The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Primary Care Clinicians' Experiences With Treatment Decision Making for Older Persons With Multiple Conditions
Open accessAbstract
BACKGROUND: Clinicians are caring for an increasing number of older patients with multiple diseases in the face of uncertainty concerning the benefits and harms associated with guideline-directed interventions. Understanding how primary care clinicians approach treatment decision making for these patients is critical to the design of interventions to improve the decision-making process. METHODS: Focus groups were conducted with 40 primary care clinicians (physicians, nurse practitioners, and physician assistants) in academic, community, and Veterans Affairs-affiliated primary care practices. Participants were given open-ended questions about their approach to treatment decision making for older persons with multiple medical conditions. Responses were organized into themes using qualitative content analysis. RESULTS: The participants were concerned about their patients' ability to adhere to complex regimens derived from guideline-directed care. There was variability in beliefs regarding, and approaches to balancing, the benefits and harms of guideline-directed care. There was also variability regarding how the participants involved patients in the process of decision making, with clinicians describing conflicts between their own and their patients' goals. The participants listed a number of barriers to making good treatment decisions, including the lack of outcome data, the role of specialists, patient and family expectations, and insufficient time and reimbursement. CONCLUSIONS: The experiences of practicing clinicians suggest that they struggle with the uncertainties of applying disease-specific guidelines to their older patients with multiple conditions. To improve decision making, they need more data, alternative guidelines, approaches to reconciling their own and their patients' priorities, the support of their subspecialist colleagues, and an altered reimbursement system.
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“Fried et al. showed that clinicians struggle with the uncertainties of applying disease-specific guidelines to their patients with multiple conditions, and would therefore benefit from a number of tools to assist them in decision making for this population [12].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [12]
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Cites
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“Second, the presence of these conditions may also increase the likelihood that the individual will experience adverse effects with any given intervention.(3,4) Finally, the polypharmacy that generally accompanies multimorbidity confers an increased risk of adverse drug events, independent of the chronic conditions.”
BackgroundUnderstanding the treatment preferences of seriously ill patients.
Fried, T., Bradley, E. H., Towle, V., & Allore, H. (2002) · New England Journal of Medicine · doi:10.1056/nejmsa012528 · Cited by 1,426
Self-citationEffectiveness of strategies for informing, educating, and involving patients
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Potential pitfalls of disease-specific guidelines for patients with multiple conditions.
Tinetti, M., Bogardus, S., & Agostini, J. V. (2004) · New England Journal of Medicine · doi:10.1056/nejmsb042458 · Cited by 969 · cited 1×
“Second, the presence of these conditions may also increase the likelihood that the individual will experience adverse effects with any given intervention.(3,4) Finally, the polypharmacy that generally accompanies multimorbidity confers an increased risk of adverse drug events, independent of the chronic conditions.”
BackgroundSelf-citationPolypharmacy and Prescribing Quality in Older People
Steinman, M. A., Landefeld, C., Rosenthal, G. E., Berthenthal, D., Sen, Ś., & Kaboli, P. (2006) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00889.x · Cited by 580
Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall
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“In addition to the studies demonstrating the risk of adverse outcomes associated with guideline-directed care, evidence also suggests that the patients who are at the highest risk for these adverse outcomes may also be the ones most likely to derive benefit from the intervention.(17) Clinicians’ descriptions of how th…”
BackgroundRisk Factors for Adverse Drug Events Among Older Adults in the Ambulatory Setting
Field, T., Gurwitz, J., Harrold, L., Rothschild, J., Debellis, K., Seger, A., Auger, J. C., Garber, L., Cadoret, C. A., Fish, L., et al. (2004) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52367.x · Cited by 315 · cited 1×
“Finally, the polypharmacy that generally accompanies multimorbidity confers an increased risk of adverse drug events, independent of the chronic conditions.(5,6) On the other hand, editorials and clinical studies remind readers that the clinical trials”
BackgroundViews of older adults on patient participation in medication-related decision making
Belcher, V. N., Fried, T., Agostini, J. V., & Tinetti, M. (2006) · Journal of general internal medicine · doi:10.1111/j.1525-1497.2006.00329.x · Cited by 279 · cited 1×
“Moreover, other clinicians noted that the reduction in risk for a disease-specific outcome might not be what was most important to the patient, an observation supported by studies indicating that the adverse effects of medications may be as, if not more, important to patients than their primary effects.(20,21) Disagre…”
ResultSelf-citationViews of Older Persons with Multiple Morbidities on Competing Outcomes and Clinical Decision‐Making
Fried, T. R., McGraw, S., Agostini, J. V., & Tinetti, M. E. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01923.x · Cited by 203 · cited 1×
“Moreover, other clinicians noted that the reduction in risk for a disease-specific outcome might not be what was most important to the patient, an observation supported by studies indicating that the adverse effects of medications may be as, if not more, important to patients than their primary effects.(20,21) Disagre…”
ResultSelf-citationPitfalls of Converting Practice Guidelines Into Quality Measures
Walter, L. C., Davidowitz, N. P., Heineken, P. A., & Covinsky, K. E. (2004) · JAMA · doi:10.1001/jama.291.20.2466 · Cited by 197
Research works printed but not linked: 1
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“Many patients are willing to take medication only if the benefits provided by the medication is far greater than the adverse effects of the medication [16].”
THE BERMUDA TRIANGLE: AGING, MULTIMORBIDITY, AND AUTOIMMUNE RHEUMATIC DISEASES
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“Productivity requirements for physicians typically dictate a quota of patients be seen per day, usually in 15-minute time slots designed for maximal efficiency rather than the highest level of patient care.(12-15,17,20) For older adults with multiple medical issues as well as psychosocial needs, short appointments are…”
BackgroundCommon medical comorbid conditions and chronic pain in HIV
Kim, D. J., & Ritchie, C. S. (2016) · doi:10.1002/9781118777374.ch7 · Cited by 1
Tricco, A. C., Tetzlaff, J., & Moher, D. (2013) · Wiley eBooks · doi:10.1002/9781118413555.ch04 · Cited by 8
“tension between delivering care to meet quality targets and fulfilling the patient's expectations;(68;69) 3.”
InfluentialChronische Herzinsuffizienz im Alter
Fischer, D., Dettmer-Flügge, A., Thiesemann, R., & Gogol, M. (2011) · Zeitschrift für Gerontologie und Geriatrie (Print) · doi:10.1007/s00391-011-0197-y · Cited by 1
Maghsoodi, A. I., Pavlov, V., Rouse, P., Walker, C., & Parsons, M. (2026) · Health Care Management Science · doi:10.1007/s10729-026-09783-5
“Care-related goals for frail older adults vary and often include well-being alongside health and functioning [36], necessitating the integration of priority setting with complex care interventions.”
van Dijk, S. V., Brusse-Keizer, M., Rodenburg, B., & Lenferink, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0338888
“Although healthcare professionals (HCPs) express the need to address multimorbidity more, they report a lack of support due to fragmented (i.e., discipline-specific) clinical guidelines [11,12].”
The effect of frailty and cognitive impairment on rational use of medicine in older adults
Ünver, Z., & Cengi̇z, Z. (2025) · Genel Tip Dergisi · doi:10.54005/geneltip.1636308
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“This siloed approach leads to predictable and costly failures: adverse drug events, preventable hospitalizations, iatrogenic complications, and poor quality of life (Fried et al., 2011).”
Alsalemi, N., Sadowski, C., Elftouh, N., Kilpatrick, K., Houle, S. J. D., Leclerc, S., Fernandez, N., & Lafrance, J. (2024) · BMJ Health & Care Informatics · doi:10.1136/bmjhci-2023-100869
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“Frailty is a public health concern as it has been shown to lead to mortality, functional decline, falls, disability, decreased quality of life, and increased health care utilization (Ament et al., 2014; Gobbens et al., 2010; Census, 2011; CIHI, 2011; Fried et al., 2011).”
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Idosos atendidos em unidade básica de saúde: experiências sobre polimedicação
Silva, C. V., Higa, E. D. F. R., Marin, M. J. S., Goulart, F. C., & Lazarini, C. A. (2019) · Revista Pesquisa Qualitativa · doi:10.33361/rpq.2019.v.7.n.14.273
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“Nevertheless, it may be difficult for physicians to administer all of the guideline-recommended preventive care screening due to time constraints, concern about harms associated with care and patient preferences (Fried et al., 2011).”
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Les déterminants de la prescription médicamenteuse en médecine générale
Darmon, D. (2014) · theses.fr (ABES) · doi:10.70675/978c23c9z46bdz4df7z82e5zcdd0b8237c93
La prise de décision médicale en gériatrie
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“Réalisées chez des médecins généralistes, des infirmières et des médecins prenant en charge des vétérans, elles ont mis en évidence une variabilité de l’opinion des cliniciens quant à l’adhésion de leurs patients âgés aux protocoles trop complexes issus de référentiels [18].”
Metadata
- Authors
- Fried, T. R., Tinetti, M. E., & Iannone, L.
- Affiliations
- Yale University (US)
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2010-09-13
- Volume
- 171
- Issue
- 1
- Pages
- 75-80
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC3021478
- OpenAlex
- W2012018261
- Cited by
- 236
- References
- 28
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 15 · 2019: 24 · 2018: 15 · 2017: 22 · 2016: 22 · 2015: 15 · 2014: 23 · 2013: 18 · 2012: 24
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University (P30AG21342)
- National Institutes of Health
- National Institute on Aging (K24AG028443, P30 AG21342, P30AG021342)
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Health Professions › General Health Professions › Patient-Provider Communication in Healthcare
- Keywords
- treatment decision-making, older adults, multimorbidity, primary care providers, guideline-directed care, medication adherence, benefits and harms, shared decision-making, barriers to decision-making, reimbursement, clinician beliefs
- MeSH terms
- Workforce, Adult, Aged, Chronic Disease, Connecticut, Decision Making, Female, Goals, Hospitals, University, Humans, Male, Middle Aged, Nurse Practitioners, Patient Compliance, Practice Patterns, Physicians', Physician Assistants, Primary Health Care, Residence Characteristics, United States, Comorbidity, Focus Groups, Narration, Qualitative Research, Medication Adherence, Physicians, Primary Care
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