The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cerebral White Matter Lesions and the Risk of Dementia
Abstract
OBJECTIVE: To study the association between white matter lesions (WML) in specific locations and the risk of dementia. DESIGN: The Rotterdam Scan Study, a prospective population-based cohort study. We scored periventricular and subcortical WML on magnetic resonance imaging and observed participants until January 2002 for incident dementia. SETTING: General population. PARTICIPANTS: We included 1077 people aged 60 to 90 years who did not have dementia at baseline. MAIN OUTCOME MEASURE: Incident dementia by Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM III-R) criteria. RESULTS: During a mean follow-up of 5.2 years, 45 participants developed dementia. Higher severity of periventricular WML increased the risk of dementia, whereas the association between subcortical WML and dementia was less prominent. The adjusted hazard ratio of dementia for each standard deviation increase in periventricular WML severity was 1.67 (95% confidence interval, 1.25-2.24). This increased risk was independent of other risk factors for dementia and partly independent of other structural brain changes on magnetic resonance imaging. CONCLUSION: White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people.
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Cites
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313
Self-citationRoth, M., Tym, E., Mountjoy, C. Q., Huppert, F. A., Hendrie, H., Verma, S., & Goddard, R. (1986) · British Journal of Psychiatry · doi:10.1192/bjp.149.6.698 · Cited by 2,090
Subcortical ischaemic vascular dementia
Román, G. C., Erkinjuntti, T., Wallin, A., Pantoni, L., & Chui, H. C. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00190-4 · Cited by 1,067
Cited by
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655
Pantoni, L. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70104-6 · Cited by 3,405
Debette, S., & Markus, H. S. (2010) · BMJ · doi:10.1136/bmj.c3666 · Cited by 2,328
White matter hyperintensities, cognitive impairment and dementia: an update
Prins, N. D., & Scheltens, P. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.10 · Cited by 1,284
Self-citationMidlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
Debette, S., Seshadri, S., Beiser, A., Au, R., Himali, J. J., Palumbo, C., Wolf, P. A., & DeCarli, C. (2011) · Neurology · doi:10.1212/wnl.0b013e318227b227 · Cited by 772
Metadata
- Authors
- Prins, N. D., van Dijk, E. J., den Heijer, T., Vermeer, S. E., Koudstaal, P. J., Oudkerk, M., Hofman, A., & Breteler, M. M. B.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2004-10-01
- Volume
- 61
- Issue
- 10
- Pages
- 1531
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2143615397
- Cited by
- 488
- References
- 3
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
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