Cited by 486Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesChild and Animal Learning Development

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index; none of the 42 sources its claims cite is checked for support yet.

Preference for Geometric Patterns Early in Life as a Risk Factor for Autism

Open access
Pierce, Karen, Conant, David, Hazin, Roxana, Stoner, Richard, Desmond, Jamie·2011·Archives of General Psychiatry

Abstract

CONTEXT: Early identification efforts are essential for the early treatment of the symptoms of autism but can only occur if robust risk factors are found. Children with autism often engage in repetitive behaviors and anecdotally prefer to visually examine geometric repetition, such as the moving blade of a fan or the spinning of a car wheel. The extent to which a preference for looking at geometric repetition is an early risk factor for autism has yet to be examined. OBJECTIVES: To determine if toddlers with an autism spectrum disorder (ASD) aged 14 to 42 months prefer to visually examine dynamic geometric images more than social images and to determine if visual fixation patterns can correctly classify a toddler as having an ASD. DESIGN: Toddlers were presented with a 1-minute movie depicting moving geometric patterns on 1 side of a video monitor and children in high action, such as dancing or doing yoga, on the other. Using this preferential looking paradigm, total fixation duration and the number of saccades within each movie type were examined using eye tracking technology. SETTING: University of California, San Diego Autism Center of Excellence. PARTICIPANTS: One hundred ten toddlers participated in final analyses (37 with an ASD, 22 with developmental delay, and 51 typical developing toddlers). MAIN OUTCOME MEASURE: Total fixation time within the geometric patterns or social images and the number of saccades were compared between diagnostic groups. RESULTS: Overall, toddlers with an ASD as young as 14 months spent significantly more time fixating on dynamic geometric images than other diagnostic groups. If a toddler spent more than 69% of his or her time fixating on geometric patterns, then the positive predictive value for accurately classifying that toddler as having an ASD was 100%. CONCLUSION: A preference for geometric patterns early in life may be a novel and easily detectable early signature of infants and toddlers at risk for autism.

Overview

Integrity signals

Registry

Crossref · 10.1001/archgenpsychiatry.2010.113

Cites

69 of 69 references verified0 citation errors · 0 not checkable

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27 Own result · 17 Not checked yet · 11 Own method · 10 Own interpretation

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  • It may state two separate claims as one. 18
  • Probably not a substantial claim. 14
  • The quote only partly states this claim. 1
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  • The paper relies on this without support.

    The paper assumes that the question of whether a preference for geometric repetition is an early autism risk factor has not yet been examined.

    “The extent to which a preference for looking at geometric repetition is an early risk factor for autism has yet to be examined.”
    “The early developmental profile of unusual preferences for visual repetition in autism is largely unknown and unexplored.”
  • The paper relies on this without support.

    The paper assumes, on anecdotal grounds, that children with autism often prefer to attend to visual repetition.

    “Many children with autism engage in a variety of repetitive behaviors 26 and, anecdotally, often prefer to attend to visual repetition, such as the moving blade of a fan or the spinning of a car wheel.”
  • The paper relies on this without support.

    The paper assumes that a prior study found that eye gaze patterns at 6 months did not predict later diagnostic outcome.

    “examined the clinical outcome of these subjects and found that, contrary to their expectations, eye gaze patterns at 6 months did not predict diagnostic outcome.”
  • The paper relies on this without support.

    The geometric preference seen in a subgroup of ASD toddlers at 14-42 months is present earlier in life and is not caused by the ASD diagnosis.

    “some infants at risk for an ASD begin life with an unusual preference for geometric repetition.”
  • The paper relies on this without support.

    The exclusion of about 20% of the sample due to poor compliance did not substantially bias the results.

    “approximately 20% of the overall sample was dropped from analyses because of poor compliance during testing, with the impact of such exclusion unknown.”
  • The paper relies on this without support.

    The one-third of the sample that completed test-retest reliability is representative of the whole sample.

    “only one-third of the overall sample participated in test-retest reliability.”
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Citations

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Research works printed but not linked: 7

  1. Neumann D, Spezio ML, Piven J, Adolphs R. Looking you in the mouth. Soc Cogn Affect Neurosci. 2006; 1(3):194-202. [PubMed: 18985106]
  2. Bryson SE, Zwaigenbaum L, Brian J, Roberts W, Szatmari P, Rombough V, McDermott C. A prospective case series of high-risk infants who developed autism. J Autism Dev Disord. 2007; 37(1):12-24. [PubMed: 17211728]
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  4. Elsabbagh M, Volein A, Holmboe K, Tucker L, Csibra G, Baron-Cohen S, Bolton P, Charman T, Baird G, Johnson MH. Visual orienting in the early broader autism phenotype. J Child Psychol Psychiatry. 2009; 50(5):637-642. [PubMed: 19298466]
  5. Luyster R, Gotham K, Guthrie W, Coffing M, Petrak R, Pierce K, Bishop S, Esler A, Hus V, Oti R, Richler J, Risi S, Lord C. The Autism Diagnostic Observation Schedule-toddler module. J Autism Dev Disord. 2009; 39(9):1305-1320. [PubMed: 19415479]
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  7. Mottron L, Dawson M, Soulières I, Hubert B, Burack J. Enhanced perceptual functioning in autism. J Autism Dev Disord. 2006; 36(1):27-43. [PubMed: 16453071]

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Metadata

Authors
Pierce, K., Conant, D., Hazin, R., Stoner, R., & Desmond, J.
Affiliations
University of California San Diego (US)
Venue
Archives of General Psychiatry
Published
2011-01-03
Volume
68
Issue
1
Pages
101
ISSN
0003-990X (ISSN-L)
OpenAlex
W2122623425
Cited by
486
References
68
Citations by year
2026: 26 · 2025: 29 · 2024: 28 · 2023: 25 · 2022: 26 · 2021: 41 · 2020: 62 · 2019: 32 · 2018: 50 · 2017: 30 · 2016: 30 · 2015: 24 · 2014: 23 · 2013: 18 · 2012: 30
FWCI
11.44
Type
journal article
Language
en
Open access
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH080134, P50MH081755)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
Keywords
autism spectrum disorder, early risk factors, toddlers, preferential looking, visual fixation, saccades, social image, early detection, developmental delay
MeSH terms
Age Factors, California, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Female, Fixation, Ocular, Humans, Infant, Male, Neuropsychological Tests, Pattern Recognition, Visual, Photic Stimulation, Risk Factors, Saccades, Early Diagnosis

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