The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Association of Dopamine Agonist Use With Impulse Control Disorders in Parkinson Disease
Open accessAbstract
OBJECTIVE: To determine the frequency and correlates of impulse control disorders (ICDs) in Parkinson disease (PD). DESIGN: An unstructured screening interview for ICDs (compulsive gambling, buying, and sexual behavior) followed by a telephone-administered structured interview for screen-positive patients. SETTING: Two university-affiliated movement disorders centers. PARTICIPANTS: A convenience sample of 272 patients with idiopathic PD who were screened for psychiatric complications. MAIN OUTCOME MEASURES: Presence of compulsive gambling, buying, or sexual behavior as assessed by the Minnesota Impulsive Disorders Interview. RESULTS: Eighteen patients (6.6%) with PD met criteria for an ICD at some point during the course of PD, including 11 (4.0%) with an active ICD. Compulsive gambling and compulsive sexual behavior were equally common. In a multivariate model, treatment with a dopamine agonist (P = .01) and a history of ICD symptoms prior to PD onset (P = .02) predicted current ICD. There were no differences between the dopamine agonists in their association with ICDs (P = .21), and daily doses of dopamine agonists were higher in patients with an ICD than in dopamine agonist-treated patients without an ICD (P < .001). CONCLUSIONS: Patients with PD treated with a dopamine agonist should be made aware of the risk of developing an ICD and monitored clinically. Because dopamine agonists are increasingly being used for other indications, future research should assess the dopamine agonist-associated risk for ICDs in other populations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“impulse-control disorder (ICD) development in PD patients has been associated with dopamine agonist pharmacotherapy (Weintraub et al., 2006”
From Remote delivery of psychological interventions for Parkinson's disease. (2018) · cites this paper as Weintraub et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
Sheikh (1986) · doi:10.1300/j018v05n01_09 · Cited by 7,236
An algorithm (decision tree) for the management of Parkinson’s disease (2001):
Olanow, C. W., Watts, R. L., & Koller, W. C. (2001) · Neurology · doi:10.1212/wnl.56.suppl_5.s1 · Cited by 724
Compulsive buying: descriptive characteristics and psychiatric comorbidity.
Ga, C., Faber, R., de Zwaan, M., Raymond, N. C., Sm, S., Ekern, Tb, M., Crosby, R. D., Sj, C., & Ed, E. (1994) · PubMed · Cited by 664
Giovannoni, G. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.4.423 · Cited by 587
Pathological Gambling Caused by Drugs Used to Treat Parkinson Disease
Dodd, M. L., Klos, K. J., Bower, J. H., Geda, Y. E., Josephs, K. A., & Ahlskog, J. E. (2005) · Archives of Neurology · doi:10.1001/archneur.62.9.noc50009 · Cited by 563
Flagged first, then by citations
Research works printed but not linked: 2
- [4]American Psychiatric Association. Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association; 2000. Diagnostic and Statistical Manual of Mental Disorders. [Google Scholar]
- [6]Tyne HL, Medley G, Ghadiali E, Steigner MJ. Gambling in Parkinson’s disease. Movement Disorders. 2004;19(suppl 9):S195. [Google Scholar]
Cited by
Sorted by citations
Items 101–200 of 661
Improving Response Inhibition in Parkinson’s Disease with Atomoxetine
Ye, Z., Altena, E., Nombela, C., Housden, C. R., Maxwell, H., Rittman, T., Huddleston, C., Rae, C. L., Regenthal, R., Sahakian, B. J., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.024 · Cited by 114
The risky business of dopamine agonists in Parkinson disease and impulse control disorders.
Claassen, D. O., van den Wildenberg, W. P. M., Ridderinkhof, K. R., Jessup, C. K., Harrison, M. B., Wooten, G. F., & Wylie, S. A. (2011) · Behavioral Neuroscience · doi:10.1037/a0023795 · Cited by 104
“DAA doses were converted to levodopa equivalent daily dose (LEDD) values (Weintraub et al., 2006).”
How central is dopamine to pathological gambling or gambling disorder?
Potenza, M. N. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00206 · Cited by 107
“However, factors seemingly unrelated to dopamine (e.g., age of PD onset, marital status and geographic location) have also been associated with these conditions in PD (Voon et al., 2006; Weintraub et al., 2006, 2010; Potenza et al., 2007), highlighting the complicated etiologies of these disorders.”
BackgroundSelf-citationImpulsivity and apathy in Parkinson's disease
Sinha, N., Manohar, S., & Husain, M. (2013) · Journal of Neuropsychology · doi:10.1111/jnp.12013 · Cited by 125
“…agonists is now recognized as the strongest risk factor for ICDs in PD (Driver-Dunckley, Samanta, & Stacy, 2003; Grosset et al., 2006; Voon et al., 2006; Weintraub et al., 2006), while l-dopa may confer an independent risk (Weintraub, Koester et al., 2010; but see Grosset, Cardoso, & Lees, 2011).”
BackgroundMacDonald, H. J., Kleppe, R., Szigetvari, P. D., & Haavik, J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1492126 · Cited by 124
Impulse Control and Related Disorders in Parkinson's Disease
Lim, S., Evans, A. H., & Miyasaki, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1444.006 · Cited by 99
Allen, R. P., Chen, C., Soaita, A., Wohlberg, C. J., Knapp, L. E., Peterson, B. T., Garcı́a-Borreguero, D., & Miceli, J. J. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.03.003 · Cited by 100
“Moreover, experience with long-term use of dopaminergic agents in managing RLS has revealed significant problems with early morning rebound of symptoms, augmentation, and the development of compulsive/ impulsive behaviors [9–14].”
BackgroundInsights into pathophysiology of punding reveal possible treatment strategies
Fasano, A. A., & Petrovic, I. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.95 · Cited by 100
Ambermoon, P., Carter, A., Hall, W., Dissanayaka, N. N., & O’Sullivan, J. D. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03218.x · Cited by 99
“Prior history of impulsive behaviour A history of impulsive behaviour has been reported in approximately one-third (19 of 64) of patients with an ICD [23,25,26,31,39].”
BackgroundResultInfluentialConversano, C., Marazziti, D., Carmassi, C., Baldini, S., Barnabei, G., & Dell’Osso, L. (2012) · Harvard Review of Psychiatry · doi:10.3109/10673229.2012.694318 · Cited by 104
Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease
Potenza, M. N., Voon, V., & Weintraub, D. A. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0680 · Cited by 94
Self-citationBarrus, M. M., & Winstanley, C. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2225-15.2016 · Cited by 93
“, 2005) and in the iatrogenic development of GD in parkinsonian patients (Weintraub et al., 2006), choice patterns on the rGT are not predominantly driven by the dopamine system.”
BackgroundSexual dysfunction in Parkinson's disease
Meco, G., Rubino, A., Caravona, N., & Valente, M. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.10.008 · Cited by 94
Behavioural Adverse Effects of Dopaminergic Treatments in Parkinsonʼs Disease
Antonini, A., & Cilia, R. (2009) · Drug Safety · doi:10.2165/00002018-200932060-00004 · Cited by 94
Pramipexole modulates the neural network of reward anticipation
Ye, Z., Hammer, A., Càmara, E., & Münte, T. F. (2010) · Human Brain Mapping · doi:10.1002/hbm.21067 · Cited by 101
“Pramipexole and other dopamine agonists have been reported to cause pathological gambling, an impulse control disorder creating serious life problems for afflicted individuals [Dodd et al., 2005; Weintraub et al., 2006].”
BackgroundImpact of Newer Pharmacological Treatments on Quality of Life in Patients with Parkinson???s Disease
Gallagher, D. A., & Schrag, A. E. (2008) · CNS Drugs · doi:10.2165/00023210-200822070-00003 · Cited by 97
Impulse control disorders in Parkinson's disease: prevalence and possible risk factors
Weintraub, D. A. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70794-1 · Cited by 90
“Second, the reported values for all disorders may underestimate the true frequencies, as some studies relied on information documented in charts during routine clinical care, and in one of the aforementioned screening studies [20] active ICD cases were rarely documented in the clinical record.”
BackgroundResultInfluentialSelf-citationCognitive dysfunctions and pathological gambling in patients with Parkinson's disease
Santangelo, G., Vitale, C., Trojano, L., Verde, F., Grossi, D., & Barone, P. (2009) · Movement Disorders · doi:10.1002/mds.22472 · Cited by 89
Medical Management of Parkinson’s Disease
Encarnacion, E. V., & Hauser, R. A. (2009) · Springer eBooks · doi:10.1007/978-3-540-69960-6_90 · Cited by 89
Remote delivery of psychological interventions for Parkinson's disease.
Swalwell, C., Pachana, N. A., & Dissanayaka, N. N. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218000340 · Cited by 87
Wang, S. Z., Yan, J.-Y., Lo, Y.-K., Carvey, P. M., & Ling, Z. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.022 · Cited by 86
“…compared to the SN DA neurons despite clinical presentations (e.g. pathological gambling and impulse control disorders) suggesting mesolimbic and mesocortical involvements (Stocchi and Brusa, 2000; Weintraub et al., 2006; Perretta et al., 2005; Torta and Castelli, 2008; Bertrand et al., 1996).”
BackgroundPettorruso, M., Martinotti, G., Fasano, A. A., Loria, G., Nicola, M. D., Risio, L. D., Ricciardi, L., Conte, G., Janiri, L., & Bentivoglio, A. R. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.12.013 · Cited by 88
“E-mail address: mauro.pettorruso@hotmail.it (M. Pettorruso). studies, ICDs were strongly associated with the use of dopamine agonists in general, without associations with specific molecules (Weintraub et al., 2006, 2010; Voon et al., 2011).”
BackgroundParallel Roles for Dopamine in Pathological Gambling and Psychostimulant Addiction
Zack, M. H., & Poulos, C. X. (2009) · Current Drug Abuse Reviews · doi:10.2174/1874473710902010011 · Cited by 87
“In addition, DA agonists often promote excessive-compulsive behaviors apart from PG, including compulsive sexual behavior and in some cases, alcohol abuse [134,135].”
BackgroundParkinson’s disease-related disorders in the impulsive-compulsive spectrum
Wolters, E. C., van der Werf, Y. D., & van den Heuvel, O. A. (2008) · Journal of Neurology · doi:10.1007/s00415-008-5010-5 · Cited by 85
Pathological gambling in Parkinson's disease. A comprehensive review.
Santangelo, G., Barone, P., Trojano, L., & Vitale, C. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.02.007 · Cited by 88
Behavioral effects of levodopa
Beaulieu‐Boire, I., & Lang, A. E. (2014) · Movement Disorders · doi:10.1002/mds.26121 · Cited by 83
Obeso, I., Wilkinson, L., & Jahanshahi, M. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2793-x · Cited by 91
“agonist medication for the treatment of the motor symptoms of the disorder (Weintraub et al. 2006; Evans et al. 2009).”
BackgroundZahodne, L. B., Susatia, F., Bowers, D., Ong, T. L., Jacobson, C. E., Okun, M. S., Rodriguez, R. L., Malaty, I. A., Foote, K. D., & Fernandez, H. H. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.1.56 · Cited by 86
Piray, P., Zeighami, Y., Bahrami, F., Eissa, A. M., Hewedi, D. H., & Moustafa, A. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4063-13.2014 · Cited by 85
“In addition, Weintraub et al. (2006) investigated ICD in a large sample of PD patients and reported that those with ICDs were more likely to have had ICDs before the onset of PD.”
BackgroundResultBiundo, R., Formento‐Dojot, P., Facchini, S., Vallelunga, A., Ghezzo, L., Foscolo, L., Meneghello, F., & Antonini, A. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.08.001 · Cited by 80
“We also confirmed evidence pointing to patient's age as robust risk factor for the development of impulsive behaviours [7,46,47] but did not support the male predisposition for ICDs.”
Enhanced creative thinking under dopaminergic therapy in Parkinson disease
Faust‐Socher, A., Kenett, Y. N., Cohen, O. S., Hassin‐Baer, S., & Inzelberg, R. (2014) · Annals of Neurology · doi:10.1002/ana.24181 · Cited by 82
“In addition to other ICD features, patients suffering from DDS tend to overuse dopaminergic therapy.(13) It was debated that obsessive drawing or writing might be interpreted as another ICD associated with dopaminergic therapy.”
BackgroundDopamine Agonists and the Suppression of Impulsive Motor Actions in Parkinson Disease
Wylie, S. A., Claassen, D. O., Huizenga, H. M., Schewel, K. D., Ridderinkhof, K. R., Bashore, T. R., & van den Wildenberg, W. P. M. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00241 · Cited by 76
“Dosages for the dopamine medications were converted to levodopa equivalent daily dose (LEDD) values (Weintraub et al., 2006).”
BackgroundHuman behavioral assessments in current research of Parkinson’s disease
Asakawa, T., Fang, H., Sugiyama, K., Nozaki, T., Kobayashi, S. S., Hong, Z., Suzuki, K., Mori, N., Yang, Y., Hua, F., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.036 · Cited by 75
Caregiver Burden and the Nonmotor Symptoms of Parkinson's Disease
Hiseman, J. P., & Fackrell, R. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.035 · Cited by 82
Barake, M., Evins, A. E., Stoeckel, L. E., Pachas, G. N., Nachtigall, L. B., Miller, K. K., Biller, B. M. K., Tritos, N. A., & Klibanski, A. (2013) · Pituitary · doi:10.1007/s11102-013-0480-6 · Cited by 74
“In PD, no association was found between the specific DA used and the occurrence of an ICD [5, 20].”
BackgroundPapay, K., Mamikonyan, E., Siderowf, A. D., Duda, J. E., Lyons, K. E., Pahwa, R., Driver‐Dunckley, E. D., Adler, C. H., & Weintraub, D. A. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.11.015 · Cited by 73
“Thus, ICD behaviors are currently under-recognized and under-managed in clinical practice [5].”
BackgroundSelf-citationSingh, A., Kandimala, G., Dewey, R. B., & O’Suilleabhain, P. E. (2007) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2007.01.009 · Cited by 73
Decision making under risk and under ambiguity in Parkinson's disease
Delazer, M., Sinz, H., Zamarian, L., Stockner, H., Seppi, K., Wenning, G. K., Benke, T., & Poewe, W. H. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.02.034 · Cited by 72
“…medication in PD increases the frequency of impulse control disorders (for a review see Voon, Potenza, & Thomsen, 2007), which are associated with excessive gambling in a subgroup of PD patients (e.g., Drapier et al., 2006; Grosset et al., 2006; Molina et al., 2000; Weintraub et al., 2006).”
BackgroundIntertemporal choice in Parkinson's disease
Milenkova, M., Mohammadi, B., Kollewe, K., Schrader, C., Fellbrich, A., Wittfoth, M., Dengler, R., & Münte, T. F. (2011) · Movement Disorders · doi:10.1002/mds.23756 · Cited by 72
Impulse control disorders in Parkinson's disease in a Chinese population
Fan, W., Ding, H., Ma, J., & Chan, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.074 · Cited by 72
Impulse control disorders in Parkinson disease and RBD
Baig, F., Kelly, M. J., Lawton, M., Ruffmann, C., Rolinski, M., Klein, J. C., Barber, T. R., Lo, C., Ben‐Shlomo, Y., Okai, D., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007942 · Cited by 71
Impulse Control Disorders and Pathological Gambling in Patients With Parkinson Disease
Stamey, W., & Jankovic, J. J. (2008) · The Neurologist · doi:10.1097/nrl.0b013e31816606a7 · Cited by 68
“Premortem mood dysfunction in Huntington chorea has been found to correlate more with striosome loss than with matrix.92 No postmortem studies, however, have been performed in PD patients with and without ICD and PG.”
BackgroundInfluentialDemetriades, P., Rickards, H. E., & Cavanna, A. E. (2011) · Parkinson s Disease · doi:10.4061/2011/658415 · Cited by 68
“This is consistent with previous studies showing that patients with young onset PD are more likely to present with ICDs [34], findings which may reflect a confounding effect of prescribing of dopamine agonists to younger PD patients [35].”
McKeon, A. B., Josephs, K. A., Klos, K. J., Hecksel, K. A., Bower, J. H., Bostwick, J. M., & Ahlskog, J. E. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.04.004 · Cited by 67
Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease
Quattrone, A., Bagnato, A., Annesi, G., Novellino, F., Morgante, L., Savettieri, G., Zappia, M., Tarantino, P., Candiano, I. C. C., Annesi, F., et al. (2007) · Movement Disorders · doi:10.1002/mds.21701 · Cited by 66
Madden, G. J., Smith, N. G., Brewer, A. T., Pinkston, J. W., & Johnson, P. S. (2008) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2008.90-333 · Cited by 65
“…evidence suggests that Parkinson patients treated with selective D2/D3 dopamine agonists are at greater risk of developing impulse control disorders such as hypersexuality, compulsive shopping, and pathological gambling (Dodd et al., 2005; Lu, Bharmal, & Suchowersky, 2006; Weintraub et al., 2006).”
BackgroundNakum, S., & Cavanna, A. E. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.02.017 · Cited by 70
Compulsive habits in restless legs syndrome patients under dopaminergic treatment
Pourcher, E., Rémillard, S., & Cohen, H. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.010 · Cited by 64
“Recent reports have enlightened the possible induction by dopaminergic drugs, particularly DA agonists, of compulsive behavior in idiopathic PD [11–18] and also in RLS [19,20].”
BackgroundImpact of Sex on the Nonmotor Symptoms and the Health-Related Quality of Life in Parkinson’s Disease
Kovács, M. Á., Makkos, A., Aschermann, Z., Janszky, J., Komoly, S., Weintraut, R., Karádi, K., & Kovács, N. (2016) · Parkinson s Disease · doi:10.1155/2016/7951840 · Cited by 67
“In agreement with some studies [65, 66] and in opposition to other papers [67, 68], we did not find significant differences in the prevalence of global ICD symptoms between both sexes.”
ResultParkinson disease: Not just a movement disorder
Pandya, M. A., Kubu, C. S., & Giroux, M. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75a.07005 · Cited by 62
Antonini, A., Chaudhuri, К. R., Boroojerdi, B., Asgharnejad, M., Bauer, L., Grieger, F., & Weintraub, D. A. (2016) · European Journal of Neurology · doi:10.1111/ene.13078 · Cited by 62
“The Minnesota Impulsive Disorders Interview (MIDI) is a screening tool used to monitor the presence of ICDs; the MIDI or modified versions have been used previously in studies of patients with PD [2,11,14,24].”
MethodSelf-citationEisinger, R. S., Ramirez‐Zamora, A., Carbunaru, S., Ptak, B., Peng-Chen, Z., Okun, M. S., & Gunduz, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00086 · Cited by 62
“For instance, a history of ICDs prior to PD diagnosis is a contributing risk factor for the development of ICDs after dopamine agonist use for PD treatment (11).”
BackgroundSafety and Tolerability of Pharmacotherapies for Parkinson’s Disease in Geriatric Patients
Klietz, M., Greten, S., Wegner, F., & Höglinger, G. U. (2019) · Drugs & Aging · doi:10.1007/s40266-019-00654-z · Cited by 63
Parkinsonism and Related Disorders
Slow, E., & Lang, A. E. (2019) · DeckerMed Transitional Year Weekly Curriculum™ · doi:10.2310/tywc.1178 · Cited by 62
Optogenetics and its application in neural degeneration and regeneration
Xu, X., Ordaz, J. D., & Wu, W. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.213532 · Cited by 63
“However, these therapies have many potential side effects such as: nausea, constipation, orthostasis, psychosis, impulse control disorders, depression, and mania (Weintraub et al., 2006; Temel, 2010; Connolly and Lang, 2014).”
BackgroundThe role of dopamine pharmacotherapy and addiction-like behaviors in Parkinson’s disease
Napier, T. C., Kirby, A. E., & Persons, A. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109942 · Cited by 60
Resting-state brain networks in patients with Parkinson's disease and impulse control disorders
Tessitore, A., Santangelo, G., Micco, R. D., Giordano, A., Raimo, S., Amboni, M., Esposito, F., Barone, P., Tedeschi, G., & Vitale, C. (2017) · Cortex · doi:10.1016/j.cortex.2017.06.008 · Cited by 60
Predictors of punding in Parkinson's disease: Results from a questionnaire survey
Lawrence, A. J., Blackwell, A. D., Barker, R. A., Spagnolo, F., Clark, L., Aitken, M. R. F., & Sahakian, B. J. (2007) · Movement Disorders · doi:10.1002/mds.21702 · Cited by 59
Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
Heldmann, M., Berding, G., Voges, J., Bogerts, B., Galazky, I., Müller, U., Baillot, G., Heinze, H., & Münte, T. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036572 · Cited by 60
“A similar behavioral pattern is known from Parkinson patients treated with drugs affecting dopaminergic D2/D3 receptors [21,22] known to give rise to a number of impulse control disorders [21] but also from Figure 1.”
BackgroundRelating mode of action to clinical practice: Dopaminergic agents in Parkinson's disease
Riederer, P. F., Gerlach, M., Müller, T. H., & Reichmann, H. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.06.015 · Cited by 59
“Similarly, case reports of impulse control disorders have been associated with these newer agents [133–137].”
BackgroundColeman, E., Dickenson, J. A., Girard, A., Rider, G. N., Candelario-Pérez, L. E., Becker-Warner, R., Kovic, A. G., & Munns, R. (2018) · Sexual Addiction & Compulsivity · doi:10.1080/10720162.2018.1515050 · Cited by 57
“…has been associated with reward and modulation of positive affect, has been implied in the onset of hypersexual behavior (Callesen, Scheel-Kr€uger, Kringelbach, & Møller, 2013; Cooper et al., 2009; Evans, Strafella, Weintraub, & Stacy, 2009; Politis et al., 2013; Weintraub et al., 2006, 2010).”
BackgroundThe role of dopamine in risk taking: a specific look at Parkinson’s disease and gambling
Clark, C. A., & Dagher, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00196 · Cited by 69
“663 Quickfall, J., and Suchowersky, O. (2007). Pathological gambling associated with”
BackgroundBrain circuitry of compulsivity and impulsivity
Grant, J. E., & Kim, S. W. (2013) · CNS Spectrums · doi:10.1017/s109285291300028x · Cited by 61
“These medications have been hypothesized to result in impulsivity (for example, gambling disorder) in some vulnerable patients.(26) Although less reported than the impulsive behaviors, punding (a stereotyped, repetitive, purposeless behavior that could be best characterized as a compulsion) has also been reported as r…”
BackgroundAtomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease
Borchert, R. J., Rittman, T., Passamonti, L., Ye, Z., Sami, S. A. K., Jones, S. P., Nombela, C., Rodríguez, P. V., Vatansever, D., Rae, C. L., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.18 · Cited by 63
“Dopaminergic therapy does not satisfactorily restore executive functions in PD (Weintraub et al, 2006; Rowe et al, 2008), due in part to deficits in non-dopaminergic systems.”
Impulse-Control Disorders in Parkinson's Disease
Ferrara, J. M., & Stacy, M. A. (2008) · CNS Spectrums · doi:10.1017/s1092852900013778 · Cited by 57
“Whereas disruptive or compulsive behaviors appear to be linked to levodopa replacement therapy, destructive behaviors are more often associated with behavioral addiction, predominantly in PD patients using dopamine agonists [8,12].”
BackgroundDopaminergic signaling of uncertainty and the aetiology of gambling addiction
Zack, M. H., George, R. S., & Clark, L. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109853 · Cited by 62
Castagnola, E., Garg, R., Rastogi, S. K., Cohen‐Karni, T., & Cui, X. T. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113440 · Cited by 56
Impulsive and Compulsive Behaviors in Parkinson’s Disease: The Norwegian ParkWest Study
Erga, A. H., Alves, G. W., Larsen, J. P., Tysnes, O., & Pedersen, K. F. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160977 · Cited by 56
Wu, K., Politis, M., & Piccini, P. (2009) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.075820 · Cited by 55
Randomized, controlled trial of rasagiline as an add‐on to dopamine agonists in Parkinson's disease
Hauser, R. A., Silver, D. E., Choudhry, A., Eyal, E., Isaacson, S., & for the ANDANTE study investigators (2014) · Movement Disorders · doi:10.1002/mds.25877 · Cited by 55
Parkinson's disease--Part 3: Neuropsychiatric symptoms.
Weintraub, D. A., Comella, C. L., & Horn, S. S. (2008) · PubMed · Cited by 55
Self-citationValença, G. T., Glass, P. G., Negreiros, N. N., Duarte, M. B., Ventura, L. M. G. B., Mueller, M., & Filho, J. O. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.03.004 · Cited by 55
Current Status of Symptomatic Medical Therapy in Parkinson’s Disease
Factor, S. A. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2007.12.001 · Cited by 55
“Once there is degeneration or loss of presynaptic neurons, however, it becomes a potent postsynaptic receptor stimulator, and it was these findings that led to its use in PD.”
BackgroundInfluentialWhen and how should treatment be started in Parkinson disease?
Lang, A. E. (2009) · Neurology · doi:10.1212/wnl.0b013e318198e177 · Cited by 55
Extrastriatal dopaminergic changes in Parkinson's disease patients with impulse control disorders
Lee, J., Seo, S. H., Kim, Y. K., Yoo, H. B., Kim, Y. E., Song, I. C., Lee, J., & Jeon, B. S. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305549 · Cited by 55
Sexuality in patients with Parkinson's disease, Alzheimer's disease, and other dementias
Bronner, G., Aharon‐Peretz, J., & Hassin‐Baer, S. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63247-0.00017-1 · Cited by 56
A Combination of Dopamine Genes Predicts Success by Professional Wall Street Traders
Sapra, S., Beavin, L. E., & Zak, P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030844 · Cited by 54
“Evidence from Parkinson’s disease patients also shows an association between treatment with dopamine agonists and risk-taking and impulse control disorders [25,26].”
BackgroundClaassen, D. O., van den Wildenberg, W. P. M., Harrison, M. B., van Wouwe, N. C., Kanoff, K. E., Neimat, J. S., & Wylie, S. A. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.017 · Cited by 60
“All dopamine medications were converted to levodopa daily dose equivalent (LEDD) using previously reported formulas (Weintraub et al., 2006).”
Cognitive Impairment in Parkinson’s Disease and Dementia with Lewy Bodies: A Spectrum of Disease
Gross, R. G., Siderowf, A. D., & Hurtig, H. I. (2007) · Neurosignals · doi:10.1159/000109756 · Cited by 53
Self-citationDang, D., Cunnington, D., & Swieca, J. (2011) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31820d6699 · Cited by 53
Qamar, M. A., Sauerbier, A., Politis, M., Carr, H. J., Loehrer, P. A., & Chaudhuri, К. R. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-016-0006-9 · Cited by 53
Depression as a Risk Factor for Impulse Control Disorders in Parkinson Disease
Marín‐Lahoz, J., Sampedro, F., Martínez‐Horta, S., Pagonabarraga, J., & Kulisevsky, J. (2019) · Annals of Neurology · doi:10.1002/ana.25581 · Cited by 53
“They are related to PD treatment, particularly to dopamine agonists (DAs).(10) This association with DAs makes ICDs a potentially avoidable disorder.”
BackgroundResultJimenez‐Gomez, C., Osentoski, A., & Woods, J. H. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32834afebe · Cited by 52
“This study was designed to assess whether, as observed with humans (e.g. Weintraub et al., 2006), pramipexole would produce dose-dependent increases in compulsive behavior.”
Treatment of early Parkinson's disease
Pahwa, R., & Lyons, K. E. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000113 · Cited by 52
Dopamine agonist‐induced pathological gambling in restless legs syndrome due to multiple sclerosis
Evans, A. H., & Butzkueven, H. (2007) · Movement Disorders · doi:10.1002/mds.21303 · Cited by 52
Psychosocial issues in young-onset Parkinson's disease: Current research and challenges
Calne, S. M., Lidstone, S. C., & Kumar, A. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.07.012 · Cited by 52
“Another study found that pathological gambling and hypersexuality were equally common [44].”
BackgroundPrevalence of Problem and Pathological Gambling in Parkinson’s Disease
Crockford, D. N., Quickfall, J., Currie, S. R., Furtado, S., Suchowersky, O., & el‐Guebaly, N. (2008) · Journal of Gambling Studies · doi:10.1007/s10899-008-9099-3 · Cited by 51
Orío, L., Wee, S., Newman, A. H., Pulvirenti, L., & Koob, G. F. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00211.x · Cited by 52
“For example, a tendency towards impulsive behavior and emergence of psychotic reactions, two sideeffects associated with repeated administration of dopamine agonists in patients (Wolters 1999; Weintraub et al. 2006), are likely to be important limiting factors in addiction therapy.”
BackgroundImpulse-Control Disorders in Parkinson’s Disease: A Meta-Analysis and Review of Case–Control Studies
Molde, H., Moussavi, Y., Kopperud, S. T., Erga, A. H., Hansen, A. L., & Pallesen, S. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00330 · Cited by 52
Fenu, S., Wardas, J., & Morelli, M. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833109a0 · Cited by 49
Sharma, A., Goyal, V., Behari, M., Srivastva, A., Shukla, G., & Vibha, D. (2014) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.144311 · Cited by 51
Neuropsychiatry of Parkinson's disease
Kümmer, A., & Teixeira, A. L. (2009) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2009000500033 · Cited by 49
van Wouwe, N. C., Kanoff, K. E., Claassen, D. O., Spears, C. A., Neimat, J. S., van den Wildenberg, W. P. M., & Wylie, S. A. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00930 · Cited by 52
“Dosages for the dopamine medications were converted to levodopa equivalent daily dose (LEDD) values (Weintraub et al., 2006).”
Shotbolt, P., Moriarty, J., Costello, A. D. L., Jha, A., David, A. S., Ashkan, K., & Samuel, M. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.08.016 · Cited by 48
“These figures are considerably higher than the earlier published figures of 6% in the general PD population [25,26].”
ResultAvailable and emerging treatments for Parkinson’s disease: a review
Stacy, M. A., Hickey, P., & Stacy, M. A. (2011) · Drug Design Development and Therapy · doi:10.2147/dddt.s11836 · Cited by 51
Long term follow-up of Parkinson's disease patients with impulse control disorders
Sohtaoğlu, M., Demiray, D. Y., Kenangıl, G., Özekmekçi, S., & Erginöz, E. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.02.006 · Cited by 48
“In fact, our findings and the previous studies suggest that the development of ICDs is associated with male predominance and early onset of PD [1,2,6,8,9,14,15].”
Pathological Gambling Associated With Aripiprazole or Dopamine Replacement Therapy
Grall‐Bronnec, M., Sauvaget, A., Perrouin, F., Leboucher, J., Etcheverrigaray, F., Challet‐Bouju, G., Gaboriau, L., Derkinderen, P., Jolliet, P., & Victorri‐Vigneau, C. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000444 · Cited by 48
Iowa Gambling Task in Parkinson's Disease
Poletti, M., Cavedini, P., & Bonuccelli, U. (2011) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2010.524150 · Cited by 48
“Finally, the topic of decision-making ability in PD patients is discussed in relation to the phenomenon of impulse control disorders (ICD), a psychiatric complication observed with increasing frequency in medicated PD patients ( Voon & Fox, 2007 ; Weintraub et al, 2006 ).”
BackgroundKieburtz, K. D., & The Parkinson Study Group PramiBID Investigators (2010) · Movement Disorders · doi:10.1002/mds.23396 · Cited by 47
“The MMIDI was used to classify a participant as screening positive for an impulse disorder using high and low thresholds in each of three categories: gambling, sexual behavior, and buying.(17,18) The Epworth Sleepiness Scale (ESS) at Week 12 was also analyzed as a dichotomous variable (<10, 10).”
MethodKim, Y. E., Kim, H. J., Kim, H., Lee, J., Yun, J. Y., Kim, J. Y., Paek, S.-H., & Jeon, B. S. (2013) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2012.07.020 · Cited by 47
“It is well known that mood disorders may be related with ICD.22 ICD may be caused by activation of the dopaminergic system, while depression may be associated with inactivation this system.23 In our study, changes in the depression score paralleled changes in ICRB, indicating that mood disorders may be related to ICRB.”
BackgroundInfluential
Metadata
- Authors
- Weintraub, D., Siderowf, A. D., Potenza, M. N., Goveas, J., Morales, K. H., Duda, J. E., Moberg, P. J., & Stern, M. B.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-07-01
- Volume
- 63
- Issue
- 7
- Pages
- 969
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC1761054
- OpenAlex
- W2035890213
- Cited by
- 662
- References
- 17
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 12 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 36 · 2019: 38 · 2018: 23 · 2017: 32 · 2016: 40 · 2015: 26 · 2014: 40 · 2013: 45 · 2012: 40
- FWCI
- 30.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K23MH067894)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- Parkinson's disease, impulse control disorders, dopamine agonists, gambling addiction, compulsive buying, compulsive sexual behavior, psychiatric complications, adverse drug reactions, risk factors, dose-response relationship
- MeSH terms
- Pramipexole, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Gambling, Humans, Disruptive, Impulse Control, and Conduct Disorders, Indoles, Male, Middle Aged, Parkinson Disease, Pergolide, Risk Factors, Sexual Behavior, Sexual Dysfunction, Physiological, Thiazoles, Logistic Models, Dopamine Agonists, Benzothiazoles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
