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Cited by 371Obesity, Physical Activity, DietPhysical Activity and HealthHealth and Lifestyle Studies

Effect of Exercise on 24-Month Weight Loss Maintenance in Overweight Women

Open access
Jakicic, John M.·2008·Archives of Internal Medicine
DOI 10.1001/archinte.168.14.1550PMC PMC2829743
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Abstract

BACKGROUND: Debate remains regarding the amount of physical activity that will facilitate weight loss maintenance. METHODS: Between December 1, 1999, and January 31, 2003, 201 overweight and obese women (body mass index [calculated as weight in kilograms divided by height in meters squared], 27 to 40; age range, 21-45 years) with no contraindications to weight loss or physical activity were recruited from a hospital-based weight loss research center. Participants were assigned to 1 of 4 behavioral weight loss intervention groups. They were randomly assigned to groups based on physical activity energy expenditure (1000 vs 2000 kcal/wk) and intensity (moderate vs vigorous). Participants also were told to reduce intake to 1200 to 1500 kcal/d. A combination of in-person conversations and telephone calls were conducted during the 24-month study period. RESULTS: Weight loss did not differ among the randomized groups at 6 months' (8%-10% of initial body weight) or 24 months' (5% of initial body weight) follow-up. Post-hoc analysis showed that individuals sustaining a loss of 10% or more of initial body weight at 24 months reported performing more physical activity (1835 kcal/wk or 275 min/wk) compared with those sustaining a weight loss of less than 10% of initial body weight (P < .001). CONCLUSIONS: The addition of 275 mins/wk of physical activity, in combination with a reduction in energy intake, is important in allowing overweight women to sustain a weight loss of more than 10%. Interventions to facilitate this level of physical activity are needed.

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Crossref · 10.1001/archinte.168.14.1550

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  • Engaging in at least 275 minutes per week of physical activity is associated with more sustained weight maintenance after initial successful weight loss.

    “engaging in 275 min per week of physical activity is associated with more sustained weight maintenance after initial successful weight loss (26).”

    From The Benefits of Exercise Training in Combination With Weight Loss Therapies (2025) · cites this paper as [26]

    The Discussion reports that higher physical activity was associated with sustaining at least 10% weight loss through 24 months in overweight women. But its 275 minutes per week is an increase above sedentary baseline activity, not an unqualified total-activity threshold; the paper also identifies reduced energy intake as important. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Retrospective analyses of RCTs consistently showed that individuals who engaged in greater amounts of exercise experienced less weight regain, with a dose-response relationship.

    “As recently summarized,13 this is in contrast with retrospective analyses of these RCTs that consistently showed that individuals who engaged in greater amounts of exercise experienced less weight regain, with a dose–response relationship”

    From Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity: An overview of 12 systematic reviews and 149 studies (2021) · cites this paper as [44]

    The Results by Percent Weight Loss Achieved at 24 Months (page unavailable) show that women who maintained at least 10% weight loss reported more physical activity than women in the lower weight-loss categories. This supports an association in a secondary analysis of this trial, but the paper does not establish a consistent dose–response relationship across multiple RCTs or directly compare weight regain by exercise amount. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Prior research has linked long-term weight control to several behaviors: increasing physical activity, monitoring body weight, reducing calorie and fat intake, and using meal replacements.

    “All participants also reported at baseline and years 1–4, as well as at year 8, the number of weeks in the prior year that they engaged in behaviors previously determined to be associated with long-term weight control: 1) increasing physical activity;27–29 2) monitoring body weight;30,31 3) reducing calorie and fat intake;32,33 and 4) using meal replacements.33”

    From Eight-year weight losses with an intensive lifestyle intervention: The look AHEAD study (2014) · cites this paper as [29]

  • Relatively large volumes of exercise (≥250 min/week) might be needed to prevent weight regain.

    “and that relatively large volumes of exercise (≥250 min/week) might be needed to prevent weight regain.”

    From Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity: An overview of 12 systematic reviews and 149 studies (2021) · cites this paper as [44]

  • On average, the more exercise carried out, the greater the weight loss.

    “On the average, the more exercise carried out, the greater the weight loss.”

    From Appetite control and energy balance: Impact of exercise (2015) · cites this paper as [6]

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1 of the 33 references couldn’t be matched to a known paper.

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  1. [13]Institute of Medicine Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Protein and Amino Acids (Macronutrients): A Report of the Panel on Macronutrients, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes 2002 The National Academies Press Washington, DC

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Authors
Jakicic, J. M.
Affiliations
University of Pittsburgh (US)
Corresponding author
Jakicic, John M.
ORCID
Jakicic, John M.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2008-07-28
Volume
168
Issue
14
Pages
1550
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.168.14.1550
PMC
PMC2829743
OpenAlex
W2141214903
Cited by
370
References
33
Citations by year
2026: 15 · 2025: 13 · 2024: 10 · 2023: 15 · 2022: 10 · 2021: 28 · 2020: 16 · 2019: 16 · 2018: 16 · 2017: 21 · 2016: 24 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 19
FWCI
32.12
Type
journal article
Language
en
Open access
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (HL 64991, R01HL064991)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Health Professions › General Health Professions › Health and Lifestyle Studies
Keywords
weight loss maintenance, physical activity, overweight women, obesity, energy expenditure, exercise intensity, caloric restriction, behavioral weight loss, telephone counseling, weight loss sustainability
MeSH terms
Adult, Energy Intake, Exercise Therapy, Female, Follow-Up Studies, Humans, Middle Aged, Surveys and Questionnaires, Retrospective Studies, Time Factors, Weight Loss, Treatment Outcome, Overweight

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