Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010 · see citing works

Receptor-mediated regional sympathetic nerve activation by leptin.

Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979 · see citing works

Agouti-related peptide–expressing neurons are mandatory for feeding

Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800 · see citing works

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.004 · Cited by 695 · see citing works

Widespread recombinase expression using FLPeR (Flipper) mice

Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602 · see citing works

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

Suzuki, A., Tsukio, M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A. C., Higuchi, T., Fukumoto, M., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00134-0 · Cited by 589 · see citing works

Key enzyme in leptin-induced anorexia

Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585 · see citing works

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

Schwartz, M. W., Sipols, A. J., Marks, J. L., Sanacora, G., White, J. D., Scheurink, A., Kahn, S. E., Baskin, D. G., Woods, S. C., & Figlewicz, D. P. (1992) · Endocrinology · doi:10.1210/endo.130.6.1597158 · Cited by 555 · see citing works

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

Backman, S. A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J. K., Tsao, M., Shannon, P. T., Bolon, B. N., Ivy, G. O., et al. (2001) · Nature Genetics · doi:10.1038/ng782 · Cited by 511 · see citing works

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Kitamura, T., Feng, Y., Kitamura, Y., Chua, S. C., Xu, A. W., Barsh, G. S., Rossetti, L., & Accili, D. (2006) · Nature Medicine · doi:10.1038/nm1392 · Cited by 449 · see citing works

Central insulin action in energy and glucose homeostasis

Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29063 · Cited by 438 · see citing works

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y.-J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308617100 · Cited by 436 · see citing works

Virus-Assisted Mapping of Neural Inputs to a Feeding Center in the Hypothalamus

DeFalco, J., Tomishima, M. J., Liu, H., Zhao, C., Cai, X., Marth, J. D., Enquist, L. W., & Friedman, J. M. (2001) · Science · doi:10.1126/science.1056602 · Cited by 422 · see citing works

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

Sipols, A. J., Baskin, D. G., & Schwartz, M. W. (1995) · Diabetes · doi:10.2337/diab.44.2.147 · Cited by 389 · see citing works

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385 · see citing works

Role for neuronal insulin resistance in neurodegenerative diseases

Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Alber, J., Galldiks, N., Kustermann, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308724101 · Cited by 339 · see citing works

A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat

Ferré, P., Leturque, A., Burnol, A., Pénicaud, L., & Girard, J. R. (1985) · Biochemical Journal · doi:10.1042/bj2280103 · Cited by 337 · see citing works

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27123 · Cited by 326 · see citing works

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

Sleeman, M. W., Wortley, K. E., Lai, K. V., Gowen, L. C., Kintner, J., Kline, W. O., García, K., Stitt, T. N., Yancopoulos, G. D., Wiegand, S. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1178 · Cited by 255 · see citing works

A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

Zhao, A. Z., Huan, J.-N., Gupta, S., Pal, R., & Sahu, A. (2002) · Nature Neuroscience · doi:10.1038/nn885 · Cited by 242 · see citing works

Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes

Wijesekara, N., Konrad, D., Eweida, M., Jefferies, C., Liadis, N., Giacca, A., Crackower, M. A., Suzuki, A., Mak, T. W., Kahn, C. R., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1135-1145.2005 · Cited by 237 · see citing works

Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue

Kurlawalla-Martinez, C., Stiles, B. L., Wang, Y., Devaskar, S. U., Kahn, B. B., & Wu, H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2498-2510.2005 · Cited by 189 · see citing works

Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin

Rahmouni, K., Morgan, D. A., Morgan, G. M., Liu, X., Sigmund, C. D., Mark, A. L., & Haynes, W. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21737 · Cited by 187 · see citing works

Induction of Uncoupling Protein Expression in Brown and White Adipose Tissue by Leptin**This work was supported by a research grant from the American Diabetes Association, USPHS Grant DK-53981, and a research grant from the USDA (NRICGP/USDA 9800699).

Commins, S. P., Watson, P. M., Padgett, M. A., Dudley, A. C., Argyropoulos, G. A., & Gettys, T. W. (1999) · Endocrinology · doi:10.1210/endo.140.1.6399 · Cited by 185 · see citing works

Inactivation of Signal Transducer and Activator of Transcription 3 in Proopiomelanocortin (Pomc) Neurons Causes Decreased Pomc Expression, Mild Obesity, and Defects in Compensatory Refeeding

Xu, A. W., Marie, L. S., Kaelin, C. B., & Barsh, G. S. (2006) · Endocrinology · doi:10.1210/en.2006-1119 · Cited by 165 · see citing works

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

Air, E. L., Benoit, S. C., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · Endocrinology · doi:10.1210/endo.143.6.8948 · Cited by 131 · see citing works

Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes

Stiles, B. L., Kuralwalla-Martinez, C., Guo, W., Gregorian, C., Wang, Y., Tian, J., Magnuson, M. A., & Wu, H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2772-2781.2006 · Cited by 130 · see citing works

Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: Neuronal involvement in food-intake regulation

Yamada, T., Katagiri, H., Ishigaki, Y., Ogihara, T., Imai, J., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Niijima, A., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.001 · Cited by 123 · see citing works

Immunocytochemical Detection of Phosphatidylinositol 3-kinase Activation by Insulin and Leptin

Niswender, K. D., Gallis, B. M., Blevins, J. E., Corson, M. A., Schwartz, M. W., & Baskin, D. G. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305100302 · Cited by 116 · see citing works

Untitled work

Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.009 · Cited by 597 · see citing works

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

Jordan, S. D., Krüger, M., Willmes, D. M., Redemann, N., Wunderlich, F. T., Brönneke, H. S., Merkwirth, C., Kashkar, H., Olkkonen, V. M., Böttger, T., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2211 · Cited by 522 · see citing works

Recent advances in understanding leptin signaling and leptin resistance

Morris, D. L., & Rui, L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00274.2009 · Cited by 467 · see citing works

Structure, production and signaling of leptin

Münzberg, H., & Morrison, C. D. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.010 · Cited by 455 · see citing works

Signaling pathways in obesity: mechanisms and therapeutic interventions

Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 456 · see citing works

Leptin signaling and leptin resistance

Zhou, Y., & Rui, L. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0263-5 · Cited by 417 · see citing works

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

Toll-like receptors: linking inflammation to metabolism

Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 327 · see citing works

Selective Insulin and Leptin Resistance in Metabolic Disorders

Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 304 · see citing works

Leptin and brain–adipose crosstalks

Caron, A., Lee, S., Elmquist, J. K., & Gautron, L. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.7 · Cited by 284 · see citing works

Targeting PI3K/AKT signaling pathway in obesity

Savova, M. S., Mihaylova, L. V., Tews, D., Wabitsch, M., & Georgiev, M. I. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114244 · Cited by 288 · see citing works

Leptin signalling pathways in hypothalamic neurons

Kwon, O., Kim, K. W., & Kim, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2133-1 · Cited by 283 · see citing works

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 276 · see citing works

CNS leptin and insulin action in the control of energy homeostasis

Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 275 · see citing works

Leptin as a key regulator of the adipose organ

Picó, C., Palou, M., Pomar, C. A., Rodríguez, A. M., & Palou, A. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09687-5 · Cited by 276 · see citing works

A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

Butler, A. A., & Kozak, L. P. (2010) · Diabetes · doi:10.2337/db09-1471 · Cited by 263 · see citing works

Advances in understanding the interrelations between leptin resistance and obesity

Pan, H., Guo, J., & Su, Z. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.003 · Cited by 247 · see citing works

Hormone and glucose signalling in POMC and AgRP neurons

Belgardt, B., Okamura, T., & Brüning, J. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179192 · Cited by 245 · see citing works

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 239 · see citing works

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J. G., Morgan, D. A., Mostoslavsky, R., Stuart, R. C., Perelló, M., Vianna, C. R., Nillni, E. A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.010 · Cited by 225 · see citing works

Cancer Cachexia: More Than Skeletal Muscle Wasting

Schmidt, S. F., Rohm, M., Herzig, S., & Díaz, M. B. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.10.001 · Cited by 219 · see citing works

Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond

Könner, A. C., Klöckener, T., & Brüning, J. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.027 · Cited by 215 · see citing works

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

Ren, H., Orozco, I. J., Su, Y., Suyama, S., Juárez, R. G., Horváth, T. L., Wardlaw, S. L., Plum, L., Arancio, O., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.04.032 · Cited by 201 · see citing works

Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism

Xiao, H., Sun, X., Lin, Z., Yang, Y., Zhang, M., Xu, Z., Liu, P., Liu, Z., & Huang, H. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.023 · Cited by 197 · see citing works

Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

Könner, A. C., Hess, S., Tovar, S., Mesaros, A., Sánchez-Lasheras, C., Evers, N., Verhagen, L. A. W., Brönneke, H. S., Kleinridders, A., Hampel, B., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.021 · Cited by 194 · see citing works

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age

Vogt, M. C., & Brüning, J. C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.004 · Cited by 188 · see citing works

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

Joseph, C. J., Quach, J., Walkley, C. R., Lane, S., Celso, C. L., & Purton, L. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.010 · Cited by 183 · see citing works

Leptin receptor signaling: pathways to leptin resistance

Wauman, J. (2011) · Frontiers in bioscience · doi:10.2741/3885 · Cited by 179 · see citing works

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

Plum, L., Lin, H. V., Dutia, R., Tanaka, J., Aizawa, K. S., Matsumoto, M., Kim, A. J., Cawley, N. X., Paik, J.-H., Loh, Y. P., et al. (2009) · Nature Medicine · doi:10.1038/nm.2026 · Cited by 176 · see citing works

The Leptin Receptor Complex: Heavier Than Expected?

Wauman, J., Zabeau, L., & Tavernier, J. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00030 · Cited by 178 · see citing works

The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity

Satoh, A., Stein, L. R., & Imai, S. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_7 · Cited by 171 · see citing works

Thyroid hormones induce browning of white fat

Martínez‐Sánchez, N., Moreno‐Navarrete, J. M., Contreras, C., Rial‐Pensado, E., Fernø, J., Nogueiras, R., Diéguez, C., Fernández‐Real, J. M., & López, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0425 · Cited by 166 · see citing works

Hypothalamic Leptin Signaling Regulates Hepatic Insulin Sensitivity via a Neurocircuit Involving the Vagus Nerve

German, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., & Morton, G. J. (2009) · Endocrinology · doi:10.1210/en.2009-0445 · Cited by 164 · see citing works

Selective leptin resistance revisited

Mark, A. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00180.2013 · Cited by 162 · see citing works

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

Al‐Qassab, H., Smith, M. A., Irvine, E. E., Guillermet‐Guibert, J., Claret, M., Choudhury, A. I., Selman, C., Piipari, K., Clements, M., Lingard, S. J., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.008 · Cited by 158 · see citing works

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

Belgardt, B., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Klöckener, T., Alessi, D. R., Kloppenburg, P., & Brüning, J. C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.006 · Cited by 157 · see citing works

There and Back Again: Leptin Actions in White Adipose Tissue

Martínez‐Sánchez, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176039 · Cited by 135 · see citing works

The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane

Guo, D., Cui, H., Zhang, Q., Morgan, D. A., Thedens, D. R., Nishimura, D. Y., Grobe, J. L., Sheffield, V. C., & Rahmouni, K. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005890 · Cited by 132 · see citing works

Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity

Mesaros, A., Koralov, S. B., Rother, E., Wunderlich, F. T., Ernst, M. B., Barsh, G. S., Rajewsky, K., & Brüning, J. C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.007 · Cited by 128 · see citing works

Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators

Sánchez-Lasheras, C., Könner, A. C., & Brüning, J. C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.08.002 · Cited by 120 · see citing works

PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis

Xu, Y., Hill, J. W., Fukuda, M., Gautron, L., Sohn, J., Kim, K. W., Lee, C. E., Choi, M. J., Lauzon, D. A., Dhillon, H., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.002 · Cited by 111 · see citing works

Hypothalamic mTORC1 Signaling Controls Sympathetic Nerve Activity and Arterial Pressure and Mediates Leptin Effects

Harlan, S. M., Guo, D., Morgan, D. A., Fernandes‐Santos, C., & Rahmouni, K. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.017 · Cited by 100 · see citing works

The pathophysiology of abdominal adipose tissue depots in health and disease

Walker, G. E., Marzullo, P., Ricotti, R., Bona, G., & Prodam, F. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0023 · Cited by 90 · see citing works

Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

St‐Pierre, J., & Tremblay, M. L. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.004 · Cited by 88 · see citing works

Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin

Bell, B., Harlan, S. M., Morgan, D. A., Guo, D., & Rahmouni, K. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.006 · Cited by 89 · see citing works

Central Regulation of Metabolism by Protein Tyrosine Phosphatases

Tsou, R. C., & Bence, K. K. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00192 · Cited by 85 · see citing works

Leptin Receptor Signaling in the Hypothalamus Regulates Hepatic Autonomic Nerve Activity via Phosphatidylinositol 3-Kinase and AMP-Activated Protein Kinase

Tanida, M., Yamamoto, N., Morgan, D. A., Kurata, Y., Shibamoto, T., & Rahmouni, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1828-14.2015 · Cited by 80 · see citing works

Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis

Hu, F., Xu, Y., & Liu, F. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00121.2016 · Cited by 76 · see citing works

Intracellular Leptin-Signaling Pathways in Hypothalamic Neurons: The Emerging Role of Phosphatidylinositol-3 Kinase-Phosphodiesterase-3B-cAMP Pathway

Sahu, A. (2011) · Neuroendocrinology · doi:10.1159/000326785 · Cited by 74 · see citing works

Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice

Gelling, R. W., Yan, W., Al‐Noori, S., Pardini, A. W., Morton, G. J., Ogimoto, K., Schwartz, M. W., & Dempsey, P. J. (2008) · Endocrinology · doi:10.1210/en.2008-0775 · Cited by 74 · see citing works

Angiotensin AT1A receptors on leptin receptor–expressing cells control resting metabolism

Claflin, K. E., Sandgren, J. A., Lambertz, A. M., Weidemann, B. J., Littlejohn, N. K., Burnett, C. M.-L., Pearson, N. A., Morgan, D. A., Gibson-Corley, K. N., Rahmouni, K., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88641 · Cited by 74 · see citing works

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Kyriakou, E., Schmidt, S., Dodd, G. T., Pfuhlmann, K., Simonds, S. E., Lenhart, D., Geerlof, A., Schriever, S. C., Angelis, M. D., Schramm, K. ‐., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01224 · Cited by 74 · see citing works

Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine?

Genchi, V. A., D’Oria, R., Palma, G., Caccioppoli, C., Cignarelli, A., Natalicchio, A., Laviola, L., Giorgino, F., & Perrini, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126445 · Cited by 75 · see citing works

CNS-targets in control of energy and glucose homeostasis

Kleinridders, A., Könner, A. C., & Brüning, J. C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.006 · Cited by 72 · see citing works

Metabolic Role of PTEN in Insulin Signaling and ResistancePreprint

Li, Y. Z., Cristofano, A. D., & Woo, M. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036137 · Cited by 70 · see citing works

PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake

Iskandar, K., Cao, Y., Hayashi, Y., Nakata, M., Takano, E., Yada, T., Zhang, C., Ogawa, W., Oki, M., Chua, S. C., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2009 · Cited by 67 · see citing works

Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex

Wang, L., Opland, D. M., Tsai, S. J., Luk, C. T., Schroer, S. A., Allison, M. B., Elia, A., Furlonger, C. L., Suzuki, A., Paige, C. J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3527 · Cited by 66 · see citing works

A Novel lnc-RNA, Named lnc-ORA, Is Identified by RNA-Seq Analysis, and Its Knockdown Inhibits Adipogenesis by Regulating the PI3K/AKT/mTOR Signaling Pathway

Cai, R., Tang, G., Zhang, Q., Yong, W., Zhang, W., Xiao, J., Wei, C., He, C., Yang, G., & Pang, W. (2019) · Cells · doi:10.3390/cells8050477 · Cited by 65 · see citing works

Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance

Qiu, J., Bosch, M. A., Meza, C., Navarro, U.-V., Nestor, C. C., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2017) · Endocrinology · doi:10.1210/en.2017-00793 · Cited by 62 · see citing works

The PI3K signaling pathway mediates the biological effects of leptin

Donato, J., Frazão, R., & Elias, C. F. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000700002 · Cited by 60 · see citing works

Incendiary Leptin

Seoane‐Collazo, P., Martínez‐Sánchez, N., Milbank, E., & Contreras, C. (2020) · Nutrients · doi:10.3390/nu12020472 · Cited by 58 · see citing works

Imaging modalities for diagnosis and monitoring of cancer cachexia

Han, J., Harrison, L., Patzelt, L., Wu, M., Junker, D., Herzig, S., Díaz, M. B., & Karampinos, D. C. (2021) · EJNMMI Research · doi:10.1186/s13550-021-00834-2 · Cited by 55 · see citing works

Functional Role of c-Jun-N-Terminal Kinase in Feeding Regulation

Unger, E. K., Piper, M. L., Olofsson, L. E., & Xu, A. W. (2009) · Endocrinology · doi:10.1210/en.2009-0711 · Cited by 50 · see citing works

Elevated Fra-1 expression causes severe lipodystrophy

Luther, J., Drießler, F., Megges, M., Heß, A., Herbort, B., Mandic, V., Zaiss, M. M., Reichardt, A., Zech, C., Tuckermann, J. P., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.079855 · Cited by 47 · see citing works

Metabolic actions of hypothalamic SIRT1

Coppari, R. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.01.002 · Cited by 47 · see citing works

Thermogenic adipocytes: From cells to physiology and medicine

Díaz, M. B., Herzig, S., & Vegiopoulos, A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.002 · Cited by 44 · see citing works

Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends?

Evans, M. C., Lord, R. A., & Anderson, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179210 · Cited by 44 · see citing works

A chromatin perspective of adipogenesis

Musri, M. M., Gomis, R., & Párrizas, M. (2010) · Organogenesis · doi:10.4161/org.6.1.10226 · Cited by 43 · see citing works

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH–dependent sympathetic drive

Perino, A., Beretta, M., Kilić, A., Ghigo, A., Carnevale, D., Repetto, I. E., Braccini, L., Longo, D. L., Liebig‐Gonglach, M., Zaglia, T., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005485 · Cited by 43 · see citing works

Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential

Gavello, D., Carbone, E., & Carabelli, V. (2016) · Channels · doi:10.1080/19336950.2016.1164373 · Cited by 43 · see citing works

PI3K signaling in the pathogenesis of obesity: The cause and the cure

Beretta, M., Bauer, M. W., & Hirsch, E. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.11.004 · Cited by 41 · see citing works

PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction

García-Galiano, D., Borges, B. C., Donato, J., Allen, S. J., Bellefontaine, N., Wang, M., Zhao, J. J., Kozloff, K. M., Hill, J. W., & Elias, C. F. (2017) · JCI Insight · doi:10.1172/jci.insight.96728 · Cited by 39 · see citing works

Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin

Harlan, S. M., & Rahmouni, K. (2012) · Clinical Autonomic Research · doi:10.1007/s10286-012-0168-4 · Cited by 39 · see citing works

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism

Rother, E., Könner, A. C., & Brüning, J. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00685.2007 · Cited by 38 · see citing works

Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons

Huang, Y., He, Z., Gao, Y., Lieu, L., Yao, T. S., Sun, J. M., Liu, T., Javadi, C. S., Box, M., Afrin, S., et al. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00061 · Cited by 35 · see citing works

Acute selective ablation of rat insulin promoter-expressing (RIP HER ) neurons defines their orexigenic nature

Rother, E., Belgardt, B., Tsaousidou, E., Hampel, B., Waisman, A., Myers, M. G., & Brüning, J. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206147109 · Cited by 34 · see citing works

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse

Dubois, E., Jacoby, M., Blockmans, M., Pernot, E., Schiffmann, S. N., Foukas, L. C., Henquin, J., Vanhaesebroeck, B., Erneux, C., & Schurmans, S. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.06.012 · Cited by 33 · see citing works

Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice

Kim, E., Lim, S.-M., Kim, M., Yoo, S., & Kim, Y. (2017) · Nutrients · doi:10.3390/nu9101049 · Cited by 32 · see citing works

History and future of leptin: Discovery, regulation and signaling

Münzberg, H., Heymsfield, S. B., Berthoud, H., & Morrison, C. D. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156026 · Cited by 36 · see citing works

Impact of adipokines and myokines on fat browning

Rodrı́guez, A., Catalán, V., Ramírez, B., Unamuno, X., Portincasa, P., Gómez‐Ambrosi, J., Frühbeck, G., & Becerril, S. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00736-2 · Cited by 30 · see citing works

The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling

Koch, C. E., Ganjam, G. K., Steger, J., Legler, K., Stöhr, S., Schumacher, D., Hoggard, N., Heldmaier, G., & Tups, A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003005 · Cited by 30 · see citing works

PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin

Harlan, S. M., & Rahmouni, K. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.03.004 · Cited by 29 · see citing works

MicroRNA miR-7 and miR-17-92 in the Arcuate Nucleus of Mouse Hypothalamus Regulate Sex-Specific Diet-Induced Obesity

Gao, Y.-X., Li, J., Zhang, Z., Zhang, R., Pollock, A., & Sun, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1618-y · Cited by 27 · see citing works

Whole-Body and Hepatic Insulin Resistance in Obese Children

Ibarra‐Reynoso, L. D. R., Pisarchyk, L., Pérez-Luque, E. L., Garay‐Sevilla, M. E., & Malacara, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113576 · Cited by 27 · see citing works

Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling

Metlakunta, A. S., Sahu, M., Yasukawa, H., Dhillon, S. S., Belsham, D. D., Yoshimura, A., & Sahu, A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00794.2010 · Cited by 27 · see citing works

PI3K and AKT at the Interface of Signaling and Metabolism

Solinas, G., & Becattini, B. (2022) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-06566-8_13 · Cited by 25 · see citing works

Molecular pathways regulating the formation of brown‐like adipocytes in white adipose tissue

Fu, J., Li, Z., Zhang, H., Mao, Y., Wang, A., Wang, X., Zou, Z., & Zhang, X. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2600 · Cited by 26 · see citing works

Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?

Münzberg, H., Floyd, Z. E., & Chang, J. S. (2021) · Physiology · doi:10.1152/physiol.00038.2020 · Cited by 23 · see citing works

The Leptin Signaling

Liu, J., Yang, X., Yu, S., & Zheng, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_7 · Cited by 24 · see citing works

Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females

Qiu, J., Bosch, M. A., Zhang, C., Rønnekleiv, O. K., & Kelly, M. J. (2019) · Neuroendocrinology · doi:10.1159/000501560 · Cited by 24 · see citing works

Comparative analysis of gene expression profiles in differentiated subcutaneous adipocytes between Jiaxing Black and Large White pigs

Zhang, D., Wu, W., Huang, X. S., Xu, K., Zheng, C. C., & Zhang, J. (2021) · BMC Genomics · doi:10.1186/s12864-020-07361-9 · Cited by 23 · see citing works

Inter-organ regulation of adipose tissue browning

Wang, S., & Yang, X. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2420-x · Cited by 23 · see citing works

Leptin Downregulates Angulin-1 in Active Crohn’s Disease via STAT3

Hu, J.-C. E., Bojarski, C., Branchi, F., Fromm, M., & Krug, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217824 · Cited by 21 · see citing works

Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ

Mazuecos, L., Pintado, C., Rubio, B., Guisantes-Batán, E., Andrés, A., & Gallardo, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094624 · Cited by 21 · see citing works

3,5 Diiodo-l-Thyronine (T2) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality

Senese, R., Cioffi, F., Matteis, R. D., Petito, G., de Lange, P., Silvestri, E., Lombardi, A., Moreno, M., Goglia, F., & Lanni, A. (2019) · Cells · doi:10.3390/cells8030256 · Cited by 21 · see citing works

Increased fat:carbohydrate oxidation ratio in Il1ra −/− mice on a high-fat diet is associated with increased sympathetic tone

Chida, D., Hashimoto, O., Kuwahara, M., Sagara, H., Osaka, T., Tsubone, H., & Iwakura, Y. (2008) · Diabetologia · doi:10.1007/s00125-008-1075-z · Cited by 20 · see citing works

Mesenchymal lineage cells and their importance in B lymphocyte niches

Green, A., Rudolph-Stringer, V., Chantry, A., Wu, J. Y., & Purton, L. (2017) · Bone · doi:10.1016/j.bone.2017.11.018 · Cited by 18 · see citing works

ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

Zhang, X., Tang, L., Wang, X., Shen, C., Xiong, W., Shen, Y., Wan, Y.-H., Wu, Y., Wang, Y.-C., Zhang, H., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03634-7 · Cited by 18 · see citing works

Direct effects of leptin on brown and white adipose tissue.

Siegrist-Kaiser, C. A., Pauli, V., Juge-Aubry, C. E., Boss, O., Pernin, A., Chin, W. W., Cusin, I., Rohner‐Jeanrenaud, F., Burger, A. G., Zapf, J., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119834 · Cited by 366 · see citing works

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398 · see citing works

1523-P: A Leptin-Mediated Interoceptive Network between the Brain and Brown Adipose Tissue

MUNOZ, M. D., YANG, X., Irizarry, V. C. T., LUO, P., CARRILLO-SÁENZ, L., ANTONY, N., LIEW, C. W., & Xu, P. (2023) · Diabetes · doi:10.2337/db23-1523-p

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

Hill, J. W., Williams, K. W., Ye, C., Luo, J., Balthasar, N., Coppari, R., Cowley, M. A., Cantley, L. C., Lowell, B. B., & Elmquist, J. K. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32964 · Cited by 348 · see citing works

Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels

Ke, Y., Qiu, J., Ogus, S., Shen, W., Kraemer, F. B., & Chehab, F. F. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.053 · Cited by 17 · see citing works