Cited by 467Bone health and osteoporosis researchHip and Femur FracturesMenopause: Health Impacts and Treatments

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A Model of Lifetime Osteoporosis Impact

Chrischilles, Elizabeth A.·1991·Archives of Internal Medicine

DOI 10.1001/archinte.1991.00400100100017

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Abstract

The study goal was to use population-based data to model aspects of lifetime osteoporosis impact not previously studied, specifically: (1) to estimate person-years of fracture-related functional impairment against the trajectory of functional status in the general population; (2) jointly to consider hip, vertebral, and Colles' fractures in estimating the percent of women who will ever fracture; and (3) to estimate the lifetime number of fractures expected in a cohort of 10,000 50-year-old white postmenopausal women. The model estimates that 54% of 50-year-old women will sustain osteoporosis-related fractures during their remaining lifetimes. Beyond the functional impairment expected in similarly aged, unfractured women, osteoporosis-related fractures are estimated to cause 6.7% of women to become dependent in basic activities of daily living; 7.8% are expected to require nursing home care for an average of 7.6 years.

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“Osteoporosis affects 20% to 30% of postmenopausal women,(5) and half of all women aged $ 50 years will experience a fragility fracture in their lifetimes.(6) The prevalence of osteoporosis will continue to increase as the US population ages, with the proportion of Americans aged $ 65 years, which was 12% in 2006, expe…”
Background
Expected lifetime numbers, risks, and burden of osteoporotic fractures for 50-year old Chinese women: a discrete event simulation incorporating FRAX
Jiang, Y., & Ni, W. (2015) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-015-0724-9 · Cited by 11
Transdermal hormone therapy and bone health
SHULMAN, L. P. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s937 · Cited by 12
“At the age of 50, a woman has a 40% lifetime chance of an osteoporotic fracture and a 16% chance of a hip fracture (Chrischilles et al 1991).”
Sheep model for osteoporosis: The effects of peripheral hormone therapy on centrally induced systemic bone loss in an osteoporotic sheep model
Oheim, R., Simon, M. J. K., Steiner, M., Vettorazzi, E., Barvencik, F., Ignatius, A. A., Amling, M., Clarke, I. J., Pogoda, P., & Beil, F. T. (2017) · Injury · doi:10.1016/j.injury.2017.02.009 · Cited by 12
Social and economic impact of osteoporosis. A review of the literature
Schütte, H. E. (1995) · European Journal of Radiology · doi:10.1016/0720-048x(95)00628-4 · Cited by 12
Effect of combined treatment with alendronate and calcitriol on femoral neck strength in osteopenic rats
Nakamura, Y., Naito, M., Hayashi, K., Fotovati, A., & Abu‐Ali, S. (2008) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-3-51 · Cited by 12
A survey of bone abnormalities detection using machine learning algorithms
Barhoom, A. M., Jubair, M. R., & Abu-Naser, S. S. (2023) · AIP conference proceedings · doi:10.1063/5.0133139 · Cited by 11
Hip fracture as the tracer condition
Javaid, M. K., Chana, J., & Cooper, C. C. (2013) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2014.03.003 · Cited by 11
Next-Generation Biomaterials for Bone-Tissue Regeneration: Mg-Alloys on the Move
Naqvi, R. B., Joya, Y. F., & Karim, M. R. A. (2018) · Key engineering materials · doi:10.4028/www.scientific.net/kem.778.306 · Cited by 11
“Approximately one-third of these patients are hospitalized and subjected to surgeries for implant replacement incurring significant health care expenditure [2].”
Background
Personal and Societal Burden of Osteoporotic Fractures
Fox, C., Edwards, M. H., Dennison, E. M., & Cooper, C. C. (2015) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-015-9181-1 · Cited by 11
Early mobilization reduces the medical care cost and the risk of disuse syndrome in patients with acute osteoporotic vertebral fractures
Norimoto, M., Yamashita, M., Yamaoka, A., Yamashita, K., Abe, K., Eguchi, Y., Furuya, T., Orita, S., Inage, K., Shiga, Y., et al. (2021) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2021.09.011 · Cited by 11
Is screening for osteoporosis worthwhile?
Walker-Bone, K. E., Reid, D. M., & Cooper, C. C. (1998) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011738 · Cited by 11
Assessment of femoral bone fragility and fracture risk by ultrasonic measurements at the calcaneus
Boonen, S., & Nicholson, P. (1998) · Age and Ageing · doi:10.1093/ageing/27.2.231 · Cited by 11
“The life-time risk of a hip fracture is 15.6-17.5% in women and 5.2-6.0% in men, depending on the method of analysis [2, 3]- Ultimately, 19% of hip fracture victims will require long-term institutional care because of the fracture [ 4 ].”
Influential
Teriparatide in postmenopausal osteoporosis: uncovering novel insights into efficacy and safety compared to other treatments – a systematic review and meta-analysis
Vithran, D. T. A., Essien, A. E., Rahmati, M., Opoku, M., Yon, D. K., Sánchez, G. F. L., Koyanagi, A., Smith, L., Shin, J. I., Xiao, W., et al. (2024) · EFORT Open Reviews · doi:10.1530/eor-23-0205 · Cited by 10
“Fractures at critical sites, such as the hip, carry significant morbidity and mortality risks ( 4, 5, 6, 7, 8 ).”
Verifying the effectiveness of romosozumab re-administration on bone mineral density
Kobayakawa, T., & Nakamura, Y. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae196 · Cited by 10
A Prospective Study of Falls Following Hip Fracture in Community Dwelling Older Adults
Hall, S. E., Williams, J. A., & Criddle, R. A. (2001) · Australian Journal on Ageing · doi:10.1111/j.1741-6612.2001.tb00357.x · Cited by 10

Authors: Chrischilles, E. A.
Affiliations: University of Iowa (US)
Corresponding author: Chrischilles, Elizabeth A.
ORCID: Chrischilles, Elizabeth A.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1991-10-01
Volume: 151
Issue: 10
Pages: 2026
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1991.00400100100017
OpenAlex: W2094251460
Cited by: 467
References: 36
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 15
FWCI: 8.13
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: osteoporosis, hip fracture, vertebral fractures, Colles' fracture, functional disability, activities of daily living, nursing home care, postmenopausal women, fracture risk prediction model
MeSH terms: Colles' Fracture, Female, Fractures, Spontaneous, Health Status, Hip Fractures, Humans, Markov Chains, Mathematical Computing, Middle Aged, Prognosis, Recurrence, Models, Statistical, Cohort Studies, Osteoporosis, Postmenopausal, Spinal Fractures

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A Model of Lifetime Osteoporosis Impact

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