Cited by 517Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., Perl, D. P.·1995·Archives of Neurology

DOI 10.1001/archneur.1995.00540250089017

Open this paper in CoChat — free account

Abstract

OBJECTIVE: To determine the relationships between dementia severity and the extent of histopathologic lesions in a variety of brain regions. Neocortical and hippocampal ratings for neurofibrillary tangles (NFTs) and senile plaques (SPs) were compared in 70 cases of clinically and neuropathologically confirmed Alzheimer's disease. DESIGN: Neuropathologic case series. Dementia severity was assessed by postmortem chart review with use of the extended Clinical Dementia Rating Scale (CDR). Linear association between CDR scores and NFT and SP scores were assessed by partial correlation, controlling for age at death. SETTING: Studies were conducted at the Alzheimer's Disease Research Center of the Mount Sinai Medical Center, New York, NY. MAIN OUTCOME MEASURE: Association between CDR scores and neuropathologic changes assessed with the Consortium to Establish a Registry for Alzheimer's Disease semiquantitative scale. RESULTS: Among these lesion scores, only NFTs showed a significant association with CDR score, and only for neocortical regions. In particular, NFT densities in the superior temporal cortex were most strongly correlated with dementia severity, followed by those in the inferior parietal and midfrontal cortex. No such correlations were apparent for the amygdala, hippocampus, or entorhinal cortex. Medial temporal lobe structures displayed high NFT scores, even in cases of mild dementia. Senile plaques did not correlate significantly with CDR score in any region. CONCLUSIONS: These data support the notion that neocortical neuronal degeneration, as indicated by NFT formation, is a critical determinant of the clinical progression of Alzheimer's disease and suggest that medial temporal lobe structures may represent the initial site of NFT formation. While SP density correlates with age at death, there is no correlation between SP counts and dementia severity. These results further suggest that the clinical presentation of dementia may be closely related to neurodegeneration in neocortical regions within the temporal lobe.

Integrity signals

Registry

Crossref · 10.1001/archneur.1995.00540250089017

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380

Show all 40 references

Sorted by citations

Items 301–400 of 517

Proposals for Re-evaluation of Current Autopsy Criteria for the Diagnosis of Alzheimer’s Disease
Jellinger, K. A., & Bancher, C. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00071-7 · Cited by 23
The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition
Eskandari-Sedighi, G., Daude, N., Gapeshina, H., Sanders, D. W., Kamali-Jamil, R., Yang, J., Shi, B., Wille, H., Ghetti, B., Diamond, M. I., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0215-7 · Cited by 22
Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.
Kow, R. L., Strovas, T. J., McMillan, P. J., Jacobi, A. M., Behlke, M. A., Saxton, A. D., Latimer, C. S., Keene, C. D., & Kraemer, B. C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105148 · Cited by 22
Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Hoglund, Z. T., Ruiz‐Uribe, N. E., del Sastre, E., Woost, B., Bader, E., Bailey, J. J., Hyman, B. T., Zwang, T. J., & Bennett, R. E. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02751-9 · Cited by 22
Neocortical Variation of Aβ Load in Fully Expressed, Pure Alzheimer's Disease
Cupidi, C., Capobianco, R., Goffredo, D., Marcon, G., Ghetti, B. F., Bugiani, O., Tagliavini, F., & Giaccone, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1205 · Cited by 22
Magnetic resonance imaging of Alzheimer's disease
Xanthakos, S. A., Krishnan, K. R. R., Kim, D. M., & Charles, H. C. (1996) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(96)00035-8 · Cited by 22
Cortical load of PHF-tau in Alzheimer's disease is correlated to cholinergic dysfunction
Arendt, T., Holzer, M., Gertz, H., & Brückner, M. K. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050175 · Cited by 23
PM2.5 triggers tau aggregation in a mouse model of tauopathy
Liu, C., Meng, L., Gao, Y., Chen, J., Zhu, M., Xiong, M., Xiao, T., Gu, X., Liu, C., Li, T., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.176703 · Cited by 22
Primary age-related tauopathy
Richardson, T. E., Walker, J. M., Farrell, K. W., Oliveira, T. G., White, C. L., & Crary, J. F. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02943-x · Cited by 25
Differential Binding and Conformational Dynamics of Tau Microtubule-Binding Repeats with a Preformed Amyloid-β Fibril Seed
Song, Z., Gatch, A. J., Sun, Y., & Ding, F. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00014 · Cited by 21
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 25
Exposure to 3-Nitropropionic Acid Mitochondrial Toxin Induces Tau Pathology in Tangle-Mouse Model and in Wild Type-Mice
Lahiani-Cohen, I., Touloumi, O., Lagoudaki, R., Grigoriadis, N., & Rosenmann, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00321 · Cited by 21
Should Alzheimer's disease be equated with human brain ageing?: A maladaptive interaction between brain evolution and senescence
Neill, D. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.06.004 · Cited by 22
Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys
Ridley, R. M., Baker, H. F., Leow-Dyke, A., & Cummings, R. M. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.02.025 · Cited by 21
Two distinct subgroups of senile dementia of Alzheimer type: Quantitative study of neurofibrillary tangles
Mizuno, Y., Ikeda, K., Tsuchiya, K., Ishihara, R., & Shibayama, H. (2003) · Neuropathology · doi:10.1046/j.1440-1789.2003.00514.x · Cited by 21
Alzheimer's Disease Pathology in Non-Demented Elderly
Kazee, A. M., & Johnson, E. M. (1998) · Journal of Alzheimer s Disease · doi:10.3233/jad-1998-1202 · Cited by 21
Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease
Lee, W. J., Cho, H., Baek, M. S., Kim, H., Lee, J., Ryu, Y. H., Lyoo, C. H., & Seong, J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01061-0 · Cited by 20
In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models
Higuchi, M., Maeda, J., Ji, B., Maruyama, M., Okauchi, T., Tokunaga, M., Ono, M., & Suhara, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.003 · Cited by 20
Phosphoproteome analysis of an early onset mouse model ( T g CRND 8) of A lzheimer's disease reveals temporal changes in neuronal and glia signaling pathways
Wang, F., Blanchard, A. P., Elisma, F., Granger, M. W., Xu, H., Bennett, S. A. L., Figeys, D., & Zou, H. (2013) · PROTEOMICS · doi:10.1002/pmic.201200415 · Cited by 20
Progressive tauopathy in P301S tau transgenic mice is associated with a functional deficit of the olfactory system
Yang, S., Kuan, W., & Spillantini, M. G. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13333 · Cited by 20
GERIATRIC BIOSCIENCE: Hippocampal and Neocortical Involvement in Normal Brain Aging and Dementia: Morphological and Neurochemical Profile of the Vulnerable Circuits
Hof, P. R., & Morrison, J. H. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb03748.x · Cited by 20
Self-citation
Human in vivo evidence of associations between herpes simplex virus and cerebral amyloid-beta load in normal aging
Cantero, J. L., Atienza, M., Sastre, I., & Bullido, M. J. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01437-4 · Cited by 19
Characterization of Japanese-American men with a single neocortical AD lesion type
Petrovitch, H., Ross, G. W., He, Q., Uyehara‐Lock, J. H., Markesbery, W. R., Davis, D. G., Nelson, J. R., Masaki, K., Launer, L. J., & White, L. R. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.026 · Cited by 19
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration
Kow, R. L., Black, A. H., Saxton, A. D., Liachko, N. F., & Kraemer, B. C. (2022) · GeroScience · doi:10.1007/s11357-022-00526-2 · Cited by 18
Alzheimer’s Disease: Current Perspectives and Advances in Physiological Modeling
Boder, E. J., & Banerjee, I. A. (2021) · Bioengineering · doi:10.3390/bioengineering8120211 · Cited by 18
Physical activity improves the visual–spatial working memory of individuals with mild cognitive impairment or Alzheimer’s disease: a systematic review and network meta-analysis
Deng, J., Wang, H., Fu, T., Xu, C., Zhu, Q., Guo, L., & Zhu, Y. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1365589 · Cited by 17
Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity?
Walker, L. C., Rosen, R. F., & LeVine, H. (2008) · PubMed · Cited by 17
Spatial Analysis of the Neuronal Density of Aminergic Brainstem Nuclei in Primary Neurodegenerative and Vascular Dementia: A Comparative Immunocytochemical and Quantitative Study Using a Graph Method
Yang, Y. M., Beyreuther, K. T., & Schmitt, H. P. (1999) · Analytical Cellular Pathology · doi:10.1155/1999/256382 · Cited by 17
Apolipoprotein E allelotype is associated with neuropathological findings in Alzheimer's disease
Kumar, N. T., Liestøl, K., Løberg, E. M., Reims, H. M., & Mæhlen, J. (2015) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-015-1772-1 · Cited by 16
SPOP loss of function protects against tauopathy
Eck, R. J., Kow, R. L., Black, A. H., Liachko, N. F., & Kraemer, B. C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207250120 · Cited by 16
Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases
Lester, E., & Parker, R. (2023) · The Neuroscientist · doi:10.1177/10738584231154551 · Cited by 16
Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses
Huang, Y., Hong, X., Shen, J. X., Geng, L.-J., Pan, Y.-H., Ling, W., & Zhao, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02980 · Cited by 16
Lewy Body Dementia
Brown, D. F. (1999) · Annals of Medicine · doi:10.3109/07853899909115977 · Cited by 16
Design-led synthesis and multidimensional evaluation of novel thiadiazoles as multitarget anti-Alzheimer agents: kinetics, DFT and in silico mapping
Khan, S. A., Iqbal, T., Ali, I., Askar, K. A., Fathalla, M., Alzahrani, E., Din, N. U., Kashtoh, H., & Almehizia, A. A. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109564 · Cited by 15
Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology
Yuraszeck, T. M., Neveu, P. A., Rodriguez-Fernández, M., Robinson, A. S., Kosik, K. S., & Doyle, F. J. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000997 · Cited by 15
Should development of Alzheimer¿s disease-specific intravenous immunoglobulin be considered?
Loeffler, D. A. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0198-z · Cited by 15
Astrocytic tau pathology positively correlates with neurofibrillary tangle density in progressive supranuclear palsy
Ito, K., Arai, K., Yoshiyama, Y., Kashiwado, K., Sakakibara, Y., & Hattori, T. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0378-y · Cited by 16
Gene Knockout of tau Expression Does Not Contribute to the Pathogenesis of Prion Disease
Lawson, V., Klemm, H. M. J., Welton, J. M., Masters, C. L., Crouch, P. J., Cappai, R., & Ciccotosto, G. D. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318235b471 · Cited by 15
Subtle Changes in the Ageing Human Brain
Chance, S. A. (2006) · Nutrition and Health · doi:10.1177/026010600601800303 · Cited by 15
Involvement of ubiquitination in Alzheimer’s disease
Lin, N., Gao, X., Li, X., & Chu, W.-M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1459678 · Cited by 15
Co-Expression of Three Wild-Type 3R-Tau Isoforms Induces Memory Deficit via Oxidation-Related DNA Damage and Cell Death: A Promising Model for Tauopathies
Xu, C., Guo, J., Li, L., Wang, X., Zhou, Q., Sun, D., Zhang, S., Li, S., Ye, J., Liu, Y., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-191132 · Cited by 14
Recent Advances in Molecular Dynamics Simulations of Tau Fibrils and Oligomers
Barredo, P. A., & Balanay, M. P. (2023) · Membranes · doi:10.3390/membranes13030277 · Cited by 14
Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus
Dayton, R. D., Wang, D. B., Cain, C. D., Schrott, L. M., Ramirez, J. J., King, M. A., & Klein, R. L. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.002 · Cited by 16
Role of amyloid β peptides in the regulation of central cholinergic function and its relevance to Alzheimer's disease pathology
Kar, S. (2002) · Drug Development Research · doi:10.1002/ddr.10080 · Cited by 14
Contribution of 1H Spectroscopy to a Brief Cognitive-Functional Test Battery for the Diagnosis of Mild Alzheimer’s Disease
de Souza, A. S., de Oliveira‐Souza, R., Moll, J., Tovar-Moll, F. F., Andreiuolo, P. Â., & Bottino, C. M. C. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000334656 · Cited by 14
Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease
Ohm, D. T., Fought, A. J., RADEMAKER, A. W., Kım, G., Sridhar, J., Coventry, C., Gefen, T. D., Weıntraub, S., Bigio, E. H., Mesulam, M. M., et al. (2019) · Brain Pathology · doi:10.1111/bpa.12783 · Cited by 14
Environmental reduplicative paramnesia in a case of atypical Alzheimer’s disease
von Gunten, A., Miklossy, J., Suvà, M.-L., Hof, P. R., & Glannakopoulos, P. (2005) · Neurocase · doi:10.1080/13554790590944825 · Cited by 13
Self-citation
Pre-aggregated Aβ1–42 peptide increases tau aggregation and hyperphosphorylation after short-term application
Ott, S., Henkel, A. W., Henkel, M. K., Redzic, Z. B., Kornhuber, J., & Wiltfang, J. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0671-7 · Cited by 13
(S)-[18F]THK5117 brain uptake is associated with Aβ plaques and MAO-B enzyme in a mouse model of Alzheimer's disease
Alzghool, O. M., Rokka, J., Lopez‐Picon, F. R., Snellman, A., Helin, J. S., Okamura, N., Solin, O. H., Rinne, J. O., & Haaparanta‐Solin, M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108676 · Cited by 12
Modeling regional vulnerability to Alzheimer pathology
Royall, D. R., Palmer, R. F., Petrovitch, H., Ross, G. W., Masaki, K., & White, L. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.028 · Cited by 12
Tau Positron Emission Tomography Imaging in Degenerative Parkinsonisms
Lyoo, C. H., Cho, H., Choi, J. Y., Ryu, Y. H., & Lee, M. S. (2018) · Journal of Movement Disorders · doi:10.14802/jmd.17071 · Cited by 12
Clinical Aspects of Alzheimer’s Disease
Kurz, A., & Lauter, H. (2001) · Springer eBooks · doi:10.1007/978-3-642-59519-6_70 · Cited by 12
Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer’s Disease
Tredici, K. D., Schön, M., Feldengut, S., Ghebremedhin, E., Kaufman, S. K., Wiesner, D., Roselli, F., Mayer, B., Amunts, K., & Braak, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240483 · Cited by 11
The Temporospatial Evolution of Neuritic Plaque-Related and Independent Tauopathies: Implications for Dementia Staging
Royall, D. R., & Palmer, R. F. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131733 · Cited by 11
Untangle the mystery behind DS-associated AD – Is APP the main protagonist?
Elangovan, A., Babu, H. W. S., Iyer, M., Gopalakrishnan, A. V., & Vellingiri, B. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101930 · Cited by 12
Phos-tau peptide immunization of amyloid-tg-mice reduced non-mutant phos-tau pathology, improved cognition and reduced amyloid plaques
Benhamron, S., Rozenstein‐Tsalkovich, L., Nitzan, K., Abramsky, O., & Rosenmann, H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.02.004 · Cited by 11
Development of tau-directed Small Molecule Modulators for Alzheimer’s Disease: a Recent Patent Review (2014–2018)
Lee, H. E., Lim, D., Lee, J. Y., Lim, S. M., & Pae, A. N. (2019) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2019-0003 · Cited by 11
High-throughput quantification of Alzheimer’s disease pathological markers in the post-mortem human brain
Byrne, U. T. E., Ross, J., Faull, R. L. M., & Dragunow, M. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.09.008 · Cited by 11
Pathological Diagnosis of Alzheimer’s Disease
Geula, C. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-005-6_3 · Cited by 11
Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized with DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins
García‐Arriaza, J., Marín, M. Q., Merchán‐Rubira, J., Mascaraque, S. M., Medina, M., Ávila, J., Hernández, F., & Estéban, M. (2020) · Vaccines · doi:10.3390/vaccines8010127 · Cited by 11
Neuroimaging Biomarkers in Alzheimer’s Disease
Khan, T. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804832-0.00003-1 · Cited by 11
In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents
Ogawa, K., & Shiba, K. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/4535476 · Cited by 11
Therapeutic Approaches to Delay the Onset of Alzheimer's Disease
Kumar, R., & Atamna, H. (2011) · Journal of Aging Research · doi:10.4061/2011/820903 · Cited by 10
Part III. Neuropathology of Alzheimer's disease
Arnold, S. E. (2000) · Disease-a-Month · doi:10.1016/s0011-5029(00)90030-0 · Cited by 10
The Ratio of Mesial to Neocortical Temporal Lobe Blood Flow as a Predictor of Dementia
Cohen, R. M., Andreason, P., & Sunderland, T. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb00948.x · Cited by 10
Small‐diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease
Fertan, E., Meisl, G., & Klenerman, D. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70462 · Cited by 10
Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
Levert, S., Pilliod, J., Aumont, É., Armanville, S., Tremblay, C., Calon, F., & Leclerc, N. M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03121-w · Cited by 9
Effects of External Beam Radiation onIn VitroFormation of Abeta1-42 Fibrils and Preformed Fibrils
Patrias, L. M., Klaver, A. C., Coffey, M. P., Finke, J. M., Digambaranath, J. L., Dang, L., Martinez, A. A., & Loeffler, D. A. (2011) · Radiation Research · doi:10.1667/rr2448.1 · Cited by 9
Research Progress in the Molecular Mechanism of NLRP3 Inflammasome in Alzheimer’s Disease and Regulation by Natural Plant Products
Zu, R., Hao, L., Liu, W., Shao, S., Zheng, J., Ying, X., Zhou, Y., Li, Z., Wang, W., Li, D., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04715-w · Cited by 8
Alzheimer’s: Epidemiology, Pathophysiology, Diagnosis, and Treatments
Rahman, A. T. F., Jaiswal, A., Keshari, P., & Singh, D. K. (2025) · Springer eBooks · doi:10.1007/978-981-96-6202-9_2 · Cited by 9
Age-dependent impairment of memory and neurofibrillary tangle formation and clearance in a mouse model of tauopathy
Kubota, T., & Kirino, Y. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147496 · Cited by 8
Stereological Quantification of Plaques and Tangles in Neocortex from Alzheimer’s Disease Patients
Madsen, J. B., Folke, J., & Pakkenberg, B. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180105 · Cited by 9
Morphological Changes in Human Cerebral Cortex during Normal Aging
Bussière, T., & Hof, P. R. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50009-3 · Cited by 8
Self-citation
Tau Phosphorylation
Buée, L., & Delacourte, A. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50023-8 · Cited by 8
Alzheimer’s Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies
Hales, C. M. (2024) · Medical Clinics of North America · doi:10.1016/j.mcna.2024.10.003 · Cited by 7
Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer’s disease
Vickers, J. C., Tan, A., & Dickson, T. C. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02429-6 · Cited by 7
Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer’s disease differ according to disease severity and amyloid positivity
Park, J. E., Yun, J., Kim, S. J., Shim, W. H., Oh, J. S., Oh, M., Roh, J. H., Seo, S. W., Oh, S. J., & Kim, J. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226265 · Cited by 7
Neuropathologic correlates of trial-related instruments for Alzheimer's disease.
Cummings, J. L., Ringman, J. M., & Vinters, H. V. (2014) · Europe PMC (PubMed Central) · Cited by 7
Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseasePreprint
Travaglini, K. J., Gabitto, M. I., Ding, Y., Agrawal, A., Postupna, N. O., Mahoney, J. T., Kaplan, E. S., Melief, E. J., Goldy, J., Chakka, A. B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.01.734821 · Cited by 7
Deciphering the Structural Biology of GFAP: Connotations of Its Potency in Presaging the Diagnosis for Traumatic Brain Injury and AD
Kanuri, S. H., & Sirrkay, P. J. (2025) · Neurology International · doi:10.3390/neurolint17090134 · Cited by 7
Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer’s Disease
Colato, E., Initiative, A. D. N., Chiotis, K., Ferreira, D., Mazrina, M. S., Lemoine, L., Mohanty, R., Westman, E., Nordberg, A. K., & Rodriguez‐Vieitez, E. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210614 · Cited by 7
Regional times to equilibria and their impact on semi-quantification of [ 18 F]AV-1451 uptake
Heurling, K., Smith, R. A., Strandberg, O. T., Schain, M., Ohlsson, T. G., Hansson, O., & Schöll, M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18791430 · Cited by 6
Brain aging, Alzheimer's disease, and the role of stem cells in primate comparative studies
August, I., Semendeferi, K., & Marchetto, M. C. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25394 · Cited by 6
Patterns of Cortical Neurodegeneration in Alzheimer's Disease: Subgroups, Subtypes, and Implications for Staging Strategies
Vogt, B. A., Vogt, L. J., & Hof, P. R. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50012-3 · Cited by 6
Self-citation
Klinische Aspekte der Alzheimer-Krankheit
Kurz, A., & Lauter, H. (1999) · Springer eBooks · doi:10.1007/978-3-642-60175-0_5 · Cited by 6
Neuroimaging Biomarkers in Alzheimer’s Disease
Tripathi, S. M., Chutia, P., & Murray, A. D. (2025) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad2040037 · Cited by 7
Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer’s disease
Dallmeier, J., Gober, R., Vontell, R., Barreda, A., Dorfsman, D. A., Davis, D. A., Sun, X., Brzostowicki, D. J., Bennett, I., Garamszegi, S. P., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1286924 · Cited by 5
A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence
Soeda, Y., Hayashi, E., Nakatani, N., Ishigaki, S., Takaichi, Y., Tachibana, T., Riku, Y., CHAMBERS, J. K., Koike, R., Mohammad, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65949-7 · Cited by 5
Unravelling Alzheimer's Disease: It's Not the Whole Story, but Aβ Still Matters
Buxbaum, J. N. (2019) · The FASEB Journal · doi:10.1096/fj.201901895 · Cited by 5
Tau fibril with membrane lipids: Insight from computational modeling and simulations
Barredo, P. A., Fernandez, M. J. F., Ambe, C. E., & Balanay, M. P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258692 · Cited by 5
Short-Term Pharmacological Induction of Arterial Stiffness and Hypertension with Angiotensin II Does Not Affect Learning and Memory and Cerebral Amyloid Load in Two Murine Models of Alzheimer’s Disease
Hendrickx, J. O., Calus, E., Deyn, P. P. D., Dam, D. V., & Meyer, G. R. Y. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052738 · Cited by 5
Dale Schenk One Year Anniversary: Fighting to Preserve the Memories
Overk, C., & Masliah, E. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171071 · Cited by 5
Cerebrospinal fluid phosphorylated tau proteins as predictors of Alzheimer’s disease in subjects with mild cognitive impairment
Šimić, G., Boban, M., & Hof, P. R. (2008) · University of Zagreb University Computing Centre (SRCE) · Cited by 5
Self-citation
Neuropathological Correlates of Dementia in Alzheimer’s Disease
Masliah, E., & Salmon, D. P. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_15 · Cited by 5
Multifocal Cortical Neurodegeneration in Alzheimer’s Disease
Vogt, B. A., Martin, A. D., Vrana, K. E., Absher, J. R., Vogt, L. J., & Hof, P. R. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_16 · Cited by 5
Self-citation
The impact of age and Alzheimer’s disease on locus coeruleus mediated neuromodulation of neural circuits and goal-directed behaviorPreprint
Joshi, S. (2023) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/bqwte · Cited by 5
Evolution of Human Susceptibility to Alzheimer's Disease: A Review of Hypotheses and Comparative Evidence
August, I., Gagneux, P., Semendeferi, K., & Marchetto, M. C. (2025) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.22054 · Cited by 4
Assessing the critical role of ceramide in the pathogenesis of Alzheimer's disease and its clinical significance
Huang, Y., Chan, H., Khoo, J.-Y., Chan, M.-L., Bender, D. A., Ponnusamy, V. K., Belaidi, A. A., & Ke, L. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106104 · Cited by 4
Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model
Parka, A., Volbracht, C., Hall, B. J., Bastlund, J. F., Nedergaard, M., Laursen, B., Botta, P., & Sotty, F. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220964 · Cited by 4
The Role of T Cells in Alzheimer's Disease Pathogenesis
Zhao, J., Wang, X., He, Y., Xu, P., Lai, L., Chung, Y., & Pan, X. (2023) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2023050145 · Cited by 4

Authors: Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
ORCID: Hof, P. R.
Purohit, D. P.
Schmeidler, J.
Davis, K. L.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1995-01-01
Volume: 52
Issue: 1
Pages: 81-88
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1995.00540250089017
OpenAlex: W2084957666
Cited by: 514
References: 40
Citations by year: 2026: 7 · 2025: 16 · 2024: 15 · 2023: 22 · 2022: 24 · 2021: 27 · 2020: 21 · 2019: 25 · 2018: 23 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 18 · 2013: 14 · 2012: 14
FWCI: 10.16
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-02219, AG 05138, P50AG005138, AG-00408, P01AG002219)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, neurofibrillary tangles, dementia severity, amyloid plaques, neocortex, hippocampus, medial temporal lobe, superior temporal cortex, inferior parietal cortex, Clinical Dementia Rating, neuropathology, neurodegeneration, clinical progression
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Female, Humans, Male, Middle Aged, Neurofibrillary Tangles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks