The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis
Abstract
Objective Immunohistochemical examination was undertaken to assess the presence of lymphocytes and lymphocyte subsets in the spinal cord in amyotrophic lateral sclerosis (ALS). Design Twenty-seven consecutive ALS autopsy cases and 11 consecutive disease--control autopsy cases were examined. Tissue sections were reacted with mouse monoclonal antibody to human leukocyte common antigen, or monoclonal antibody to human B-cell L26 antigen, and detected with immunoperoxidase techniques. Unfixed sections were reacted with antihuman Leu-3a and Leu-3b/CD4 or antihuman Leu-2a/CD8 mouse monoclonal antibody and then detected with peroxidase techniques. Setting Tertiary care hospital. Cases Amyotrophic lateral sclerosis and non-ALS control autopsy specimens. Main outcome measure Detection of lymphocytes by histological and immunohistochemical reactivity. Results Perivascular and intraparenchymal lymphocytic infiltrates were found in the spinal cord of 18 of 27 consecutive ALS autopsy cases. The lymphocytes possessed only T-cell markers; no B-cell markers could be demonstrated. T-helper cells were found in proximity to degenerating corticospinal tracts, while T-helper and T-suppressor/cytotoxic cells were demonstrated in ventral horns. Lymphocytes were present in the spinal cord of only one control specimen (multiple sclerosis) and in none of the remaining 10 control specimens. In ALS tissue, the lymphocytic infiltrates did not correlate with the rate of progression or stage of the disease…
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“These findings support earlier observations showing that the BBB and BSCB are damaged in a subset of ALS patients as demonstrated by accumulation of plasma-derived IgG in the spinal cord and motor cortex in 40% (154) to 90% (163) of studied cases, and accumulation of peripheral blood cells in 70% (164) to 100% (599) of studied cases.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [164]
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Cites
Somogyi, P., & Takagi, H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90035-5 · Cited by 572
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.
Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546
Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
McGeer, P. L., Itagaki, S., & McGeer, E. G. (1988) · Acta Neuropathologica · doi:10.1007/bf00689592 · Cited by 420
Diagnosis of Human Lymphoma with Monoclonal Antileukocyte Antibodies
Warnke, R. A., Gatter, K. C., Falini, B., Hildreth, P. D. K., Woolston, R.-E., Pulford, K. A. F., Cordell, J., Cohen, B., Wolf‐Peeters, C. D., & Mason, D. Y. (1983) · New England Journal of Medicine · doi:10.1056/nejm198311243092102 · Cited by 366
Engleman, E. G., Benike, C. J., Glickman, E., & Evans, R. L. (1981) · The Journal of Experimental Medicine · doi:10.1084/jem.154.1.193 · Cited by 301
IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis
Engelhardt, J. I., & Appel, S. H. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110068019 · Cited by 221
Self-citationSerum antibodies to GM 1 ganglioside in amyotrophic lateral sclerosis
Pestronk, A., Adams, R. N., Clawson, L., Cornblath, D. R., Kuncl, R. W., Griffin, D. E., & Drachman, D. B. (1988) · Neurology · doi:10.1212/wnl.38.9.1457 · Cited by 152
Cartun, R. W., Coles, F. B., & Pastuszak, W. (1987) · PubMed · Cited by 139
Lampson, L. A., Kushner, P. D., & Sobel, R. A. (1990) · Annals of Neurology · doi:10.1002/ana.410280311 · Cited by 128
Appel, S. H. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520030026007 · Cited by 105
Self-citationPatterns of serum IgM antibodies to GM1 and GD1a gangliosides in amyotrophic lateral sclerosis
Pestronk, A., Adams, R. N., Cornblath, D. R., Kuncl, R. W., Drachman, D. B., & Clawson, L. (1989) · Annals of Neurology · doi:10.1002/ana.410250118 · Cited by 103
Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis.
Troost, D., van den Oord, J. J., de Jong, J. M. B. V., & Swaab, D. F. (1989) · PubMed · Cited by 101
Experimental autoimmune motoneuron disease
Engelhardt, J. I., Appel, S. H., & Killian, J. M. (1989) · Annals of Neurology · doi:10.1002/ana.410260310 · Cited by 79
Self-citationAmyotrophic lateral sclerosis: An unconventional autoimmune disease?
Drachman, D. B., & Kuncl, R. W. (1989) · Annals of Neurology · doi:10.1002/ana.410260214 · Cited by 76
Bahmanyar, S., Moreau-Dubois, M.-C., Brown, P., Cathala, F., & Gajdusek, D. C. (1983) · Journal of Neuroimmunology · doi:10.1016/0165-5728(83)90009-7 · Cited by 71
Engelhardt, J. I., Appel, S. H., & Killian, J. M. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90132-7 · Cited by 65
Self-citationUptake of plasma IgG by CNS motoneurons
Fabian, R. H. (1988) · Neurology · doi:10.1212/wnl.38.11.1775 · Cited by 51
IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscle
Delbono, O., Garcia, J., Appel, S. H., & Stefani, E. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.6.c1347 · Cited by 41
Self-citationAntineural antibodies in the serum of patients with amyotrophic lateral sclerosis
Brown, R. H., Johnson, D. K., Ogonowski, M., & Weiner, H. L. (1987) · Neurology · doi:10.1212/wnl.37.1.152 · Cited by 40
Neuropathology : methods and diagnosis
Tedeschi, C. G., & Foley, J. M. (1970) · Little, Brown eBooks · Cited by 36
Appel, S. H., Engelhardt, J. I., García, J., & Stefani, E. (1991) · PubMed · Cited by 22
Self-citationLongitudinal spinal cord sections as substratum for anti-neurofilament antibody detection
Bahmanyar, S., Gajdusek, D. C., Sotelo, J., & Gibbs, C. J. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90082-x · Cited by 20
Antibodies against fetal muscle proteins in serum from patients with amyotrophic lateral sclerosis
Ordóñez, G., & Sotelo, J. (1989) · Neurology · doi:10.1212/wnl.39.5.683 · Cited by 15
Motor neuron reactivity of sera from animals with autoimmune models of motor neuron destruction
Engelhardt, J. I., & Appel, S. H. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90143-b · Cited by 14
Self-citationPanzara, M. A., Oksenberg, J. R., Begovich, A. B., Erlich, H., Murray, R. S., Appel, S. H., & Steinman, L. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90984-f · Cited by 4
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The changing scene of amyotrophic lateral sclerosis
Robberecht, W., & Philips, T. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3430 · Cited by 957
Raivich, G., Bohatschek, M., Kloss, C. U. A., Werner, A., Jones, L. L., & Kreutzberg, G. W. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00007-7 · Cited by 843
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Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N., & Banati, R. B. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.012 · Cited by 737
Metadata
- Authors
- Engelhardt, J. I., Tajti, J., & Appel, S. H.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1993-01-01
- Volume
- 50
- Issue
- 1
- Pages
- 30-36
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2069781018
- Cited by
- 318
- References
- 25
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 14 · 2023: 19 · 2022: 20 · 2021: 10 · 2020: 16 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 14 · 2012: 19
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyotrophic lateral sclerosis, spinal cord, lymphocyte infiltration, T cells, T helper cells, suppressor/cytotoxic T cells, corticospinal tract degeneration, ventral horn, B cells, CD45, CD4, CD8, neuroinflammation
- MeSH terms
- Adult, Aged, Amyotrophic Lateral Sclerosis, B-Lymphocytes, Female, Humans, Male, Middle Aged, Spinal Cord, CD4-Positive T-Lymphocytes, CD4 Antigens, CD8 Antigens, Leukocyte Common Antigens, T-Lymphocytes, Regulatory
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