Alzheimer Degeneration in Down Syndrome: Electrophysiologic Alterations and Histopathologic Findings
Abstract
Progressive electroencephalographic disorganization and decreased voltage amplitude in the late components of the averaged visual evoked potentials were recorded in the last two years of life of a patient with Down disease and Alzheimer degeneration. Taken together with quantitative histopathologic findings, the electrophysiologic alterations are interpreted in terms of recent evidence from an experimental animal model of dementia. Neurons with neurofibrillary degeneration become electrically inactive and contribute to the loss of voltage generators associated with neuron death in Alzheimer disease. Loss of voltage generators may result in disfacillitation and disinhibition of surviving neurons, thus causing the loss of normal rhythms.
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Secreted Aβ40 and Aβ42 during HN cell aging has implications in the development of Aβ-related neuropathology and resembles Aβ deposition during brain aging and in AD.
“Secreted Aβ40 and Aβ42 during HN cell aging has implications in the development of Aβ-related neuropathology and resembles Aβ deposition during brain aging and in AD (Crapper et al., 1975; Pelvig et al., 2003; Terry, 1983).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Crapper et al., 1975
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- Authors
- Crapper, D. R.
- Corresponding author
- Crapper, Donald R.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1975-09-01
- Volume
- 32
- Issue
- 9
- Pages
- 618
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2085408531
- Cited by
- 93
- References
- 23
- Citations by year
- 2026: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2016: 1
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Down syndrome, Alzheimer's disease, neurofibrillary degeneration, visual evoked potentials, neuronal cell death, neurodegeneration
- MeSH terms
- Adult, Alzheimer Disease, Brain Stem, Cerebral Cortex, Dementia, Down Syndrome, Electroencephalography, Evoked Potentials, Humans, Male, Memory, Short-Term, Middle Aged, Psychological Tests, Thalamus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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