Cited by 174Cardiovascular Health and Disease PreventionHealth disparities and outcomesCardiovascular Health and Risk Factors

Does low socioeconomic status potentiate the effects of heightened cardiovascular responses to stress on the progression of carotid atherosclerosis?

Open access
Lynch, J W, Everson, S A, Kaplan, G A, Salonen, R, Salonen, J T·1998·American Journal of Public Health

Abstract

OBJECTIVES: This study examined whether heightened cardiovascular reactivity and low socioeconomic status had synergistic effects on the progression of carotid atherosclerosis in a population of eastern Finnish men. METHODS: Data from the Kuopio Ischemic Heart Disease Risk Factor Study were used to measure 4-year progression of intima-media thickness in 882 men according to cardiovascular reactivity and socioeconomic status. Associations were examined in relation to risk factors and were stratified by baseline levels of atherosclerosis and prevalent ischemic heart disease. RESULTS: The effect of reactivity on atherosclerotic progression depended on socioeconomic status. Men who had heightened cardiovascular responsiveness to stress and were born into poor families, received little education, or had low incomes had the greatest atherosclerotic progression. CONCLUSIONS: An understanding of associations between individual risk factors and disease should be based on etiologic hypotheses that are conceived at the population level and involve fundamental social and economic causes of disease. This study demonstrates how examining the interaction of an individual biological predisposition will low socioeconomic status over the life course is etiologically informative for understanding the progression of atherosclerotic vascular disease.

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Crossref · 10.2105/ajph.88.3.389

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  • Current evidence suggests that lower SES may synergize with other stressors, potentiating the negative impact of stressors on accumulation of allostatic load.

    “Current evidence, for example, suggests that lower SES may synergize with other stressors, potentiating the negative impact of “stressors” on accumulation of AL. 67,83,192,193”

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Authors
Lynch, J. W., Everson, S. A., Kaplan, G. A., Salonen, R., & Salonen, J. T.
Affiliations
  • California Health and Human Services Agency (US)
  • University of Eastern Finland (FI)
Venue
American Journal of Public Health
Published
1998-03
Volume
88
Issue
3
Pages
389-394
ISSN
  • 0090-0036 (ISSN-L)
  • 1541-0048
OpenAlex
W1984088895
Cited by
174
References
44
Citations by year
2025: 1 · 2024: 1 · 2023: 5 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 9
FWCI
4.55
Type
journal article
Language
en
Open access
Locations
  • American Journal of Public Health (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Heart, Lung, and Blood Institute (HL-44199, R01HL044199)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
low socioeconomic status, cardiovascular reactivity, carotid atherosclerosis, atherosclerosis progression, intima-media thickness, stress response, social determinants of health, educational attainment, income, ischemic heart disease, men, life course
MeSH terms
Arteriosclerosis, Blood Pressure, Carotid Arteries, Carotid Artery Diseases, Educational Status, Exercise Test, Humans, Male, Middle Aged, Poverty, Risk Factors, Stress, Psychological, Disease Progression

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