades, and this pro-glutamatergic effect was further potentiated by antidepressants, whereas fully abrogated by the TrkB antagonist K252a [179 – 182].”
Kryzhanovskii, S., Miroshkina, I., & Ionova, E. O. (2021) · Human Physiology · doi:10.1134/s0362119721040071
- Authors
- Yagasaki, Y., Numakawa, T., Kumamaru, E., Hayashi, T., Su, T.-P., & Kunugi, H.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- National Institute on Drug Abuse (US)
- Corresponding author
- Numakawa, Tadahiro
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 281
- Issue
- 18
- Pages
- 12941-12949
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2059583297
- Cited by
- 122
- References
- 50
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Japan Foundation for Aging and Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- antidepressants, sigma-1 receptor, brain-derived neurotrophic factor, BDNF signaling, phospholipase C-gamma, glutamate release, imipramine, fluvoxamine, TrkB, cortical neurons, BD1047
- MeSH terms
- Sigma-1 Receptor, Animals, Antidepressive Agents, Antidepressive Agents, Tricyclic, Imipramine, Neurons, Calcium Channels, Signal Transduction, Fluvoxamine, Receptors, sigma, Receptors, Cytoplasmic and Nuclear, Neurotransmitter Agents, Antidepressive Agents, Second-Generation, Glutamic Acid, Brain-Derived Neurotrophic Factor, Rats, Inositol 1,4,5-Trisphosphate Receptors
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