Effectiveness of Collaborative Care for Depression in Human Immunodeficiency Virus Clinics
Abstract
Background Depression is common among persons with the human immunodeficiency virus (HIV) and is associated with unfavorable outcomes. Methods A single-blind randomized controlled effectiveness trial at 3 Veterans Affairs HIV clinics (HIV Translating Initiatives for Depression Into Effective Solutions [HITIDES]). The HITIDES intervention consisted of an off-site HIV depression care team (a registered nurse depression care manager, pharmacist, and psychiatrist) that delivered up to 12 months of collaborative care backed by a Web-based decision support system. Participants who completed the baseline telephone interview were 249 HIV-infected patients with depression, of whom 123 were randomized to the intervention and 126 to usual care. Participant interview data were collected at baseline and at the 6- and 12-month follow-up visits. The primary outcome was depression severity measured using the 20-item Hopkins Symptom Checklist (SCL-20) and reported as treatment response (≥50% decrease in SCL-20 item score), remission (mean SCL-20 item score, Results Intervention participants were more likely to report treatment response (33.3% vs 17.5%) (odds ratio, 2.50; 95% confidence interval [CI], 1.37-4.56) and remission (22.0% vs 11.9%) (2.25; 1.11-4.54) at 6 months but not 12 months. Intervention participants reported more depression-free days during the 12 months (β = 19.3; 95% CI, 10.9-27.6; P Conclusion The HITIDES intervention improved depression and HIV symptom outcomes and may ser…
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In the HIV Translating Initiatives for Depression into Effective Solutions study, HIV patients were randomized to a clinical/delivery system intervention (collaborative care for depression) at 3 VA clinics, whereas the same clinics participated in a nonrandomized, exploratory implementation strategy as well.
“In another example (not in Table 4), the “HIV Translating Initiatives for Depression into Effective Solutions study,”35 human immunodeficiency virus (HIV) patients were randomized to a clinical/delivery system intervention (collaborative care for depression) at 3 VA clinics, whereas the same clinics participated in a nonrandomized, exploratory implementation strategy as well.”
From Effectiveness-implementation Hybrid Designs: Combining Elements of Clinical Effectiveness and Implementation Research to Enhance Public Health Impact (2012) · cites this paper as [35]
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- Authors
- Pyne, J. M., Fortney, J. C., Curran, G. M., Tripathi, S., Atkinson, J. H., Kilbourne, A. M., Hagedorn, H. J., Rimland, D., Rodriguez-Barradas, M. C., Monson, T., Bottonari, K. A., Asch, S. M., & Gifford, A. L.
- Affiliations
- Central Arkansas Veterans Healthcare System (US)
- University of California San Diego (US)
- University of Michigan (US)
- University of Minnesota (US)
- Emory University (US)
- Boston University (US)
- ORCID
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2010-11-08
- Volume
- 171
- Issue
- 1
- Pages
- 23-31
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2062018676
- Cited by
- 132
- References
- 11
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 13 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 15 · 2016: 8 · 2015: 15 · 2014: 4 · 2013: 11 · 2012: 12
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- collaborative care, depression, HIV, web-based decision support, treatment response, remission, medication adherence, health-related quality of life, veterans, antidepressant adherence, HIV treatment adherence, primary care integration, Veterans Affairs clinics
- MeSH terms
- Adult, Antidepressive Agents, Cooperative Behavior, Depression, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Nurse Administrators, Patient Care Team, Pharmacists, Primary Health Care, Psychiatry, Quality of Life, Severity of Illness Index, Time Factors, HIV Infections, Odds Ratio, Treatment Outcome, Anti-HIV Agents, Medication Adherence
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