CoChat
Sign Up
Cited by 266Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Levothyroxine Treatment of Subclinical Hypothyroidism, Fatal and Nonfatal Cardiovascular Events, and Mortality

Open access
Razvi, Salman, Weaver, Jolanta U., Butler, Timothy J., Pearce, Simon H. S.·2012·Archives of Internal Medicine
DOI 10.1001/archinternmed.2012.1159
Open this paper in CoChat — free account

Abstract

BACKGROUND Subclinical hypothyroidism (SCH) has been associated with ischemic heart disease (IHD); however, it is unknown whether treatment of SCH with levothyroxine sodium will reduce the risk of IHD. The aim of this study was to investigate the association between levothyroxine treatment of SCH with IHD morbidity and mortality. METHODS We used the United Kingdom General Practitioner Research Database to identify individuals with new SCH (serum thyrotropin levels of 5.01-10.0 mIU/L and normal free thyroxine levels) recorded during 2001 with outcomes analyzed until March 2009. All analyses were performed separately for younger (40-70 years) and older (>70 years) individuals. Hazard ratios (HRs) for IHD events (fatal and nonfatal) were calculated after adjustment for conventional IHD risk factors, baseline serum thyrotropin levels, and initiation of levothyroxine treatment as a time-dependent covariate. RESULTS Subclinical hypothyroidism was identified in 3093 younger and 1642 older individuals. For a median follow-up period of 7.6 years, 52.8% and 49.9% of younger and older patients with SCH were treated with levothyroxine, respectively. There were 68 incident IHD events in 1634 younger patients treated with levothyroxine (4.2%) vs 97 IHD events in 1459 untreated individuals (6.6%) (multivariate-adjusted HR, 0.61; 95% CI, 0.39-0.95). In contrast, in the older group there were 104 events in 819 treated patients (12.7%) vs 88 events in 823 untreated individuals (10.7%) (HR, 0.99; 95% CI, 0.59-1.33). CONCLUSIONS Treatment of SCH with levothyroxine was associated with fewer IHD events in younger individuals, but this was not evident in older people. An appropriately powered randomized controlled trial of levothyroxine in SCH examining vascular outcomes is now warranted.

Overview

Integrity signals

Registry

Crossref · 10.1001/archinternmed.2012.1159

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 30 references

Cited by

Sorted by citations

Items 101–200 of 266

Related

See all

Metadata

Authors
Razvi, S., Weaver, J. U., Butler, T. J., & Pearce, S. H. S.
Corresponding author
Razvi, Salman
ORCID
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2012-05-28
Volume
172
Issue
10
Pages
811-7
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinternmed.2012.1159
OpenAlex
W2127148210
Cited by
266
References
30
Citations by year
2026: 9 · 2025: 15 · 2024: 13 · 2023: 16 · 2022: 13 · 2021: 20 · 2020: 22 · 2019: 26 · 2018: 16 · 2017: 23 · 2016: 16 · 2015: 20 · 2014: 23 · 2013: 24 · 2012: 10
FWCI
19.73
Type
journal article
Language
en
Open access
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
Medical Research Council (G0500783)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, levothyroxine, ischemic heart disease, cardiovascular events, mortality, thyroid-stimulating hormone, age differences, thyroid hormone replacement, cardiovascular risk

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review