Opioid osteoporosis
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Among fentanyl-exposed patients, LAIB was superior to TMB for urine samples negative for fentanyl.
“Both buprenorphine treatments were effective in reducing opioid withdrawal and cravings, but LAIB was superior to TMB for urine samples negative for fentanyl among patients who were fentanyl-exposed.12”
From Oral Health Risks of Transmucosal Buprenorphine: Commentary on Tuan et al. and Zheng et al. (2025) · cites this paper as [12]
Direct comparisons showing comparable outcomes for long-acting injectable buprenorphine relative to TMB suggest that LAIB may be a viable alternative for patients at high risk of oral health problems, including fentanyl-exposed patients who may need higher sublingual doses.
“Direct comparisons showing comparable outcomes for long-acting injectable buprenorphine (LAIB) relative to TMB suggest LAIB may be a viable treatment alternative for patients at high risk for oral health problems, including patients exposed to fentanyl who may require higher sublingual doses.”
From Oral Health Risks of Transmucosal Buprenorphine: Commentary on Tuan et al. and Zheng et al. (2025) · cites this paper as [12]
Both LAIB and TMB were effective in reducing opioid withdrawal and cravings.
“Both buprenorphine treatments were effective in reducing opioid withdrawal and cravings, but LAIB was superior to TMB for urine samples negative for fentanyl among patients who were fentanyl-exposed.12”
From Oral Health Risks of Transmucosal Buprenorphine: Commentary on Tuan et al. and Zheng et al. (2025) · cites this paper as [12]
Post hoc comparisons from a randomized controlled trial comparing LAIB with TMB showed notable but underpowered group differences favoring LAIB for urine samples negative for any opioid.
“Post hoc comparisons from a randomized controlled trial comparing LAIB to TMB showed notable, but underpowered, group differences favoring the former for urine samples negative for any opioid.”
From Oral Health Risks of Transmucosal Buprenorphine: Commentary on Tuan et al. and Zheng et al. (2025) · cites this paper as [12]
Testosterone therapy may be justifiable in men receiving opioids who may suffer from opioid-induced suppression of testosterone levels and associated sexual dysfunction, osteoporosis, and/or muscle atrophy.
“Testosterone therapy may be justifiable in patients with some of these conditions, such as men receiving opioids, who may suffer from opioid-induced suppression of testosterone levels 32 and sexual dysfunction, 33 osteoporosis, and/or muscle atrophy.34”
From Who Gets Testosterone? Patient Characteristics Associated with Testosterone Prescribing in the Veteran Affairs System: a Cross-Sectional Study (2017) · cites this paper as [34]
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- Authors
- Daniell, H. W.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2004-02-09
- Volume
- 164
- Issue
- 3
- Pages
- 338
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2811380478
- Cited by
- 52
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- opioid analgesics, osteoporosis, bone loss, bone mineral density, drug-induced bone disease
- MeSH terms
- Analgesics, Opioid, Dose-Response Relationship, Drug, Female, Humans, Hypogonadism, Male, Opioid-Related Disorders, Osteoporosis, Bone Density, Muscle, Skeletal, Fractures, Bone
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