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Relationship Between Amygdala Responses to Masked Faces and Mood State and Treatment in Major Depressive Disorder
Open accessAbstract
CONTEXT: Major depressive disorder (MDD) is associated with behavioral and neurophysiological evidence of mood-congruent processing biases toward explicitly presented, emotionally valenced stimuli. However, few studies have investigated such biases toward implicitly presented stimuli. OBJECTIVE: To investigate differential amygdala responses to sad, happy, and neutral faces presented below the level of explicit conscious awareness using a backward masking task in unmedicated participants with MDD and healthy controls (HCs). DESIGN: Initial cross-sectional design followed by a longitudinal treatment trial using functional magnetic resonance imaging. SETTING: Psychiatric outpatient clinic at the National Institute of Mental Health. PARTICIPANTS: We studied 22 unmedicated, currently depressed people with MDD (dMDD), 16 unmedicated individuals with MDD in full remission (rMDD), and 25 HCs. INTERVENTION: Ten dMDD participants underwent 8 weeks of antidepressant treatment with the selective serotonin reuptake inhibitor sertraline hydrochloride. MAIN OUTCOME MEASURES: Amygdala region-of-interest and whole-brain analyses evaluated the hemodynamic response during exposure to masked sad vs masked happy faces, to masked sad vs neutral faces, and to masked happy vs neutral faces. RESULTS: The dMDD participants showed greater amygdala responses than HCs to masked sad faces, whereas HCs showed greater amygdala responses to masked happy faces. The bias toward sad faces also was evident in rMDD participants relative to HCs and did not differ between dMDD and rMDD participants. This processing bias reversed toward the normative pattern in dMDD participants after sertraline treatment. CONCLUSIONS: Emotional-processing biases occur in amygdala responses to sad faces presented below the level of conscious awareness in dMDD or rMDD individuals and to happy faces in HCs. By influencing the salience of social stimuli, mood-congruent processing biases in the amygdala may contribute to dysfunction in conscious perceptions and social interactions in MDD. Our data suggest, however, that the negative bias resolves and a positive bias develops in patients with MDD during selective serotonin reuptake inhibitor treatment.
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“Thus, blunted dlPFC activation has been accompanied by exaggerated amygdalar activation when (1) viewing and reappraising negative pictures [167], (2) processing subliminal negative stimuli [168, 169] (Fig. 4d) and negative words”
From Prefrontal cortex and depression (2022) · cites this paper as [168]
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“emerged in fully remitted adults with past MDD [168]”
From Prefrontal cortex and depression (2022) · cites this paper as [168]
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“Indeed, several meta-analyses concluded that antidepressants facilitate positive emotional stimuli processing in MDD patients and reduce the activity of negative emotions (Delaveau et al. 2011), concomitant with a normalization of amygdala activity (Chen et al. 2014; Victor et al. 2010).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Victor et al. 2010
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“Antidepressant treatment modifies this, and hyperactive responses in the amygdala are normalised following 7 days'46 or longer44,45 treatment with an SSRI.”
From The effects of drugs on human models of emotional processing: an account of antidepressant drug treatment (2015) · cites this paper as [45]
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“Enhanced recognition of sad facial expressions has also been consistently reported in acutely depressed patients.73,[143][144][145][146][147][148]”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [73]
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“A recent study by Victor and colleagues, 73 however, found that remitted patients with MDD showed exaggerated responses in the amygdala to masked sad faces and a lack of amygdalar response to masked happy faces compared with controls.”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [73]
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“Similarly, Victor and colleagues 73 found that an exaggerated response in the amygdala to masked sad faces and reduced amygdala activity to masked happy faces were reversed following administration of a 4-week treatment regimen of sertraline.”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [73]
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Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
(1970) · Cited by 24,983
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · cited 1×
“Projections from the hippocampus to the amygdala provide input during emotional processing about the environmental context,(43) whereas the thalamus plays a role in gating the transmission of sensory information to other brain regions based on the anticipated salience of this information within the behavioral context.…”
BackgroundCo-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Wechsler Abbreviated Scale of Intelligence
Dumont, R., Willis, J. O., Veizel, K., & Zibulsky, J. (2014) · Wiley eBooks · doi:10.1002/9781118660584.ese2519 · Cited by 5,546
The Emotional Brain: The Mysterious Underpinnings of Emotional Life
LeDoux, J. E. (2004) · Medical Entomology and Zoology · Cited by 4,212
The NimStim set of facial expressions: Judgments from untrained research participants.
Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., Marcus, D. J., Westerlund, A., Casey, B., & Nelson, C. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.05.006 · Cited by 3,454
Research works printed but not linked: 2
- [18]First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P) New York, NY New York State Psychiatric Institute, Biometrics Research 2002
- [31]Mai JK Assheuer J Paxinos G Atlas of the Human Brain 2 San Diego, CA Academic Press 2003
Cited by
Sorted by citations
Neural mechanisms of the cognitive model of depression.
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3027 · Cited by 1,718
Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788
Self-citationPrecision psychiatry: a neural circuit taxonomy for depression and anxiety
Williams, L. M. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00579-9 · Cited by 641
Prefrontal cortex and depression
Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 667
Metadata
- Authors
- Victor, T. A., Furey, M. L., Fromm, S. J., Öhman, A., & Drevets, W. C.
- Affiliations
- National Institutes of Health (US)
- Karolinska Institutet (SE)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-11-01
- Volume
- 67
- Issue
- 11
- Pages
- 1128
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC3253452
- OpenAlex
- W2060926272
- Cited by
- 400
- References
- 59
- Citations by year
- 2026: 13 · 2025: 8 · 2024: 23 · 2023: 11 · 2022: 14 · 2021: 48 · 2020: 18 · 2019: 19 · 2018: 21 · 2017: 26 · 2016: 26 · 2015: 41 · 2014: 30 · 2013: 39 · 2012: 36
- FWCI
- 42.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- John D. and Catherine T. MacArthur Foundation
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health (Z01MH002792)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- major depressive disorder, amygdala, masked faces, backward masking, implicit emotional processing, sertraline, selective serotonin reuptake inhibitors, remitted depression, antidepressant response
- MeSH terms
- Adult, Affect, Amygdala, Awareness, Brain Mapping, Major Depressive Disorder, Emotions, Facial Expression, Female, Form Perception, Happiness, Humans, Magnetic Resonance Imaging, Male, Perceptual Masking, Social Perception, Wechsler Scales, Selective Serotonin Reuptake Inhibitors, Sertraline
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