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Cited by 363

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Mortality and Coronary Heart Disease Among Men Studied for 23 Years

Ancel B. Keys·1971·Archives of Internal Medicine
DOI 10.1001/archinte.128.2.201
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Abstract

Twenty-year coronary heart disease (CHD) incidence is analyzed for 279 men, CHD-free at the ages of 47 through 57 years and characterized by three examinations before 20 annual follow-up examinations. Sixty men developed CHD, 42 dying or suffering infarction. Among 20 entry characteristics, three had major predictive power, especially for CHD death or infarction: cold pressor test, a high level of serum cholesterol, and systolic blood pressure. Smoking and relative weight seemed unimportant. Major CHD incidence was proportional to cholesterol to the 3.4 power. Five-variable multiple logistic analysis permitted placement of men into deciles of estimated risk differing more than tenfold in CHD incidence. The combination of only cholesterol and systolic pressure was nearly as good. The multiple logistic coefficients applied to five-year data on 1,287 men among whom 182 CHD developed in 182 yielded satisfactory agreement between observed and predicted distributions of CHD cases in classes of estimated risk.

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Metadata

Authors
Keys, A. B.
Venue
Archives of Internal Medicine
Publisher
American Medical Association
Published
1971-08-01
Volume
128
Issue
2
Pages
201-201
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.128.2.201
OpenAlex
W2052814555
Cited by
363
References
0
FWCI
6.85
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.