Cited by 400Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

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Meta-analytical Comparison of Voxel-Based Morphometry Studies in Obsessive-Compulsive Disorder vs Other Anxiety Disorders

Radua, Joaquim, van den Heuvel, Odile A., Surguladze, Simon, Mataix-Cols, David·2010·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2010.70

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Abstract

CONTEXT: Whether obsessive-compulsive disorder (OCD) is adequately classified as an anxiety disorder is a matter of considerable debate. OBJECTIVES: To quantitatively compare structural brain changes in OCD and other anxiety disorders using novel voxel-based meta-analytical methods and to generate an online database to facilitate replication and further analyses by other researchers. DATA SOURCES: The PubMed, ScienceDirect, and Scopus databases were searched between 2001 (the date of the first voxel-based morphometry study in any anxiety disorder) and 2009. All voxel-based morphometry studies comparing patients with any anxiety disorder and healthy controls were retrieved. Manual searches were also conducted. Authors were contacted soliciting additional data. STUDY SELECTION: Thirty-seven data sets were identified, of which 26 (including 639 patients with anxiety disorders and 737 healthy controls) met inclusion criteria. DATA EXTRACTION: Coordinates were extracted from clusters of significant gray matter difference between patients and controls. Demographic, clinical, and methodological variables were extracted from each study or obtained from the authors. DATA SYNTHESIS: Patients with anxiety disorders (including OCD) showed decreased bilateral gray matter volumes in the dorsomedial frontal/anterior cingulate gyri. Individuals with OCD had increased bilateral gray matter volumes (vs healthy controls and vs individuals with other anxiety disorders) in the lenticular/caudate nuclei, while patients with other anxiety disorders (mainly panic and posttraumatic stress disorders) had decreased gray matter volumes in the left lenticular nucleus. The findings remained largely unchanged in quartile and jackknife sensitivity analyses. Controlling for potential confounders such as age or antidepressant medication had little impact on the results. CONCLUSIONS: The meta-analysis consistently revealed common as well as distinct neural substrates in OCD and other anxiety disorders. These results have implications for the current debate surrounding the classification of OCD in the DSM-V.

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“This may be due to the small sample size of the existing VBM studies, which may increase false-positive and false-negative results and only draw limited conclusions (Chen & Yan, 2018; Cremers et al., 2017; Radua et al., 2010).”
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“Moreover, a meta-analysis found that voxel-based morphometry studies consistently report gray-matter reductions in the anterior cingulate cortex and insula in OCD patients [43].”
Background
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“With regard to subcortical volumes, striatum (caudate nucleus and putamen) and thalamus have been traditionally implicated in OCD pathophysiology and previous VBM studies have reported increased striatum and thalamus volumes (Eng et al., 2015; Radua et al., 2010).”
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“Subsequently, a quantitative comparison of brain activity abnormalities between OHE and MHE patients was performed by calculating the difference between each LC group in each voxel, and then standard randomization tests were used to establish statistical significance (Radua et al., 2010).”
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Authors: Radua, J., van den Heuvel, O. A., Surguladze, S., & Mataix-Cols, D.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2010-07-01
Volume: 67
Issue: 7
Pages: 701-11
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2010.70
OpenAlex: W2111531007
Cited by: 400
References: 104
Citations by year: 2026: 14 · 2025: 18 · 2024: 21 · 2023: 21 · 2022: 31 · 2021: 18 · 2020: 22 · 2019: 21 · 2018: 20 · 2017: 33 · 2016: 25 · 2015: 30 · 2014: 30 · 2013: 34 · 2012: 33
FWCI: 33.65
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: obsessive-compulsive disorder, anxiety disorders, gray matter volume, brain structural changes, dorsomedial frontal cortex, anterior cingulate cortex, caudate nucleus, lentiform nucleus, panic disorder, post-traumatic stress disorder, DSM-V, voxel-based morphometry
MeSH terms: Adult, Anxiety Disorders, Brain, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Obsessive-Compulsive Disorder, Online Systems, Psychiatric Status Rating Scales, Psychometrics, Diagnostic and Statistical Manual of Mental Disorders

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Meta-analytical Comparison of Voxel-Based Morphometry Studies in Obsessive-Compulsive Disorder vs Other Anxiety Disorders

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