Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient
Open accessAbstract
Vitamin C supplementation is generally regarded as benign. There has been a resurgence of interest in the general medical community regarding the use of vitamin C most notably in the care of sepsis. Nonetheless, caution must be taken if supraphysiologic vitamin C supplementation is being administered as it should be considered a medication just like any other. We present a case of hemolysis in a glucose-6-phosphate dehydrogenase- (G6PD-) deficient patient receiving high-dose vitamin C infusions for his rheumatoid arthritis.
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High-dose intravenous ascorbate caused haemolytic anaemia in patients lacking G6PD.
“Patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency showed haemolytic anaemia following high-dose intravenous ascorbate therapy56–59.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [57]
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- Authors
- Quinn, J., Gerber, B., Fouche, R., Kenyon, K., Blom, Z., & Muthukanagaraj, P.
- Affiliations
- East Carolina University (US)
- Corresponding author
- Quinn, Joseph
- Venue
- Case Reports in Medicine
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-4
- ISSN
- 1687-9627 (ISSN-L)
- 1687-9635
- PMC
- PMC5727655
- OpenAlex
- W2768522828
- Cited by
- 37
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 11 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Case Reports in Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Methemoglobinemia and Tumor Lysis Syndrome
- Keywords
- vitamin C, high-dose intravenous vitamin C, glucose-6-phosphate dehydrogenase deficiency, hemolysis, rheumatoid arthritis, sepsis, drug-induced hemolysis
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