Propranolol as Primary Therapy for Thyrotoxicosis: Results of a Long-Term Prospective Study
Abstract
It has been suggested that propranolol hydrochloride alone is effective in the treatment of thyrotoxicosis. To test this hypothesis, eight mildly thyrotoxic individuals were prospectively studied for an average of eight months, during which propranolol alone was administered and thyroid function tests, cardiac systolic time intervals, and body densities were sequentially measured. Two patients became euthyroid. The others had adequate but incomplete symptomatic control. Weight loss was not corrected, but no changes in lean body mass were induced. The augmented myocardial contractility of thyrotoxicosis, as determined by systolic time intervals, improved but failed to return completely to normal. Thus, systolic time intervals are a practical means of following the peripheral response to chronic beta-adrenergic blockage in thyrotoxic patients. However, these observations do not support the use of propranolol alone as the first choice of therapy for thyrotoxicosis.
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The rate of remission with ATD therapy is much higher than historical rates of spontaneous remission.
“In fact, the rate of remission with ATD therapy is much higher (112) than the historical rates of spontaneous remission (113).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [113]
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- Authors
- Mazzaferri, E. L.
- Corresponding author
- Mazzaferri, Ernest L.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1976-01-01
- Volume
- 136
- Issue
- 1
- Pages
- 50
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1978665526
- Cited by
- 73
- References
- 26
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2016: 1
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- propranolol, thyrotoxicosis, hyperthyroidism treatment, beta-adrenergic blockade, systolic time intervals, cardiac contractility, lean body mass, weight loss, thyroid function, cardiac function
- MeSH terms
- Adult, Body Composition, Body Weight, Clinical Trials as Topic, Female, Heart Rate, Humans, Hyperthyroidism, Iodine Radioisotopes, Male, Middle Aged, Ohio, Propranolol, Prospective Studies, Thyrotropin, Thyroxine, Triiodothyronine
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