The clinical course of palpitations in medical outpatients
Abstract
OBJECTIVE: The aim of this study was to describe the longitudinal course of patients who were referred for ambulatory electrocardiographic monitoring because of palpitations. METHODS: A prospective, follow-up examination was conducted of patients who had been studied 6 months previously when referred for monitoring. The inception cohort consisted of 145 consecutive patients with palpitations and 70 asymptomatic, nonpatient volunteers. At follow-up, the patients completed the same research battery as at inception, consisting of structured interviews and self-report questionnaires. These assessed cardiac symptoms, medical care use, role impairment, somatization, hypochondriacal fears and beliefs, and psychiatric disorder. RESULTS: At 6 months' follow-up, 130 patients with palpitations (89.7% of the original cohort) and 69 nonpatients (98.6%) were reinterviewed. Eighty-four percent of the patients had recurrent palpitations during the 6-month follow-up period. At follow-up, patients with palpitations scored significantly higher than the comparison group on measures of cardiac symptoms and role impairment, and had made more physician visits in the preceding 6 months. They had a higher prevalence of panic disorder and more psychopathologic symptoms, somatized more, and were more hypochondriacal. Psychiatric symptoms and the tendency to amplify bodily sensation, measured at inception, were significant but modest predictors of subsequent palpitations. There was considerable confusion and misunderstanding among patients as to the findings of their ambulatory electrocardiogram and the presence or absence of panic disorder. CONCLUSIONS: Patients with palpitations remain symptomatic and functionally impaired and have increased rates of physician visits in the 6 months following Holter monitoring. They also continue to have elevated rates of panic disorder and to evidence some confusion about the cause of their symptoms.
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Previously unexplained symptoms can cause anxiety and have a significant impact on quality of life even in the absence of underlying arrhythmia.
“Even in the absence of underlying arrhythmia, previously unexplained symptoms can cause anxiety and can have a significant impact on quality of life [29].”
From Multi-centre Randomised Controlled Trial of a Smartphone-based Event Recorder Alongside Standard Care Versus Standard Care for Patients Presenting to the Emergency Department with Palpitations and Pre-syncope: The IPED (Investigation of Palpitations in the ED) study (2019) · cites this paper as [29]
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- Authors
- Barsky, A. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Barsky, Arthur J.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1995-09-11
- Volume
- 155
- Issue
- 16
- Pages
- 1782
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1989888730
- Cited by
- 61
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl043216-08)
- National Heart, Lung, and Blood Institute (HL 43216)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- palpitations, Holter monitoring, panic disorder, somatization, health anxiety, role impairment, health care utilization, cardiac symptoms, psychiatric comorbidity, symptom recurrence
- MeSH terms
- Disabled Persons, Persons with Disabilities, Health Services, Humans, Outpatients, Prospective Studies, Surveys and Questionnaires, Role, Tachycardia, Electrocardiography, Ambulatory, Panic Disorder
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