White matter hyperintensities, cognitive impairment and dementia: an update

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969 · see citing works

MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging

Fazekas, F., Chawluk, J. B., Alavi, A. A., Hurtig, H. I., & Zimmerman, R. A. (1987) · American Journal of Roentgenology · doi:10.2214/ajr.149.2.351 · Cited by 5,347 · see citing works

Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811 · see citing works

The Cardiovascular Health Study: design and rationale.

Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

Pantoni, L. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70104-6 · Cited by 3,405 · see citing works

The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis

Debette, S., & Markus, H. S. (2010) · BMJ · doi:10.1136/bmj.c3666 · Cited by 2,328 · see citing works

Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313 · see citing works

A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT

Wahlund, L., Barkhof, F., Fazekas, F., Bronge, L. H., Augustin, M., Sjögren, M. J. C., Wallin, A., Adèr, H. J., Leys, D., Pantoni, L., et al. (2001) · Stroke · doi:10.1161/01.str.32.6.1318 · Cited by 1,797 · see citing works

Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590 · see citing works

Clinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly People: The Cardiovascular Health Study

Longstreth, W. T., Manolio, T. A., Arnold, A., Burke, G. L., Bryan, N., Jungreis, C. A., Enright, P. L., O'Leary, D., & Fried, L. (1996) · Stroke · doi:10.1161/01.str.27.8.1274 · Cited by 1,464 · see citing works

Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial

Forette, F., Seux, M.-L., Staessen, J. A., Thijs, L., Birkenhäger, W. H., Babarskiene, M.-R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03086-4 · Cited by 1,441 · see citing works

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales

(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338 · see citing works

Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study

de Leeuw, F.-E. (2001) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.1.9 · Cited by 1,291 · see citing works

Pathogenesis of Leukoaraiosis: A Review

Pantoni, L., & Garcia, J. H. (1997) · Stroke · doi:10.1161/01.str.28.3.652 · Cited by 1,225 · see citing works

Subcortical ischaemic vascular dementia

Román, G. C., Erkinjuntti, T., Wallin, A., Pantoni, L., & Chui, H. C. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00190-4 · Cited by 1,067 · see citing works

A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging

Scheltens, P., Barkhof, F., Leys, D., Pruvo, J., Nauta, J. J. P., Vermersch, P., Steinling, M., & Valk, J. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90041-v · Cited by 920 · see citing works

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.

Snowdon, D. A., Greiner, L. H., Mortimer, J. A., et al. (1997) · PubMed · Cited by 846 · see citing works

Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

Gouw, A. A., Seewann, A., van der Flier, W. M., Barkhof, F., Rozemuller, A. M., Scheltens, P., & Geurts, J. J. G. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.204685 · Cited by 766 · see citing works

Leuko-Araiosis

Hachinski, V. C., Potter, P., & Merskey, H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130013009 · Cited by 755 · see citing works

Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial

Erkinjuntti, T., Kurz, A., Gauthier, S., Bullock, R., Lilienfeld, S., & Damaraju, C. V. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08267-3 · Cited by 752 · see citing works

Cerebral small-vessel disease and decline in information processing speed, executive function and memory

Prins, N. D., van Dijk, E. J., den Heijer, T., Vermeer, S. E., JOLLES, J., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2005) · Brain · doi:10.1093/brain/awh553 · Cited by 732 · see citing works

Vascular risk factors for Alzheimer’s disease:

Breteler, M. M. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00110-4 · Cited by 664 · see citing works

Cerebral amyloid angiopathy in the elderly

Viswanathan, A., & Greenberg, S. M. (2011) · Annals of Neurology · doi:10.1002/ana.22516 · Cited by 643 · see citing works

Hypertension and cerebral white matter lesions in a prospective cohort study

de Leeuw, F. ‐., de Groot, J. C., Oudkerk, M., Witteman, J. C. M., Hofman, A., van Gijn, J., & Breteler, M. M. B. (2002) · Brain · doi:10.1093/brain/awf077 · Cited by 614 · see citing works

Progression of Cerebral Small Vessel Disease in Relation to Risk Factors and Cognitive Consequences: Rotterdam Scan Study

van Dijk, E. J., Prins, N. D., Vrooman, H. A., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2008) · Stroke · doi:10.1161/strokeaha.107.513176 · Cited by 580 · see citing works

Efficacy and Safety of Memantine in Patients With Mild to Moderate Vascular Dementia: A Randomized, Placebo-Controlled Trial (MMM 300)

Orgogozo, J.-M., Rigaud, A.-S., Stöffler, A., Möbius, H.-J., & Forette, F. (2002) · Stroke · doi:10.1161/01.str.0000020094.08790.49 · Cited by 539 · see citing works

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger’s Report

Pantoni, L., & García, J. H. (1995) · Stroke · doi:10.1161/01.str.26.7.1293 · Cited by 536 · see citing works

. The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults.

DeCarli, C., Murphy, D. G. M., Tranh, M., Grady, C. L., Haxby, J. V., Gillette, J. A., Salerno, J. A., Gonzales-Aviles, A., Honvitz, B., Rapoport, S. I., et al. (1995) · Neurology · doi:10.1212/wnl.45.11.2077 · Cited by 531 · see citing works

Cerebral White Matter Lesions and the Risk of Dementia

Prins, N. D., van Dijk, E. J., den Heijer, T., Vermeer, S. E., Koudstaal, P. J., Oudkerk, M., Albert Hofman, D., & Breteler, M. M. B. (2004) · Archives of Neurology · doi:10.1001/archneur.61.10.1531 · Cited by 488 · see citing works

Cerebral microinfarcts: the invisible lesions

Smith, E. E., Schneider, J. A., Wardlaw, J. M., & Greenberg, S. M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70307-6 · Cited by 456 · see citing works

Impact of Age-Related Cerebral White Matter Changes on the Transition to Disability – The LADIS Study: Rationale, Design and Methodology

Pantoni, L., Basile, A. M., Pracucci, G., Asplund, K., Bogousslavsky, J., Chabriat, H., Erkinjuntti, T., Fazekas, F., Ferro, J. M., Hennerici, M. G., et al. (2004) · Neuroepidemiology · doi:10.1159/000081050 · Cited by 440 · see citing works

Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD

Yoshita, M., Fletcher, E., Harvey, D., Ortega, M., Martinez, O., Mungas, D. M., Reed, B. R., & DeCarli, C. S. (2006) · Neurology · doi:10.1212/01.wnl.0000249119.95747.1f · Cited by 434 · see citing works

Periventricular cerebral white matter lesions predict rate of cognitive decline

de Groot, J. C., de Leeuw, F., Oudkerk, M., van Gijn, J., Albert Hofman, D., JOLLES, J., & Breteler, M. M. B. (2002) · Annals of Neurology · doi:10.1002/ana.10294 · Cited by 431 · see citing works

Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

Inzitari, D., Pracucci, G., Poggesi, A., Carlucci, G., Barkhof, F., Chabriat, H., Erkinjuntti, T., Fazekas, F., Ferro, J. M., Hennerici, M., et al. (2009) · BMJ · doi:10.1136/bmj.b2477 · Cited by 415 · see citing works

White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging

Barber, R., Scheltens, P., Gholkar, A. R., Ballard, C. G., McKeith, I. G., Ince, P. G., Perry, R., & O'Brien, J. T. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.1.66 · Cited by 414 · see citing works

White Matter Hyperintensities on MRI in the Neurologically Nondiseased Elderly

Ylikoski, A., Erkinjuntti, T., Raininko, R., Sarna, S. J., Sulkava, R. O., & Tilvis, R. S. (1995) · Stroke · doi:10.1161/01.str.26.7.1171 · Cited by 409 · see citing works

White matter lesion progression, brain atrophy, and cognitive decline: The Austrian stroke prevention study

Schmidt, R., Ropele, S., Enzinger, C., Petrovic, K., Smith, S., Schmidt, H., Matthews, P. M., & Fazekas, F. (2005) · Annals of Neurology · doi:10.1002/ana.20630 · Cited by 408 · see citing works

Cognitive function, dementia and type 2 diabetes mellitus in the elderly

Strachan, M. W. J., Reynolds, R. M., Marioni, R. E., & Price, J. F. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.228 · Cited by 402 · see citing works

Cerebral microbleeds on MRI

Koennecke, H. (2006) · Neurology · doi:10.1212/01.wnl.0000194266.55694.1e · Cited by 371 · see citing works

Brain Infarction and the Clinical Expression of Alzheimer Disease

Román, G. C. (1997) · JAMA · doi:10.1001/jama.1997.03550020045023 · Cited by 350 · see citing works

MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease

Mungas, D., Jagust, W. J., Reed, B. R., Kramer, J. H., Weiner, M. W., Schuff, N., Norman, D., Mack, W. J., Willis, L., & Chui, H. C. (2001) · Neurology · doi:10.1212/wnl.57.12.2229 · Cited by 341 · see citing works

Patterns of MRI lesions in CADASIL

Chabriat, H., Levy, C., Taillia, H., Iba-Zizen, M.-T., Vahedi, K., Joutel, A., Tournier-Lasserve, E., & Bousser, M.-G. (1998) · Neurology · doi:10.1212/wnl.51.2.452 · Cited by 339 · see citing works

Periventricular venous collagenosis: association with leukoaraiosis.

Moody, D. M., Brown, W. R., CHALLA, V. R., & Anderson, R. L. (1995) · Radiology · doi:10.1148/radiology.194.2.7824728 · Cited by 310 · see citing works

Visual Rating of Age-Related White Matter Changes on Magnetic Resonance Imaging

Kapeller, P., Barber, R., Vermeulen, R. J., Adèr, H. J., Scheltens, P., Freidl, W., Almkvist, O., Moretti, M., del Ser, T., Vaghfeldt, P., et al. (2003) · Stroke · doi:10.1161/01.str.0000049766.26453.e9 · Cited by 304 · see citing works

2001–2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease?

The LADIS Study Group (2011) · Cerebrovascular Diseases · doi:10.1159/000334498 · Cited by 297 · see citing works

Executive dysfunction in subcortical ischaemic vascular disease

Kramer, J. H. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.217 · Cited by 269 · see citing works

White matter hyperintensities and cognition: Testing the reserve hypothesis

Brickman, A. M., Siedlecki, K. L., Muraskin, J., Manly, J. J., Luchsinger, J. A., Yeung, L., Brown, T. R., DeCarli, C. S., & Stern, Y. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.013 · Cited by 265 · see citing works

Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence

Brickman, A. M., Zahodne, L. B., Guzman, V. A., Narkhede, A., Meier, I. B., Griffith, E. Y., Provenzano, F. A., Schupf, N., Manly, J. J., Stern, Y., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.019 · Cited by 253 · see citing works

Magnetic Resonance Imaging of the Brain in Diabetes

Schmidt, R., Launer, L. J., Nilsson, L., Pająk, A., Sans, S., Berger, K., Breteler, M. M. B., de Ridder, M. A. J., Dufouil, C., Fuhrer, R., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.687 · Cited by 250 · see citing works

Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative

Carmichael, O. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.284 · Cited by 248 · see citing works

Small Vessel Disease and Alzheimer’s Dementia: Pathological Considerations

Kalaria, R. N. (2002) · Cerebrovascular Diseases · doi:10.1159/000049150 · Cited by 243 · see citing works

Defining and Categorizing Leukoencephalopathies of Unknown Origin: MR Imaging Approach

van der Knaap, M. S., Breiter, S. N., Naidu, S., Hart, A. A. M., & Valk, J. (1999) · Radiology · doi:10.1148/radiology.213.1.r99se01121 · Cited by 240 · see citing works

High Blood Pressure and Cerebral White Matter Lesion Progression in the General Population

Verhaaren, B. F. J., Vernooij, M. W., de Boer, R., Albert Hofman, D., Niessen, W. J., van der Lugt, A., & Ikram, M. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00430 · Cited by 236 · see citing works

THE NUN STUDY

Shapira, I. L. (2008) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2008.0118 · Cited by 233 · see citing works

Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations

Yates, P. A., Villemagne, V. L., Ellis, K. A., Desmond, P. M., Masters, C. L., & Rowe, C. C. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2013.00205 · Cited by 231 · see citing works

Genome‐wide association studies of cerebral white matter lesion burden

Fornage, M., Debette, S., Bis, J. C., Schmidt, H., Ikram, M. A., Dufouil, C., Sigurdsson, S. O., Lumley, T., DeStefano, A. L., Fazekas, F., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22403 · Cited by 220 · see citing works

Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia.

Román, G. C., & Kalaria, R. N. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.004 · Cited by 213 · see citing works

Neuropathology of white matter changes in Alzheimer’s disease and vascular dementia

Englund, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051183 · Cited by 213 · see citing works

Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?

Erkinjuntti, T., Ketonen, L., Sulkava, R. O., Sipponen, J. T., Vuorialho, M., & Iivanainen, M. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.1.37 · Cited by 196 · see citing works

A fully automated method for quantifying and localizing white matter hyperintensities on MR images

Wu, M., Rosano, C., Butters, M. A., Whyte, E. M., Nable, M., Crooks, R., MELTZER, C. C., Reynolds, C. F., & Aizenstein, H. J. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.09.003 · Cited by 194 · see citing works

Vascular risk factors and longitudinal changes on brain MRI

Knopman, D. S., Penman, A. D., Catellier, D., Coker, L. H., Shibata, D. K., Sharrett, A. R., & Mosley, T. H. (2011) · Neurology · doi:10.1212/wnl.0b013e31821d753f · Cited by 191 · see citing works

Subcortical vascular dementia

Price, C. C., Jefferson, A. L., Merino, J. G., Heilman, K. M., & Libon, D. J. (2005) · Neurology · doi:10.1212/01.wnl.0000168877.06011.15 · Cited by 191 · see citing works

<scp>CADASIL</scp> and <scp>CARASIL</scp>

Tikka, S., Baumann, M., Siitonen, M., Pasanen, P., Pöyhönen, M., Myllykangas, L., Viitanen, M., Fukutake, T., Cognat, E., Joutel, A., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12181 · Cited by 189 · see citing works

Cognitive Function and Brain Structure in Persons With Type 2 Diabetes Mellitus After Intensive Lowering of Blood Pressure and Lipid Levels: A Randomized Clinical Trial

Williamson, J. D., Launer, L. J., Bryan, R. N., Coker, L. H., Lazar, R. M., Gerstein, H. C., Murray, A. M., Sullivan, M. D., Horowitz, K. R., Ding, J., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13656 · Cited by 187 · see citing works

Measuring progression of cerebral white matter lesions on MRI

Prins, N. D., van Straaten, E. C. W., van Dijk, E. J., Simoni, M., van Schijndel, R. A., Vrooman, H. A., Koudstaal, P. J., Scheltens, P., Breteler, M. M. B., & Barkhof, F. (2004) · Neurology · doi:10.1212/01.wnl.0000123264.40498.b6 · Cited by 186 · see citing works

Vascular Factors and Alzheimer Disease

Skoog, I. G., Kalaria, R. N., & Breteler, M. M. B. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912003-00016 · Cited by 183 · see citing works

FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities

Maillard, P., Carmichael, O. T., Harvey, D. J., Fletcher, E. M., Reed, B., Mungas, D., & DeCarli, C. S. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3146 · Cited by 174 · see citing works

Blood Pressure and White-Matter Disease Progression in a Biethnic Cohort: Atherosclerosis Risk in Communities (ARIC) Study

Gottesman, R. F., Coresh, J., Catellier, D. J., Sharrett, A. R., Rose, K. M., Coker, L. H., Shibata, D. K., Knopman, D. S., Jack, C. R., & Mosley, T. H. (2010) · Stroke · doi:10.1161/strokeaha.109.566992 · Cited by 173 · see citing works

Subcortical Ischemic Vascular Dementia

Chui, H. C. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.04.003 · Cited by 169 · see citing works

Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment

Fazekas, G., Fazekas, F., Schmidt, R., Kapeller, P., Offenbacher, H., & Krejs, G. J. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00226-7 · Cited by 164 · see citing works

Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer’s disease and vascular dementia

Akinyemi, R., Mukaetova-Ladinska, E., Attems, J., Ihara, M., & Kalaria, R. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990037 · Cited by 152 · see citing works

Incidence of cerebral microbleeds in preclinical Alzheimer disease

Yates, P. A., Desmond, P. M., Phal, P. M., Steward, C., Szoeke, C., Salvado, O., Ellis, K. A., Martins, R. N., Masters, C. L., Ames, D., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000285 · Cited by 150 · see citing works

Prevention of Dementia by Intensive Vascular Care (PreDIVA)

Richard, E., den Heuvel, E. V., van Charante, E. P. M., Achthoven, L., Vermeulen, M., Bindels, P., & van Gool, W. A. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819783a4 · Cited by 146 · see citing works

Donepezil in Vascular Dementia: Combined Analysis of Two Large-Scale Clinical Trials

Román, G. C., Wilkinson, D. G., Doody, R. S., Black, S. E., Salloway, S. P., & Schindler, R. J. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000088494 · Cited by 141 · see citing works

Brain imaging in type 2 diabetes

Brundel, M., Kappelle, L. J., & Biessels, G. J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.023 · Cited by 127 · see citing works

Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study

van der Flier, W. M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.064998 · Cited by 124 · see citing works

Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

Lockhart, S. N., Mayda, A. B. V., Roach, A. E., Fletcher, E. M., Carmichael, O. T., Maillard, P., Schwarz, C. G., Yonelinas, A. P., Charan Ranganath, A., & DeCarli, C. S. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00056 · Cited by 124 · see citing works

Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study

Gouw, A. A., van der Flier, W. M., van Straaten, E. C. W., Barkhof, F., Ferro, J. M., Bäezner, H., Pantoni, L., Inzitari, D., Erkinjuntti, T., Wahlund, L., et al. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0193-5 · Cited by 120 · see citing works

The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Ahearn, T. S., Mustafa, N., & Whalley, L. J. (2011) · Brain · doi:10.1093/brain/awr259 · Cited by 119 · see citing works

Plasma amyloid β, apolipoprotein E, lacunar infarcts, and white matter lesions

van Dijk, E. J., Prins, N. D., Vermeer, S. E., Albert Hofman, D., van Duijn, C. M., Koudstaal, P. J., & Breteler, M. M. B. (2004) · Annals of Neurology · doi:10.1002/ana.20050 · Cited by 119 · see citing works

Decline in intelligence is associated with progression in white matter hyperintensity volume

Garde, E. (2005) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.2004.055905 · Cited by 118 · see citing works

Aortic Atherosclerosis at Middle Age Predicts Cerebral White Matter Lesions in the Elderly

de Leeuw, F., de Groot, J. C., Oudkerk, M., Witteman, J. C. M., Albert Hofman, D., van Gijn, J., & Breteler, M. M. B. (2000) · Stroke · doi:10.1161/01.str.31.2.425 · Cited by 116 · see citing works

Effect of pravastatin on cerebral infarcts and white matter lesions

ten Dam, V. H., van den Heuvel, D. M. J., van Buchem, M. A., Westendorp, R. G. J., Bollen, E. L. E. M., Ford, I., de Craen, A. J. M., & Blauw, G. J. (2005) · Neurology · doi:10.1212/01.wnl.0000161844.00797.73 · Cited by 113 · see citing works

Strategic involvement of cholinergic pathways and executive dysfunction: Does location of white matter signal hyperintensities matter?

Swartz, R. H., Sahlas, D. J., & Black, S. E. (2003) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1053/jscd.2003.5 · Cited by 111 · see citing works

Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study

Biesbroek, J. M., Kuijf, H. J., van der Graaf, Y., Vincken, K. L., Postma, A., Mali, W. P. T. M., Biessels, G. J., Geerlings, M. I., & on behalf of the SMART Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0060541 · Cited by 108 · see citing works

Ambulatory blood pressure and the brain

Goldstein, I. B., Bartzokis, G., Guthrie, D., & Shapiro, D. (2005) · Neurology · doi:10.1212/01.wnl.0000164712.24389.bb · Cited by 107 · see citing works

Fully-Automated White Matter Hyperintensity Detection with Anatomical Prior Knowledge and without FLAIR

Schwarz, C. G., Fletcher, E., DeCarli, C. S., & Carmichael, O. T. (2009) · Lecture notes in computer science · doi:10.1007/978-3-642-02498-6_20 · Cited by 100 · see citing works

White Matter Lesion Progression in LADIS

Schmidt, R., Berghold, A., Jokinen, H., Gouw, A. A., van der Flier, W. M., Barkhof, F., Scheltens, P., Petrovic, K., Madureira, S., Verdelho, A., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.662593 · Cited by 98 · see citing works

Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats

Kimura, S., Saito, H., Minami, M., Togashi, H., Nakamura, N., Nemoto, M., & Parvez, H. S. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00312-7 · Cited by 97 · see citing works

Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy

Swan, G. E., DeCarli, C. S., Miller, B. L., Reed, T., Wolf, P. A., & Carmelli, D. (2000) · Neurology · doi:10.1212/wnl.54.11.2108 · Cited by 96 · see citing works

Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

Bink, D. I., Ritz, K., Aronica, E., van der Weerd, L., & Daemen, M. J. A. P. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.140 · Cited by 95 · see citing works

An automated procedure for the assessment of white matter hyperintensities by multispectral (T1, T2, PD) MRI and an evaluation of its between-centre reproducibility based on two large community databases

Maillard, P., Delcroix, N., Crivello, F., Dufouil, C., Gicquel, S., Joliot, M., Tzourio‐Mazoyer, N., Alpérovitch, A., Tzourio, C., & Mazoyer, B. M. (2007) · Neuroradiology · doi:10.1007/s00234-007-0312-3 · Cited by 94 · see citing works

Vascular risk factors and Alzheimer’s disease

O'Brien, J. T., & Markus, H. S. (2014) · BMC Medicine · doi:10.1186/s12916-014-0218-y · Cited by 93 · see citing works

Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D)

Vinters, H. V., Natté, R., Maat–Schieman, M. L. C., van Duinen, S. G., Hegeman-Kleinn, I. M., Welling‐Graafland, C., Haan, J., & Roos, R. A. C. (1998) · Acta Neuropathologica · doi:10.1007/s004010050793 · Cited by 92 · see citing works

Reliability and Sensitivity of Visual Scales versus Volumetry for Evaluating White Matter Hyperintensity Progression

Gouw, A. A., van der Flier, W. M., van Straaten, E. C. W., Pantoni, L., de Bastos-Leite, A. J., Inzitari, D., Erkinjuntti, T., Wahlund, L., Ryberg, C., Schmidt, R., et al. (2008) · Cerebrovascular Diseases · doi:10.1159/000113863 · Cited by 88 · see citing works

Cerebral small vessel disease affects white matter microstructure in mild cognitive impairment

Papma, J. M., de Groot, M., de Koning, I., Mattace-Raso, F. U. S., van der Lugt, A., Vernooij, M. W., Niessen, W. J., Swieten, J. C. V., Koudstaal, P. J., Prins, N. D., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22370 · Cited by 84 · see citing works

Associations between White Matter Hyperintensities and β Amyloid on Integrity of Projection, Association, and Limbic Fiber Tracts Measured with Diffusion Tensor MRI

Chao, L. L., DeCarli, C. S., Kriger, S., Truran, D., Zhang, Y., Laxamana, J., Villeneuve, S., Jagust, W. J., Sanossian, N., Mack, W. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065175 · Cited by 83 · see citing works

Vascular Care in Patients With Alzheimer Disease With Cerebrovascular Lesions Slows Progression of White Matter Lesions on MRI: The Evaluation of Vascular Care in Alzheimer’s Disease (EVA) Study

Richard, E., Gouw, A. A., Scheltens, P., & van Gool, W. A. (2010) · Stroke · doi:10.1161/strokeaha.109.571281 · Cited by 82 · see citing works

MRI Markers for Mild Cognitive Impairment: Comparisons between White Matter Integrity and Gray Matter Volume Measurements

Zhang, Y., Schuff, N. W., Camacho, M. R., Chao, L. L., Fletcher, T. P., Yaffe, K. S., Woolley, S. C., Madison, C. A., Rosen, H. J., Miller, B. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066367 · Cited by 82 · see citing works

Age- and sex-specific rates of leukoaraiosis in TIA and stroke patients

Simoni, M., Li, L., Paul, N. L. M., Grüter, B. E., Schulz, U. G., Küker, W., & Rothwell, P. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826b951e · Cited by 80 · see citing works

Immunohistochemical study of cerebral amyloid angiopathy. III. Widespread alzheimer A4 peptide in cerebral microvessel walls colocalizes with gamma trace in patients with leukoencephalopathy

Vinters, H. V., Secor, D. L., Pardridge, W. M., & Gray, F. (1990) · Annals of Neurology · doi:10.1002/ana.410280108 · Cited by 76 · see citing works

White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment

Guzman, V. A., Carmichael, O. T., Schwarz, C. G., Tosto, G., Zimmerman, M. E., Brickman, A. M., & Initiative, A. D. N. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.11.009 · Cited by 74 · see citing works

Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls

Barnes, J., Carmichael, O. T., Leung, K. K., Schwarz, C. G., Ridgway, G. R., Bartlett, J. W., Malone, I. B., Schott, J. M., Rossor, M. N., Biessels, G. J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.003 · Cited by 70 · see citing works

Vascular Care in Patients with Alzheimer's Disease with Cerebrovascular Lesions—A Randomized Clinical Trial

Richard, E., Kuiper, R., Dijkgraaf, M. G. W., van Gool, W. A., & for the Evaluation of Vascular care in Alzheimer's disease Study Group (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02217.x · Cited by 67 · see citing works

Homocysteine as a Risk Factor for Cognitive Impairment in Stroke Patients

Sachdev, P. S., Valenzuela, M., Brodaty, H., Wang, X. L., Looi, J. C., Lorentz, L., Howard, L., Jones, M., Zagami, A. S., Gillies, D., et al. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000068481 · Cited by 67 · see citing works

Dynamic Temporal Change of Cerebral Microbleeds: Long-Term Follow-Up MRI Study

Lee, S., Lee, S., Kim, B. J., Park, H.-K., Kim, C.-K., Jung, K., & Roh, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025930 · Cited by 63 · see citing works

Metabolic Syndrome, Prediabetes, and Brain Abnormalities on MRI in Patients With Manifest Arterial Disease: The SMART-MR Study

Tiehuis, A. M., van der Graaf, Y., Mali, W. P. T. M., Vincken, K. L., Muller, M., & Geerlings, M. I. (2014) · Diabetes Care · doi:10.2337/dc14-0154 · Cited by 63 · see citing works

Vascular Disease and Risk Factors are Associated With Cognitive Decline in the Alzheimer Disease Spectrum

Lorius, N., Locascio, J. J., Rentz, D. M., Johnson, K. A., Sperling, R. A., Viswanathan, A., & Marshall, G. A. (2014) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000043 · Cited by 62 · see citing works

The Neuropathology of Vascular Disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)

Richardson, K., Stephan, B. C. M., Ince, P. G., Brayne, C., & Matthews, F. E. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322654 · Cited by 61 · see citing works

Vascular and neurodegenerative pathways—will they meet?

Kalaria, R. N., & Ihara, M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.164 · Cited by 60 · see citing works

Frequency of white matter lesions and silent lacunar infarcts

van Dijk, E. J., Prins, N. D., Vermeer, S. E., Koudstaaf, P. J., & Breteler, M. M. B. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_2 · Cited by 59 · see citing works

The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments

Kim, H. J., Kang, S. J., Kim, C., Kim, G. H., Jeon, S., Lee, J. M., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K. H., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.002 · Cited by 58 · see citing works

Two novel HTRA1 mutations in a European CARASIL patient

Bianchi, S., Palma, C. D., Gallus, G. N., Taglia, I., Poggiani, A., Rosini, F., Rufa, A., Muresanu, D. F., Cerase, A., Dotti, M. T., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000202 · Cited by 57 · see citing works

17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status

Adib‐Samii, P., Rost, N. S., Traylor, M., Devan, W. J., Biffi, A., Lanfranconi, S., Fitzpatrick, K. M., Bevan, S., Kanakis, A. S., Valant, V., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.679936 · Cited by 47 · see citing works

Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial

Cyarto, E., Lautenschlager, N. T., Desmond, P. M., Ames, D. J., Szoeke, C. E. I., Salvado, O., Sharman, M. J., Ellis, K. A., Phal, P. M., Masters, C. L., et al. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-167 · Cited by 47 · see citing works

Progression of cerebral white matter lesions in Alzheimer's disease: a new window for therapy?

de Leeuw, F.-E. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.053686 · Cited by 45 · see citing works

Automated White Matter Total Lesion Volume Segmentation in Diabetes

Maldjian, J. A., Whitlow, C. T., Saha, B. N., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3590 · Cited by 44 · see citing works

Pathophysiology of Cerebral Small Vessels in Vascular Cognitive Impairment

Pantoni, L., & Simoni, M. (2003) · International Psychogeriatrics · doi:10.1017/s1041610203008974 · Cited by 44 · see citing works

The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke

Lee, S., Kim, J., Lee, K.-S., An, J., Kim, W., Kim, Y.-I., Kim, B., & Jung, S. L. (2008) · BMC Neurology · doi:10.1186/1471-2377-8-31 · Cited by 43 · see citing works

White Matter Hyperintensities are associated with Amyloid Burden in APOE4 Non-Carriers

Noh, Y., Seo, S. W., Jeon, S., Lee, J. M., Kim, J., Kim, G. H., Cho, H., Yoon, C. W., Kim, H. J., Ye, B. S., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130461 · Cited by 42 · see citing works

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

Nicoll, J. A. R., Savva, G. M., Stewart, J., Matthews, F. E., Brayne, C., & Ince, P. G. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01130.x · Cited by 41 · see citing works

MELAS and Reversible Vasoconstriction of the Major Cerebral Arteries

Yoshida, T., Ouchi, A., Miura, D., et al. (2013) · Internal Medicine · doi:10.2169/internalmedicine.52.0188 · Cited by 34 · see citing works

Pre-clinical models of human cerebral small vessel disease: Utility for clinical application

Hainsworth, A. H., Brittain, J. F., & Khatun, H. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.046 · Cited by 33 · see citing works

The long‐term efficacy and tolerability of donepezil in patients with vascular dementia

Wilkinson, D. G., Román, G. C., Salloway, S., Hecker, J. R., Boundy, K. L., Kumar, D., Posner, H. B., & Schindler, R. J. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2340 · Cited by 27 · see citing works

Association of C hr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J ‐ SHIPP study

Tabara, Y., Igase, M., Okada, Y., Nagai, T., Uetani, E., Kido, T., Ochi, N., Takita, R., Yamamoto, M., Kohara, K., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03879.x · Cited by 22 · see citing works

Effect of White Matter Hyperintensity on Medial Temporal Lobe Atrophy in Alzheimer’s Disease

Jang, J., Kim, S., Na, H. Y., Ahn, S., Lee, S. J., Kwak, K.-H., Lee, M. A., Hsiung, G. R., Choi, B., & Youn, Y. C. (2013) · European Neurology · doi:10.1159/000345999 · Cited by 21 · see citing works

Dysglycemia, brain volume and vascular lesions on MRI in a memory clinic population

Exalto, L. G., van der Flier, W. M., Scheltens, P., Vrenken, H., & Biessels, G. J. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.12.003 · Cited by 18 · see citing works

The Genetics of Small-Vessel Disease

Bersano, A., Debette, S., Zanier, E. R., Lanfranconi, S., Simoni, M. G. D., Zuffardi, O., & Micieli, G. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712802430081 · Cited by 16 · see citing works

Pathology of Vascular Disease

Pusey, C. D., & Cook, H. T. (2001) · CRC Press eBooks · doi:10.1201/9781420040395.sec1 · Cited by 13 · see citing works

Brain Imaging Findings in Elderly Adults and Years of Life, Healthy Life, and Able Life over the Ensuing 16 Years: The Cardiovascular Health Study

Longstreth, W. T., Diehr, P. H., Yee, L. M., et al. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13068 · Cited by 12 · see citing works

[Cerebral white matter lesions in the elderly: vascular risk factors and cognitive consequences].

Fe, D. L., Jc, D. G., & van Gijn, J. (2001) · PubMed · Cited by 10 · see citing works

Untitled work

Solano (2000) · doi:10.1002/1531-8249(200002)47:2 · Cited by 3 · see citing works

Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis

Shi, L., Chen, S.-J., Ma, M.-Y., Bao, Y.-P., Han, Y., Wang, Y.-M., Shi, J., Vitiello, M. V., & Lu, L. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.06.010 · Cited by 1,009 · see citing works

White matter changes in Alzheimer’s disease: A focus on myelin and oligodendrocytes

Nasrabady, S. E., Rizvi, B., Goldman, J. E., & Brickman, A. M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0515-3 · Cited by 723 · see citing works

Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595 · see citing works

White matter hyperintensities are a core feature of Alzheimer’s disease: evidence from the dominantly inherited Alzheimer network

Lee, S., Viqar, F., Zimmerman, M. E., Narkhede, A., Tosto, G., Benzinger, T. L. S., Marcus, D. S., Fagan, A. M., Goate, A., Fox, N. C., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24647 · Cited by 542 · see citing works

White matter aging drives microglial diversity

Safaiyan, S., Besson-Girard, S., Kaya, T., Cantuti-Castelvetri, L., Liu, L., Ji, H., Schifferer, M., Gouna, G., Usifo, F., Kannaiyan, N., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.027 · Cited by 477 · see citing works

A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms

Baykara, E., Gesierich, B., Adam, R., Tuladhar, A. M., Biesbroek, J. M., Koek, H. L., Ropele, S., Jouvent, E., Initiative, A. D. N., Chabriat, H., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24758 · Cited by 386 · see citing works

Longitudinal association between hippocampus atrophy and episodic-memory decline

Gorbach, T., Pudas, S., Lundquist, A., Orädd, G., Josefsson, M., Salami, A., de Luna, X., & Nyberg, L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.12.002 · Cited by 245 · see citing works

Nutrition for the ageing brain: Towards evidence for an optimal diet

Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241 · see citing works

White matter hyperintensity topography in Alzheimer's disease and links to cognition

Garnier‐Crussard, A., Bougacha, S., Wirth, M., Dautricourt, S., Sherif, S., Landeau, B., Gonneaud, J., De Flores, R., de la Sayette, V., Vivien, D., et al. (2022) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12410 · Cited by 170 · see citing works

White matter hyperintensities in Alzheimer's disease: Beyond vascular contribution

Garnier‐Crussard, A., Cotton, F., Krolak‐Salmon, P., & Chételat, G. (2023) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13057 · Cited by 139 · see citing works

White matter hyperintensities across the adult lifespan: Relation to age, Aβ load, and cognition

Garnier-Crussard, A., Bougacha, S., Wirth, M., André, C., Delarue, M., Landeau, B., Mézenge, F., Kuhn, E., Gonneaud, J., Chocat, A., et al. (2020) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-020-00669-4 · Cited by 130 · see citing works

Structural network efficiency predicts conversion to dementia

Tuladhar, A. M., van Uden, I. W. M., Rutten-Jacobs, L. C. A., Lawrence, A., van der Holst, H., van Norden, A., de Laat, K., van Dijk, E., Claassen, J. A. H. R., Kessels, R. P. C., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002502 · Cited by 109 · see citing works

Associations of White Matter Hyperintensities with Cognitive Decline: A Longitudinal Study

Wang, Y.-L., Chen, W., Cai, W.-J., Hu, H., Xu, W., Wang, Z.-T., Cao, X.-P., Tan, L., Yu, J.-T., & Initiative, A. D. N. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-191005 · Cited by 92 · see citing works

<i>APOE</i> ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

Mirza, S. S., Saeed, U., Knight, J., Ramirez, J., Stuss, D. T., Keith, J., Nestor, S. M., Yu, D., Swardfager, W., Rogaeva, E., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008377 · Cited by 67 · see citing works

Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

Study, F. T. A., Brugulat-Serrat, A., Salvadó, G., Sudre, C. H., Grau-Rivera, O., Suárez-Calvet, M., Falcon, C., Sánchez-Benavides, G., Gramunt, N., Fauria, K., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00151-2 · Cited by 64 · see citing works

White matter hyperintensities are associated with subthreshold amyloid accumulation

Moscoso, A., Rey-Bretal, D., Silva-Rodríguez, J., Aldrey, J. M., Cortés, J., Pías-Peleteiro, J., Ruibal, Á., & Aguiar, P. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116944 · Cited by 49 · see citing works

Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients

Biesbroek, J. M., Coenen, M., DeCarli, C., Fletcher, E. M., Maillard, P. M., Initiative, A. D. N., Barkhof, F., Barnes, J., Benke, T., Chen, C. P. L. H., et al. (2024) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13765 · Cited by 38 · see citing works

MRI assessment of whole-brain structural changes in aging

Guo, H., Siu, W., D’Arcy, R., Black, S., Grajauskas, L., Singh, S., Zhang, Y., Rockwood, K., & Song, X. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s139515 · Cited by 39 · see citing works

Regional associations of white matter hyperintensities and early cortical amyloid pathology

Lorenzini, L., Ansems, L. T., Lopes Alves, I., Ingala, S., Vállez García, D., Tomassen, J., Sudre, C., Salvadó, G., Shekari, M., Operto, G., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac150 · Cited by 36 · see citing works

Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span

Luo, J., Ma, Y., Agboola, F. J., Grant, E., Morris, J. C., McDade, E., Fagan, A. M., Benzinger, T. L. S., Hassenstab, J., Bateman, R. J., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207378 · Cited by 35 · see citing works

Detection of white matter lesion regions in MRI using SLIC0 and convolutional neural network

Diniz, P. H. B., Valente, T. L. A., Diniz, J. O. B., Silva, A. C., Gattass, M., Ventura, N., Muniz, B. C., & Gasparetto, E. L. (2018) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2018.04.011 · Cited by 34 · see citing works

Systematic review and meta-analyses of word production abilities in dysfunction of the basal ganglia: Stroke, small vessel disease, Parkinson’s disease, and Huntington’s disease

Camerino, I., Ferreira, J., Vonk, J. M., Kessels, R. P. C., de Leeuw, F.-E., Roelofs, A., Copland, D., & Piai, V. (2024) · Neuropsychology Review · doi:10.1007/s11065-022-09570-3 · Cited by 27 · see citing works

Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease

Littau, J. L., Velilla, L., Hase, Y., Villalba‐Moreno, N. D., Hagel, C., Drexler, D., Osorio Restrepo, S., Villegas, A., Lopera, F., Vargas, S., et al. (2022) · Brain Pathology · doi:10.1111/bpa.13097 · Cited by 20 · see citing works

Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities

Cha, W.-J., Yi, D., Ahn, H., Byun, M. S., Chang, Y. Y., Choi, J.-M., Kim, K., Choi, H., Jung, G., Kang, K. M., et al. (2024) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-024-01417-8 · Cited by 20 · see citing works

White matter hyperintensities affect transcranial electrical stimulation in the aging brain

Indahlastari, A., Albizu, A., Boutzoukas, E. M., O’Shea, A., & Woods, A. J. (2021) · Brain Stimulation · doi:10.1016/j.brs.2020.11.009 · Cited by 14 · see citing works

APOE4 and Confluent White Matter Hyperintensities Have a Synergistic Effect on Episodic Memory Impairment in Prodromal Dementia

Kumar, D., Yatawara, C., Wang, B., Wong, B., Tan, Y. J., Zailan, F. Z., Ng, K. P., & Kandiah, N. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215556 · Cited by 12 · see citing works

White matter hyperintensity modulates the amyloid‐tau‐cognition association and anti‐amyloid treatment efficacy in asymptomatic older adults

Lin, Z., Hong, Y., Hu, Y., Xiao, Q., Peng, S., Wu, D., Guo, T., & Jiang, D. (2025) · Alzheimer's &amp; Dementia · doi:10.1002/alz.70990 · Cited by 2 · see citing works

Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease

Maniega, S. M., Chappell, F. M., Hernández, M. C. V., Armitage, P. A., Makin, S., Heye, A. K., Thrippleton, M. J., Sakka, E., Shuler, K., Dennis, M. S., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16635657 · Cited by 171 · see citing works

Maturation of the brainstem and cerebellar white matter tracts from the neonatal period to adolescence: a diffusion tensor imaging study

Poretti, A., Meoded, A., & Huisman, T. (2013) · Neuropediatrics · doi:10.1055/s-0033-1337861 · Cited by 1 · see citing works

Structural connectivity in white matter using the projected diffusion-tensor distance.

Sato, T., Hasan, K. M., Alexander, A. L., et al. (2001) · PubMed · Cited by 3 · see citing works

Assessment of neonatal brain development by diffusion tensor imaging

Yu, B. (2012) · Chinese Journal of Magnetic Resonance Imaging

Advance in Diffusion Tensor Imaging in Assessment of White Matter Fiber Tracts Injury and Prognosis of Stroke(rerview)

Xiao-y, Z. (2010) · Zhongguo kangfu lilun yu shijian