Brüning, Jens C.

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature

Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth Factors

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Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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A guide to analysis of mouse energy metabolism

Tschöp, M. H., Speakman, J. R., Arch, J. R. S., Auwerx, J., Brüning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., et al. (2012) · Nature Methods

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

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Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

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Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityPancreatic function and diabetes

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The role of insulin receptor signaling in the brain

Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism

Regulation of Appetite and ObesityMetabolism, Diabetes, and Cancer

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FOXO1 couples metabolic activity and growth state in the vascular endothelium

Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M. F., Lim, R., Zimmermann, B., Aspalter, I. M., Franco, C. A., Boettger, T., et al. (2016) · Nature

FOXO transcription factor regulationAngiogenesis and VEGF in Cancer

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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

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Hypothalamic inflammation in obesity and metabolic disease

Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

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Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.

Wang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J. C., Kahn, C. R., Clayton, D. A., Barsh, G. S., et al. (1999) · Nature Genetics

Mitochondrial Function and PathologyCardiac electrophysiology and arrhythmias

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Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

Willenborg, S., Sanin, D. E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J. L., et al. (2021) · Cell Metabolism

Wound Healing and TreatmentsImmune cells in cancer

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Hunger-Driven Motivational State Competition

Burnett, C. J., Li, C., Webber, E., Tsaousidou, E., Xue, S. Y., Brüning, J. C., & Krashes, M. J. (2016) · Neuron

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

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HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus

Steuernagel, L., Lam, B. Y. H., Klemm, P., Dowsett, G. K. C., Bauder, C. A., Tadross, J. A., Hitschfeld, T. S., del Rio Martin, A., Chen, W., de Solis, A. J., et al. (2022) · Nature Metabolism

Single-cell and spatial transcriptomicsPancreatic function and diabetes

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Neuronal control of peripheral insulin sensitivity and glucose metabolism

Ruud, J., Steculorum, S. M., & Brüning, J. C. (2017) · Nature Communications

Regulation of Appetite and ObesityPancreatic function and diabetes

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Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

Wunderlich, F. T., Ströhle, P., Könner, A. C., Gruber, S., Tovar, S., Brönneke, H. S., Juntti-Berggren, L., Li, L.-S., van Rooijen, N., Libert, C., et al. (2010) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesLiver physiology and pathology

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Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease

Freude, S., Hettich, M. M., Schumann, C., Stöhr, O., Koch, L., Köhler, C., Udelhoven, M., Leeser, U., Müller, M., Kubota, N., et al. (2009) · The FASEB Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Integrative neurocircuits that control metabolism and food intake

Brüning, J. C., & Fenselau, H. (2023) · Science

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

Könner, A. C., Hess, S., Tovar, S., Mesaros, A., Sánchez-Lasheras, C., Evers, N., Verhagen, L. A. W., Brönneke, H. S., Kleinridders, A., Hampel, B., et al. (2011) · Cell Metabolism

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

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The Sense of Smell Impacts Metabolic Health and Obesity

Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., Ruud, L. E., Alber, J., Tharp, K., Anderson, C. M., et al. (2017) · Cell Metabolism

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Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

Ernst, M. B., Wunderlich, C. M., Hess, S., Paehler, M., Mesaros, A., Koralov, S. B., Kleinridders, A., Husch, A., Münzberg, H., Hampel, B., et al. (2009) · The Journal of Neuroscience

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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

Timper, K., del Río-Martín, A., Cremer, A. L., Bremser, S., Alber, J., Giavalisco, P., Varela, L., Heilinger, C., Nolte, H., Trifunovic, A., et al. (2020) · Cell Metabolism

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Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss

Schmitz, J., Evers, N., Awazawa, M., Nicholls, H. T., Brönneke, H. S., Dietrich, A., Mauer, J., Blüher, M., & Brüning, J. C. (2016) · Molecular Metabolism

Adipokines, Inflammation, and Metabolic DiseasesBariatric Surgery and Outcomes

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Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation

Plum, L., Rother, E., Münzberg, H., Wunderlich, F. T., Morgan, D. A., Hampel, B., Shanabrough, M., Janoschek, R., Könner, A. C., Alber, J., et al. (2007) · Cell Metabolism

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