Cited by 467Bone health and osteoporosis researchHip and Femur FracturesMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

A Model of Lifetime Osteoporosis Impact

Chrischilles, Elizabeth A.·1991·Archives of Internal Medicine

DOI 10.1001/archinte.1991.00400100100017

Open this paper in CoChat — free account

Abstract

The study goal was to use population-based data to model aspects of lifetime osteoporosis impact not previously studied, specifically: (1) to estimate person-years of fracture-related functional impairment against the trajectory of functional status in the general population; (2) jointly to consider hip, vertebral, and Colles' fractures in estimating the percent of women who will ever fracture; and (3) to estimate the lifetime number of fractures expected in a cohort of 10,000 50-year-old white postmenopausal women. The model estimates that 54% of 50-year-old women will sustain osteoporosis-related fractures during their remaining lifetimes. Beyond the functional impairment expected in similarly aged, unfractured women, osteoporosis-related fractures are estimated to cause 6.7% of women to become dependent in basic activities of daily living; 7.8% are expected to require nursing home care for an average of 7.6 years.

Integrity signals

Registry

Crossref · 10.1001/archinte.1991.00400100100017

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Epidemiologic Research: Principles and Quantitative Methods.
Mayer, L. S., Kleinbaum, D. G., Kupper, L. L., & Morgenstern, H. (1984) · Journal of the American Statistical Association · doi:10.2307/2288427 · Cited by 2,905
EPIDEMIOLOGY OF OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES
Cummings, S. R., Kelsey, J. L., Nevitt, M. C., & O’Dowd, K. J. (1985) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036281 · Cited by 1,701
The Markov process in medical prognosis
Beck, J. R., & Pauker, S. G. (1983) · Medical Decision Making · doi:10.1177/0272989x8300300403 · Cited by 957
EPIDEMIOLOGY OF VERTEBRAL FRACTURES IN WOMEN
Melton, L. J., Kan, S. H., Frye, M. A., Wahner, H. W., O’Fallon, W. M., & Riggs, B. L. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115204 · Cited by 922
Lifetime Risks of Hip, Colles', or Vertebral Fracture and Coronary Heart Disease Among White Postmenopausal Women
Cummings, S. R. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390110045010 · Cited by 690
A Longitudinal Study of Functional Change and Mortality in the United States
Mantón, K. G. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.5.s153 · Cited by 512
Established Populations for Epidemiologic Studies of the Elderly: Resource Data Book
Kaplan, G. A. (1987) · Journal of Gerontology · doi:10.1093/geronj/42.6.688a · Cited by 420
Relationship of Lung Function to Severity of Osteoporosis in Women
Leech, J. A., Dulberg, C. S., Kellie, S., Pattee, L., & Gay, J. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.68 · Cited by 402
Survival experience of aged hip fracture patients.
Magaziner, J. S., Simonsick, E. M., Kashner, T. M., Hebel, J. R., & Kenzora, J. E. (1989) · American Journal of Public Health · doi:10.2105/ajph.79.3.274 · Cited by 383
Survival and ambulation following hip fracture.
Miller, C. W. (1978) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197860070-00010 · Cited by 377

Show all 36 references

Sorted by citations

Items 401–466 of 466

Interventions for Osteoporosis
Keating, F. S. J., & Stevenson, J. C. (2007) · Elsevier eBooks · doi:10.1016/b978-012369443-0/50035-1 · Cited by 1
Outcomes of Osteoporotic Fractures
Greendale, G. A., & Barrett-Connor, E. L. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50039-2 · Cited by 1
Work package 4
Parsons, V., Juszczyk, D., Gilworth, G., Ntani, G., McCrone, P., Hatch, S. L., Shannon, R. R., Henderson, M., Coggon, D., Molokhia, M., et al. (2021) · Cited by 1
Osteoporosis
Yuen, C. K., Kendler, D. L., Khan, A. A., Brown, J. P., & Fortier, M. P. (2002) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(17)31079-4 · Cited by 1
An Overview of Osteoporosis
Bonnick, S. L., & Lewis, L. A. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-123-7_9 · Cited by 1
MASLD and MASH increase fracture risk in humans and mice by arresting new bone formationPreprint
Goldscheitter, G., Jahagirdar, V., Seneshaw, M., Mirshahi, F., Summerlin, M., Ip, A., Coelho, A., Buettmann, E. G., Genetos, D. C., Sanyal, A. J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7775325/v1 · Cited by 1
“Fractures, especially in older individuals, have a major adverse impact on their ability to function and manage activities of daily living [11].”
Osteoporosis: We Are Neglecting Our Own
Hamdy, R. C. (2006) · Southern Medical Journal · doi:10.1097/01.smj.0000219439.05646.07 · Cited by 1
RISEDRONATE: A NEW DRUG FOR OSTEOPOROSIS AND PAGET'S DISEASE
Wattanapitayakul, S. K., & Phornchirasilp, S. (2000) · Journal of Basic and Applied Pharmacology
Diagnosi strumentale dell’osteoporosi
Causero, A., Beltrame, A., Benedetto, P. D., & Campailla, E. (2006) · Springer eBooks · doi:10.1007/978-88-470-0546-4_3
Candidate gene association study of baseline and longitudinal bone-quality traits in a healthy older population
Mukherjee, A. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Make No Bones About It—Creative Partnerships Work
Brown, M. I., King, T., Templeton, K. J., Mays, T. L., & Vargas, K. (2007) · Journal of Hospital Librarianship · doi:10.1300/j186v07n04_04
Histologische und histomorphometrische Untersuchung des Knochenstatus von 399 Männern unter besonderer Berücksichtigung des Serum- Vitamin D-Gehaltes
Keßler, S. (2010)
Trainings- und Übungstherapie zur Sturzprävention
Kerschan‐Schindl, K., & Gr, E. (2010) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Vergleich und klinische Ergebnisse von operativen Eingriffen zur Versorgung von Frakturen im Bereich des coxalen Femurendes
Grubwinkler, M. (2003) · doi:10.5282/edoc.1674
The Role of Architecture and Tissue Properties in the Structural Integrity of Human Vertebral Cancellous Bone
Cole, J. H. (2007) · eCommons (Cornell University)
Nutrition and Skeletal Health in Other Racial/Ethnic Groups
Cong, E., & Walker, M. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-2001-3_17
GENETIC ARCHITECTURE OF BONE STRENGTH RELATED PHENOTYPES: TOBAGO FAMILY HEALTH STUDY
Wang, X. (2007) · D-Scholarship@Pitt (University of Pittsburgh)
Dose-Dependent Effects of Salmon Calcitonin on Bone Turnover in Ovariectomized Rats.
Owens, B. (2004) · Digital Commons - East Tennessee State University (East Tennessee State University)
Actualización de la eficacia de los tratamientos farmacológicos en fracturas osteoporóticas no vertebrales
de Castro, A. C. P. (2007) · Revista Española de Enfermedades Metabólicas Óseas · doi:10.1016/s1132-8460(07)73497-9
Prevention and therapy of fractures in the elderly: Costs and benefits
Salvioli, G., Pula, B., Belloi, L., & Pradelli, J. M. (1996) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(96)86999-8
Riesgo de fracturas no vertebrales en mujeres posmenopáusicas en tratamiento antirresortivo
Sánchez, A. C., Gil, X. C., & Vázquez, E. R. (2009) · Progresos de Obstetricia y Ginecología · doi:10.1016/s0304-5013(09)72213-7
Oral ibandronate: a less frequently administered therapeutic option for postmenopausal osteoporosis
Reginster, J. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.13.2301
“These fractures, occurring as a consequence of the high bone turnover and loss of bone mass caused by osteoporosis, result in increased disability [1,2] and mortality [3], and impose a substantial healthcare burden [4-6].”
Background
Within the Smorgasbord of Women’s Imaging, Do We Need to Improve Our Bone Appétit?
Gellman, F. C. (2005) · Seminars in Breast Disease · doi:10.1053/j.sembd.2006.08.006
Lasofoxifene: a new-generation SERM for the treatment of postmenopausal osteoporosis
Gennari, L., Merlotti, D., & Nuti, R. (2009) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.09.55
Upper body fractures in older adults - epidemiology and injury mechanisms
Palvanen, M. (2001) · Tampere University Institutional Repository (Tampere University)
VLIYaNIE TERAPEVTIChESKOGO OBUChENIYa BOL'NYKh POSTMENOPAUZAL'NYMOSTEOPOROZOM na modifitsiruemye faktory riska i kachestvo zhizni
Кирпикова, М. Н., KOLOSKOVA, N. V., & Назарова, О. А. (2008) · Osteoporosis and Bone Diseases · doi:10.14341/osteo2008115-16
An audit of calcium supplement prescribing at an urban general practice in the UK
Fisher, B. (2011) · Cambridge Medicine Journal · doi:10.7244/cmj-1318012371
Osteoporosis: Translating State of the Art Knowledge into Daily Practice
Hamdy, R. C. (2013) · Journal of Gerontology & Geriatric Research · doi:10.4172/2167-7182.1000e120
Análisis de los factores de riesgo de las fracturas vertebrales osteoporóticas Analysis of risk factors of osteoporotic vertebral fractures
Meseguer, E. M., Ferrer, P. R., Molla, C. B., & Sancho, F. G. (2006)
Steroid-Induced Osteoporosis
Ledford, D. K. (2001) · Lung biology in health and disease · doi:10.1201/b14023-23
Osteoporosis and osteopenia
Hamdy, R. C. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781316084380.045
Fostering Resilience Among Older Adults Living with Osteoporosis and Osteoarthritis
Smith, B. J., & Bailey, W. A. (2016) · Emerging issues in family and individual resilience · doi:10.1007/978-3-319-26033-4_9
Nongynecologic conditions
(2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781316084380.035
Bioimaging and biomechanics of bone competence and implant stability
Mueller, T. L. (2010) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-006037549
Análisis de eficiencia de las estrategias para identificar mujeres posmenopáusicas con osteoporosis en México
Molina, F. C., Delezé, M., & Rodríguez, M. D. P. D. L. P. (2000) · Revista de Endocrinología y Nutrición
2 Epidemiology of Osteoporosis
Ross, P. D. (1998)
Options After Chemotherapy for Patients with Metastatic, Castration-Resistant Prostate Cancer
Lee, D. J., & Shore, N. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-78646-9_9
To assess the role of VIT. D3 in proximal femur Fracture in elderly patients
Kumar, S., Tomar, S., Chaudhary, S., Yadav, D. A., & Yadav, D. A. (2018) · International Journal of Orthopaedics Sciences · doi:10.22271/ortho.2018.v4.i4e.42
Managing Osteoporosis in Oldest of Old
Naganathan, V., & Nagaratnam, K. (2018) · Springer eBooks · doi:10.1007/978-3-319-96998-5_24
Sequenciamento paralelo em larga escala de genes candidatos para fragilidade óssea em indivíduos com osteoporose grave, familiar ou idiopática
Braz, M. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-22102018-123623
Economics of Hip Fracture Treatment
Koval, K. J., & Zuckerman, J. D. (2000) · Springer eBooks · doi:10.1007/978-1-4757-4052-3_11
Osteoporotic fractures: mortality and quality of life
Martino, G. (2007)
The Epidemiology of Fracture: Why Treatment Matters
Dennison, E. M., & Cooper, C. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-78128-6_1
Chapter 5 Osteoporosis
(1998) · Journal SOGC · doi:10.1016/s0849-5831(16)31009-6
Immunology of Osteoporosis
Kerschan‐Schindl, K., Nebot, E., & Pietschmann, P. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_153
Osteoporosis
Saag, K. G. (2008) · Springer eBooks · doi:10.1007/978-0-387-68566-3_75
Osteoporosis
Yuen, C. K., Kendler, D. L., Khan, A. A., Brown, J. P., & Fortier, M. P. (2001) · Journal SOGC · doi:10.1016/s0849-5831(16)30868-0
References
(2009) · Wiley eBooks · doi:10.1002/9780470824023.refs
Osteoporosis
Wehling, M. (2012) · Springer eBooks · doi:10.1007/978-3-7091-0912-0_12
Ação da atividade física sobre as propriedades mecânicas dos fêmures e tíbias de ratas osteopênicas
Abrahão, G. S. (2004) · doi:10.11606/d.82.2004.tde-29032006-113732
Ostéoporose
Yuen, C. K., Kendler, D. L., Khan, A. A., Brown, J. P., & Fortier, M. P. (2001) · Journal SOGC · doi:10.1016/s0849-5831(16)30872-2
Predictors of Failure Following Fixation of Trochanteric Fractures
Abdennadher, A., Hjaiej, S., Ayari, R., Mallat, Y., Triki, R., & Amri, K. (2023) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2023.11359
Factors That Influence Quality of Life in Postmenopausal Osteoporotic Women With Nonvertebral Fractures
Zannetti, E. B., Cittadini, N., Iovino, P., Maria, M. D., D’Angelo, D., Pennini, A., Vellone, E., Tarantino, U., & Alvaro, R. (2024) · Orthopaedic Nursing · doi:10.1097/nor.0000000000001028
“For example, approximately 20% of patients with hip fractures die within 1 year after the incident, and more than 50% never revert to their pre-fracture status (Chrischilles et al., 1991).”
Background
Phytoestrogen status in relation to sociodemographic factors and biomarkers of bone health in older Brisbane women
Hanna, K. L. (2006)
Att förebygga osteoporos i en svensk kommun : En beskrivning av ett tioårigt befolkningsinriktat interventionsarbete ”Vadstena en benhård kommun
Blomberg, C. (2008)
Semeiotica, epidemiologia e fattori di rischio dell’osteoporosi
Luisetto, G., & Camozzi, V. (2009) · Springer eBooks · doi:10.1007/978-88-470-1357-5_3
The effects of a 1-year recreational football protocol on bone mineral density and physical performance parameters in a group of healthy inactive 50 years old men
Finianos, B. (2021) · theses.fr (ABES) · doi:10.70675/b42d813az5fd2z4029z9fe1z9e9b441fdd27
Développement d'une approche de diagnostic du risque de fracture ostéoporotique du fémur proximal à partir d'imagerie médicale DXA basée sur des indices de qualité osseuse et du calcul par éléments finis
Zellagui, S. (2021) · doi:10.70675/4d113171z0e5dz4873z9906z62e3c6b78985
AI-Based Automated Segmentation of the Mandibular Cortex and Mental Foramen for Radiomorphometric Measurement on Panoramic Radiographs: A Feasibility Study
Görür, S. A., Önder, M., Çelik, Ö., Bayrakdar, İ. Ş., Lopes, S. L. P. D. C., Costa, A. L. F., & Orhan, K. (2026) · Diagnostics · doi:10.3390/diagnostics16203395
“However, underdiagnosis remains common [2].”
The fracture liaison service : from risk evaluation towards risk reduction?
Huntjens, K. M. B. (2014) · doi:10.26481/dis.20140221kh
Risk assessment for osteoporotic fractures among men and women from a prospective population study: the EPIC-Norfolk study
Moayyeri, A. (2012) · Apollo (University of Cambridge) · doi:10.17863/cam.16248
Different Forms of Body Activity as Therapeutical Concepts in Osteopenia
Hartard, M., Haber, P., Ilieva, D., Preisinger, E., Quittan, M., Seidl, G., Huber, J. C., Filadoro, R., & Jeschke, D. (1994) · Springer eBooks · doi:10.1007/978-4-431-68272-1_16
Twenty-five Years Before the Fall: Preventing Osteoporotic Hip Fracture
Schramm, D. M. (1994) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-1994-4307
The savings factor between treatment of osteoporosis and treatment of subsequent osteoporotic fracture in the Netherlands.
van Kuijck, J. (2013)
Osteoporose und Knochenstoffwechsel
Pientka, L. (2000) · Springer eBooks · doi:10.1007/978-3-642-59691-9_68
The orthopaedic treatment of fragility fractures.
(2007) · PubMed Central · Cited by 43

Authors: Chrischilles, E. A.
Affiliations: University of Iowa (US)
Corresponding author: Chrischilles, Elizabeth A.
ORCID: Chrischilles, Elizabeth A.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1991-10-01
Volume: 151
Issue: 10
Pages: 2026
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1991.00400100100017
OpenAlex: W2094251460
Cited by: 467
References: 36
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 15
FWCI: 8.13
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: osteoporosis, hip fracture, vertebral fractures, Colles' fracture, functional disability, activities of daily living, nursing home care, postmenopausal women, fracture risk prediction model
MeSH terms: Colles' Fracture, Female, Fractures, Spontaneous, Health Status, Hip Fractures, Humans, Markov Chains, Mathematical Computing, Middle Aged, Prognosis, Recurrence, Models, Statistical, Cohort Studies, Osteoporosis, Postmenopausal, Spinal Fractures

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Model of Lifetime Osteoporosis Impact

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks