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Effect of Exercise on 24-Month Weight Loss Maintenance in Overweight Women
Open accessAbstract
BACKGROUND: Debate remains regarding the amount of physical activity that will facilitate weight loss maintenance. METHODS: Between December 1, 1999, and January 31, 2003, 201 overweight and obese women (body mass index [calculated as weight in kilograms divided by height in meters squared], 27 to 40; age range, 21-45 years) with no contraindications to weight loss or physical activity were recruited from a hospital-based weight loss research center. Participants were assigned to 1 of 4 behavioral weight loss intervention groups. They were randomly assigned to groups based on physical activity energy expenditure (1000 vs 2000 kcal/wk) and intensity (moderate vs vigorous). Participants also were told to reduce intake to 1200 to 1500 kcal/d. A combination of in-person conversations and telephone calls were conducted during the 24-month study period. RESULTS: Weight loss did not differ among the randomized groups at 6 months' (8%-10% of initial body weight) or 24 months' (5% of initial body weight) follow-up. Post-hoc analysis showed that individuals sustaining a loss of 10% or more of initial body weight at 24 months reported performing more physical activity (1835 kcal/wk or 275 min/wk) compared with those sustaining a weight loss of less than 10% of initial body weight (P < .001). CONCLUSIONS: The addition of 275 mins/wk of physical activity, in combination with a reduction in energy intake, is important in allowing overweight women to sustain a weight loss of more than 10%. Interventions to facilitate this level of physical activity are needed.
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“engaging in 275 min per week of physical activity is associated with more sustained weight maintenance after initial successful weight loss (26).”
From The Benefits of Exercise Training in Combination With Weight Loss Therapies (2025) · cites this paper as [26]
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“As recently summarized,13 this is in contrast with retrospective analyses of these RCTs that consistently showed that individuals who engaged in greater amounts of exercise experienced less weight regain, with a dose–response relationship”
From Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity: An overview of 12 systematic reviews and 149 studies (2021) · cites this paper as [44]
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“All participants also reported at baseline and years 1–4, as well as at year 8, the number of weeks in the prior year that they engaged in behaviors previously determined to be associated with long-term weight control: 1) increasing physical activity;27–29 2) monitoring body weight;30,31 3) reducing calorie and fat intake;32,33 and 4) using meal replacements.33”
From Eight-year weight losses with an intensive lifestyle intervention: The look AHEAD study (2014) · cites this paper as [29]
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“and that relatively large volumes of exercise (≥250 min/week) might be needed to prevent weight regain.”
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“On the average, the more exercise carried out, the greater the weight loss.”
From Appetite control and energy balance: Impact of exercise (2015) · cites this paper as [6]
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“The effect is clearly present whether the exercise is measured in minutes of activity per week or in kcal energy expended.”
From Appetite control and energy balance: Impact of exercise (2015) · cites this paper as [6]
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“There is clear evidence from large scale controlled trials that PA carried out over long periods of time produces a dose-dependent reduction in body weight [5, 6].”
From Appetite control and energy balance: Impact of exercise (2015) · cites this paper as [6]
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Metadata
- Authors
- Jakicic, J. M.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Jakicic, John M.
- ORCID
- Jakicic, John M.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2008-07-28
- Volume
- 168
- Issue
- 14
- Pages
- 1550
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC2829743
- OpenAlex
- W2141214903
- Cited by
- 370
- References
- 33
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 10 · 2023: 15 · 2022: 10 · 2021: 28 · 2020: 16 · 2019: 16 · 2018: 16 · 2017: 21 · 2016: 24 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 19
- FWCI
- 32.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 64991, R01HL064991)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Lifestyle Studies
- Keywords
- weight loss maintenance, physical activity, overweight women, obesity, energy expenditure, exercise intensity, caloric restriction, behavioral weight loss, telephone counseling, weight loss sustainability
- MeSH terms
- Adult, Energy Intake, Exercise Therapy, Female, Follow-Up Studies, Humans, Middle Aged, Surveys and Questionnaires, Retrospective Studies, Time Factors, Weight Loss, Treatment Outcome, Overweight
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