Cited by 467Bone health and osteoporosis researchHip and Femur FracturesMenopause: Health Impacts and Treatments

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A Model of Lifetime Osteoporosis Impact

Chrischilles, Elizabeth A.·1991·Archives of Internal Medicine

DOI 10.1001/archinte.1991.00400100100017

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Abstract

The study goal was to use population-based data to model aspects of lifetime osteoporosis impact not previously studied, specifically: (1) to estimate person-years of fracture-related functional impairment against the trajectory of functional status in the general population; (2) jointly to consider hip, vertebral, and Colles' fractures in estimating the percent of women who will ever fracture; and (3) to estimate the lifetime number of fractures expected in a cohort of 10,000 50-year-old white postmenopausal women. The model estimates that 54% of 50-year-old women will sustain osteoporosis-related fractures during their remaining lifetimes. Beyond the functional impairment expected in similarly aged, unfractured women, osteoporosis-related fractures are estimated to cause 6.7% of women to become dependent in basic activities of daily living; 7.8% are expected to require nursing home care for an average of 7.6 years.

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Authors: Chrischilles, E. A.
Affiliations: University of Iowa (US)
Corresponding author: Chrischilles, Elizabeth A.
ORCID: Chrischilles, Elizabeth A.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1991-10-01
Volume: 151
Issue: 10
Pages: 2026
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1991.00400100100017
OpenAlex: W2094251460
Cited by: 467
References: 36
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 15
FWCI: 8.13
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: osteoporosis, hip fracture, vertebral fractures, Colles' fracture, functional disability, activities of daily living, nursing home care, postmenopausal women, fracture risk prediction model
MeSH terms: Colles' Fracture, Female, Fractures, Spontaneous, Health Status, Hip Fractures, Humans, Markov Chains, Mathematical Computing, Middle Aged, Prognosis, Recurrence, Models, Statistical, Cohort Studies, Osteoporosis, Postmenopausal, Spinal Fractures

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A Model of Lifetime Osteoporosis Impact

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