Cited by 194Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

Open access
Könner, A. Christine, Hess, Simon, Tovar, Sulay, Mesaros, Andrea, Sánchez-Lasheras, Carmen, Evers, Nadine, Verhagen, Linda A.W., Brönneke, Hella S. +4 more·2011·Cell Metabolism

Abstract

Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydroxylase (Th)-expressing cells of mice (IR(ΔTh)). IR inactivation in Th-expressing cells of mice resulted in increased body weight, increased fat mass, and hyperphagia. While insulin acutely stimulated firing frequency in 50% of dopaminergic VTA/SN neurons, this response was abolished in IR(ΔTh) mice. Moreover, these mice exhibited an altered response to cocaine under food-restricted conditions. Taken together, these data provide in vivo evidence for a critical role of insulin signaling in catecholaminergic neurons to control food intake and energy homeostasis.

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Crossref · 10.1016/j.cmet.2011.03.021

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  • In lean healthy individuals, peripheral and central insulin infusion suppresses appetite and feeding.

    “in lean healthy individuals, peripheral and even central infusion of insulin suppresses appetite and feeding”

    From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Konner et al., 2011

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Authors
Könner, A. C., Hess, S., Tovar, S., Mesaros, A., Sánchez-Lasheras, C., Evers, N., Verhagen, L. A. W., Brönneke, H. S., Kleinridders, A., Hampel, B., Kloppenburg, P., & Brüning, J. C.
Affiliations
  • University of Cologne (DE)
  • Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
Corresponding author
Brüning, Jens C.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2011-06
Volume
13
Issue
6
Pages
720-728
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2051037127
Cited by
194
References
48
Citations by year
2026: 3 · 2025: 6 · 2024: 10 · 2023: 17 · 2022: 11 · 2021: 24 · 2020: 9 · 2019: 12 · 2018: 8 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 12 · 2013: 17 · 2012: 19
FWCI
7.67
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • European Commission (FP7-HEALTH-2009-241592)
  • Deutsche Forschungsgemeinschaft (BR 1492/7-1, KL 762/2-2, KL 762/4-1)
  • Bundesministerium für Bildung und Forschung (FKZ01GIO845)
  • Universität zu Köln
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
insulin signaling, insulin receptor, dopaminergic neurons, catecholaminergic neurons, energy homeostasis, dietary intake, hyperphagia, body weight, fat mass, ventral tegmental area, substantia nigra, dietary restriction, tyrosine hydroxylase, food reward
MeSH terms
Action Potentials, Animals, Calorimetry, Indirect, Catecholamines, Cocaine, Eating, Energy Metabolism, Homeostasis, Hyperinsulinism, Insulin, Mesencephalon, Mice, Inbred ICR, Motor Activity, Neurons, Receptor, Insulin, Tyrosine 3-Monooxygenase, Signal Transduction, Gene Expression, Receptors, Dopamine D2, Mice, Knockout, Adiposity, Mice

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