Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations
Abstract
Clinical records and neuropathological specimens from 36 patients with autopsy-demonstrated idiopathic Parkinson disease (PD) were reviewed independently and the results compared. Nine (31%) of the 29 patients with adequate clinical data had severe dementia and 7 (24%) had mild dementia. The cerebral cortex showed senile plaques and fibrillary tangles in 15 of the 36 patients (42%). These changes were found in all 9 patients with severe dementia, in 3 of the 7 with mild dementia, and in 3 of the 13 patients with normal mental status. The prevalence of pathologically established Alzheimer changes and dementia among the patients with PD (33%) was over six times that found in an age-matched population (5.1%). Survival after the onset of PD with Alzheimer disease was shorter than in PD without Alzheimer disease.
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In Lewy body dementia, Lewy related pathology affects corticolimbic regions and is often associated with concurrent Alzheimer type pathologic change.
“In Lewy body dementia, Lewy related pathology affects corticolimbic regions and is often associated with concurrent Alzheimer type pathologic change [120, 121].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [120]
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“In Lewy body dementia, Lewy related pathology affects corticolimbic regions and is often associated with concurrent Alzheimer type pathologic change [120, 121].”
BackgroundClassification and basic pathology of Alzheimer disease
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- Authors
- Boller, F., Mizutani, T., Roessmann, U., & Gambetti, P.
- Affiliations
- Case Western Reserve University (US)
- ORCID
- Gambetti, Pierluigi
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1980-04
- Volume
- 7
- Issue
- 4
- Pages
- 329-335
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2048391579
- Cited by
- 451
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 17.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Parkinson's disease, dementia, Alzheimer's disease, clinicopathological correlation, amyloid plaques, neurofibrillary tangles, cerebral cortex
- MeSH terms
- Age Factors, Aged, Alzheimer Disease, Cerebral Cortex, Dementia, Female, Hippocampus, Humans, Male, Middle Aged, Parkinson Disease, Neurocognitive Disorders
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