Lewy Body Pathology in Familial Alzheimer Disease: Evidence for Disease- and Mutation-Specific Pathologic Phenotype
Open accessAbstract
BACKGROUND: The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood. OBJECTIVE: To examine LBP in the brainstem, limbic cortex, and neocortex of a large number of familial AD cases with mutations in 2 presenilin (PSEN) genes. METHODS: Twenty-five familial AD cases with 9 known PSEN 1 mutations and 14 familial AD cases with a single PSEN 2 mutation (N141I) were examined for LBP using alpha-synuclein immunohistochemistry and sampling of multiple brainstem and cortical regions. RESULTS: The amygdala was the most vulnerable site for LBP. In fact, virtually all (24 [96%] of 25 cases) of the PSEN 1 mutation cases had LBP in the amygdala. The PSEN 1 mutation cases also had more frequent LBP in the amygdala and neocortex than those with the PSEN 2 mutation. However, within families with a single mutation of either PSEN 1 or PSEN 2, there was frequent variability of the LBP. CONCLUSION: These findings suggest that there are genetic influences on the presence of LBP in familial AD as demonstrated by the differences between PSEN 1 and PSEN 2 mutation cases.
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Lewy bodies are frequent in some early-onset familial AD cases.
“LBs are frequent in the setting of moderate-to-severe levels of AD neuropathologic change [27,59], including some early-onset familial AD cases [32,33].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [32]
Neocortical LBD is correlated with greater likelihood of cognitive impairment.
“For cases with incomplete clinical history, we note that “Neocortical LBD” is correlated with greater likelihood of cognitive impairment [1,11-13,22,31-33,38,46,49,52].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [32]
The Results compare neocortical Lewy body pathology across familial Alzheimer disease mutations, not across levels of cognitive impairment. The Comment section says detailed clinical evaluations were often unavailable. Searches for cognitive impairment and dementia status found no analysis linking neocortical pathology to a greater likelihood of impairment. (LLM, conf=0.76)
Experimental — accuracy not yet measuredMore than 90% of patients with autosomal dominant Alzheimer's disease due to mutations in the PSEN1 gene exhibit αSyn pathology specifically in the amygdala.
“more than 90% of patients with ADAD due to mutations in the PSEN1 gene exhibit αSyn pathology specifically in the amygdala [25].”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [25]
Individuals with PSEN1 mutations have increased, yet heterogeneous limbic Lewy-related pathology.
“two studies have shown that individuals with PSEN1 mutations have increased, yet heterogeneous limbic LRP [22, 25].”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [25]
LRP occurs specifically in the amygdala of PSEN1 mutation carriers.
“This notion can exemplified by the occurrence of LRP specifically in the amygdala of PSEN1 mutation carriers [25].”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [25]
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 3,151 · see citing works
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933 · see citing works
(1998) · Europe PMC (PubMed Central) · Cited by 1,594 · see citing works
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity
Hansen, L., Salmon, D., Galasko, D., Masliah, E., Katzman, R., DeTeresa, R., Thal, L., Pay, M. M., Hofstetter, R., Klauber, M., et al. (1990) · Neurology · doi:10.1212/wnl.40.1.1 · Cited by 1,068 · see citing works
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
(1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00057-2 · Cited by 981 · see citing works
Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14
Schellenberg, G. D., Bird, T. D., Wijsman, E. M., Orr, H. T., Anderson, L., Nemens, E. J., White, J. A., Bonnycastle, L. L., Weber, J. L., Alonso, M. E., et al. (1992) · Science · doi:10.1126/science.1411576 · Cited by 945 · see citing works
Self-citationA Familial Alzheimer's Disease Locus on Chromosome 1
Levy‐Lahad, E., Wijsman, E. M., Nemens, E. J., Anderson, L., Goddard, K. A. B., Weber, J. L., Bird, T. D., & Schellenberg, G. D. (1995) · Science · doi:10.1126/science.7638621 · Cited by 811 · see citing works
Self-citationHamilton, R. L. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00269.x · Cited by 754 · see citing works
Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533 · see citing works
Self-citationProspective validation of Consensus criteria for the diagnosis of dementia with Lewy bodies
McKeith, I. G., Ballard, C. G., Perry, R. H., Ince, P. G., O'Brien, J. T., Neill, D., Lowery, K., Jaros, E., Barber, R., Thompson, P., et al. (2000) · Neurology · doi:10.1212/wnl.54.5.1050 · Cited by 458 · see citing works
Clinico‐Neuropathological Correlation of Alzheimer's Disease in a Community‐Based Case Series
Lim, A., Tsuang, D. W., Kukull, W. A., Nochlin, D., Leverenz, J. B., McCormick, W. C., Bowen, J., Teri, L. L., Thompson, J. C., Peskind, E. R., et al. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb02571.x · Cited by 450 · see citing works
Self-citationHolmes, C., Cairns, N. J., Lantos, P. L., & MANN, A. H. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.174.1.45 · Cited by 359 · see citing works
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Duda, J. E., Giasson, B. I., Mabon, M. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Annals of Neurology · doi:10.1002/ana.10279 · Cited by 329 · see citing works
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
Merdes, A., Hansen, L. A., Jeste, D. V., Galasko, D. R., Hofstetter, C. R., Ho, G. J., Thal, L. J., & Corey‐Bloom, J. (2003) · Neurology · doi:10.1212/01.wnl.0000065889.42856.f2 · Cited by 320 · see citing works
Genotyping and sequence analysis of apolipoprotein E isoforms*1
EMI, M. (1988) · Genomics · doi:10.1016/0888-7543(88)90130-9 · Cited by 301 · see citing works
Litvan, I., MacIntyre, A. T., Goetz, C. G., Wenning, G. K., Jellinger, K. A., Verny, M., Bartko, J. J., Jankovic, J. J., McKee, A. C., Brandel, J., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.969 · Cited by 298 · see citing works
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
Dickson, D. W., Ruan, D. T., Crystal, H., Mark, M. H., Davies, P., Kress, Y., & Yen, S. H. (1991) · Neurology · doi:10.1212/wnl.41.9.1402 · Cited by 293 · see citing works
Lewy body-related ?-synucleinopathy in the aged human brain
Jellinger, K. A. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0138-7 · Cited by 253 · see citing works
Neuropathologic and clinical features of Parkinson's disease in Alzheimer's disease patients
Ditter, S. M., & Mirra, S. S. (1987) · Neurology · doi:10.1212/wnl.37.5.754 · Cited by 250 · see citing works
Martí-Massó, J. F., & Martínez, J. R. (2000) · PubMed · Cited by 231 · see citing works
Mega, M. S., Masterman, D. L., Benson, D. F., Vinters, H. V., Tomiyasu, U., Craig, A. H., Foti, D. J., Kaufer, D., Scharre, D. W., Fairbanks, L. A., et al. (1996) · Neurology · doi:10.1212/wnl.47.6.1403 · Cited by 203 · see citing works
Mann, D. M. A., Iwatsubo, T., Cairns, N. J., Lantos, P. L., Nochlin, D., Sumi, S. M., Bird, T. D., Poorkaj, P., Hardy, J., Hutton, M., et al. (1996) · Annals of Neurology · doi:10.1002/ana.410400205 · Cited by 184 · see citing works
Self-citationProgression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies
Marui, W., Iseki, E., Nakai, T., Miura, S., Kato, M., Uéda, K., & Kosaka, K. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00006-0 · Cited by 161 · see citing works
Bird, T. D., Lampe, T. H., Nemens, E. J., Miner, G. W., Sumi, S. M., & Schellenberg, G. D. (1988) · Annals of Neurology · doi:10.1002/ana.410230106 · Cited by 147 · see citing works
Self-citationResearch Evaluation and Prospective Diagnosis of Dementia With Lewy Bodies
López, O. L., Becker, J. T., Kaufer, D., Hamilton, R. L., Sweet, R. A., Klunk, W. E., & DeKosky, S. T. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.43 · Cited by 144 · see citing works
Parkinson's Disease in Patients With Alzheimer's Disease
Leverenz, J. B., & Sumi, S. M. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520070020010 · Cited by 141 · see citing works
Self-citationLuis, C. A., Barker, W., Gajaraj, K., Harwood, D. G., Petersen, R., Kashuba, A., Waters, C., Jimison, P., Pearl, G. S., Petito, C. K., et al. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199907)14:7 · Cited by 140 · see citing works
Regional Distribution of α-Synuclein Pathology in Unimpaired Aging and Alzheimer Disease
Parkkinen, L., Soininen, H. S., & Alafuzoff, I. I. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.363 · Cited by 129 · see citing works
Gómez‐Isla, T., Growdon, W. B., McNamara, M. J., Nochlin, D., Bird, T. D., Arango, J. C., Lopera, F., Kosik, K. S., Lantos, P. L., Cairns, N. J., et al. (1999) · Brain · doi:10.1093/brain/122.9.1709 · Cited by 128 · see citing works
Self-citationPhenotype of chromosome 14–linked familial Alzheimer's disease in a large kindred
Lampe, T., Bird, T. D., Nochlin, D., Nemens, E., Risse, S. C., Sumi, S., Koerker, R., Leaird, B., Wier, M., & Raskind, M. (1994) · Annals of Neurology · doi:10.1002/ana.410360308 · Cited by 106 · see citing works
Self-citationEpitope mapping of LB509, a monoclonal antibody directed against human α-synuclein
Jakes, R., Crowther, R. A., Lee, V. M. ‐., Trojanowski, J. Q., Iwatsubo, T., & Goedert, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00411-5 · Cited by 103 · see citing works
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Hulette, C., Mirra, S. S., Wilkinson, W. E., Heyman, A., Fillenbaum, G. G., & Clark, C. (1995) · Neurology · doi:10.1212/wnl.45.11.1991 · Cited by 98 · see citing works
Clinical, Pathological, and Biochemical Spectrum of Alzheimer Disease Associated With PS-1 Mutations
Lleó, A., Berezovska, O., Growdon, J. H., & Hyman, B. T. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200403000-00006 · Cited by 92 · see citing works
Nochlin, D., Bird, T. D., Nemens, E. J., Ball, M. J., & Sumi, S. M. (1998) · Annals of Neurology · doi:10.1002/ana.410430124 · Cited by 75 · see citing works
Self-citationA novel presenilin‐1 mutation: Increased β‐amyloid and neurofibrillary changes
Gómez‐Isla, T., Wasco, W., Pettingell, W. P., Gurubhagavatula, S., Schmidt, S. D., Jondro, P. D., McNamara, M. J., Rodes, L., Di-Blasi, T., Growdon, W. B., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410410618 · Cited by 75 · see citing works
Familial Dementia With Lewy Bodies
Tsuang, D. W., Dalan, A. M., Eugenio, C. J., Poorkaj, P., Limprasert, P., Spada, A. R. L., Steinbart, E. J., Bird, T. D., & Leverenz, J. B. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1622 · Cited by 67 · see citing works
Self-citationRosenberg, C. K., Pericak‐Vance, M. A., Saunders, A. M., Gilbert, J. R., Gaskell, P. C., & Hulette, C. M. (2000) · Acta Neuropathologica · doi:10.1007/s004019900155 · Cited by 64 · see citing works
Missense mutations in the chromosome 14 familial Alzheimer's disease presenilin 1 gene
Poorkaj, P., Sharma, V., Anderson, L., Nemens, E. J., Alonso, M. E., Orr, H. T., White, J. A., Heston, L. L., Bird, T. D., & Schellenberg, G. D. (1998) · Human Mutation · doi:10.1002/(sici)1098-1004(1998)11:3 · Cited by 60 · see citing works
Self-citationAmyloid (Aβ) deposition in chromosome 1–linked Alzheimer's disease: The volga german families
Mann, D. M. A., Iwatsubo, T., Nochlin, D., Sumi, S. M., Levy‐Lahad, E., & Bird, T. D. (1997) · Annals of Neurology · doi:10.1002/ana.410410110 · Cited by 51 · see citing works
Self-citationLeverenz, J. B., & McKeith, I. G. (2002) · Medical Clinics of North America · doi:10.1016/s0025-7125(02)00012-3 · Cited by 22 · see citing works
Self-citationCharacteristics of familial Alzheimer's disease in nine kindreds of Volga German ancestry.
Bird, T. D., Lampe, T. H., Nemens, E. J., Sumi, S. M., Nochlin, D., Schellenberg, G. D., & Wijsman, E. M. (1989) · PubMed · Cited by 19 · see citing works
Self-citationClinical, Pathological, and Biochemical Spectrum of Alzheimer Disease Associated With PS-1 Mutations
Lleó, A. (2004) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.12.2.146 · Cited by 18 · see citing works
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
Jellinger, K. A. (2004) · Neurology · doi:10.1212/wnl.62.1.160 · Cited by 17 · see citing works
Dickson, D. W. (1990) · Neurology · doi:10.1212/wnl.40.7.1147 · Cited by 14 · see citing works
CHARACTERISTICS OF FAMILIAL ALZHEIMER??S DISEASE IN NINE KINDREDS OF VOLGA GERMAN ANCESTRY
Bird, T. D., Lampe, T. H., Nemens, E. J., Sumi, S. M., Nochlin, D., Schellenberg, G. D., Wijsman, E. M., & Miner, G. D. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802030-00135 · Cited by 11 · see citing works
Self-citationNeuropathologic and clinical features of Parkinsonʼs disease in Alzheimerʼs disease patients
Ditter, S., & Mirra, S. (1987) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198701040-00011 · Cited by 6 · see citing works
Price (1999) · doi:10.1002/1531-8249(199903)45:3
Flagged first, then by citations
Research works printed but not linked: 1
- Lippa CF, Schmidt ML, Lee VM, Trojanowski JQ. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol 1999;45:353-357. [PubMed: 10072050]
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Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · see citing works
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citationMontine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · see citing works
Self-citationClassification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031 · see citing works
Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972 · see citing works
Self-citationVan Deerlin, V. M., Leverenz, J. B., Bekris, L. M., Bird, T. D., Yuan, W., Elman, L. B., Clay, D., Wood, E. M., Chen-Plotkin, A. S., Martinez-Lage, M., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70071-1 · Cited by 723 · see citing works
Self-citationBateman, R. J., Aisen, P. S., De Strooper, B., Fox, N. C., Lemere, C. A., Ringman, J. M., Salloway, S., Sperling, R. A., Windisch, M., & Xiong, C. (2010) · Alzheimer's Research & Therapy · doi:10.1186/alzrt59 · Cited by 573 · see citing works
α-synuclein in the pathophysiology of Alzheimer’s disease
Twohig, D., & Nielsen, H. M. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0320-x · Cited by 374 · see citing works
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Spina, S., La Joie, R., Petersen, C., Nolan, A. L., Cuevas, D., Cosme, C., Hepker, M., Hwang, J.-H., Miller, Z. A., Huang, E. J., et al. (2021) · Brain · doi:10.1093/brain/awab099 · Cited by 278 · see citing works
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Ryan, N. S., & Rossor, M. N. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.92 · Cited by 176 · see citing works
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease
for the Dominantly Inherited Alzheimer Network (DIAN), Twohig, D., Rodriguez-Vieitez, E., Sando, S. B., Berge, G., Lauridsen, C., Møller, I., Grøntvedt, G. R., Bråthen, G., Patra, K., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0624-z · Cited by 68 · see citing works
Vergallo, A., Bun, R., Toschi, N., Baldacci, F., Zetterberg, H., Blennow, K., Cavedo, E., Lamari, F., Habert, M., Dubois, B., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3053 · Cited by 59 · see citing works
Winslow, A. R., Moussaud, S., Zhu, L., Post, K. L., Dickson, D. W., Berezovska, O., & McLean, P. J. (2014) · Brain · doi:10.1093/brain/awu119 · Cited by 48 · see citing works
Kaneko, H., Kakita, A., Kasuga, K., Nozaki, H., Ishikawa, A., Miyashita, A., Kuwano, R., Ito, G., Iwatsubo, T., Takahashi, H., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4244-07.2007 · Cited by 44 · see citing works
- Authors
- Leverenz, J. B., Fishel, M. A., Peskind, E. R., Montine, T. J., Nochlin, D., Steinbart, E., Raskind, M. A., Schellenberg, G. D., Bird, T. D., & Tsuang, D.
- Affiliations
- VA Puget Sound Health Care System (US)
- University of Washington (US)
- ORCID
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-03-01
- Volume
- 63
- Issue
- 3
- Pages
- 370
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC1892620
- OpenAlex
- W2012635225
- Cited by
- 139
- References
- 51
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS048595)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Lewy body pathology, familial Alzheimer's disease, presenilin 1 mutations, alpha-synuclein, amygdala, brainstem, neocortex, limbic cortex
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Brain, Female, Genotype, Humans, Immunohistochemistry, Male, Membrane Proteins, Middle Aged, Mutation, Neuropsychological Tests, Neurites, Lewy Bodies, alpha-Synuclein, Presenilin-1, Presenilin-2
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