Escitalopram and Enhancement of Cognitive Recovery Following Stroke
Open accessAbstract
CONTEXT: Adjunctive restorative therapies administered during the first few months after stroke, the period with the greatest degree of spontaneous recovery, reduce the number of stroke patients with significant disability. OBJECTIVE: To examine the effect of escitalopram on cognitive outcome. We hypothesized that patients who received escitalopram would show improved performance in neuropsychological tests assessing memory and executive functions than patients who received placebo or underwent Problem Solving Therapy. DESIGN: Randomized trial. SETTING: Stroke center. PARTICIPANTS: One hundred twenty-nine patients were treated within 3 months following stroke. The 12-month trial included 3 arms: a double-blind placebo-controlled comparison of escitalopram (n = 43) with placebo (n = 45), and a nonblinded arm of Problem Solving Therapy (n = 41). OUTCOME MEASURES: Change in scores from baseline to the end of treatment for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Trail-Making, Controlled Oral Word Association, Wechsler Adult Intelligence Scale-III Similarities, and Stroop tests. RESULTS: We found a difference among the 3 treatment groups in change in RBANS total score (P < .01) and RBANS delayed memory score (P < .01). After adjusting for possible confounders, there was a significant effect of escitalopram treatment on the change in RBANS total score (P < .01, adjusted mean change in score: escitalopram group, 10.0; nonescitalopram group, 3.1) and the change in RBANS delayed memory score (P < .01, adjusted mean change in score: escitalopram group, 11.3; nonescitalopram group, 2.5). We did not observe treatment effects in other neuropsychological measures. CONCLUSIONS: When compared with patients who received placebo or underwent Problem Solving Therapy, stroke patients who received escitalopram showed improvement in global cognitive functioning, specifically in verbal and visual memory functions. This beneficial effect of escitalopram was independent of its effect on depression. The utility of antidepressants in the process of poststroke recovery should be further investigated. Trial Registration clinicaltrials.gov Identifier: NCT00071643.
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HDAC inhibition increases expression of plasticity-related factors and promotes ocular dominance plasticity in the visual cortex.
“HDAC inhibition increases the expression of plasticity-related factors and promotes OD plasticity in the visual cortex194,205,206.”
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 114,103 · see citing works
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701 · see citing works
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
Adams, H. P., Bendixen, B. H., Kappelle, L. J., Biller, J., Love, B. B., Gordon, D., & Marsh, E. E. (1993) · Stroke · doi:10.1161/01.str.24.1.35 · Cited by 12,350 · see citing works
Self-citationTissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,745 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Further analysis of the data by Akaike's information criterion and the finite corrections
Sugiura, N. (1978) · Communication in Statistics- Theory and Methods · doi:10.1080/03610927808827599 · Cited by 2,148 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
THE TOKEN TEST: A SENSITIVE TEST TO DETECT RECEPTIVE DISTURBANCES IN APHASICS
Renzi, E. D., & Vignolo, L. A. (1962) · Brain · doi:10.1093/brain/85.4.665 · Cited by 1,868 · see citing works
Social Class and Mental Illness: A Community Study
Hollingshead, A. B., & Redlich, F. C. (2007) · American Journal of Public Health · doi:10.2105/ajph.97.10.1756 · Cited by 1,845 · see citing works
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722 · see citing works
The Atlas of Heart Disease and Stroke
Mackay, J., Mensah, G. A., & Mendis, S. (2004) · Medical Entomology and Zoology · Cited by 1,550 · see citing works
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works
The atlas of heart disease and stroke
Beevers, D. G. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001852 · Cited by 1,251 · see citing works
Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101 · see citing works
Adult brain neurogenesis and psychiatry: a novel theory of depression
Jacobs, B. L., van Praag, H., & Gage, F. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000712 · Cited by 964 · see citing works
The antidepressant fluoxetine restores plasticity in the adult visual cortex
Vetencourt, J. F. M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., F. O'Leary, O., Castrén, E., & Maffei, L. (2008) · Science · doi:10.1126/science.1150516 · Cited by 890 · see citing works
Multilingual Aphasia Examination
(2012) · Springer eBooks · doi:10.1007/springerreference_183669 · Cited by 814 · see citing works
Erkinjuntti, T., Kurz, A., Gauthier, S., Bullock, R., Lilienfeld, S., & Damaraju, C. V. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08267-3 · Cited by 752 · see citing works
Fluoxetine targets early progenitor cells in the adult brain
Encinas, J. M., Vaahtokari, A., & Enikolopov, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601992103 · Cited by 637 · see citing works
Evidence for stroke-induced neurogenesis in the human brain
Jin, K., Wang, X., Xie, L., Mao, X. O., Zhu, W. P., Wang, Y., Shen, J., Mao, Y. Q., Banwait, S., & Greenberg, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603512103 · Cited by 627 · see citing works
Spatial Relational Memory Requires Hippocampal Adult Neurogenesis
Dupret, D., Revest, J., Koehl, M., Ichas, F., Giorgi, F. D., Costet, P., Abrous, D. N., & Piazza, P. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001959 · Cited by 595 · see citing works
A Reevaluation of the Duration of Survival after the Onset of Dementia
Wolfson, C. M., Wolfson, D. B., Asgharian, M., M’lan, C. E., Østbye, T., Rockwood, K. J., & Hogan, D. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441501 · Cited by 553 · see citing works
Banasr, M., Héry, M., Printemps, R., & Daszuta, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300320 · Cited by 539 · see citing works
Kavirajan, H., & Schneider, L. S. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70195-3 · Cited by 497 · see citing works
Mynors‐Wallis, L., Gath, D. H., Lloyd-Thomas, A. R., & Tomlinson, D. (1995) · BMJ · doi:10.1136/bmj.310.6977.441 · Cited by 491 · see citing works
Golden, C. J., Freshwater, S. M., & Golden, Z. L. (2002) · PsycTESTS Dataset · doi:10.1037/t06065-000 · Cited by 449 · see citing works
Donepezil in vascular dementia: A randomized, placebo-controlled study
Wilkinson, D., Doody, R., Helme, R., Taubman, K., Mintzer, J., Kertesz, A., Pratt, R. D., & the Donepezil 308 Study Group* (2003) · Neurology · doi:10.1212/01.wnl.0000078943.50032.fc · Cited by 392 · see citing works
Black, S., Román, G. C., Geldmacher, D. S., Salloway, S., Hecker, J., Burns, A., Perdomo, C., Kumar, D., & Pratt, R. (2003) · Stroke · doi:10.1161/01.str.0000091396.95360.e1 · Cited by 386 · see citing works
Vascular cognitive impairment: current concepts and clinical developments
Moorhouse, P., & Rockwood, K. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70040-1 · Cited by 358 · see citing works
Escitalopram and Problem-Solving Therapy for Prevention of Poststroke Depression
Robinson, R. G., Jorge, R. E., Moser, D. J., Ación, L., Solodkin, A., Small, S. L., Fonzetti, P., Hegel, M. T., & Arndt, S. V. (2008) · JAMA · doi:10.1001/jama.299.20.2391 · Cited by 355 · see citing works
Self-citationStroemer, R. P., Kent, T. A., & Hulsebosch, C. E. (1998) · Stroke · doi:10.1161/01.str.29.11.2381 · Cited by 349 · see citing works
Dam, M., Tonin, P., Boni, A., Pizzolato, G., Casson, S., Ermani, M., Freo, U., Piron, L., & Battistin, L. (1996) · Stroke · doi:10.1161/01.str.27.7.1211 · Cited by 346 · see citing works
The role of 5-HT1A receptors in learning and memory
Ögren, S. O., Eriksson, T. M., Elvander-Tottie, E., D’Addario, C., Ekstrom, J. C., Svenningsson, P., Meister, B., Kehr, J., & Stiedl, O. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.023 · Cited by 341 · see citing works
Mortality and Poststroke Depression: A Placebo-Controlled Trial of Antidepressants
Jorge, R. E., Robinson, R. G., Arndt, S. V., & STARKSTEIN, S. E. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1823 · Cited by 339 · see citing works
Self-citationThe pilot Stroke Data Bank: definition, design, and data.
Kunitz, S. C., Gross, C. R., Heyman, A., Kase, C. S., Mohr, J. P., Price, T. R., & Wolf, P. A. (1984) · Stroke · doi:10.1161/01.str.15.4.740 · Cited by 334 · see citing works
Manji, H. K., Duman, R. S., Duman, F. A. R. S., & PhD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4260 · Cited by 330 · see citing works
Improved Recovery in Activities of Daily Living Associated With Remission of Poststroke Depression
Chemerinski, E., Robinson, R. G., & Kosier, J. T. (2001) · Stroke · doi:10.1161/01.str.32.1.113 · Cited by 301 · see citing works
Self-citationAntidepressant Therapy After Stroke
REDING, M. J. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520080011011 · Cited by 297 · see citing works
Chemistry of the mind: Neurochemical modulation of prefrontal cortical function
Robbins, T. W. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20717 · Cited by 292 · see citing works
Repairing the human brain after stroke. II. Restorative therapies
Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21412 · Cited by 285 · see citing works
Increased Generation of Neuronal Progenitors after Ischemic Injury in the Aged Adult Human Forebrain
Macas, J., Nern, C., Plate, K. H., & Momma, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4667-06.2006 · Cited by 274 · see citing works
Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation.
Riedel, W. J., Klaassen, T., Deutz, N. E. P., van Someren, A., & van Praag, H. M. (1999) · Psychopharmacology · doi:10.1007/s002130050845 · Cited by 271 · see citing works
Social class and mental illness; A community study
Pare, C. M. B. (1959) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(59)90067-4 · Cited by 269 · see citing works
Serotonin and Human Cognitive Performance
Schmitt, J. A. J., Wingen, M., Ramaekers, J. G., Evers, E. A. T., & Riedel, W. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698909 · Cited by 258 · see citing works
Long-Term Plasticity of Visually Evoked Potentials in Humans is Altered in Major Depression
Normann, C., Schmitz, D., Fürmaier, A., Döing, C., & Bach, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.006 · Cited by 243 · see citing works
5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
Radley, J. J., & Jacobs, B. L. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03477-7 · Cited by 231 · see citing works
Markus, C. R., Olivier, B., & de Haan, E. H. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.6.1051 · Cited by 230 · see citing works
Bondareff, W., Alpert, M., Friedhoff, A. J., Richter, E. M., Clary, C. M., & Batzar, E. D. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.729 · Cited by 202 · see citing works
Treatment of Cognitive Impairment After Poststroke Depression: A Double-Blind Treatment Trial
Kimura, M., Robinson, R. G., & Kosier, J. T. (2000) · Stroke · doi:10.1161/01.str.31.7.1482 · Cited by 197 · see citing works
Self-citationPeng, Q., Masuda, N., Jiang, M., Li, Q., Zhao, M., Ross, C. A., & Duan, W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.015 · Cited by 173 · see citing works
Donepezil in Vascular Dementia: Combined Analysis of Two Large-Scale Clinical Trials
Román, G. C., Wilkinson, D. G., Doody, R. S., Black, S. E., Salloway, S. P., & Schindler, R. J. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000088494 · Cited by 141 · see citing works
A randomized, placebo-controlled study of donepezil in poststroke aphasia
Berthier, M. L., Green, C., Higueras, C., Fernández, I., Hinojosa, J., & Martín, M. C. (2006) · Neurology · doi:10.1212/01.wnl.0000242626.69666.e2 · Cited by 139 · see citing works
Gladstone, D. J., Danells, C., Armesto, A., McIlroy, W., Staines, W., Graham, S. J., Herrmann, N., Szalai, J. P., & Black, S. (2006) · Stroke · doi:10.1161/01.str.0000195169.42447.78 · Cited by 132 · see citing works
Functional Independence Measure
Mackintosh, S. F. (2009) · Australian Journal of Physiotherapy · doi:10.1016/s0004-9514(09)70066-2 · Cited by 130 · see citing works
Klijn, C. J. M., & Hankey, G. J. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00558-1 · Cited by 127 · see citing works
Tissue plasminogen activator for acute ischemic stroke
関, 厚., & 横田, 裕. (2011) · Kyūkyū igaku · Cited by 125 · see citing works
Amphetamines for improving recovery after stroke
Martinsson, L., Hårdemark, H., & Eksborg, S. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002090.pub2 · Cited by 123 · see citing works
Acute administration of citalopram facilitates memory consolidation in healthy volunteers
Harmer, C. J., Bhagwagar, Z., Cowen, P. J., & Goodwin, G. M. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1151-x · Cited by 112 · see citing works
The effects of serotonin manipulations on emotional information processing and mood
Merens, W., van der Does, W. A. J., & Spinhoven, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.032 · Cited by 108 · see citing works
Selective Effects of Acute Serotonin and Catecholamine Depletion on Memory in Healthy Women
Harrison, B. J., Olver, J. S., Norman, T. R., Burrows, G. D., Wesnes, K. A., & Nathan, P. J. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040225 · Cited by 107 · see citing works
Stroke and Vascular Cognitive Impairment
Hachinski, V. (2007) · Stroke · doi:10.1161/01.str.0000260101.08944.e9 · Cited by 102 · see citing works
Lavretsky, H., Roybal, D. J., Ballmaier, M., Toga, A. W., & Kumar, A. A. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0801 · Cited by 89 · see citing works
Survival Study of Vascular Dementia in Rochester, Minnesota
Knopman, D. S., Rocca, W. A., Cha, R. H., Edland, S. D., & Kokmen, E. (2003) · Archives of Neurology · doi:10.1001/archneur.60.1.85 · Cited by 89 · see citing works
Effects of amphetamines and small related molecules on recovery after stroke in animals and man
Goldstein, L. B. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00249-x · Cited by 88 · see citing works
Effects of amphetamine and/or l-dopa and physiotherapy after stroke ? a blinded randomized study
Sonde, L., & Lökk, J. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00728.x · Cited by 86 · see citing works
Societal Costs of Vascular Cognitive Impairment in Older Adults
Rockwood, K. J., Brown, M. G., Merry, H. R., SKETRIS, I. S., & Fisk, J. D. (2002) · Stroke · doi:10.1161/01.str.0000017878.85274.44 · Cited by 83 · see citing works
Evers, E. A. T., Tillie, D. E., van der Veen, F. M., Lieben, C. K. J., Jolles, J., Deutz, N. E. P., & Schmitt, J. A. J. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2141-y · Cited by 72 · see citing works
Does Cognitive Impairment Cause Poststroke Depression?
Murata, Y., Kimura, M., & Robinson, R. G. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200011000-00007 · Cited by 71 · see citing works
Self-citationBooij, L., Merens, W., Markus, C. R., & van der Does, W. A. J. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881105057466 · Cited by 68 · see citing works
Finkel, S. I., Richter, E. M., & Clary, C. M. (1999) · International Psychogeriatrics · doi:10.1017/s104161029900561x · Cited by 57 · see citing works
Sambeth, A., Riedel, W. J., Tillie, D. E., Blokland, A., Postma, A., & Schmitt, J. A. J. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108089577 · Cited by 39 · see citing works
Predictors of response to problem-solving treatment of depression in primary care
Hegel, M. T., Barrett, J. E., Cornell, J. E., & Oxman, T. E. (2002) · Behavior Therapy · doi:10.1016/s0005-7894(02)80014-4 · Cited by 38 · see citing works
Noradrenergic modulation of hemiplegia: Facilitation and maintenance of recovery
Feeney, D. M., Smet, A. M. D., & Rai, S. (2004) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2004-00274 · Cited by 34 · see citing works
Adult Neurogenesis and the Diseased Brain
Vandenbosch, R., Borgs, L., Beukelaers, P., et al. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709787458371 · Cited by 33 · see citing works
Amphetamines for improving recovery after stroke
Martinsson, L., Wahlgren, N., & Hårdemark, H. (2003) · doi:10.1002/14651858.cd002090 · Cited by 33 · see citing works
Amphetamines and related drugs in motor recovery after stroke
Goldstein, L. B. (2003) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/s1047-9651(02)00060-8 · Cited by 30 · see citing works
Advances in adjuvant pharmacotherapy for motor rehabilitation: Effects of levodopa
Scheidtmann, K. (2004) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2004-00271 · Cited by 25 · see citing works
Tissue Plasminogen Activator for Acute Ischemic Stroke
Caplan, L. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910143411618 · Cited by 25 · see citing works
Norrving, B. G., & Adams, R. J. (2006) · Stroke · doi:10.1161/01.str.0000200554.95094.09 · Cited by 23 · see citing works
Management of acute ischemic stroke
Lopez-Yunez, A. M., & Biller, J. (1998) · ACC Current Journal Review · doi:10.1016/s1062-1458(98)00048-8 · Cited by 19 · see citing works
King, P., Song, X., & Rockwood, K. J. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000224603.52403.dc · Cited by 16 · see citing works
Fluoxetine targets early progenitor cells in the adult brain
Buckley, P. F. (2007) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)70596-6 · Cited by 15 · see citing works
Spatial relational memory requires hippocampal adult neurogenesis
Nora, A. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/conf.neuro.08.2009.09.009 · Cited by 13 · see citing works
Does Cognitive Impairment Cause Poststroke Depression?
Murata, Y. (2000) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.8.4.310 · Cited by 13 · see citing works
Management of Acute Ischemic Stroke
Leira, E. C. C., & Adams, H. P. (1999) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30027-2 · Cited by 6 · see citing works
Self-citationEvers, E. A. T., Tillie, D. E., van der Veen, F. M., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2140-z · Cited by 4 · see citing works
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Castrén, E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1 · Cited by 190 · see citing works
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“These mechanisms might account for the positive effect of an SSRI on human motor recovery(17) and cognitive performance.(18) Other small studies have reported positive effects of antidepressants on aphasia (but see Laska et al).”
BackgroundBaune, B. T., & Renger, L. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.05.013 · Cited by 115 · see citing works
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- Authors
- Jorge, R. E., Acion, L., Moser, D., Adams, H. P., & Robinson, R. G.
- Affiliations
- University of Iowa (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-02-01
- Volume
- 67
- Issue
- 2
- Pages
- 187
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC3718472
- OpenAlex
- W2140658948
- Cited by
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- References
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- FWCI
- 22.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Archives of General Psychiatry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- AstraZeneca
- Sanofi
- National Institute of Mental Health (R01-MH65134, R01MH065134)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- escitalopram, stroke, cognitive recovery, antidepressants, memory, executive function, problem-solving therapy, stroke recovery, depression, neuropsychological outcomes
- MeSH terms
- Aged, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Problem Solving, Citalopram, Selective Serotonin Reuptake Inhibitors, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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