CoChat
Sign Up
Cited by 562Metabolism, Diabetes, and CancerCancer Risks and FactorsPancreatic and Hepatic Oncology Research

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Diabetes Mellitus and the Risk of Cancer: Results From a Large-Scale Population-Based Cohort Study in Japan

Inoue, Manami·2006·Archives of Internal Medicine
DOI 10.1001/archinte.166.17.1871
Open this paper in CoChat — free account

Abstract

BACKGROUND: An association between diabetes mellitus (DM) and cancer has long been speculated, but no conclusive evidence has been obtained. METHODS: We prospectively examined the association between a history of DM and subsequent risk of cancer in the Japan Public Health Center-Based Prospective Study. A total of 97 771 general Japanese persons (46 548 men and 51 223 women) aged 40 to 69 years who responded to the baseline questionnaire, from January 1990 to December 1994, were followed up for cancer incidence through December 31, 2003. At baseline, 6.7% of men and 3.1% of women had a history of DM. RESULTS: A total of 6462 cases of newly diagnosed cancer were identified. In men, a 27% increase in the risk of total cancer incidence was observed in those with a history of DM (n = 3907 [366 with DM]; hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.14-1.42). The HR was especially high for those with cancer of the liver (n = 312 [52 with DM]; HR, 2.24; 95% CI, 1.64-3.04), pancreas (n = 118 [16 with DM]; HR, 1.85; 95% CI, 1.07-3.20), and kidney (n = 99 [13 with DM]; HR, 1.92; 95% CI, 1.06-3.46). We also observed a moderately increased risk of colon cancer (n = 491 [46 with DM]; HR, 1.36; 95% CI, 1.00-1.85) and of stomach cancer with borderline significance (n = 977 [87 with DM]; HR, 1.23; 95% CI, 0.98-1.54). In women, a borderline significant increase in risk was observed for the incidence of total cancer (n = 2555 [104 with DM]; HR, 1.21; 95% CI, 0.99-1.47), while statistical significance was observed for the incidence of stomach cancer (n = 362 [20 with DM]; HR, 1.61; 95% CI, 1.02-2.54) and liver cancer (n = 120 [10 with DM]; HR, 1.94; 95% CI, 1.00-3.73) and borderline significance was observed for the incidence of ovarian cancer (n = 74 [5 with DM]; HR, 2.42; 95% CI, 0.96-6.09). CONCLUSION: Patients with DM drawn from the general Japanese population may be at increased risk of total cancer and of cancer in specific sites.

Overview

Integrity signals

Registry

Crossref · 10.1001/archinte.166.17.1871

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 59 references

Cited by

Sorted by citations

Items 401–500 of 562

Related

See all

Metadata

Authors
Inoue, M.
Affiliations
National Cancer Centre Japan (JP)
Corresponding author
Inoue, Manami
ORCID
Inoue, Manami
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2006-09-25
Volume
166
Issue
17
Pages
1871
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.166.17.1871
OpenAlex
W2096623507
Cited by
561
References
59
Citations by year
2026: 3 · 2025: 6 · 2024: 20 · 2023: 21 · 2022: 29 · 2021: 24 · 2020: 28 · 2019: 29 · 2018: 22 · 2017: 35 · 2016: 22 · 2015: 31 · 2014: 41 · 2013: 51 · 2012: 55
FWCI
6.75
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Keywords
diabetes mellitus, cancer risk, cancer incidence, liver cancer, pancreatic cancer, kidney cancer, colon cancer, gastric cancer, sex differences, Japan Public Health Center-based Prospective Study, Japanese adults, prospective cohort, hazard ratio, cancer mortality, cancer prevention, lifestyle modification, cancer survivorship, cancer survivorship support services
MeSH terms
Adult, Aged, Diabetes Mellitus, Digestive System Neoplasms, Female, Humans, Japan, Male, Middle Aged, Neoplasms, Prospective Studies, Risk Factors, Incidence, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review