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Comparison of Patients' Compliance With Prescribed Oral and Inhaled Asthma Medications
Abstract
BACKGROUND: Noncompliance with medications is one of the most serious problems facing health care today. However, methods to measure compliance have many limitations. METHODS: To measure specific drug compliance and dosing frequency of two asthma medications, we used medical records data and pharmacy claims data from 276 patients who had concurrent prescriptions for inhaled anti-inflammatory agents and oral theophylline. Patients were randomly selected from the pharmacy claims data files of a health maintenance organization. The patients' medical records were reviewed, and records that did not contain clear documentation of the medication, dose, and dosing frequency were excluded. Data from the remaining 119 medical records were compared with data from pharmacy claims to calculate compliance rates for each medication. RESULTS: Our calculations showed that patients were significantly more compliant with prescribed theophylline medication than with two inhaled anti-inflammatory medications (P = .0001). No significant differences in compliance were found relative to prescribed dosing frequency (twice daily or less compared with three times daily or more) for either medication (P = .6517). CONCLUSIONS: Comparison of medical record data with pharmacy claims data is an effective indirect measure of patients' compliance with prescribed oral theophylline and inhaled anti-inflammatory agents. Additional interventions must be pursued for patients with asthma regarding adherence to regimens for their prescribed inhaled anti-inflammatory agents.
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Citations
Cited by
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Biofeedback treatment for asthma.
Lehrer, P. M., Vaschillo, E., Vaschillo, B., Lu, S.-E., Scardella, A., Siddique, M., & Habib, R. H. (2004) · Chest · doi:10.1378/chest.126.2.352 · Cited by 264
Cochrane, G. M., Horne, R., & Chanez, P. (1999) · Respiratory Medicine · doi:10.1016/s0954-6111(99)90260-3 · Cited by 246
A simple and valid tool distinguished efficacy from effectiveness studies
Gartlehner, G., Hansen, R. A., Nissman, D., Lohr, K. N., & Carey, T. S. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.01.011 · Cited by 207
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Janmeja, A. K., Das, S. K., Bhargava, R., & Chavan, B. S. (2005) · Respiration · doi:10.1159/000086251 · Cited by 50
Metadata
- Authors
- Kelloway, J. S.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1994-06-27
- Volume
- 154
- Issue
- 12
- Pages
- 1349-1349
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2136210090
- Cited by
- 334
- References
- 0
- FWCI
- 18.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kelloway, J. S. (1994). Comparison of Patients' Compliance With Prescribed Oral and Inhaled Asthma Medications. Archives of Internal Medicine. https://doi.org/10.1001/archinte.154.12.1349
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