Appel, Stanley H.

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 966

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

Beers, D. R., Henkel, J. S., Xiao, Q., Zhao, W., Wang, J., Yen, A. A., Siklos, L., McKercher, S. R., & Appel, S. H. (2006) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 733

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

Miller, T. M., Pestronk, A., David, W., Rothstein, J., Simpson, E., Appel, S. H., Andres, P. L., Mahoney, K., Allred, P., Alexander, K., et al. (2013) · The Lancet Neurology

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 617

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica

Barrier Structure and Function StudiesAmyotrophic Lateral Sclerosis Research

Cited by 354

Microglia in ALS: The Good, The Bad, and The Resting

Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 353

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

Engelhardt, J. I., Tajti, J., & Appel, S. H. (1993) · Archives of Neurology

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 318

Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury

Zhao, W., Beers, D. R., Henkel, J. S., Zhang, W., Urushitani, M., Julien, J., & Appel, S. H. (2010) · Glia

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 288

TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

Cady, J., Koval, E. D., Benitez, B. A., Zaidman, C., Jockel-Balsarotti, J., Allred, P., Baloh, R. H., Ravits, J., Simpson, E., Appel, S. H., et al. (2014) · JAMA Neurology

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 262

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

Appel, S. H., Beers, D. R., & Henkel, J. S. (2010) · Trends in Immunology

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 256

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

Zhao, W., Beers, D. R., Bell, S., Wang, J., Wen, S., Baloh, R. H., & Appel, S. H. (2015) · Experimental Neurology

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 241

TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss

Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M.-Y., et al. (2017) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 239

Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis

Dunckley, T., Huentelman, M. J., Craig, D. W., Pearson, J. V., Szelinger, S., Joshipura, K., Halperin, R. F., Stamper, C., Jensen, K. R., Letizia, D., et al. (2007) · New England Journal of Medicine

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 236

IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis

Engelhardt, J. I., & Appel, S. H. (1990) · Archives of Neurology

Amyotrophic Lateral Sclerosis ResearchPeripheral Neuropathies and Disorders

Cited by 221

Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia

Xiao, Q., Zhao, W., Beers, D. R., Yen, A. A., Xie, W., Henkel, J. S., & Appel, S. H. (2007) · Journal of Neurochemistry

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 174

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

Henkel, J. S., Beers, D. R., Wen, S., Bowser, R., & Appel, S. H. (2009) · Neurology

Barrier Structure and Function StudiesAmyotrophic Lateral Sclerosis Research

Cited by 153

Functional alterations of myeloid cells during the course of Alzheimer’s disease

Thome, A. D., Faridar, A., Beers, D. R., Thonhoff, J. R., Zhao, W., Wen, S., Pascual, B., Masdeu, J. C., & Appel, S. H. (2018) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 83

Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: Examining a more efficient trial design

Miller, R. G., Moore, D. H., Forshew, D. A., Katz, J. S., Barohn, R. J., Valan, M., Bromberg, M. B., Goslin, K. L., Graves, M. C., McCluskey, L. F., et al. (2011) · Neurology

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 70

Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade

Whitson, J. S., & Appel, S. H. (1995) · Neurobiology of Aging

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 41

Apolipoprotein E ɛ4 in bulbar-onset motor neuron disease

Smith, R. G., Haverkamp, L. J., Case, S., Appel, V., & Appel, S. H. (1996) · The Lancet

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 37